著者

坂井 道彦

出版者

日本農薬学会

巻号頁・発行日

vol.35, no.4, pp.548-554, 2010 (Released:2012-12-06)

著者

吉本 武雄 小川 三郎 宇田川 隆敏 沼田 智

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.14, no.2, pp.259-268, 1989-05-20 (Released:2010-08-05)

参考文献数

23

被引用文献数

8 10

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Etofenprox is a new synthetic insecticide discovered and developed by Mitsui Toatsu Chemicals, Inc. In 1979 we began searching for a compound with insecticidal activity, comparable to existing pyrethroids, but with low toxicity to fish as to be used in paddy fields. While examining a new active substance after repeatedly testing a number of hypotheses and ideas, we found a lead skeleton that has ether linkage within the molecule, not ester linkage as in the case of existing pyrethroids. Then we tried to optimize the insecticidal activity around the lead skeleton, and as a result, 2-(4-ethoxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether (etofenprox) was selected as a candidate for development. It is now registered for agricultural use in Japan and some countries in Southeast Asia. Etofenprox is a compound composed of carbon, hydrogen and oxygen only, and effective as a contact and stomach poison against many kinds of insect pests in crops, animals and public health fields. Etofenprox has several favourable properties compared with conventional insecticides: It is low in acute mammalia toxicity and fish toxicity, high in compatibility with other pesticides, causes no skin and eye irritation, has a small impact on natural enemies, no phytotoxicity, no cross-resistance to carbamates and organophosphorous insecticides, no BPH resurgence.

著者

塩野義製薬株式会社植物薬品開発部

出版者

日本農薬学会

雑誌

日本農薬学会誌(Journal of Pesticide Science) (ISSN:1348589X)

巻号頁・発行日

vol.16, no.2, pp.349-353, 1991

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アイオキシニルの安全性評価のための各種毒性試験を実施した.本剤は原体, 乳剤, 水和剤とも劇物に指定されている.ウサギにおいて乳剤では高度の眼刺激性および中等度の皮膚刺激性, 水和剤では非常に軽度の眼刺激性が認められたが, 両製剤とも実使用濃度希釈液では眼・皮膚刺激性は認められなかった.また水和剤ではモルモットにおける皮膚感作性が陽性であった.亜急性毒性試験, 慢性毒性/発がん性試験では, 中間・高用量群においてラットおよびマウス肝障害, ラットに体重増加の抑制, 脱毛および甲状腺ろ胞上皮過形成の発生頻度の上昇が認められたが, 発がん性は認められなかった.マウスにおける2世代繁殖/催奇形性併合試験, ウサギにおける催奇形性試験では, 繁殖に及ぼす影響も催奇形性も認められなかった.変異原性に関しては, in vitro染色体異常試験の代謝活性化法の場合のみ疑陽性と判定されたが, 小核試験を始めその他の変異原性試験の結果はすべて陰性であった.薬理試験では特異的な薬理作用は認められなかった.アイオキシニルは昭和42年, 30%乳剤の麦類で初回登録を取得し, その後トウモロコシ, バレイショ, タマネギ, リンゴおよび公園・庭園等に順次適用拡大を行なった.さらに平成元年には芝専用剤である6%水和剤の登録を取得した.アイオキシニルの登録保留基準値は, 麦・雑穀, 果実, 野菜, イモ類についておのおの0.1 ppmと設定されている.アイオキシニルは定められた使用基準を遵守すれば安全性の高い農薬であり, 有用な農業資材の一つとして上市以来好評を得ている.

著者

Kotaro Mori Hideya Tokuoka Hisashi Miyagawa Yoshiaki Nakagawa

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.1, pp.120-123, 2021-02-20 (Released:2021-02-26)

参考文献数

22

---

Benzoylphenylureas (BPUs) were discovered as novel type insecticides about a half century ago; many analogs have been launched as insecticides and acaricides. BPUs are known to inhibit chitin synthesis in insects and other arthropods, but they have no effect against microorganisms such as fungi. We designed new chitin synthesis inhibitors based on the hypothesis that biomolecules that play important roles in cellulose and chitin biosynthesis are similar. In the full automatic modeling system (FAMS), the cellulose synthase was selected as a template three-dimensional structure. Thus, we focused on the structure of cellulose synthase inhibitor, isoxaben, to develop new chemistry. The 1,1-diethylethyl [-C(CH3)(CH2CH3)2] group of isoxaben was changed to a 4-substituted phenyl group bearing Cl, Et, or Ph. These compounds significantly inhibited chitin synthesis in the cultured integument of the rice stem borer Chilo suppressalis. The activity of the 4-ethylphenyl analog was enhanced 30-fold by adding piperonyl butoxide to the culture medium.

著者

富沢 元博 山本 出

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.18, no.1, pp.91-98, 1993-02-20 (Released:2010-08-05)

参考文献数

18

被引用文献数

81 123

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ツマグロヨコバイへの殺虫力, ミツバチ頭部のニコチン性アセチルコリンレセプター画分のα-ブンガロトキシン結合部位への結合親和性に関して, イミダクロプリドと19種の類縁化合物の化学構造活性相関をニコチノイドと比較した結果, これら二つのグループは結合部位, 必須化学構造部分 (3-ピリジルメチルアミノ) を同じくし, 化学構造活性相関も類似していることを認めた. ニコチノイドではアミノ窒素原子の塩基性が高く生体内でのイオン化度が高いのに対し, イミダクロプリド関連化合物ではこの窒素原子に部分正荷電を与える隣接電子吸引性基を有する特徴を示す.

著者

高橋 正三 武川 恒 高橋 孝志 土井 隆行

出版者

日本農薬学会

雑誌

日本農薬学会誌(Journal of Pesticide Science) (ISSN:1348589X)

巻号頁・発行日

vol.13, no.3, pp.501-503, 1988

被引用文献数

2 11

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ワモンゴキブリの性フェロモンの一つペリプラノンA (PA) とそのエピマー (EPA) を使って, <i>Periplaneta</i> 属, <i>Blatta</i> 属6種の雄に対する性フェロモン活性を実験室内で生物検定した. PAのワモンゴキブリに対するフェロモン活性はペリプラノンB (PB) の約1/1000で, EPAの活性はPAの約1/1000であった. PA, EPAおよびPAとPBの混合物はワモンゴキブリ以外にヤマトゴキブリ, トビイロゴキブリ, コワモンゴキブリ, トウヨウゴキブリの雄にもフェロモン活性があった.

著者

Christopher Browning Alastair G. McEwen Kotaro Mori Taiyo Yokoi Dino Moras Yoshiaki Nakagawa Isabelle M. L. Billas

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.1, pp.88-100, 2021-02-20 (Released:2021-02-26)

参考文献数

58

被引用文献数

7

---

The ecdysone receptor (EcR) possesses the remarkable capacity to adapt structurally to different types of ligands. EcR binds ecdysteroids, including 20-hydroxyecdysone (20E), as well as nonsteroidal synthetic agonists such as insecticidal dibenzoylhydrazines (DBHs). Here, we report the crystal structures of the ligand-binding domains of Heliothis virescens EcR/USP bound to the DBH agonist BYI09181 and to the imidazole-type compound BYI08346. The region delineated by helices H7 and H10 opens up to tightly fit a phenyl ring of the ligands to an extent that depends on the bulkiness of ring substituent. In the structure of 20E-bound EcR, this part of the ligand-binding pocket (LBP) contains a channel filled by water molecules that form an intricate hydrogen bond network between 20E and LBP. The water channel present in the nuclear receptor bound to its natural hormone acts as a critical molecular adaptation spring used to accommodate synthetic agonists inside its binding cavity.

著者

小波本 直忠

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.2, no.4, pp.405-411, 1977-11-20 (Released:2010-08-05)

参考文献数

17

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セスジツチイナゴの角膜および円錐晶体を含む複眼の組織は280nmまでの近紫外線および可視光線を, 牛の眼のレンズは380nmまでの可視光線のみを透過した. このことから, 280~380nmの近紫外線は昆虫の視覚にとっては重要な意義を持っているが, 脊椎動物の視覚には無意味であることが明らかとなった. 昆虫眼の紫外線受容複合体のモデルとしてのレチニル-チアゾリジン-4-カルボン酸の光反応および暗反応から, L-システインおよびヒドロキシルアミンはレチナールとの暗反応により昆虫眼における近紫外線の機能に異常を起こすモデル物質であり, 一方, これらの化合物とレチナールから生成された近紫外線感受性複合体は光吸収および光化学反応により昆虫の眼の構造と機能に選択的害作用を及ぼすモデル物質であることが示された. なお, この選択性を新しい昆虫制御剤の作用機構に利用する可能性も提案された.

著者

Jingbo Li Heping Han Lianyang Bai Qin Yu

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.45, no.2, pp.109-113, 2020-05-20 (Released:2020-05-20)

参考文献数

34

被引用文献数

1 9

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Glyphosate is often tank-mixed with auxinic herbicide 2,4-D for grass and broadleaf weed control. Here we examined the possible interaction of 2,4-D and glyphosate in barnyard grass, Echinochloa colona (L.) Link. The results showed that 2,4-D antagonizes glyphosate remarkably in glyphosate-resistant populations but only marginally in susceptible populations. This antagonism is related to reduced glyphosate uptake and (to a lesser extent) translocation. As 2,4-D has multiple, unpredictable effects on other herbicides, care must be taken when tank-mixing herbicides with 2,4-D.

著者

吉田 忠晴

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.36, no.4, pp.497-502, 2011-11-25 (Released:2012-11-10)

参考文献数

30

著者

Changmann Yoon Shin-Ho Kang Jeong-Oh Yang Doo-Jin Noh Pandiyan Indiragandhi Gil-Hah Kim

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.34, no.2, pp.77-88, 2009-05-25 (Released:2009-06-01)

参考文献数

32

被引用文献数

22 34

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The repellent efficacy of 17 essential oils against the German cockroach, Blattella germanica was examined using a T-tube olfactometer. Five oils repelled B. germanica with good efficacy, ranging from 70.0 to 96.7%. Four of these oils, grapefruit, lemon, lime, and orange, were from the citrus family Rutaceae. These citrus essential oils showed similar repellent activity against two more cockroach species, such as Periplaneta americana and P. fuliginosa. Gas chromatography (GC) and GC-mass spectrometry analyses revealed that the major components responsible for the repellent activity of the citrus oils were limonene, β-pinene and γ-terpinene. Limonene appears to be the main component responsible for the repellent activity rather than β-pinene and γ-terpinene. The repellent efficacy of these components varied with different doses and the cockroach species tested. It is likely that minor components of the oils also contributed to the overall repellent activity of citrus essential oils, except orange oil. The activity of orange oil is almost solely attributed to the activity of limonene. Also, the repellent activity of citrus oil and that of each of the terpenoids makes little difference to the efficacy of a repellant against the three species of cockroaches.

著者

本間 環

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.20, no.4, pp.545-551, 1995-11-20 (Released:2010-08-05)

参考文献数

34

著者

高橋 英光 高草 伸生 鈴木 順次 岸本 孝

出版者

日本農薬学会

雑誌

日本農薬学会誌(Journal of Pesticide Science) (ISSN:1348589X)

巻号頁・発行日

vol.23, no.2, pp.193-200, 1998

被引用文献数

27

著者

Eikoh Satoh Ryota Kasahara Kosuke Fukatsu Takao Aoki Hiroto Harayama Tetsuya Murata

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.46, no.1, pp.109-114, 2021-02-20 (Released:2021-02-26)

参考文献数

8

被引用文献数

5

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Benzpyrimoxan (5-(1,3-dioxan-2-yl)-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrimidine, NNI-1501) was discovered as a novel insecticide structurally characterized by a pyrimidine derivative substituted with 1,3-dioxanyl and 4-trifluoromethylbenzyloxy groups. The compound showed remarkable activity against nymphs of rice planthoppers, including strains resistant to existing insecticides. Furthermore, benzpyrimoxan had low adverse effects on pollinators and beneficial arthropods. Because of these features, benzpyrimoxan is expected to be a suitable part of an integrated pest management strategy. In this report, the history of the discovery to reach benzpyrimoxan and details of the structure–activity relationships are described.

著者

宮腰 昶宏 水橋 福太郎

出版者

日本農薬学会

巻号頁・発行日

vol.36, no.4, pp.544-548, 2011 (Released:2013-10-08)

著者

Kotaro Koiwai Kana Morohashi Kazue Inaba Kana Ebihara Hirotatsu Kojima Takayoshi Okabe Ryunosuke Yoshino Takatsugu Hirokawa Taiki Nampo Yuuta Fujikawa Hideshi Inoue Fumiaki Yumoto Toshiya Senda Ryusuke Niwa

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

pp.D20-072, (Released:2021-02-04)

参考文献数

40

被引用文献数

6

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Insect growth regulators (IGRs) can be developed by elucidating the molecular mechanisms of insect-specific biological events. Because insect molting, and metamorphosis are controlled by ecdysteroids, their biosynthetic pathways can serve as targets for IGR development. The glutathione S-transferase Noppera-bo (Nobo), which is conserved in dipteran and lepidopteran species, plays an essential role in ecdysteroid biosynthesis. Our previous study using 17β-estradiol as a molecular probe revealed that Asp113 of Drosophila melanogaster Nobo (DmNobo) is essential for its biological function. However, to develop IGRs with a greater Nobo inhibitory activity than 17β-estradiol, further structural information is warranted. Here, we report five novel non-steroidal DmNobo inhibitors. Analysis of crystal structures of complexes revealed that DmNobo binds these inhibitors in an Asp113-independent manner. Among amino acid residues at the substrate-recognition site, conformation of conserved Phe39 was dynamically altered upon inhibitor binding. Therefore, these inhibitors can serve as seed compounds for IGR development.

著者

匂坂 勝之助

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.15, no.3, pp.465-471, 1990-08-20 (Released:2010-08-05)

参考文献数

19

著者

木村 清

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.36, no.1, pp.112-114, 2011-02-25 (Released:2012-11-10)

参考文献数

6

著者

Atsushi Okazawa Takatoshi Wakabayashi Toshiya Muranaka Yukihiro Sugimoto Daisaku Ohta

出版者

Pesticide Science Society of Japan

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.45, no.4, pp.230-237, 2020-11-20 (Released:2020-11-20)

参考文献数

48

被引用文献数

5

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Orobanchaceae root parasitic weeds cause serious agricultural damage worldwide. Although numerous studies have been conducted to establish an effective control strategy for the growth and spread of root parasitic weeds, no practical method has been developed so far. Previously, metabolomic analyses were conducted on germinating seeds of a broomrape, Orobanche minor, to find novel targets for its selective control. Interestingly, planteose metabolism was identified as a possible target, and nojirimycin (NJ) selectively inhibited the germination of O. minor by intercepting planteose metabolism, although its precise mode of action was unclear. Here, transcriptome analysis by RNA-Seq was conducted to obtain molecular insight into the effects of NJ on germinating O. minor seeds. Differential gene expression analysis results suggest that NJ alters sugar metabolism and/or signaling, which is required to promote seed germination. This finding will contribute to understanding the effect of NJ and establishing a novel strategy for parasitic weed control.

著者

門出 健次 高杉 光雄

出版者

日本農薬学会

雑誌

Journal of Pesticide Science (ISSN:1348589X)

巻号頁・発行日

vol.20, no.3, pp.339-343, 1995-08-20 (Released:2010-08-05)

参考文献数

16