著者

阿波 圭介 佐藤 宏樹 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.1, pp.135-144, 2012-01-01 (Released:2012-01-01)

参考文献数

39

被引用文献数

1

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Topical dermatological formulations of non-steroidal anti-inflammatory drugs (NSAIDs) are reported to show their pharmacological effect partially through the systemic circulation, and to induce systemic side effects. However, pharmaceutical equivalence and pharmacokinetic bioequivalence between brand-name and generic products are not required. Therefore, we aimed to predict systemic drug exposure from brand-name and nine generic ketoprofen tapes. In vitro release profiles were examined using the paddle-over-disk method, then analyzed by the W. I. Higuchi equation incorporating an initial burst effect. Pharmacokinetic parameters were estimated from observed release profiles and the reported time-plasma concentration profile of the brand-name product. Plasma concentration profiles of generic products were predicted from the observed release profiles and the pharmacokinetic parameters of the brand-name product. In vitro release profiles differed markedly, and estimated release rates for initial burst effect and at 24 hours ranged from 4.20 to 88.75% and from 45.27 to 95.83%, respectively. The predicted plasma concentration profile of each product reflected its release profile, and estimated Cmax ranged from 61.70 to 290.30 ng/mL (0.46- to 2.15-fold vs. brand-name product). Generic products were classified into three types, i.e., systemic exposure comparable with, higher than and lower than that of brand-name product. Cmax was predicted to increase with enhanced skin permeability for all products, but the increase rates differed among products. These results suggest that safety and efficacy differ between brand-name and generic ketoprofen tapes. Healthcare professionals should carefully monitor systemic side effects, especially when switching from brand-name to generic products for which higher systemic exposure is predicted.

著者

木﨑 速人 白石 朗 鳥居 雄治 石井 貴之 馬来 秀行 三木 晶子 佐藤 宏樹 山本 大輔 小西 ゆかり 舟橋 健一 臼井 順信 堀 里子 澤田 康文

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.22, no.1, pp.44-52, 2020-05-29 (Released:2020-06-13)

参考文献数

6

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Objective: In order to ensure the safety of nursing home residents, it is very important to implement appropriate assistance to ensure compliance with necessary medication. The purpose of this study is to identify issues and to plan solutions for medication assistance.Design: We conducted a workshop involving care workers (CWs), nurses and pharmacists together.Methods: Using the KJ method, participants extracted problems related to medication assistance and planned solutions in a mixed group of CWs, nurses and pharmacists. Questionnaire surveys were conducted for the participants before, immediately after, and 3 months after the workshop.Results: A number of important and urgent issues related to medication assistance were identified. There were differences in the recognition patterns of the importance and urgency of the issues among the three categories of participants. In addition, many possible solutions were proposed. Among these solutions, 25% had been implemented by at least two participants. More than 75 % of participants felt that their awareness of the value of cooperation in medication assistance had been improved by participating in the workshop.Conclusion: These results suggest that a workshop with a group of CWs, nurses and pharmacists in one place is a useful approach for extracting problems and planning effective solutions related to cooperation in medication assistance.

著者

松岡 紗代 三木 晶子 佐藤 宏樹 堀 里子 澤田 康文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.9, pp.592-598, 2012-09-10 (Released:2013-09-12)

参考文献数

9

被引用文献数

5 5

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Non-steroidal anti-inflammatory drug (NSAID) patches tend to be prescribed in larger amounts than are actually used and surplus patches are often kept at patients' homes. Improper use of these patches without the advice of healthcare professionals might result in serious adverse effects. This study investigated patients' opinions and requests regarding the prescribed amount of NSAID patches, and their intended use of surplus patches. A web-based questionnaire survey was conducted on patients who had been prescribed NSAID patches within the previous year. There were 618 respondents. Patients who described the amount of patches prescribed as “just the amount needed" and “quite or somewhat excessive" amounted to 41%and 40%of the respondents, respectively. Forty-three-percent of respondents had at some time requested a larger prescribed amount or an additional prescription. Sixty-four-percent of them received the prescription they requested. Also, 61 % of respondents had unused NSAID patches at their homes, and many of them intended to use these patches as they felt necessary. Patients who believed that NSAID patches do not induce side effects amounted to 24%, while 54%of patients had at some time suffered symptoms possibly due to systemic or local side effects of NSAID patches. Considering the above results, healthcare professionals should provide suitable and sufficient information about NSAIDs patches to patients, and take steps to minimize the numbers of unused patches remaining at the patients' homes in order to avoid improper use of NSAID patches and to reduce medication costs.

著者

栗本 蕗 堀 里子 佐藤 宏樹 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.9, pp.1023-1034, 2013 (Released:2013-09-01)

参考文献数

22

被引用文献数

1

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For drug fostering and evolution, it is important to collect information directly from patients on the efficacy and safety of drugs as well as patient needs. At present, however, information gathered by healthcare professionals, pharmaceutical companies, or governments is not sufficient. There is concern that patients may fail to recognize the importance of providing information voluntarily. The present study was conducted to provide drug information to patients/consumers, to enlighten them on the importance of providing drug information by themselves, and to develop an Internet website, called “Minkusu,” for collecting drug information from patients. This website is based on a registration system (free of charge). It is designed to provide information on proper drug use, and to collect opinions about drugs. As of May 31, 2012, a total of 1149 people had been registered. The male/female ratio of registered members was approximately 1:1, and patients/consumers accounted for 23%. According to the results of a questionnaire survey, several patient/consumer members appreciated the usefulness of the information service, and they took an opportunity to know of the concepts of drug development and evolution (Ikuyaku, in Japanese) through the information services provided by this site. In conclusion, the developed information system would contribute to the proper use of drugs by patients/consumers and to the promotion of drug development and evolution.

著者

平山 匡彦 田中 秀和 鈴木 慎太郎 井上 広平 永富 亜紀 作元 誠司 北原 敏弘 宮﨑 長一郎 吉谷 清光 佐藤 宏樹 堀 里子 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.8, pp.913-922, 2013 (Released:2013-08-01)

参考文献数

2

被引用文献数

1

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This study was conducted among 252 inhabitants aged 16 years or older of small remote islands in Gotoh. The survey was conducted in a direct interview format based on a questionnaire. In the interview, the respondents were asked about the statuses of their Internet usage, purchase/use/storage of nonprescription drugs, acquisition of information regarding nonprescription drugs, as well as regulations pertaining to the sale of nonprescription drugs, including the use of postal services. Among the respondents, 7.5% were Internet users, whereas people who had past experiences in purchasing nonprescription drugs through Internet accounted for as few as 0.8% of the total number of respondents; 63.9% of the inhabitants of small remote islands did not use nonprescription drugs, additionally, most inhabitants of small remote islands did not express any need for nonprescription drugs sold through Internet. Further, the findings suggested that a large number of people felt the need for the presence of pharmacists and experts to provide them with explanations and information regarding nonprescription drugs. However, because a large number of these people were unaware of the existence of pharmacists, it is important that in the future, pharmacists should conduct “consultation meetings and briefings regarding medications.” These meeting may be held in a continuous manner in these small remote islands, such that the inhabitants recognize the difference in a pharmacists' profession. It is essential that “family pharmacies/pharmacists” play a central role in promoting the supply, management, and proper use of pharmaceutical products.

著者

明貝 怜美 澤井 夏海 須藤 洋行 佐藤 宏樹 藤田 行代志 三島 八重子 木﨑 速人 堀 里子 澤田 康文

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.24, no.1, pp.11-16, 2022-05-31 (Released:2022-06-11)

参考文献数

7

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Objective: Pharmacists at insurance pharmacies play an important role in the pharmaceutical care of outpatients receiving cancer chemotherapy. This study aimed to clarify the actual status of insurance pharmacies' involvement in cancer chemotherapy and associated issues, based on an analysis of prescription inquiries made to doctors by pharmacists at an insurance pharmacy.Design: This was a retrospective observational study.Methods: The data was collected in one insurance pharmacy, which received prescriptions mainly from Gunma Prefectural Cancer Center. Among 2, 258 inquiries recorded from January 2015 to May 2018, inquires related to oral anticancer drugs or supportive care medicine were extracted. The frequency of inquiries for each item, or the frequencies of factors that lead to inquiries were calculated. Inquiries considered to have potentially led to the prevention or avoidance of adverse drug reactions (ADRs), so-called “preavoidance” inquiries, were also extracted.Results: Four hundred and forty inquiries related to 20 oral anticancer drugs were included in the analysis. The prescriptions were changed after 92.7% of all prescription inquiries. Prescription inquiries for drugs with rest periods were more frequent than those for drugs without rest periods. The most common inquiries were about the medication schedules stated on the prescription, followed by inquiries about supportive care drugs. Approximately 60% of the pharmacy inquiries were related to“pre-avoidance”inquiries. Most of the pre-avoidance inquiries concerned prevention of ADRs, though these inquiries also contributed to“reduction or avoidance of mental anxiety”. The prescription inquiries were triggered by information collected by pharmacists from patient interviews and from medication histories.Conclusion: Our findings suggest that inquiries to the prescribing doctors by pharmacists at insurance pharmacies contribute significantly to the appropriate use of anticancer drugs.

著者

川上 未知 木﨑 速人 矢野 良太郎 山村 真一 吉岡 ゆうこ 鈴木 順子 宮本 光雄 藤田 道男 堀 里子

雑誌

日本薬学会第142年会(名古屋)

巻号頁・発行日

2022-02-01

著者

泉 太郎 堀 里子 佐藤 宏樹 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.5, pp.617-627, 2012 (Released:2012-05-01)

参考文献数

8

被引用文献数

3

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Aggravation of asthmatic response (asthmatic attack, 2 cases) and adverse events (tremor, 1 case) due to a switch from a brand-name tulobuterol tape to a generic tape were recently reported. These changes disappeared after reformulation from generic to the brand-name tape. To investigate this issue, we conducted a questionnaire survey on changes of asthmatic response, adverse events and product usability due to a switch between tulobuterol tapes. We identified 44 cases (18 from doctors, 26 from pharmacists) in which changes of asthmatic response or adverse events had occurred due to a switch between tulobuterol tapes. Aggravation of asthmatic response had occurred in 30 cases and adverse events in 21 cases due to switch from brand-name tulobuterol tape to generic tape. As regards change of product usability, we obtained 96 relevant responses (18 from doctors, 78 cases pharmacists), and the major response was that generic tulobuterol tape peeled off the skin more easily than did the brand-name tape (60 cases). These results suggest that changes of asthmatic response, adverse events and product usability should be carefully monitored when switching tulobuterol tapes.

著者

田中 真吾 朝比奈 泰子 佐藤 宏樹 三木 晶子 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.6, pp.757-766, 2014-06-01 (Released:2014-06-01)

参考文献数

30

被引用文献数

1 1

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It has been reported the use of nonsteroid anti-inflammatory drugs (NSAIDs) in late pregnancy was associated with potentially fetal toxicity (contraction of fetal ductus areteriosus). According to the package inserts in Japan, many oral NSAIDs are contraindicated to women in late pregnancy, but several oral and topical NSAIDs with case reports of fetal toxicity are not. In the present study, a web-based questionnaire survey was conducted in pharmacists/physicians to determine their awareness of fetal toxicity caused by NSAIDs, as well as their attitudes regarding the use of NSAIDs in late pregnancy. Responses were obtained from 427 pharmacists, 22 obstetricians, and 160 non-obstetric physicians. Of the non-obstetric respondents, more than 40% had no knowledge of fetal ductus arteriosus contraction caused by oral ibuprofen, and most of them were not aware of the relevant warning statement on the package insert. In contrast, these were familiar to nearly 100% of the obstetricians. As for ketoprofen tape, only 20-40% of the pharmacists/physicians were aware of the warning statement, and nearly all respondents did not confirm whether the patient was in late pregnancy. The majority of the respondents answered that oral ibuprofen, ketoprofen tape and NSAID-containing OTC drugs should not be used in late pregnancy after they knew the warning statements in late pregnancy. This survey suggests that the fetal toxicity of NSAIDs is not well recognized by pharmacists/physicians. It would be necessary to make it thoroughly known to them through such as enrichment of safety information on the package inserts, accompanying with the evidence.

著者

平山 匡彦 田中 秀和 鈴木 慎太郎 永富 亜紀 作元 誠司 北原 敏弘 宮崎 長一郎 吉谷 清光 佐藤 宏樹 堀 里子 三木 晶子 澤田 康文

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.15, no.2, pp.57-63, 2013 (Released:2013-09-05)

参考文献数

2

被引用文献数

1

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Objective: The revised Pharmaceutical Affairs Act that came into force in June 2009 prohibits the sale of nonprescription drugs via mail.  However, as a provisional measure, regular users and inhabitants of remote islands who do not have access to pharmacies or drug stores are allowed to purchase nonprescription drugs via mail until the end of May 2013.  This study involves a survey on the purchasing of nonprescription drugs by Internet-illiterate inhabitants of the remote Goto Islands, Nagasaki Prefecture, Japan.Methods: Our process began with the distribution of questionnaires via mail to inhabitants of the remote Goto Islands, of whom 3,819 were randomly selected.  The responses were sent between January 22 and February 26, 2011.  We analyzed problems presented by 522 inhabitants who were Internet-illiterate.Results: The results revealed that 57.3% of the respondents living on large islands—with pharmacies, drug stores, and pharmacists— (e.g., Fukueshima) and 85.3% of respondents living on small islands scattered around large islands—with none of the abovementioned amenities— (e.g., Maeshima) were Internet-illiterate.  Additionally, a majority of the respondents (more than 80%) felt no need to purchase nonprescription drugs over the Internet.  However, considering that a handful of these inhabitants do, or will at some time need to purchase nonprescription drugs over the Internet, we strive to establish an optimal system for supplying medications to these Internet-illiterate inhabitants.Conclusion: Community pharmacists need to establish close relationships with the Internet illiterate (particularly those living on small islands) and promote the overall appropriate use of medicinal products.

著者

河添 仁 土屋 雅美 藤堂 真紀 原 梓 大西 友美子 大里 洋一 堀 里子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.143, no.8, pp.683-691, 2023-08-01 (Released:2023-08-01)

参考文献数

10

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This study aimed to clarify diverse values toward career visions for hospital pharmacists. A self-administered online questionnaire survey was delivered to live and on-demand release attendees at a symposium about sustainable career paths for pharmacists at the 32nd annual meeting of the Japanese Society of Pharmaceutical Health Care and Sciences between September 23rd and November 14th, 2022. Correspondence analyses of text mining were conducted to assess the association between the participants’ perspectives on career visions and their backgrounds consisting of sex and generation. The recovery rate was 81.9% (136/166). The majority of respondents were women (61.4%), aged ≥40 years (66.1%). Correspondence analysis of career vision for pharmacists showed that respondents who were ≥20–30 years were associated with the research topic, whereas those who were ≥40 years were associated with the director of a pharmacy and worked until retirement age. In contrast, there was no difference in career visions for pharmacists based on sex. The median satisfaction score of the symposium was 6 [interquartile range (IQR): 5–6] in the entire population, as conveyed using a seven-point Likert scale. Interestingly, the median satisfaction scores of the symposium were significantly higher for men in management positions than women in non-management and management positions (p=0.0106 and p=0.0031, respectively). In conclusion, we believe that career support tailored to everyone’s values could enable hospital pharmacists to realize their career visions.

著者

朝比奈 泰子 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.2, pp.271-275, 2010-02-01 (Released:2010-02-01)

参考文献数

25

被引用文献数

1

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Hyperkalemia is common in patients with renal disease, and is sometimes caused by dietary potassium intake. We aimed to determine and compare the content of potassium in nine brands of glucosamine supplements sold in the Japanese market and via the Internet. The potassium content was 0.165-3 mg per daily dose in Japanese products, which contained glucosamine hydrochloride or N-acetylglucosamine, while the content in foreign products, in which glucosamine was sulfated, was 197-280 mg. Our results show that the potassium content in glucosamine sulfate supplements can correspond to 20% of the maximum daily intake of potassium by patients on hemodialysis, because the products sometimes contain glucosamine as glucosamine sulfate potassium chloride for stabilization. Although it is not permitted to sell glucosamine sulfate as food in Japan, consumers can easily buy foreign products that contain glucosamine sulfate via the Internet, and those products rarely indicate the potassium content. Health professionals should pay attention to patients' use of glucosamine supplements, especially when patients' dietary potassium intake needs to be restricted.

著者

森 玲奈 孫 大輔 渡辺 雄貴 北村 智 堀 里子

出版者

日本教育工学会

雑誌

日本教育工学会論文誌 (ISSN:13498290)

巻号頁・発行日

pp.S44038, (Released:2020-11-09)

参考文献数

11

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本研究では高齢者の学習課題の中で健康に関する学習に焦点を当て,自己調整学習理論を参照し,主体的に健康について学ぶことができるワークショップを設計・実践・評価することを目的とする.ワークショップ「すまけん」は,参加者に健康情報の取得へのネットの活用可能性の理解と利用の自己効力感の向上を促すものである.その結果,事前に比べて事後のヘルスリテラシーの自己効力感並びにスマートフォン活用の自己効力感が高まっていた.またワークシートの記述内容の分析から,すまけんワークショップ内では,殆どの参加者が健康情報の探索を学んだことが示された.

著者

玉木 啓文 佐藤 宏樹 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.10, pp.1305-1312, 2018-10-01 (Released:2018-10-01)

参考文献数

17

被引用文献数

1 1

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Similar-appearing press-through package (PTP) sheets (also known as blister packs) that contain different medicines may result in incorrect medication due to confusion errors. To evaluate the significance of this problem and to identify the factors that may lead to such errors, we conducted a questionnaire survey for pharmacists. Three hundred and eighty-two pairs of PTP sheets with similar appearance were included in the questionnaire. Factors related to color (sheet color at the front of the sheet 90.9%, color of tablet/capsule 57.1%, print color at the front of the sheet 45.9%) were most frequently selected as influencing the perceived similarity of the reported pairs, followed by tablet/capsule shape (46.2%), sheet size (32.4%), and mark and character positioning on sheets (6.8%). In the pairs of similar PTP sheets, pairs manufactured by the same pharmaceutical company accounted for 15%. The frequency of confusion errors or near-errors due to similar appearance of PTP sheets was highest at the time of collecting PTP sheets from the medicine shelf and returning the sheets to the medicine shelf, followed by the time of inspection of prepared medicines and medication instructions. The questionnaire results also indicate that patients themselves can confuse similar PTP sheets and take the wrong medicine. Further quantitative studies are needed to clarify the key factors that cause confusion errors due to similar appearance and to identify potential remedial measures.

著者

松本 優作 木崎 速人 池田 裕樹 仲村 昌平 喜納 信也 永井 尭範 那須 隆史 宮本 興治 堀 里子

出版者

公益社団法人日本薬学会

雑誌

日本薬学会第140年会(京都)

巻号頁・発行日

2020-02-01

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目的:現在,国家戦略特区の過疎地等で認められている遠隔薬剤指導(オンライン服薬指導)は,オンライン診療と合わせて医療へのアクセシビリティ改善への寄与が期待されている。本研究では,実際にへき地で実証運用されているオンライン服薬指導を利用する患者が感じるその利点や課題点を,インタビュー調査により探索的に検討した。方法:2019年10月に,オンライン服薬指導を受けた経験のある患者を対象として,インタビューガイドに基づく半構造化インタビューを実施した。インタビュー内容は逐語録化し,コーディング,カテゴリ化(<>で示す)を複数の研究者で行い,質的に分析した。結果・考察:対象者の年代は60代が3名,90代が1名,性別は男女2名ずつであった。患者はオンライン診療・服薬指導に関して,<病院・薬局に行かずに薬の入手が可能>,<医療機関が遠い地域での診療の簡便化>といった地理的課題の解消による利点を挙げるだけでなく,<自分の都合で診療時間の設定が可能>,<働き世代の通院に掛ける時間の省略>といった利便性の向上についても実感していた。一方で,<高齢者のタブレット端末の操作の難しさ>が課題点として指摘された。へき地在住者は高齢で独居の場合が多いことから,高齢者を対象としてタブレット端末への抵抗感をなくしたり,操作を支援したりする取り組みが必要であると考えられた。本調査では,オンライン上での医師への相談から受診を勧められ,疾患に気づいた経験をもつ患者がいた一方で,これまで薬剤師との接点がなかったためか,オンライン上で薬剤師に相談した経験をもつ患者は少なかった。今後,へき地でのオンライン服薬指導の有用性を向上させるためには,へき地における医療や健康サポートにおける薬剤師の関わり方についても同時に検討していく必要があると考えられた。

著者

壁矢 健司 佐藤 宏樹 堀 里子 三木 晶子 三浦 康正 澤田 康文

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.21, no.2, pp.49-56, 2019-08-31 (Released:2019-10-10)

参考文献数

12

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Objective:Marketing specialists (MSs) from pharmaceutical wholesalers might shore up post-marketing surveillance (PMS) by pharmaceutical manufacturers. The purposes of this study were as follows: to research problems in PMS found by market specialists, to find solutions for these problems, and motivating MSs to work on PMS. Methods: We conducted a workshop with 12 MSs, who were already working on PMS operations. Participants were divided into three groups. Each group discussed problems with their PMS operations using the KJ method, discussed the potential solutions for the problems, and finally presented them in a plenary debate session. Questionnaire surveys were conducted for the participants before, immediately after, and 6 months after the workshop. Results: This workshop revealed two crucial and urgent problems on PMS faced by MSs: lack of feedbacks to clinical site and lack of publicity of the significance of PMS by MSs. Several solutions were suggested: browsing system of collected information, publication of the stages of improvement in pharmaceutical preparations and packaging, and distributing leaflets about PMS by MSs. In addition, this workshop conferred a positive influence on the participants: in the post-workshop questionnaires, most of the participants answered that they could well understand the problems (92%) and the solutions (75%) on PMS, and that they could improve their attitudes toward PMS operations (83%). . Conclusion: This workshop was quite effective for most of the participants in searching the problems, considering the solutions, and improving their attitudes. Organization of several such workshops might result in better PMS by MSs.

著者

中嶋 瞳 三木 晶子 佐藤 宏樹 堀 里子 澤田 康文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.6, pp.360-368, 2014-06-10 (Released:2015-06-10)

参考文献数

14

被引用文献数

1

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Among the adverse effects of anticancer drugs, critical effects have attracted the most attention. However, non-critical adverse effects that lower the quality of life of cancer patients have been gaining recognition. For example, the package insert of tegafur・gimeracil・oteracil potassium (S-1) was modified and lacrimal duct obstruction was added to the list of critical adverse effects on September 25, 2012. In a similar vein, this study aimed to examine the awareness of healthcare professionals regarding the adverse effects of anticancer drugs on the eyes. A web-based questionnaire survey was administered to medical doctors and pharmacists. We received responses from 38 doctors and 123 pharmacists. Only 39.5% (15) of the doctors and 33.3% (41) of the pharmacists were aware of the adverse effects of anticancer drugs on the eyes. Among respondents who had observed these adverse effects, only 12.5% (1/8) of doctors and 11.1% (2/18) of pharmacists reported them to the authorities or the pharmaceutical companies. The results suggest that the adverse effects of anticancer drugs on the eyes should gain more recognition among healthcare professionals. Therefore, we would like to encourage them in obtaining information concerning the safety of medicines and to report all observed adverse effects regardless of their severity.

著者

玉木 啓文 佐藤 宏樹 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.4, pp.525-529, 2012 (Released:2012-04-01)

参考文献数

4

被引用文献数

1 2

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Confusion of drug names is one of the most common causes of drug-related medical errors. A similarity measure of drug names, “vwhtfrag”, was developed to discriminate whether drug name pairs are likely to cause confusion errors, and to provide information that would be helpful to avoid errors. The aim of the present study was to evaluate and improve vwhtfrag. Firstly, we evaluated the correlation of vwhtfrag with subjective similarity or error rate of drug name pairs in psychological experiments. Vwhtfrag showed a higher correlation to subjective similarity (college students: r=0.84) or error rate than did other conventional similarity measures (htco, cos1, edit). Moreover, name pairs that showed coincidences of the initial character strings had a higher subjective similarity than those which had coincidences of the end character strings and had the same vwhtfrag. Therefore, we developed a new similarity measure (vwhtfrag+), in which coincidence of initial character strings in name pairs is weighted by 1.53 times over coincidence of end character strings. Vwhtfrag+ showed a higher correlation to subjective similarity than did unmodified vwhtfrag. Further studies appear warranted to examine in detail whether vwhtfrag+ has superior ability to discriminate drug name pairs likely to cause confusion errors.

著者

大槻 純男 堀 里子 寺崎 哲也

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.122, no.1, pp.55-64, 2003 (Released:2003-06-24)

参考文献数

50

被引用文献数

7 12

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血液脳関門(blood-brain barrier: BBB)は,血液と脳を隔てる関門組織として存在し薬物の脳への透過性を制限していることは,古くから認識されていた.近年のBBB研究の成果によって,BBBには栄養物質を脳へ供給する輸送系だけではなく,脳から血液方向の排出(efflux)輸送系の存在が明らかになり,それら輸送系の機能が薬物の脳移行性に大きな影響を与えていることが明らかになりつつある.血液から脳への輸送を行うinflux輸送系は,薬物を脳へ移行する通り道となる.BBBに発現するアミノ酸輸送系の一つであるsystem Lによって,L-DOPAは脳内に輸送される.また,一部の塩基性のµ-opioid peptide analogueは,BBBと電荷的相互作用を介したtranscytosisによって脳内に移行する.一方,排出輸送系によって排出されてしまうために脳内分布が低下してしまうケースも存在する.排出輸送に関わる分子としてATP-binding cassette(ABC)トランスポーターのABCB1(MDR1)が存在する.この輸送系は,ATP水解エネルギーを利用して,比較的脂溶性の高い薬物を血中に排出する.また,内因性物質の排出輸送系によっても薬物が脳から排出される.ドパミンの代謝物であるhomovanillic acidは,organic anion transporter 3(OAT3)が関与する排出輸送系によって脳から排出される.このOAT3が関与する排出輸送系によって6-mercaptopurineやacyclovir等が排出され脳への移行が制限されている可能性が示唆されている.また,BBBにはシナプスと同様にセロトニンやノルエピネフリンのトランスポーターが発現していることから,これらトランスポーターを阻害する抗うつ薬による相互作用が考えられる.現在,血液脳関門に発現し薬物の輸送に関わる輸送系や,薬物と相互作用する輸送系が徐々に明らかになりつつある.今後,このようなBBBの輸送系の解明は中枢作動薬の開発や中枢疾患の病因解明に重要な知見となるであろう.