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Rabies is a zoonotic disease caused by the rabies virus. While the salivary glands are important as exit and propagation sites for the rabies virus, the mechanisms of rabies excretion remain unclear. Here, we investigated the histopathology of the salivary glands of rabid dogs and analyzed the mechanism of excretion into the oral cavity. Mandibular and parotid glands of 22 rabid dogs and three control dogs were used. Mild to moderate non-suppurative sialadenitis was observed in the mandibular glands of 19 of the 22 dogs, characterized by loss of acinar epithelium and infiltration by lymphoplasmacytic cells. Viral antigens were detected in the mucous acinar epithelium, ganglion neurons and myoepithelium. Acinar epithelium and lymphocytes were positive for anti-caspase-3 antibodies and TUNEL staining. In contrast, no notable findings were observed in the ductal epithelial cells and serous demilune. In the parotid gland, the acinar cells, myoepithelium and ductal epithelium all tested negative. These findings confirmed the path through which the rabies virus descends along the facial nerve after proliferation in the brain to reach the ganglion neurons of the mandibular gland, subsequently traveling to the acinar epithelium via the salivary gland myoepithelium. Furthermore, the observation that nerve endings passing through the myoepithelium were absent from the ductal system suggested that viral proliferation and cytotoxicity could not occur there, ensuring that secretions containing the virus are efficiently excreted into the oral cavity.

2015-08-17 23:41:30
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2 0 0 0 世界の中の古墳時代研究 : 比較考古学の観点から (考古学研究会第60回総会研究集会報告(下))

著者: 辻田淳一郎
出版者: 考古学研究会
雑誌: 考古学研究 (ISSN:03869148)
巻号頁・発行日: vol.61, no.3, pp.15-28, 2014

2015-08-17 23:30:03
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https://ci.nii.ac.jp/naid/40020325803

2 0 0 0 OA FFT解析によるフルート族の音色

著者: 大蔵康義
出版者: 日本大学
雑誌: 日本大学芸術学部紀要 (ISSN:03855910)
巻号頁・発行日: vol.35, pp.65-76, 2001

2015-08-17 23:09:16
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https://ci.nii.ac.jp/naid/110004497173

2 0 0 0 OA 旧伏見宮家別邸銚子瑞鶴荘の庭について(昭和60年度日本造園学会研究発表論文集3)

著者: 鈴木誠
出版者: 社団法人日本造園学会
雑誌: 造園雑誌 (ISSN:03877248)
巻号頁・発行日: vol.48, no.5, pp.61-66, 1985-03-30

摘要 20年以上放置され荒廃した明治期の庭,旧伏見宮家別邸銚子福鶴荘の庭を発掘調査し,実測,文献,ヒアリングにより往時の姿を推定した。特に主庭部分については旧景観の図上復元を試みた結果,明冶期の庭園の特徴とされる自然を生かした借景庭園てあることがわかった。また,千葉県銚子犬吠埼という庭の立地の意味するものもあわせて考察した。