著者

Kuwayama Hidekazu Miyanaga Yukihiro Urushihara Hideko Ueda Masahiro

出版者

Public Library of Science

雑誌

PLoS ONE (ISSN:19326203)

巻号頁・発行日

vol.8, no.12, pp.e81811, 2013-12

被引用文献数

5

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Background:The life-cycle of cellular slime molds comprises chronobiologically regulated processes. During the growth phase, the amoeboid cells proliferate at a definite rate. Upon starvation, they synthesize cAMP as both first and second messengers in signalling pathways and form aggregates, migrating slugs, and fruiting bodies, consisting of spores and stalk cells, within 24 h. In Dictyostelium discoideum, because most growth-specific events cease during development, proliferative and heterochronic mutations are not considered to be interrelated and no genetic factor governing the entire life-cycle duration has ever been identified.Methodology/Principal Findings:Using yeast 2-hybrid library screening, we isolated a Dictyostelium discoideum RabGAP, Dd Rbg-3, as a candidate molecule by which the Dictyostelium Gα2 subunit directs its effects. Rab GTPase-activating protein, RabGAP, acts as a negative regulator of Rab small GTPases, which orchestrate the intracellular membrane trafficking involved in cell proliferation. Deletion mutants of Dd rbg-3 exhibited an increased growth rate and a shortened developmental period, while an overexpression mutant demonstrated the opposite effects. We also show that Dd Rbg-3 interacts with 2 Gα subunits in an activity-dependent manner in vitro. Furthermore, both human and Caenorhabditis elegans rbg-3 homologs complemented the Dd rbg-3–deletion phenotype in D. discoideum, indicating that similar pathways may be generally conserved in multicellular organisms.Conclusions/Significance:Our findings suggest that Dd Rbg-3 acts as a key element regulating the duration of D. discoideum life-span potentially via trimeric G-protein cascades.

著者

佐藤 豊実

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(C)2008-2012

著者

加藤 光保

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2012

著者

笹 公和

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2011

著者

Sakurai Yoko Kakushima Kuniyuki Ohmori Kenji Yamada Keisaku Iwai Hiroshi Shiraishi Kenji Nomura Shintaro

出版者

Optical Society of America

雑誌

Optics Express (ISSN:10944087)

巻号頁・発行日

vol.22, no.2, pp.1997-2006, 2014-01

被引用文献数

3

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Low-temperature photoluminescence (PL) spectra of electron-hole systems in Si nanowires (NWs) prepared by thermal oxidization of Si fin structures were studied. Mapping of PL reveals that NWs with uniform width are formed over a large area. Annealing temperature dependence of PL peak intensities was maximized at 400 °C for each NW type, which are consistent with previous reports. Our results confirmed that the micro-PL demonstrated here is one of the important methods for characterizations of

著者

森田 展彰

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2010-2012

著者

磯崎 洋

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金)研究成果報告書:基盤研究(B)2009-2012

著者

Vladisavljević Goran T. Khalid Nauman Neves Marcos A. Kuroiwa Takashi Nakajima Mitsutoshi Uemura Kunihiko Ichikawa Sosaku Kobayashi Isao

出版者

Elsevier B.V.

雑誌

Advanced drug delivery reviews (ISSN:0169409X)

巻号頁・発行日

vol.65, no.11-12, pp.1626-1663, 2013-11

被引用文献数

248 9

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Microfluidics is an emerging and promising interdisciplinary technology which offers powerful platforms for precise production of novel functional materials (e.g., emulsion droplets, microcapsules, and nanoparticles as drug delivery vehicles- and drug molecules) as well as high-throughput analyses (e.g., bioassays, detection, and diagnostics). In particular, multiphase microfluidics is a rapidly growing technology and has beneficial applications in various fields including biomedicals, chemicals, and foods. In this review, we first describe the fundamentals and latest developments in multiphase microfluidics for producing biocompatible materials that are precisely controlled in size, shape, internal morphology and composition. We next describe some microfluidic applications that synthesize drug molecules, handle biological substances and biological units, and imitate biological organs. We also highlight and discuss design, applications and scale up of droplet- and flow-based microfluidic devices used for drug discovery and delivery.

著者

石橋 延幸

巻号頁・発行日

2013

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科学研究費助成事業(科学研究費補助金) 研究成果報告書:基盤研究(C) 2008-2012

著者

ARIMURA Mitsuharu KOGA Hiroki IWATA Ken-ichi

出版者

電子情報通信学会

雑誌

IEICE transactions on fundamentals of electronics, communications and computer sciences (ISSN:09168508)

巻号頁・発行日

vol.E96.A, no.12, pp.2443-2446, 2013-12

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In this letter, we first introduce a stronger notion of the optimistic achievable coding rate and discuss a coding theorem. Next, we give a necessary and sufficient condition under which the coding rates of all the optimal FF codes asymptotically converge to a constant.

著者

ARIMURA Mitsuharu KOGA Hiroki IWATA Ken-ichi

出版者

電子情報通信学会

雑誌

IEICE transactions on fundamentals of electronics, communications and computer sciences (ISSN:09168508)

巻号頁・発行日

vol.E96.A, no.12, pp.2332-2342, 2013-12

被引用文献数

1

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In this paper we consider fixed-to-fixed length (FF) coding of a general source X with vanishing error probability and define two kinds of optimalities with respect to the coding rate and the redundancy, where the redundancy is defined as the difference between the coding rate and the symbolwise ideal codeword length. We first show that the infimum achievable redundancy coincides with the asymptotic width W(X) of the entropy spectrum. Next, we consider the two sets $\mCH(\bX)$ and $\mCW(\bX)$ and investigate relationships between them, where $\mCH(\bX)$ and $\mCW(\bX)$ denote the sets of all the optimal FF codes with respect to the coding rate and the redundancy, respectively. We give two necessary and sufficient conditions corresponding to $\mCH(\bX) \subseteq \mCW(\bX)$ and $\mCW(\bX) \subseteq \mCH(\bX)$, respectively. We can also show the existence of an FF code that is optimal with respect to both the redundancy and the coding rate.

著者

天野 恵美理

出版者

京都大学大学院文学研究科哲学研究室

雑誌

京都大学文学部哲学研究室紀要 : Prospectus

巻号頁・発行日

vol.12, pp.132-138, 2010-02

著者

黒田 末寿

出版者

京都大学東南アジア研究所実践型地域研究推進室

雑誌

実践型地域研究最終報告書 : ざいちのち

巻号頁・発行日

pp.73-84, 2012-03

著者

Yamamoto Miyuki

出版者

京都大学大学院英文学研究会

雑誌

Zephyr (ISSN:09193146)

巻号頁・発行日

vol.13, pp.41-57, 1999-11-15

著者

Sasaoka Norio Sakamoto Megumi Kanemori Shoko Kan Michiru Tsukano Chihiro Takemoto Yoshiji Kakizuka Akira

出版者

Public Library of Science

雑誌

PloS one (ISSN:19326203)

巻号頁・発行日

vol.9, no.1, 2014-01-29

被引用文献数

22

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ホップ抽出物でアルツハイマー病の発症を抑えることに成功 -認知症の発症と進行の予防につながると期待-. 京都大学プレスリリース. 2014-01-30.

著者

Hiraoka Yoshinori Matsuoka Tatsuhiko Ohno Mikiko Nakamura Kazuhiro Saijo Sayaka Matsumura Shigenobu Nishi Kiyoto Sakamoto Jiro Chen Po-Min Inoue Kazuo Fushiki Tohru Kita Toru Kimura Takeshi Nishi Eiichiro

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-02-04

被引用文献数

33

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「体温恒常性維持のメカニズムの解明」に成功. 京都大学プレスリリース. 2014-02-04.

著者

Hattanji Tsuyoshi Ueda Mariko Song Wonsuh Ishii Nobuyuki Hayakawa Yuichi S. Takaya Yasuhiko Matsukura Yukinori

出版者

Elsevier B.V.

雑誌

Geomorphology (ISSN:0169555X)

巻号頁・発行日

vol.204, pp.485-492, 2014-01

被引用文献数

17

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Field and laboratory experiments were performed to examine dissolution rates of limestone in stream flow. Field experiments were conducted in three stream sites (A–C) with different lithological or hydrological settings around a limestone plateau in the Abukuma Mts., Japan. Sites A and B are allogenic streams, which flow from non-limestone sources into dolines, and site C has a karst spring source. Tablets made of limestone from the same plateau with a diameter of 3.5 cm and a thickness of 1 cm were placed in the streams for 3 years (2008–2011) where alkalinity, pH and major cation concentrations were measured periodically. The saturation indices of calcite (SIc) of stream water were − 2.8 ± 0.4 at site A, − 2.5 ± 0.4 at site B and − 0.5 ± 0.4 at site C. Annual weight loss ratios for tablets were extremely high at site A (0.11–0.14 mg cm− 2 d− 1), high at site B (0.05 mg cm− 2 d− 1), and low at site C (0.005 mg cm− 2 d− 1). The contrasting rates of weight loss are mainly explained by chemical conditions of stream water. In addition, laboratory experiments for dissolution of limestone tablets using a flow-through apparatus revealed that flow conditions around the limestone tablet is another important factor for dissolution in the stream environment. These results revealed that limestone dissolves at a rapid rate where water unsaturated to calcite continuously flows, such as in an allogenic stream.

著者

渡邊 達也

巻号頁・発行日

2013

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Thesis (Ph. D. in Science)--University of Tsukuba, (B), no. 2624, 2013.1.31

著者

金 美貞

巻号頁・発行日

2013

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Thesis (Ph. D. in Agricultural Science)--University of Tsukuba, (A), no. 6523, 2013.3.25

著者

野村 純平

巻号頁・発行日

2013

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Thesis (Ph. D. in Agricultural Science)--University of Tsukuba, (B), no. 2631, 2013.2.28