著者

Ibuki Fukuyama Takafumi Nakano

出版者

The Japanese Society of Soil Zoology

雑誌

Edaphologia (ISSN:03891445)

巻号頁・発行日

vol.103, pp.33-34, 2018 (Released:2019-11-30)

著者

Daisuke Yakabe Yusuke Fukuyama Masahiro Araki Toshihiro Nakamura

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.86, no.1, pp.167, 2021-12-24 (Released:2021-12-24)

参考文献数

1

被引用文献数

2

著者

Megumi Fukuyama Minoru Horie Koichi Kato Hisaaki Aoki Shuhei Fujita Yoko Yoshida Hisanori Sakazaki Takako Toda Michihiko Ueno Gaku Izumi Nobuo Momoi Jun Muneuchi Takeru Makiyama Yoshihisa Nakagawa Seiko Ohno

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0195, (Released:2023-06-28)

参考文献数

38

被引用文献数

1

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Background: Cardiac calmodulinopathy, characterized by a life-threatening arrhythmia and sudden death in the young, is extremely rare and caused by genes encoding calmodulin, namely calmodulin 1 (CALM1), CALM2, and CALM3.Methods and Results: We screened 195 symptomatic children (age 0–12 years) who were suspected of inherited arrhythmias for 48 candidate genes, using a next-generation sequencer. Ten probands were identified as carrying variants in any of CALM1–3 (5%; median age 5 years), who were initially diagnosed with long QT syndrome (LQTS; n=5), catecholaminergic polymorphic ventricular tachycardia (CPVT; n=3), and overlap syndrome (n=2). Two probands harbored a CALM1 variant and 8 probands harbored 6 CALM2 variants. There were 4 clinical phenotypes: (1) documented lethal arrhythmic events (LAEs): 4 carriers of N98S in CALM1 or CALM2; (2) suspected LAEs: CALM2 p.D96G and D132G carriers experienced syncope and transient cardiopulmonary arrest under emotional stimulation; (3) critical cardiac complication: CALM2 p.D96V and p.E141K carriers showed severe cardiac dysfunction with QTc prolongation; and (4) neurological and developmental disorders: 2 carriers of CALM2 p.E46K showed cardiac phenotypes of CPVT. Beta-blocker therapy was effective in all cases except cardiac dysfunction, especially in combination with flecainide (CPVT-like phenotype) and mexiletine (LQTS-like).Conclusions: Calmodulinopathy patients presented severe cardiac features, and their onset of LAEs was earlier in life, requiring diagnosis and treatment at the earliest age possible.

著者

Satoru Sasaki Hiroyuki Kawamori Takayoshi Toba Ryo Takeshige Yusuke Fukuyama Takashi Hiromasa Hiroyuki Fujii Tomoyo Hamana Yuto Osumi Seigo Iwane Tetsuya Yamamoto Shota Naniwa Yuki Sakamoto Koshi Matsuhama Yuta Fukuishi Toshiro Shinke Ken-ichi Hirata Hiromasa Otake

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0312, (Released:2023-10-07)

参考文献数

20

被引用文献数

2

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Background: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86.Conclusions: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.

著者

Ban Hiroshi Yamamoto Hiroki Hanakawa Takashi Urayama Shin-Ichi Aso Toshihiko Fukuyama Hidenao Ejima Yoshimichi

出版者

The Society for Neuroscience

雑誌

The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:02706474)

巻号頁・発行日

vol.33, no.43, pp.16992-17007, 2013-10-23

被引用文献数

35

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モノの背後を見る脳の仕組みを解明 -視対象の部分像から全体像を復元する第1次視覚野の活動をfMRIで観察-. 京都大学プレスリリース. 2013-10-23.

著者

Noriaki Fukuyama

出版者

The Botanical Society of Japan

雑誌

植物学雑誌 (ISSN:0006808X)

巻号頁・発行日

vol.49, no.583, pp.438-444, 1935 (Released:2007-05-24)

著者

Mari Ichikawa Takeshi Aiba Seiko Ohno Daichi Shigemizu Junichi Ozawa Keiko Sonoda Megumi Fukuyama Hideki Itoh Yoshihiro Miyamoto Tatsuhiko Tsunoda Takeru Makiyama Toshihiro Tanaka Wataru Shimizu Minoru Horie

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0486, (Released:2016-10-25)

参考文献数

33

被引用文献数

1 17

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Background:Mutations inANK2have been reported to cause various arrhythmia phenotypes. The prevalence ofANK2mutation carriers in inherited primary arrhythmia syndrome (IPAS), however, remains unknown in Japanese. Using a next-generation sequencer, we aimed to identifyANK2mutations in our cohort of IPAS patients, in whom conventional Sanger sequencing failed to identify pathogenic mutations in major causative genes, and to assess the clinical characteristics ofANK2mutation carriers.Methods and Results:We screened 535 probands with IPAS and analyzed 46 genes including wholeANK2exons using a bench-top NGS (MiSeq, Illumina) or performed whole-exome-sequencing using HiSeq2000 (Illumina). As a result, 12 of 535 probands (2.2%, aged 0–61 years, 5 males) were found to carry 7 different heterozygousANK2mutations.ANK2-W1535R was identified in 5 LQTS patients and 1 symptomatic BrS and was predicted as damaging by multiple prediction software. In total, as to phenotype, there were 8 LQTS, 2 BrS, 1 IVF, and 1 SSS/AF. Surprisingly, 4/8 LQTS patients had the acquired type of LQTS (aLQTS) and suffered torsades de pointes. A total of 7 of 12 patients had documented malignant ventricular tachyarrhythmias.Conclusions:VariousANK2mutations are associated with a wide range of phenotypes, including aLQTS, especially with ventricular fibrillation, representing “ankyrin-B” syndrome.

著者

Masao Yoshinaga Yumiko Ninomiya Yuji Tanaka Megumi Fukuyama Koichi Kato Seiko Ohno Minoru Horie Hiromitsu Ogata

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0409, (Released:2023-12-01)

参考文献数

32

被引用文献数

1

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Background: This study was performed to clarify the clinical findings of pediatric patients diagnosed with long QT syndrome (LQTS) through electrocardiographic screening programs and to predict their outcome using Holter electrocardiographic approaches.Methods and Results: This retrospective study included pediatric patients with a Schwartz score of ≥3.5 who visited the National Hospital Organization Kagoshima Medical Center between April 2005 and March 2019. Resting 12-lead and Holter electrocardiograms were recorded at every visit. The maximum resting QTc and maximum Holter QTc values among all recordings were used for statistical analyses. To test the prognostic value of QTc for the appearance of cardiac events after the first hospital visit, receiver operating characteristic curves were used to calculate the area under the curve (AUC). Among 207 patients, 181 (87%) were diagnosed through screening programs. The prevalence of cardiac events after the first hospital visit was 4% (8/207). Among QTc at diagnosis, maximum resting QTc, and maximum Holter QTc, only maximum Holter QTc value was a predictor (P=0.02) of cardiac events after the hospital visit in multivariate regression analysis. The AUC of the maximum Holter QTc was significantly superior to that of maximum resting QTc.Conclusions: The maximum Holter QTc value can be used to predict the appearance of symptoms in pediatric patients with LQTS.

著者

Yuta NISHIYAMA Yasuhiro FUKUYAMA Takuya MARUO Shinichiro YODA Masataka IWANO Shinpei KAWARAI Hideki KAYANUMA Kensuke ORITO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.21-0060, (Released:2021-06-18)

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Tegafur is a prodrug of fluoropyrimidine 5-fluorouracil (5-FU), while TS-1TM is an oral fixed-dose combination of three active drugs, tegafur, gimeracil, and oteracil. This pilot study evaluated the safety of tegafur/gimeracil/oteracil in the treatment of cancers in dogs. Tegafur/gimeracil/oteracil was administered orally at a mean dose of 1.1 mg/kg twice daily on alternate days, Monday-Wednesday-Friday, every week to 11 dogs with tumors. Partial response and stable disease were observed in one dog each, whereas six exhibited progressive disease. Three dogs were not assessed. Adverse events, the most serious being grade 2, were noted in seven dogs. Adverse events were acceptable, and the drug was effective in some dogs. Therefore, tegafur/gimeracil/oteracil may be useful for treating malignant solid tumors in canines.

著者

Tomoko Suyama Shinobu Sugihara Ryuji Suyama Naoki Fukuyama Naoki Suyama Yuta Ito Ryota Seto Kaori Kinoshita Shihori Kitae Kinya Shirota

出版者

Tottori University Medical Press

雑誌

Yonago Acta Medica (ISSN:13468049)

巻号頁・発行日

vol.66, no.3, pp.345-354, 2023 (Released:2023-08-25)

参考文献数

36

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Background Transcatheter aortic valve implantation (TAVI) has recently become more common as a treatment for severe, symptomatic aortic stenosis (AS). Cognitive impairment (CI) is strongly associated with the prognosis of TAVI patients. However, some cognitive assessments currently in use are difficult to perform routinely in the clinical setting. To easier CI evaluation, we investigated whether CI using the clock-drawing test (CDT), one part of the Mini-Cog, affects the postoperative prognosis of TAVI patients with AS.Methods The present study enrolled 52 patients (median age, 85 years; 28.8% male) who underwent TAVI and were discharged between 2019 and 2021. The outcome was readmission for all causes within one year of discharge and patients were grouped according to whether they were readmitted or not. Cognitive function was assessed using the Mini-Cog which combines verbal playback and CDT.Results Of the 52, 11 patients (21.2%) comprised readmission group, including 4 (36.4%) each for fracture and infection, and 1 (9.1%) each for heart failure, subdural hematoma, and pneumothorax. Median Mini-Cog score was lower in the readmission group than in the non-readmission group (4 vs. 5; P < 0.05). The frequency of Mini-Cog score < 3 (indicative of CI) and CDT failure were significantly higher in the readmission group than in the non-readmission group, respectively (46% vs. 7%, P < 0.01) (46% vs. 12%, P < 0.05). Both of Mini-Cog score < 3 and CDT failure were independently associated with readmission. The areas under the curve showed CDT was an indicator of readmission with similar accuracy to the Mini-Cog score < 3. Kaplan-Meier curves showed significant differences in readmission after 1 year between the 2 Mini-Cog groups with scores of < 3 or ≥ 3 points and CDT failure and success.Conclusion The CDT may be a very easy and simple screening assessment of preoperative CI with readmission within one year after TAVI.

著者

Kenji Kawatoko Yasuyoshi Washio Tomoyuki Ohara Satoru Fukuyama Takanori Honda Jun Hata Taro Nakazawa Keiko Kan-o Hiromasa Inoue Koichiro Matsumoto Tomohiro Nakao Takanari Kitazono Isamu Okamoto Toshiharu Ninomiya

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230207, (Released:2023-12-02)

参考文献数

48

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Background: Studies on the association between preserved ratio impaired spirometry (PRISm) and dementia are limited. Indeed, PRISm has often been overlooked or ignored as an index of lung function impairment. Therefore, we investigated the association of PRISm with the risk for the development of dementia in an older Japanese population.Methods: A total of 1202 community-dwelling, older Japanese participants aged ≥65 years without dementia were followed up for a median of 5.0 years. Participants were categorized by spirometry as follows: normal spirometry (FEV1/FVC ≥0.70 and FEV1 ≥80% predicted), PRISm (≥0.70 and <80%), airflow limitation (AFL) Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2 to 4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazards model.Results: During the follow-up period, 122 participants developed dementia. The age- and sex-adjusted incidences of dementia in the participants with normal spirometry, PRISm, AFL GOLD 1, and AFL GOLD 2 to 4 were 20.5, 37.0, 18.4, and 28.6 per 1000 person-years, respectively. Participants with PRISm had a higher risk of dementia (HR 2.04 [95%CI, 1.19-3.49]) than those with normal spirometry after adjusting for confounders. Moreover, both reduced FEV1% predicted values and FVC% predicted values were associated with the risk for dementia.Conclusion: PRISm was associated with an increased risk of dementia in a general older Japanese population.

著者

Masahiro Fukuyama Yohei Sato Jun Hayakawa Manabu Ohyama

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

vol.66, no.1, pp.9-13, 2016 (Released:2017-03-25)

参考文献数

20

被引用文献数

3 4

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Cutaneous metaplastic synovial cysts (CMSCs) are rare tumors typically comprising a solitary, well-circumscribed cystic mass that is not connected to the joint. Synovial cysts have been reported predominantly by orthopedists or pathologists; however, the presence of CMSC is not generally well recognized by dermatologists. Herein, we report a CMSC in a 68-year-old woman receiving systemic corticosteroid therapy for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). We attempt to delineate the clinical characteristics of this unusual neoplasm by reviewing the literature, focusing especially on dermatological descriptions. Histologic examination of the surgical specimen in the current case revealed that the cystic wall was lined with layers of flattened synovial cell-like cells and connective tissues, mimicking the synovial membrane. Positive immunoreactivity of the lining cells against vimentin was detected, but no immunoreactivity against cytokeratin, carcinoembryonic antigen (CEA), CD68, or S-100 was detected. The pathogenesis of CMSC remains unclear, but it has been tightly linked to direct traumatic stimuli or relative tissue fragility, which potentially accounts for CMSC development in our case. Most CMSCs reported by dermatologists are located on the extremities, whereas those described by other specialists tend to be distributed more globally. Preoperative diagnoses are often either epidermal cyst or suture/foreign body granuloma. Incomplete surgical excision of usual synovial cysts may lead to local recurrence, which has been reported in oral and maxillofacial surgery, but not in dermatologic surgery. This fact could be explained by the technical difficulties of surgical excision related to anatomical location. Dermatologists need to be aware of CMSC, and CMSC should be included in the differential diagnosis of subcutaneous cysts.

著者

KAZUYUKI SOGAWA MIKA KOBAYASHI JUN SUZUKI AKIHIRO SANDA YOSHIO KODERA MASAFUMI FUKUYAMA

出版者

The Society for Antibacterial and Antifungal Agents, Japan

雑誌

Biocontrol Science (ISSN:13424815)

巻号頁・発行日

vol.23, no.2, pp.77-80, 2018 (Released:2018-06-16)

参考文献数

19

被引用文献数

2 4

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Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1.30 µg. These findings suggest that the water-soluble polyphenols contained in olives have inhibitory activity against SLO-induced hemolysis.

著者

Daiki FUKUYAMA Keiji SHINODA Daigo TAKAGI Yasuhiro KOBAYASHI

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.117, no.1, pp.220506, 2022 (Released:2022-10-18)

参考文献数

21

被引用文献数

2

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The compositional dependence of the intensity and electric field gradient (EFG) tensors for Fe2+ at the M1 sites, Fe2+ at the M2 sites, and Fe3+ at the M1 sites in Ca–rich pyroxene were obtained from Mössbauer spectra of crystallographically oriented single–crystal thin sections of four Ca–rich natural pyroxenes. Components of the intensity tensor (IXX, IYY, IXY, and IZZ) for Fe2+ at the M1 sites in Wo50 Ca–rich pyroxene were almost the same; the averages of the IXX, IYY, IXY, and IZZ components were 0.342, 0.477, 0.039, and 0.681, respectively. Intensity tensor for Fe2+ at the M1 sites of Wo40 Ca–rich pyroxene was different from the Wo50. Whereas principal axes of EFG tensors for Fe2+ at the M1 sites of Wo50 pyroxenes had the same direction, principal axes of VXX and VYY of EFG of Wo40 had different directions from that from Wo50. The difference of intensity and EFG tensors between Wo50 and Wo40 suggests that the intensity and EFG tensors for Fe2+ at M1 sites are dependent on the Ca contents and are independent of Fe contents. Some intensity and EFG tensors for Fe2+ at the M2 sites and Fe3+ at the M1 sites in Ca–rich pyroxene were also obtained. However, the compositional dependence of the intensity and EFG tensors has yet to be clarified, because the number of examples is insufficient.

著者

Yuichi Sawayama Takashi Yamamoto Yukinori Tomita Kohei Asada Noriaki Yagi Megumi Fukuyama Akashi Miyamoto Hiroshi Sakai Tomoya Ozawa Tetsuichiro Isono Daiki Hira Tomohiro Terada Minoru Horie Yoshihisa Nakagawa

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.84, no.9, pp.1575-1581, 2020-08-25 (Released:2020-08-25)

参考文献数

18

被引用文献数

5 13

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Background:The association between cytochrome P450 (CYP) 2C19 genotypes and adverse events in patients treated with clopidogrel or prasugrel after percutaneous coronary intervention (PCI) in the Japanese population is unclear.Methods and Results:This study consisted of 1,580 patients whoseCYP2C19genotypes were assessed at Shiga University of Medical Science Hospital, and 193 clopidogrel-treated and 217 prasugrel-treated patients who were followed more than 1 year after receiving PCI were analyzed. Among 1,580 patients, the prevalence of normal, intermediate, and poor metabolizers was 32%, 49%, and 17%, respectively. Overall incidence of the primary outcome, defined as a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, ischemic stroke, or major bleeding was not significantly different between the clopidogrel and prasugrel groups (adjusted hazard ratio [HR] 1.98, 95% confidence interval [CI] 0.85–4.61, P=0.12). Among patients with theCYP2C19loss-of-function (LOF) allele, however, the incidence of the primary outcome was significantly higher in the clopidogrel group (adjusted HR 3.19, 95% CI 1.10–9.24, P=0.03), whereas no difference was observed among patients without theCYP2C19LOF allele (adjusted HR 0.67, 95% CI 0.14–3.26, P=0.62).Conclusions:Among patients with theCYP2C19LOF allele, the use of clopidogrel was significantly associated with increased adverse events. Thus, further investigation is needed to establish the practical use ofCYP2C19genotyping.

著者

Daisuke Yakabe Yusuke Fukuyama Masahiro Araki Toshihiro Nakamura

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0583, (Released:2021-08-31)

参考文献数

1

被引用文献数

2

著者

Yuta NISHIYAMA Yasuhiro FUKUYAMA Takuya MARUO Shinichiro YODA Masataka IWANO Shinpei KAWARAI Hideki KAYANUMA Kensuke ORITO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.83, no.8, pp.1206-1211, 2021 (Released:2021-08-06)

参考文献数

27

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Tegafur is a prodrug of fluoropyrimidine 5-fluorouracil (5-FU), while TS-1TM is an oral fixed-dose combination of three active drugs, tegafur, gimeracil, and oteracil. This pilot study evaluated the safety of tegafur/gimeracil/oteracil in the treatment of cancers in dogs. Tegafur/gimeracil/oteracil was administered orally at a mean dose of 1.1 mg/kg twice daily on alternate days, Monday-Wednesday-Friday, every week to 11 dogs with tumors. Partial response and stable disease were observed in one dog each, whereas six exhibited progressive disease. Three dogs were not assessed. Adverse events, the most serious being grade 2, were noted in seven dogs. Adverse events were acceptable, and the drug was effective in some dogs. Therefore, tegafur/gimeracil/oteracil may be useful for treating malignant solid tumors in canines.

著者

福山 博文 フクヤマ ヒロフミ FUKUYAMA Hirofumi

出版者

鹿児島大学

雑誌

地域政策科学研究 (ISSN:13490699)

巻号頁・発行日

no.11, pp.27-40, 2014-03

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The purpose of this paper is to estimate both a performance model and a salary model of professional sports players by using a performance data in Major League Baseball (MLB), a performance data in NipponProfessional Baseball (NPB) and an annual salary data in NPB on foreign players who transferred the register to Japan from 2001 to 2013. As a result, the performance in MLB that influenced the salary when foreign players transferred the register to NPB was the total number of Home Run in MLB and the fact that "he was a major leaguer," whilethe performance in MLB that influenced the performance when they transferred the register to NPB was On-Base Percentage on the average in Minor League. In this paper, we showed that general managers in NPB wereaffected by information that gave a strong impression like the number of HR in MLB when they contracted to the foreign players. Therefore, we clarified that an availability heuristics was observed in the evaluation ofprofessional sports players.本論文では,2001年から2013年にNPB(日本プロ野球)に移籍した外国人選手のアメリカでのパフォーマンス・データとNPB でのパフォーマンス・データ,NPB での契約年俸データを用いて,パフォーマンス決定モデルおよび年俸決定モデルの推定を行っている。 推定の結果,NPB 移籍1年目での出塁率(On-Base Percentage,以下,OBP)に最も影響を及ぼすアメリカでのパフォーマンスは3A通算の平均OBP であるが,外国人選手のNPB での契約年俸に最も影響を及ぼすアメリカでのパフォーマンスはメジャーリーグ通算HR(本塁打)数と移籍前年にメジャーリーグに所属していることであった。本論文では,NPB の編成担当者が外国人選手と契約する際,メジャーリーグでのHR 数など強く印象として記憶に残りやすい情報の影響を受けやすく,利用可能性ヒューリスティックスがスポーツ選手の評価においても観察されることを明らかにした。

著者

Yasuhiro FUKUYAMA Takuya MARUO Yuta NISHIYAMA Yuki NEMOTO Kaho MURAYAMA Hideki KAYANUMA Shinpei KAWARAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.20-0670, (Released:2021-01-13)

被引用文献数

3

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The preparation of modified Mohs paste, commonly used for malignant wounds, requires time and effort. Moreover, metal-containing liquid waste is generated when malignant wounds are scrubbed. Therefore, we previously changed the base material of the modified Mohs paste from zinc oxide starch powder to carboxymethyl cellulose (CMC). The novel modified Mohs paste based on CMC (moM-CMC sol) may reduce these disadvantages. In the present study, the moM-CMC sol was applied to malignant tumors in three dogs to manage bleeding and malodor. The moM-CMC sol transitioned into a gel on the tumors within an hour of application and could be easily removed. The symptoms resolved within a few days. The moM-CMC sol could be beneficial for dogs with malignant wounds.

著者

HIROFUMI FUKUYAMA

出版者

JAPANESE ECONOMIC ASSOCIATION

雑誌

The Economic Studies Quarterly (ISSN:0557109X)

巻号頁・発行日

vol.43, no.2, pp.105-117, 1992-06-20 (Released:2007-10-19)

参考文献数

18

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In a multiple output, multiple input setting, five measures of returns to scale are currently available in the literature. These measures have been useful empirical tools, but there remain some limitations regarding data availability and the choice of behavioral assumptions. To cope with these limitations, we will introduce three new measures of returns to scale and thus will close a gap in the literature. Then, we show that our three measures are theoretically equivalent to the existing five measures. Thus, the eight measures, with their corresponding data requirements and behavioral assumptions, are also reported here for the empirical purpose of gaining greater flexibility in the choice of behavioral goals and data requirements. In this way, we unify the results in the literature and our present study and, in addition, summarize the relationship among the eight measures diagrammatically.