著者

那須 隆 小池 修治 倉上 和也 青柳 優

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.22, no.1, pp.8-12, 2010-06-01 (Released:2010-10-08)

参考文献数

14

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The objective of our study was to determine the risk factors of late-onset radiation induced morphologic change and function disorder in larynx. Six cases of late-onset laryngeal necrosis and fibrosis after radiotherapy for head and neck cancers between 1994 and 2008 were evaluated. All of the patients were male with ages ranging from 57 to 74 years. The cases included three with supraglottic laryngeal cancer (T2), two with glottic laryngeal cancer (T1a), and one with an unknown origin metastatic neck tumor. Radiation injury was found from as early as 4 months up to 77 months after radiotherapy. Laryngeal late-onset radiation-induced Morphologic change and functional disorder were observed in patients having had supraglottic laryngeal cancer (T2), concurrent chemoradiotherapy, LASER surgery, or an over exposure dose. Consequently these patients were thought to be at risk for delayed radiation-induced sequelae. While almost all laryngeal necrosis was found within 6 months, supra-laryngeal fibrous stenosis was observed even beyond 24 months. It was difficult to discriminate between i Laryngeal necrosis and recurrent cancer, as well as to determine an early diagnosis of supra-laryngeal fibrous stenosis. It is, Therefore, essential that patients with risk factor of late-onset radiation-induced sequelae be followed up over the long-term.

著者

本橋 玲 渡嘉敷 亮二 平松 宏之 野本 剛輝 許斐 氏元 櫻井 恵梨子 豊村 文将 塚原 清彰 鈴木 衞

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.26, no.2, pp.93-98, 2014-12-01 (Released:2015-07-22)

参考文献数

11

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Thyroarytenoid muscle myectomy (TAM) is a useful procedure for treating adductor spasmodic dysphonia (ADSD), in addition to type II thyroplasty (TP II), and both are performed in our department in Japan. In the present study, we examined the surgical outcomes of TAM. The subjects were 31 patients who underwent TAM between 2008 and 2013 at Tokyo Medical University Hospital, who could be followed up for at least six months following surgery and whose voice quality evaluation data were available. A comparison of voice evaluations pre-surgery and six months post-surgery was made. After six months, a significant improvement was seen in all of the voice quality evaluation items, including “strangulation”, “interruption”, “tremors” and voice handicap index (VHI). There was a marked recurrence of the symptoms in two of the 31 subjects within six months. Hemorrhage and scarring were observed as postoperative complications. In addition, we gave a questionnaire to 30 of the subjects who were followed up for at least one year following surgery, which asked about the recurrence of hoarseness and the degree of satisfaction with the surgery. Fifteen subjects responded (50%). The period of continuous hoarseness had ranged from one to 24 months. No subject felt that the hoarseness was a serious impediment in daily life, and the median period required for its disappearance was four months. Symptoms recurred in three subjects, but they tended to be mild. All 15 subjected reported experiencing a benefit from the surgery. The degree of satisfaction with TAM is very high, and we consider it to be a useful procedure for adductor spasmodic dysphonia.

著者

片岡 英幸 福原 隆宏

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.26, no.2, pp.118-123, 2014-12-01 (Released:2015-07-22)

参考文献数

35

著者

栗田 卓 千年 俊一 佐藤 公則 坂崎 友 深堀 光緒子 末吉 慎太郎 梅野 博仁 中島 格

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.26, no.2, pp.69-74, 2014-12-01 (Released:2015-07-22)

参考文献数

13

被引用文献数

3

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Human papilloma virus (HPV) types 6 and 11 are thought to infect the basal cells of the squamous epithelium. These infections cause laryngeal papillomatosis and condyloma acuminatum in the uterine cervix, which manifest the same pathological phenotype. The site of predilection is the junction of the stratified squamous epithelium and simple columnar epithelium (SCJ), however, the morphological characteristics of the epithelial junction in the larynx differ from that in the uterine cervix. Therefore, these observations suggest that the developmental mechanism of underlying the onset of laryngeal papilloma differs from that of condyloma acuminatum. The newborn larynx, which is infected by HPV in case of juvenile-onset laryngeal papillomatosis, has no SCJ in the supraglottic regions. This suggests that HPV infects the laryngeal epithelium with or without SCJ. Moreover, the immaturity of the epithelia in the newborn larynx allows HPV to easily infect the tissue.In investigations of adult larynges, the basal cells of the squamous epithelium and stratified ciliated epithelium in the larynx express p63, an epithelial stem cell marker. Integrin-α6 is, the receptor for HPV, is positive in the stratified ciliated epithelium and lower half of the squamous epithelium. These findings indicate that HPV is able to infect the squamous epithelium and stratified ciliated epithelium and that both infection with HPV in epithelial stem cells and stratification of epithelial cell layer are necessary for the development of laryngeal papilloma.

著者

佐藤 公則 松島 康二 一色 信彦 田辺 正博 渡邊 雄介 枝松 秀雄

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.26, no.1, pp.1-5, 2014-06-01 (Released:2014-12-17)

参考文献数

11

被引用文献数

1 2

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When Type II thyroplasty is performed, surgical management of the dihedral angle of the midline of the thyroid cartilage is very important. Clinical histoanatomy around the anterior commissure was investigated using whole organ serial sections of the human larynx to make Type II thyroplasty successful. An inner perichondrium did not exist at the dihedral angle in the upper three-forths of the midline of the thyroid cartilage. On the other hand, the inner perichondrium was present at the lower one-forth of the midline of the posterior surface of the thyroid cartilage. The attachment of the collagenous fiber (anterior commissure tendon, Broyles, 1943) extends from the upper portion of the thyroid notch caudalward for approximately upper three-forths of the midline of posterior surface of the thyroid cartilage. The midline of the posterior surface of the thyroid cartilage is only covered with thin mucosa at the laryngeal ventricle level. It is important not to perforate the mucosa when the laryngofissure is performed. In order to make the anterior commissure the proper width, it is important to split the anterior commissure tendon at the mid-line and to spread the glottis while making sure the tendons remain attached to the bilateral thyroid cartilage.

著者

宮本 真 楠山 敏行 森 有子 中川 秀樹 田村 悦代 新美 成二 福田 宏之

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.21, no.2, pp.117-122, 2009-12-01 (Released:2014-12-26)

参考文献数

5

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Vocal fold scarring due to injury, inflammation or surgery results in stiffness of the layer structure of the vocal fold. In addition, the mucosal waves are singnificantly affected, thereby resulting in severe dysphonia. Many therapeutic strategies have been attempted for the treatment of vocal fold scarring including voice therapy, steroid injection, injection laryngoplasty, tissue engineering and regenerative medicine. Our surgical method involves the removal of the vocal fold scarring under laryngomicrosurgery. From 2001 to 2007, we performed our phonosurgery technique on 18 patients with vocal fold scarring. The 15 patients whom were observed over two months (6 men and 9 women) ranged in age from 19 to 67 years (average age, 42.9 years). Our observations involved evaluation of subjective symptoms, as well as stroboscopic and phonometer examinations. The operation is performed under the general anesthesia. The approach is to resect the vocal fold nodule-like scarring and to resect vocal fold scarring under the mucosal epithelium. Twelve of the 18 patients had satisfactory post-surgery traveling waves and phonation. Definitive strategies in the treatment of vocal fold scarring have yet to be established. Our surgical method to treat scar formation is to remove the scar tissue under the mucosa. The key point is that we strive to attain the most excellent wound healing in order to achieve the closest reproduction of a normal vocal fold structure.

著者

楯谷 一郎 平野 滋 伊藤 壽一

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.22, no.2, pp.67-70, 2010-12-01 (Released:2011-04-08)

参考文献数

13

被引用文献数

1

著者

二藤 隆春 山内 彰人 上羽 瑠美 山岨 達也

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.24, no.2, pp.97-99, 2012-12-01 (Released:2013-05-10)

参考文献数

13

著者

松島 康二 金沢 英哲 一色 信彦 田辺 正博 枝松 秀雄

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.23, no.1, pp.26-29, 2011-06-01 (Released:2011-09-01)

参考文献数

12

被引用文献数

3 1

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The Type 1 Thyroplasty or Medialization Thyroplasty was first reported in the 1970s by Isshiki et al for treating voice disorders resulting from vocal fold paralysis or atrophy. Since then, this therapeutic modality has gained world-wide popularity, and a number of modified methods were also reported with generally satisfactory results.Silicone block fabricated in situ had long been utilized to fix the window cartilage without any significant complication, however, containment failures from silicone bag breast implants and their resultant negative side-effect led to difficulties in obtaining silicone for any surgical treatment whatsoever. Gradually, Gore-tex, as used for correcting vascular problems, had replaced silicone, because of its ease in handling and of its excellent biocompatibility. However, it did not guarantee precision in the adjustment of medialization, especially when the window-cartilage was removed and/or when the Gore-tex sheet was packed in a wrong direction. In this respect, Titanium, well known for its excellent biocompatibility, seems better suited for precision and long-lasting effectiveness. Friedrich had already reported excellent results. Based on our abundant experience with Titanium Bridges in type 2 thyroplasty for spasmodic dysphonia, we utilized a simple thin and bendable Titanium plate so as to realize adequate medialization on site.

著者

平野 実

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.25, no.2, pp.58-65, 2013-12-01 (Released:2014-07-25)

著者

木村 美和子 田山 二朗

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.25, no.2, pp.44-48, 2013-12-01 (Released:2014-07-25)

参考文献数

12

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The purpose of this study was to compare the functional biomechanical properties of some injectable phonosurgical biomaterials commonly used for vocal fold augmentation. Linear viscoelastic shear properties of cross-linked hyaluronic acid (HA; Juvederm®), micronized AlloDerm (Cymetra®), 3% bovine collagen (Atelocollagen), and calcium hydroxylapatite (CaHA; Radiesse®) were determined as functions of frequency covering the phonatory range, and compared to those of the human vocal fold cover. Measurements of elastic shear modulus (G‘) and dynamic viscosity (η‘) were made up to 250 Hz with a controlled-strain simple-shear rheometer. Linear least-squares regression was conducted to curve-fit log G‘ and log η‘ versus log frequency, and statistical analysis was performed with one-way ANOVA. There were statistically significant differences in the magnitudes of G‘ and η‘ among the phonosurgical materials and the normal human vocal fold cover (p<0.01), whereas there was no significant difference (p<0.05) in pairwise comparisons among all materials and the normal vocal fold cover. The rheometric properties of Juvederm and Atelocollagen were the closest match to those of the vocal fold cover. These findings suggest that none of the tested injectable biomaterials are ideal implants for facilitating the functional vibratory performance of the vocal fold cover. Future studies for the development of materials with optimal viscoelastic properties are warranted.

著者

塩谷 彰浩 大久保 啓介 福田 宏之 小川 郁

出版者

The Japan Laryngological Association

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.14, no.2, pp.69-73, 2002

被引用文献数

1

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Juvenile laryngeal papillomatosis develops between the ages of 6 months and 4-5 years and runs a multiple and recurrent clinical course. There were 61 patients with laryngeal papillomatosis treated at Keio university hospital during the 20-year period between May 1981 and May 2001, of whom 20 patients were under the age of 15 at onset. The average number of repeated operations they received was 18.1, showing the pronounced multiple, recurrent trend of this disease. Treatment is basically laryngomicrosurgery using a CO<SUB>2</SUB> laser, and attempts should be made to conserve normal mucosa as much as is practicable as well as to improve phonation and respiratory function, in addition to targeting the total resection of the tumor. As the human papilloma virus, which is etiologically responsible for the formation of papillomas, grows in the mucosal epithelium, it is in principle, sufficient to vapolize the epithelial layer alone, avoiding a deeper intervention than is required. Tracheostomy should be avoided wherever feasible because it may cause tumor dissemination. Development of effective adjuvant therapy, besides surgery, is also generally anticipated. Efficacy of interferon-&alpha; in this disease has been demonstrated and indole 3 carbinol (I3C), a major component of cabbage, and the antiviral agent cidofovir are also currently used. Independently, we focused on Chinese medicines, prescribing this type of herbal medicines in anticipation of their effects for contraction of residual tumor and preventive effects against recurrence. It is worth noting that favorable results have been observed in 6 of the 10 patients receiving Chinese medicines whose therapeutic responses could be evaluated.

著者

新谷 朋子 関 伸彦 氷見 徹夫

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.22, no.2, pp.99-104, 2010-12-01 (Released:2011-04-08)

参考文献数

21

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Gastroesophageal Reflux (GERD) and Laryngopharyngeal Reflux (LPRD) may be associated with night time reflux, snoring and sleep apnea; however, uncertainty remains whether reflux episodes are related to apneic episodes. The argument that the coincidental correlation of the severity of reflux-induced symptoms with the severity of obstructive sleep apnea is evidence against precipitation of apneic episodes by reflux episodes is unconvincing. While CPAP treatment improves the symptoms of GERD and LPRD, and treating GERD improves sleep disturbance, it is uncertain whether these treatments improve sleep apnea. It is necessary to consider additional treatments of GERD such as Proton Pump Inhibitors (PPI).

著者

小林 武夫 石毛 美代子 一ノ瀬 篤司

出版者

THE JAPAN LARYNGOLOGICAL ASSOCIATION

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.25, no.1, pp.12-14, 2013-06-01 (Released:2013-09-27)

参考文献数

9

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Spasmodic dysphonia (SD) is a focal dystonia that affects the larynx. Abductor SD (ABSD) is less common than adductor SD (ADSD). ABSD is typified by breathy breaks in connected speech.A male professional classic baritone singer, age 46, presented with gradually increasing breathy unphonated breaks in singing over the course of three years. He visited various institutions and was said to have incomplete elevation of the soft palate of unknown origin, myasthenia gravis, etc. His symptoms were remarkable in pronouncing vowels following unphonated consonants. He had been exposed to neither vocal abuse nor heavy singing performances. Our diagnosis was ABSD. An injection of Botulinum toxin (BT) into the posterior cricoarytenoid muscles was done via lateral cervical approach. His voice improved remarkably. His daily conversation became smooth; however, he could not regain his previous brilliant singing voice. He was obliged to discontinue his professional singing performances.