著者

井之口 有一 堀井 令以知 中井 和子 Y. Inokuti R. Horii K. Nakai

雑誌

西京大學學術報告. 人文 = The scientific reports of Saikyo University. Humanistic science

巻号頁・発行日

vol.10, pp.22_a-1_a, 1958-10-25

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In Part I, we touched on the ancient court-lady speechs which have persisted in Daisyozi Amamonzeki nunnery. The present paper is an attempt to explain some linguistic circumstances in this nunnery. It is difficult to classify the extremely varied assertions which have been made connecting lingustic and nonlinguistic behavior. Therefore, in this paper, we will primarily ask three kinds of nonlinguistic questions : 1) What are the natures of human relation connected with Daisyozi and Imperial palace, of social circles and their manners and customs? 2) What are the year's regular functions in Daisyozi? (the Feast of the Seven Herbs of Health, Kazyo, the moonlight party and ancient customs etc.) 3) What kinds of education and recreation were done for the nuns? (the distinctive perception of public and private affairs, Kiyo and Otugi, Genzimonogatari cards and others) Thus, we intend to treat in next Parts on the correlation between some aspects of language and non-linguistic phenomena in this nunnery.

著者

NOUTOSHI Y.

雑誌

Mol. Gen. Genet.

巻号頁・発行日

vol.259, pp.256-263, 1998

被引用文献数

1 13

著者

Yasushi Ohkusa Tamie Sugawara Kiyosu Taniguchi Chiaki Miyazaki Mariko Y. Momoi Nobuhiko Okabe

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Drug Discoveries & Therapeutics (ISSN:18817831)

巻号頁・発行日

vol.12, no.6, pp.381-383, 2018-12-31 (Released:2019-01-24)

参考文献数

6

被引用文献数

1

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The Fukushima research has examined data form a cohort study of 10,000 Japanese children under 18 years old with influenza during three months to demonstrate that the relative risk of A-type abnormal behavior of patients with oseltamivir was 30 times greater than without oseltamivir. By contrast, our research group found that patients who had been administered no neuraminidase inhibitors (NI) or those administered peramivir had higher risk of abnormal behavior than those administered oseltamivir, zanamivir, or laninamivir. A plausible explanation for this gap is that the two studies specifically examined different criteria to report abnormal behavior. In actually, some A-type abnormal behavior might not be life-threatening. Our definition of severe abnormal behavior is better matched to public health concerns and comparison among incidents according to the administered drug is more appropriate as an analytical procedure.

著者

Nobutoyo Masunaga Mitsuru Abe Hisashi Ogawa Yuya Aono Syuhei Ikeda Kosuke Doi Yoshimori An Mitsuru Ishii Moritake Iguchi Masahiro Esato Hikari Tsuji Hiromichi Wada Koji Hasegawa Gregory Y.H. Lip Masaharu Akao on behalf of the Fushimi AF Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.12, pp.2983-2991, 2018-11-24 (Released:2018-11-24)

参考文献数

28

被引用文献数

16

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Background: The combination of oral anticoagulant (OAC) and antiplatelet drug (APD) increases the bleeding risk in atrial fibrillation (AF). Non-vitamin K antagonist OAC (NOAC) have been increasingly used since 2011. We investigated current status, time trends and outcomes of AF patients using combination therapy in 2011–2017. Methods and Results: The Fushimi AF Registry is a community-based prospective survey of AF patients in Fushimi-ku, Kyoto, Japan. Of 2,378 patients with OAC at enrollment, 521 (22%) received combination therapy, while 1,857 (78%) received OAC alone. When compared with OAC alone, combination therapy patients had more comorbidities, but approximately 30% had no atherosclerotic disease. From 2011 to 2017, the prevalence of combination therapy decreased from 26% to 14%. The prevalence of NOAC increased in those on combination therapy. Off-label under-dosing of NOAC increased year by year, especially in combination therapy. During follow-up, the incidence of major bleeding (hazard ratio [HR], 1.42; 95% CI: 1.03–1.95) and stroke/systemic embolism (HR, 1.48; 95% CI: 1.09–2.00) was higher in the combination therapy than in the OAC alone group. Conclusions: In Japanese AF patients receiving OAC, the prevalence of combination therapy decreased, with the proportion of NOAC use increasing in 2011–2017. Many patients, however, received off-label NOAC under-dosing, especially in the combination therapy group. Patients with combination therapy had higher incidences of major bleeding as well as stroke/systemic embolism, compared with OAC monotherapy.

著者

Nobutoyo Masunaga Mitsuru Abe Hisashi Ogawa Yuya Aono Syuhei Ikeda Kosuke Doi Yoshimori An Mitsuru Ishii Moritake Iguchi Masahiro Esato Hikari Tsuji Hiromichi Wada Koji Hasegawa Gregory Y.H. Lip Masaharu Akao on behalf of the Fushimi AF Registry Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0872, (Released:2018-10-31)

参考文献数

28

被引用文献数

16

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Background: The combination of oral anticoagulant (OAC) and antiplatelet drug (APD) increases the bleeding risk in atrial fibrillation (AF). Non-vitamin K antagonist OAC (NOAC) have been increasingly used since 2011. We investigated current status, time trends and outcomes of AF patients using combination therapy in 2011–2017. Methods and Results: The Fushimi AF Registry is a community-based prospective survey of AF patients in Fushimi-ku, Kyoto, Japan. Of 2,378 patients with OAC at enrollment, 521 (22%) received combination therapy, while 1,857 (78%) received OAC alone. When compared with OAC alone, combination therapy patients had more comorbidities, but approximately 30% had no atherosclerotic disease. From 2011 to 2017, the prevalence of combination therapy decreased from 26% to 14%. The prevalence of NOAC increased in those on combination therapy. Off-label under-dosing of NOAC increased year by year, especially in combination therapy. During follow-up, the incidence of major bleeding (hazard ratio [HR], 1.42; 95% CI: 1.03–1.95) and stroke/systemic embolism (HR, 1.48; 95% CI: 1.09–2.00) was higher in the combination therapy than in the OAC alone group. Conclusions: In Japanese AF patients receiving OAC, the prevalence of combination therapy decreased, with the proportion of NOAC use increasing in 2011–2017. Many patients, however, received off-label NOAC under-dosing, especially in the combination therapy group. Patients with combination therapy had higher incidences of major bleeding as well as stroke/systemic embolism, compared with OAC monotherapy.

著者

三浦 謙 Y. Miura

雑誌

中京大学教養論叢 = Chukyo University bulletin of the Faculty of Liberal Arts (ISSN:02867982)

巻号頁・発行日

vol.18, no.4, pp.715-723, 1978-03-20

著者

西森康則 y.nishimori

雑誌

データマイニングと統計数理研究会(第 12 回)

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We review algorithms and theory of manifold learning in machine learning.

著者

Hida H. Ito T. Katsurada H. Kitagawa K. Taguchi Y. Murase A. Yamagami A. Arai K. Hiraoka T. Itakura K. Kasio T. Kawamura H. Kimura I. Mochizuki S. Murata M. Okazaki T.

出版者

Department of Mathematics, Hokkaido University

雑誌

Hokkaido University technical report series in mathematics (ISSN:13484338)

巻号頁・発行日

vol.137, pp.1, 2008-09

著者

Daniele Pastori José Miguel Rivera-Caravaca María Asunción Esteve-Pastor Vanessa Roldán Francisco Marín Pasquale Pignatelli Francesco Violi Gregory Y.H. Lip

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-1318, (Released:2018-03-16)

参考文献数

32

被引用文献数

3

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Background:Two risk scores have been developed to predict composite outcomes in atrial fibrillation (AF): the 2MACE and TIMI-AF scores. The aim of this study was to compare the predictive ability of these scores in 2 separate warfarin-treated cohorts (one ‘real world’, one clinical trial) of AF patients.Methods and Results:The 2MACE and TIMI-AF scores were calculated in the ‘real-world’ ATHERO-AF cohort (n=907), and in the randomized controlled AMADEUS trial (n=2,265). Endpoints were major adverse cardiovascular events (MACEs), net clinical outcomes (NCO) and a combination of them, namely “clinically relevant events” (CREs). ROC curves showed similar predictive ability for MACE for 2MACE and TIMI-AF, in both the ATHERO-AF (0.698 vs. 0.688, respectively P=0.783) and AMADEUS (0.657 vs. 0.569, respectively P=0.057) cohorts. Similarly, the TIMI-AF showed a comparable c-index with 2MACE for NCOs in the ATHERO-AF (0.676 vs. 0.667, P=0.737), and AMADEUS (0.666 vs. 0.663, P=0.859) cohorts. No differences were found between the 2 scores for the prediction of CREs (0.675 vs. 0.684, P=0.740 in ATHERO-AF and 0.669 vs. 0.667, P=0.889 in AMADEUS for 2MACE and TIMI-AF, respectively).Conclusions:This study showed that the 2MACE and TIMI-AF scores had modest but significant predictive ability for composite outcomes in AF. The clinical usefulness of both scores was similar, but the 2MACE score may be simpler and easy to use.

著者

Y-h. Taguchi

出版者

The Japanese Biochemical Society/The Molecular Biology Society of Japan

雑誌

ConBio2017

巻号頁・発行日

2017-10-31

著者

山本 亞実 大城 未緒 南 由歩 竹谷 怜子 小野 久江 A. Yamamoto M. Oshiro Y. Minami R. Taketani H. Ono

雑誌

関西学院大学心理科学研究 (ISSN:21876355)

巻号頁・発行日

vol.42, pp.1-5, 2016-03-25

著者

Philippe BARON Shoken ISHII Kozo OKAMOTO Kyoka GAMO Kohei MIZUTANI Chikako TAKAHASHI Toshikazu ITABE Toshiki IWASAKI Takuji KUBOTA Takashi MAKI Riko OKI Satoshi OCHIAI Daisuke SAKAIZAWA Masaki SATOH Yohei SATOH Taichu Y. TANAKA Motoaki YASUI

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.95, no.5, pp.319-342, 2017 (Released:2017-10-04)

参考文献数

42

被引用文献数

10

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A feasibility study of tropospheric wind measurements using a coherent Doppler lidar aboard a super low altitude satellite is being conducted in Japan. The considered lidar uses a 2.05 μm laser light source of 3.75 W. In order to assess the measurement performances, simulations of wind measurements were conducted. The mission definition is presented in a companion paper (Part 1) while, in this paper, we describe the measurement simulator and characterize the errors on the retrieved line-of-sight (LOS) winds. Winds are retrieved from the Doppler-shift of the noisy backscattered signal with a horizontal resolution of 100 km along the orbit track and a vertical resolution between 0.5 and 2 km. Cloud and wind fields are the pseudo-truth of an Observing System Simulation Experiment while aerosol data are from the Model-of-Aerosol-Species-IN-the-Global-AtmospheRe (MASINGAR) constrained with the pseudo-truth wind. We present the results of the analysis of a full month of data in summer time for a near-polar orbiting satellite and a LOS nadir angle of 35°. Below ≈ 8 km, the ratio of good retrievals is 30-55 % and the median LOS wind error is better than 0.6 m s−1 (1.04 m s−1 for the horizontal wind). In the upper troposphere, the ratio is less than 15 % in the southern hemisphere and high-latitudes. However, the ratio is still 35 % in the northern Tropics and mid-latitudes where ice-clouds frequently occur. The upper-tropospheric median LOS-wind measurement error is between 1-2 m s−1 depending on the latitude (1.74-3.5 m s−1 for the horizontal wind). These errors are dominated by uncertainties induced by spatial atmospheric inhomogeneities.

著者

Shoken ISHII Philippe BARON Makoto AOKI Kohei MIZUTANI Motoaki YASUI Satoshi OCHIAI Atsushi SATO Yohei SATOH Takuji KUBOTA Daisuke SAKAIZAWA Riko OKI Kozo OKAMOTO Toshiyuki ISHIBASHI Taichu Y. TANAKA Tsuyoshi T. SEKIYAMA Takashi MAKI Koji YAMASHITA Tomoaki NISHIZAWA Masaki SATOH Toshiki IWASAKI

出版者

(公社)日本気象学会

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.95, no.5, pp.301-317, 2017 (Released:2017-10-04)

参考文献数

57

被引用文献数

15

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A working group is studying the feasibility of a future Japanese space-borne coherent Doppler wind lidar (CDWL) for global wind profile observation. This study is composed of two companion papers: an instrumental overview of the space-borne CDWL for global wind profile observation (Part 1), and the wind measurement performance (error and bias) investigated using a full-fledged space-borne CDWL simulator (Part 2). This paper aims to describe the future space-borne CDWL in terms of technical points and observation user requirements. The future mission concept is designed to have two looks for vector wind measurement with vertical resolutions of 0.5 (lower troposphere: 0-3 km), 1 (middle troposphere: 3-8 km), and 2 km (upper troposphere: 8-20 km) and horizontal resolution of < 100 km along a satellite. The altitude and orbit of the satellite are discussed from a scientific viewpoint. The candidate altitude and orbit of the satellite are 220 km and an inclination angle of 96.4° (polar orbit) or 35.1° (low-inclination-angle orbit). The technical requirements of the space-borne CDWL are a single-frequency 2-μm pulse laser with an average laser power of 3.75 W, two effective 40-cm-diameter afocal telescopes, a wide-bandwidth (> 3.4 GHz) detector, a high-speed analog-to-digital converter, and a systematic lidar efficiency of 0.08. The space-borne CDWL looks at two locations at a nadir angle of 35° at two azimuth angles of 45° and 135° (225° and 315°) along the satellite track. The future space-borne CDWL wind profile observation will fill the gap of the current global wind observing systems and contribute to the improvement of the initial conditions for numerical weather prediction (NWP), the prediction of typhoons and heavy rain, and various meteorological studies.

著者

Y. Otsuka T. Ogawa A. Saito T. Tsugawa S. Fukao S. Miyazaki

出版者

The Seismological Society of Japan, Society of Geomagnetism and Earth, Planetary and Space Sciences, The Volcanological Society of Japan , The Geodetic Society of Japan , The Japanese Society for Planetary Sciences

雑誌

Earth, Planets and Space (ISSN:13438832)

巻号頁・発行日

vol.54, no.1, pp.63-70, 2002 (Released:2010-03-09)

参考文献数

24

被引用文献数

239

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The dual frequency radio signals of the Global Positioning System (GPS) allow measurements of the total number of electrons, called total electron content (TEC), along a ray path from GPS satellite to receiver. We have developed a new technique to construct two-dimensional maps of absolute TEC over Japan by using GPS data from more than 1000 GPS receivers. A least squares fitting procedure is used to remove instrumental biases inherent in the GPS satellite and receiver. Two-dimensional maps of absolute vertical TEC are derived with time resolution of 30 seconds and spatial resolution of 0.15° × 0.15° in latitude and longitude. Our method is validated in two ways. First, TECs along ray paths from the GPS satellites are simulated using a model for electron contents based on the IRI-95 model. It is found that TEC from our method is underestimated by less than 3 TECU. Then, estimated vertical GPS TEC is compared with ionospheric TEC that is calculated from simultaneous electron density profile obtained with the MU radar. Diurnal and day-to-day variation of the GPS TEC follows the TEC behavior derived from MU radar observation but the GPS TEC is 2 TECU larger than the MU radar TEC on average. This difference can be attributed to the plasmaspheric electron content along the GPS ray path. This method is also applied to GPS data during a magnetic storm of September 25, 1998. An intense TEC enhancement, probably caused by a northward expansion of the equatorial anomaly, was observed in the southern part of Japan in the evening during the main phase of the storm.

著者

Aoki S. Fukugita M. Hashimoto S. Ishikawa K.-I. Ishizuka N. Iwasaki Y. Kanaya K. Kaneda T. Kaya S. Kuramashi Y. Okawa M. Onogi T. Tominaga S. Tsutsui N. Ukawa A. Yamada N. Yoshié T.

出版者

American Physical Society

雑誌

Physical review D (ISSN:05562821)

巻号頁・発行日

vol.62, no.9, pp.094501, 2000-10

被引用文献数

14 18

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We present a study for the pion decay constant fπ in the quenched approximation to lattice QCD with the Kogut-Susskind (KS) quark action, with the emphasis given to the renormalization problems. Numerical simulations are carried out at the couplings β=6.0 and 6.2 on 323×64 and 483×64 lattices, respectively. The pion decay constant is evaluated for all KS flavors via gauge invariant and noninvariant axial vector currents with the renormalization constants calculated by both the nonperturbative method and perturbation theory. We obtain fπ=89(6) MeV in the continuum limit as the best value using the partially conserved axial vector current, which requires no renormalization. From a study for the other KS flavors we find that the results obtained with the nonperturbative renormalization constants are well convergent among the KS flavors in the continuum limit, confirming restoration of SU(4)A, flavor symmetry, while perturbative renormalization still leaves an apparent flavor breaking effect even in the continuum limit.

著者

Sohn H.-J. Kim J.-H. Choi K.-S. Nah J.-J. Joo Y.-S. Jean Y.-H. Ahn S.-W. Kim O.-K. Kim D.-Y. Balachandran A.

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.64, no.9, pp.855-858, s・vii, 2002-09-25

被引用文献数

1 101

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7歳雄のヘラジカ(Cervus elaphus nelsoni)が体重減少,削痩,過度な流涎,歯軋り,発熱,食欲不振および呼吸困難の症状を3週間呈した後に,安楽殺され,剖検された.このヘラジカは1997年3月9日にカナダから韓国に輸入された.肉眼病変は瀰漫性の線維素性肺炎であった.組織学的には軽度な神経細胞の空胞変性と限局した脳幹部神経核の神経網の海面状変性と広範な星状膠細胞の増生が見られた.プロテアーゼ抵抗性プリオン蛋白質(PrP^<res>)に対する免疫組織化学では全ての脳組織切片で陽性であったが,延髄の閂の切片で最も顕著であった.PrP^<res>は脳および脊髄のウエスタンブロット法でも検出された.本ヘラジカと接触のあった残りのヘラジカおよびシカは淘汰され,慢性消耗性疾患は陰性であった.著者らの知る限りでは,本症例は米国およびカナダ以外の国での最初の症例であった.

著者

KAMEI Y.

雑誌

J Biol Chem

巻号頁・発行日

vol.279, pp.41114-41123, 2004

被引用文献数

13 437

著者

T. Fujita W. F. Brechue K. Kurita Y. Sato T. Abe

出版者

日本加圧トレーニング学会

雑誌

International Journal of KAATSU Training Research (ISSN:13494562)

巻号頁・発行日

vol.4, no.1, pp.1-8, 2008 (Released:2008-11-10)

参考文献数

27

被引用文献数

33 97

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Traditional high-intensity resistance training performed 2-3 times per week induces muscle hypertrophy, at least, in 5 weeks (i.e. 10-15 training sessions). To examine the effect of a higher training frequency (12 sessions in 6 days), healthy young men performed low-intensity resistance training with (n=8, LIT-BFR) and without (n=8, LIT-CON) leg blood flow restriction with cuff inflation (BFR) twice per day for 6 days. Training involved 4 sets of knee extension exercise (75 total contractions) at 20% 1-RM. Significant muscle hypertrophy was observed only in the LIT-BFR group as estimated muscle-bone cross-sectional area (CSA) (2.4%), MRI-measured mid-thigh quadriceps muscle CSA (3.5%) and quadriceps muscle volume (3.0%) increased. The resulting hypertrophic potential (% change in muscle size divided by number of training sessions; ∼0.3% per session) is similar to previously reported traditional high-intensity training (0.1 to 0.5% per session). Improved 1-RM knee extension strength (6.7%) following LIT-BFR training was accounted for by increased muscle mass as relative strength (1-RM/CSA) did not change. There was no apparent muscle damage associated with the exercise training as blood levels of creatine kinase, myoglobin, and interleukin-6 remained unchanged throughout the training period in both training groups. A single bout of training exercise with and without BFR produced no signs of blood clotting as plasma thrombin-antithrombin complex, prothrombin fragment 1,2 and D-dimer were unchanged. In conclusion, changes in muscle mass and strength following 6-day (12 sessions) of low-intensity resistance training requires BFR to produce responses comparable to the effect of several weeks of high-intensity resistance training.

著者

Hideaki Umeyama Mitsuo Iwadate Y-h. Taguchi

出版者

一般社団法人 情報処理学会

雑誌

IPSJ Transactions on Bioinformatics (ISSN:18826679)

巻号頁・発行日

vol.8, pp.14-20, 2015 (Released:2015-08-19)

参考文献数

31

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Background: Spleen tyrosine kinase (SYK) is a protein related to various diseases. Aberrant SYK expression often causes the progression and initiation of several diseases including cancer and autoimmune diseases. Despite the importance of inhibiting SYK and identifying candidate inhibitors, no clinically effective inhibitors have been reported to date. Therefore, there is a need for novel SYK inhibitors. Results: Candidate compounds were investigated using in silico screening by chooseLD, which simulates ligand docking to proteins. Using this system, known inhibitors were correctly recognized as compounds with high affinity to SYK. Furthermore, many compounds in the DrugBank database were newly identified as having high affinity to the ATP-binding sites in the kinase domain with a similar affinity to previously reported inhibitors. Conclusions: Many drug candidate compounds from the DrugBank database were newly identified as inhibitors of SYK. Because compounds registered in the DrugBank are expected to have fewer side effects than currently available compounds, these newly identified compounds may be clinically useful inhibitors of SYK for the treatment of various diseases.

著者

Y.T.

出版者

公益社団法人日本船舶海洋工学会

雑誌

造船協会雑纂 (ISSN:03861597)

巻号頁・発行日

no.113, pp.36-40, 1931-08