著者

内藤 康秀

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.54, no.5, pp.217-217, 2006 (Released:2006-10-03)

被引用文献数

3 5

著者

池田 和貴 馬場 健史

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.199-202, 2017-10-01 (Released:2017-10-15)

参考文献数

6

著者

Yukina Tatsuta Yukie Tanaka Akari Ikeda Shigeru Matsukawa Hajime Katano Shu Taira

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.6, no.3, pp.S0069-S0069, 2017-09-08 (Released:2017-09-15)

参考文献数

7

被引用文献数

8

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We compared two ionization methods, matrix assisted laser desorption/ionization (MALDI) and nanoparticle assisted laser desorption/ionization (Nano-PALDI) mass spectrometry (MS), for the analysis of amino acids derivatized with Py-Tag™ that consists pyrylium-based compound. Py-Tag is a useful stable derivatization reagent due to wide mass differences (using 13C as the sole stable labelling isotope). For Py-Tag labelled lysine, sensitive signals that showed less noise with a ten times higher sensitivity, showed a wider mass difference by Nano-PALDI MS compared to MALDI MS.

著者

前川 正充 山口 浩明 眞野 成康

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.64, no.4, pp.121-125, 2016-08-01 (Released:2016-08-15)

参考文献数

13

被引用文献数

1

著者

Peter S. Haglund Karin Löfstrand Kevin Siek Lillemor Asplund

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.2, no.Special_Issue, pp.S0018-S0018, 2013-04-15 (Released:2013-05-03)

参考文献数

23

被引用文献数

4 13

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Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC×GC TOFMS) and gas chromatography/high-resolution time-of-flight mass spectrometry (GC-HRT) were used to detect and identify halogenated natural products (HNPs) in tissue homogenate, in this case brominated analytes present in a marine snail. Two classes of brominated anthropogenic compounds, polybrominated diphenyl ethers (PBDEs) and brominated dibenzofurans, were analyzed for comparison. Following conventional preparation, the sample was analyzed using GC×GC-TOF-MS. Isotope ratio scripts were used to compile a list of putatively brominated analytes from amongst the thousands of features resolved in the two-dimensional chromatogram. The structured nature of the chromatogram was exploited to propose identifications for several classes of brominated compounds, and include additional candidates that fell marginally outside the script tolerances. The sample was subsequently analyzed by GC-HRT. The high-resolution mass spectral data confirmed many formula assignments, facilitated confident assignment of an alternate formula when an original proposal did not hold, and enabled unknown identification. Identified HNPs include hydroxylated and methoxylated PBDE analogs, polybrominated dibenzo-p-dioxins (PBDDs) and hydroxyl-PBDDs, permitting the environmental occurrence and fate of such compounds to be studied.

著者

津川 裕司 早川 英介 三浦 大典

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.203-209, 2017-10-01 (Released:2017-10-15)

参考文献数

20

被引用文献数

1

著者

平山 明由 和泉 自泰 松田 史生 石川 貴正 杉浦 悠毅 鈴木 隆弘

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.195-198, 2017-10-01 (Released:2017-10-15)

参考文献数

23

被引用文献数

1

著者

及川 彰 松田 史生 三枝 大輔

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.220-222, 2017-10-01 (Released:2017-10-15)

参考文献数

17

著者

Fumio Matsuda

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.3, no.Special_Issue_2, pp.S0038-S0038, 2014-08-01 (Released:2014-08-16)

参考文献数

38

被引用文献数

4 14

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The CASMI 2013 (Critical Assessment of Small Molecule Identification 2013, http://casmi-contest.org/) contest was held to systematically evaluate strategies used for mass spectrometry-based identification of small molecules. The results of the contest highlight that, because of the extensive efforts made towards the construction of databases and search tools, database-assisted small molecule identification can now automatically annotate some metabolite signals found in the metabolome data. In this commentary, the current state of metabolite annotation is compared with that of transcriptomics and proteomics. The comparison suggested that certain limitations in the metabolite annotation process need to be addressed, such as (i) the completeness of the database, (ii) the conversion between raw data and structure, (iii) the one-to-one correspondence between measured data and correct search results, and (iv) the false discovery rate in database search results.

著者

杉浦 悠毅 新間 秀一

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.215-219, 2017-10-01 (Released:2017-10-15)

参考文献数

3

被引用文献数

2

著者

中山 泰宗 松田 史生

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.210-214, 2017-10-01 (Released:2017-10-15)

参考文献数

14

著者

馬場 健史

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.65, no.5, pp.193-194, 2017-10-01 (Released:2017-10-15)

著者

Tohru Yamagaki

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.6, no.3, pp.K0011-K0011, 2017-09-11 (Released:2017-09-15)

著者

角野 浩史

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.63, no.1, pp.1-30, 2015-02-01 (Released:2015-02-15)

参考文献数

213

被引用文献数

3

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Because noble gases are chemically inert, scarce in the earth and meteorite (except 40Ar in the earth’s atmosphere), and highly volatile, their isotope ratios have provided important insights in research fields of earth, planetary, and environmental sciences. The progress of noble gas geochemistry and cosmochemistry has been paced by the rate of developments in mass spectrometry. In this contribution, the history and basic principles of noble gas mass spectrometry and general techniques used in most modern laboratories are overviewed. The noble gas mass spectrometry has developed with inventions of various techniques—Nier type electron ionization (EI) source, static mode operation under ultrahigh-vacuum, adequately high resolution to distinguish very minor noble gas isotopes from interferences, and numerous small tips accumulated in laboratories—to attain increasingly greater precision to distinguish the often subtle variations in isotopic compositions, higher sensitivity to measure the low abundances found in many materials, and lower blanks to remove interference from atmospheric gases. New technologies recently exploited, such as simultaneous detection of noble gas isotopes with multicollector detection system, high-transmission EI source, resonance ionization, compression EI source, post-ionization of sputtered noble gases by focused ion beam, which enable us to detect quite small amount of noble gases down to several thousands of atoms, are opening new era of noble gas mass spectrometry. The highly-sensitive noble gas mass spectrometry can be applied to continuous monitoring of activity of volcanoes or active faults and to detect trace amount of noble-gas producing elements upon neutron irradiation, such as halogens, potassium, calcium, uranium, etc.

著者

浅川 大樹 森 邦彦 平岡 賢三

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.55, no.3, pp.127-135, 2007 (Released:2007-06-15)

参考文献数

35

被引用文献数

4 4

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A new ionization method, electrospray droplet impact ionization (EDI), has been developed for matrix-free secondary-ion mass spectrometry (SIMS). The charged droplets formed by electrospraying 1 M acetic acid aqueous solution are sampled through an orifice with a diameter of 400 μm into the first vacuum chamber, transported into a quadrupole ion guide, and accelerated at 10 kV after exiting the ion guide. The droplets impact on a dry solid sample (no matrix used) deposited on a stainless steel substrate. The secondary ions formed by the impact are transported to a second quadrupole ion guide and are mass-analyzed by an orthogonal time-of-flight mass spectrometer. EDI/SIMS was found to be an easy to operate and versatile method for molecular-level surface analysis.

著者

井上 雅夫 藤原 真 小野山 勝 後藤 豊

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.35, no.2, pp.42-54, 1987 (Released:2007-05-01)

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This paper reports a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer built in this laboratory. The spectrometer consists of a 5 Tesla superconducting magnet, a cylindrical trapped ion cell with an electron beam source, electronic circuits, a microcomputer which generates pulse sequence and controls a data acquisitions system, and a personal computer.The mass spectrum of xenon isotopes has been obtained by a preliminary experiment. An intense low frequency signal of several hundreds Hz was observed along with the time domain transient signals of ion cyclotron resonance frequencies. The former can be attributed to the rotation of the center of cyclotron motion of ions about the cell axis. This rotational motion is caused by the drift due to the radial electric field component and the magnetic field gradient produced in the plane perpendicular to the cell axis.Analysis of the inhomogeneities of electric and magnetic fields inside the cell and the motion of ions has been carried out and the variation of the frequency of rotation as a function of the kinetic energy of ions has been studied.

著者

後藤 豊 天野 力 井上 雅夫

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.31, no.2, pp.115-120, 1983 (Released:2007-05-01)

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This paper reports a microcomputer based data acquisition system for Fourier transform ion cyclotron resonance (FT-ICR) mass spectroscopy. The system has been developed for a prototype spectrometer constructed with a permanent magnet whose magnetic field strength is 6,200 gauss. The system cosists of two-channel sampling ports with sample-hold circuits, a multiplexer, an A-D converter, an I/O port and a logic circuit. The logic circuit starts data acquisition synchronizing with an external trigger pulse. The acquisition is then repeated for preset number of times to accumulate data for signal averaging. An operating program for the system was written in an assembly language in order to execute high-speed data acquisition and a program for FT-ICR experiments was written using BASIC. Resolution of 40,000 was obtained with CO+ ion in residual gas.

著者

Fumio Matsuda

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.5, no.2, pp.S0052-S0052, 2016-11-23 (Released:2016-11-25)

参考文献数

105

被引用文献数

37

---

Metabolomics is a strategy for analysis, and quantification of the complete collection of metabolites present in biological samples. Metabolomics is an emerging area of scientific research because there are many application areas including clinical, agricultural, and medical researches for the biomarker discovery and the metabolic system analysis by employing widely targeted analysis of a few hundred preselected metabolites from 10–100 biological samples. Further improvement in technologies of mass spectrometry in terms of experimental design for larger scale analysis, computational methods for tandem mass spectrometry-based elucidation of metabolites, and specific instrumentation for advanced bioanalysis will enable more comprehensive metabolome analysis for exploring the hidden secrets of metabolism.

著者

Sayaka Nakamura Hiroaki Sato Reiko Tanaka Takashi Yaguchi

出版者

日本質量分析学会

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.5, no.1, pp.A0049-A0049, 2016-11-10 (Released:2016-11-08)

参考文献数

28

被引用文献数

11

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We have previously proposed a rapid identification method for bacterial strains based on the profiles of their ribosomal subunit proteins (RSPs), observed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). This method can perform phylogenetic characterization based on the mass of housekeeping RSP biomarkers, ideally calculated from amino acid sequence information registered in public protein databases. With the aim of extending its field of application to medical mycology, this study investigates the actual state of information of RSPs of eukaryotic fungi registered in public protein databases through the characterization of ribosomal protein fractions extracted from genome-sequenced Aspergillus fumigatus strains Af293 and A1163 as a model. In this process, we have found that the public protein databases harbor problems. The RSP names are in confusion, so we have provisionally unified them using the yeast naming system. The most serious problem is that many incorrect sequences are registered in the public protein databases. Surprisingly, more than half of the sequences are incorrect, due chiefly to mis-annotation of exon/intron structures. These errors could be corrected by a combination of in silico inspection by sequence homology analysis and MALDI-TOF MS measurements. We were also able to confirm conserved post-translational modifications in eleven RSPs. After these verifications, the masses of 31 expressed RSPs under 20,000 Da could be accurately confirmed. These RSPs have a potential to be useful biomarkers for identifying clinical isolates of A. fumigatus.

著者

瀬藤 光利

出版者

日本質量分析学会

雑誌

Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)

巻号頁・発行日

vol.64, no.5, pp.201-218, 2016-10-01 (Released:2016-10-15)

参考文献数

106

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For the Incentive Award of the Mass Spectrometry Society of Japan Incentive Award, this review will over view the works of mass spectrometry from Setou lab. Mainly, papers 2002–2010 are about development of imaging mass spectrometry. Papers 2010–2015 are mainly the application of imaging mass spectrometry for clinical samples. Recently, several papers are about the applications of secondary ion mass spectrometry. Most significant findings are that various lipid species have their own tissue distribution pattern in tissues and cells through these studies.