著者

大谷 道輝 佐久間 博文 高山 和郎 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.1, pp.11-18, 1997 (Released:2011-08-11)

参考文献数

24

被引用文献数

11 9

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Six kinds of well-prescribed admixtures of commercially available ointments and/or creams were selected from the prescribed sheets in our hospital. The skin permeability of corticosteroid from these admixtures was investigated by in vitro experiments using hairless mice skin. The permeability of corticosteroid through skin after adaptation of corticosteroid creams (Lidomex®) alone was approximately 9-fold larger as compared with that of the ointments only.The pemeability of conicosteroid in the admixture of Nedsona Universal®cream or Lidomex®ointment and urea ointments respectively was 3-and 5-fold larger than that from the cream and ointments alone. However, urea ointments did not influence the permeability of the drug in Lidomex®creams.This suggested that the w/o-type urea ointments more greatly enhanced the permeability of corticosteroid as compared with the o/w type urea ointments. The extent of the stability of the emulsion after mixing was related to the permeability. These results suggest that admixing ointments and/or creams should be carried done among bases having similar physicochemical characteristics.

著者

全泓 奎 大原 一興 小滝 一正

出版者

一般社団法人日本建築学会

雑誌

学術講演梗概集. F-1, 都市計画, 建築経済・住宅問題 (ISSN:13414534)

巻号頁・発行日

vol.2002, pp.1145-1146, 2002-06-30

著者

金 泓奎 大原 一興 小滝 一正

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.68, no.565, pp.183-191, 2003

被引用文献数

1 1

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Homeless people have built shacks and settled down in Shibuya-ku / Miyashita Park. In this paper I tried to investigate the need for community, especially through the participatory research by the homeless people themselves in this park. It shows that the homeless people living in the park have formed neighborhood relation and this relation contributes to sufficiency of their basic human needs, house construction through mutual support, cooperative approach for the life rebuilding. Further, it shows that they have practiced many kinds of housing activities through the homeless peoples' autonomous council, which they established, and that they also express much interest in joint resettlement. Important needs for the homeless are not only shelters, but also improvement in their living environment based on autonomous community while living together. Therefore, as a policy, preparation of systems for enabling them to practice such kind of their autonomous activities is more necessary than institutionalization.

著者

蓑輪 裕子 林 玉子 中 祐一郎 小滝 一正 大原 一興 佐藤 克志 狩野 徹 前川 佳史 堀端 克久

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.62, no.493, pp.109-115, 1997-03-30 (Released:2017-02-02)

参考文献数

9

被引用文献数

4 4

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The purpose of this research is to evaluate the effectiveness of the house remodeling support system for the elderly. We administered questionnaires and conducted interviews with recipients of house remodeling grants in Edogawa-ku in Tokyo. The results are summarized as follows; for the elderly there are many difficulties of various types. It was found to be most expensive to remodel bath equipment. Regarding support system, we determined that the elderly need subsidy program, advice concerning methods of remodeling from specialists who have some knowledge about construction and the elderly, and a rental system for technical aid because some items are too expensive and are needed only short term.

著者

林 玉子 中 祐一郎 小滝 一正 大原 一興 佐藤 克志 狩野 徹 蓑輪 裕子 安部 博雄

出版者

一般財団法人 住総研

雑誌

住宅総合研究財団研究年報 (ISSN:09161864)

巻号頁・発行日

vol.20, pp.229-240, 1994 (Released:2018-05-01)

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我が国の住宅は高齢者にとっては支障が多く,在宅生活を円滑に過ごすには適切な住宅改善を行なう事が大切である。本研究の最終的な目的は,質の高い改善を行なうための総合的サポートシステムのあり方を示すことにある。具体的には主に,全額助成を実施し,先進的なサポートシステムである「江戸川区すこやか住まい制度」の実態と問題点を明らかにした。研究方法としては,同制度の利用者,役所,協力工務店へのアンケート及び訪問調査を行なったほか,それを補完するために全国の福祉機器ショップ・メーカーヘのアンケート調査,高齢者向け住宅改善の経験のある建築士へのヒアリングを行なった。調査結果の概要は以下の通りである。①改善のプロセス:本人・家族が直接関与した場合に改善後のイメージが捉えやすくなり,ひいては問題点の少ない改善に結びつく。支援制度が改善の促進に非常に役立っている。②改善に要する費用:改善費用は手すりの設置など小規模な場合でも平均約17万円と高額で,特に設備工事,木工事にかかる費用が大きい。助成する際には見積書の統一が課題となる。③改善の効果:1.住宅性能の変化,2.本人の日常生活動作・介護負担の変化,3.意欲・生活態度の変化,を軸として捉え,改善の有効性を明らかにしたが,さらに効果を測る軸についての検討が必要である。④改善の経年的変化:再改善を行なう率は高くその原因は,身体機能や意欲の変化,当初の改善の不備等であり,今後は不必要な再改善は少なくしていくことが必要である。さらに補足調査により重要なテーマである「福祉機器」に関する実態と問題点を把握した他,改善に関する専門的知識・情報のデータベース化に向けて具体的に構成要素と内容を整理した。住宅改善サポートシステムの構築は専門職種の適切な関与,改善に関する知識の一般化,費用の助成,福祉機器の給付等,多面的な対応が必要とされていることが明らかとなった。

著者

小滝 一志

出版者

マスコミ市民フォーラム ; [1967]-

雑誌

マスコミ市民 : ジャーナリストと市民を結ぶ情報誌

巻号頁・発行日

no.606, pp.44-50, 2019-07

著者

青山 隆夫 松元 美香 中山 紀美子 中島 克佳 渋谷 文則 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.2, pp.108-114, 1997-04-10 (Released:2011-08-11)

参考文献数

16

被引用文献数

1 1

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The pyrogenic activity of 10% inulin injections prepared at a hospital pharmacy was measured using the Pyrogen test in Japanese Pharmacopeia (JP), while the endotoxin concentration in the injections was determined by the, Limulus test, which were JP Endotoxin test and a turbidmetric kinetic assay. After the intravenous administration of 30 ml of inulin injections to a rabbit, the rectal temperature rose to 1.5° compared with that before administration. As a result, the endotoxin was found in all lots of the inulin injections tested, and their values were markedly beyond the limit of Water For Injections prescribed in JP (0.25 EU/ml). In addition, the endotoxin content varied between the various lots of inulin powder, and also between the manufacturers. The endotoxin in inulin injection was removed (less than the quantitative limit of 0.031 EU/ml) by adding activated carbon black to the injection or the filtration using a Posidyne® Nylon 66 filter. No pyrogenic activity was observed in the inulin injections after the removal of endotoxin.Based on these results, the adverse effects induced by inulin injections may thus be caused by endotoxin derived from inulin. This method using either adsorption or filtration is thus considered to be useful for the removal of endotoxin when preparing inulin injections.

著者

大塚 亮子 青山 隆夫 高柳 理早 清野 敏一 清水 秀行 中村 幸一 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.3, pp.269-277, 1997-06-10 (Released:2011-08-11)

参考文献数

15

被引用文献数

1 2

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We studied the effect of advising outpatients on the rational use of ophthalmic solutions and compliance by a questionnaire (n=158), in order to establish the optimal consultation method. A total of 41.8% of the patients answered the questionnaire. In compairing the actual use of ophthalmic solutions before and after consultation, the rates of rational use increased for all items except for “applications per day”, which decreased slightly from 93.4% before the consultation to 90.2% after that. In particular, “eyelid closure” and “nasolacrimal occlusion” after instillation, and “the 5 min interval of instillation in the case of plural medication”, considerably increased from 34.8% before the consultation to 60.6% after that, from 9.5% to 50.8% and from 45.9% to 73.8%, respectively. The compliance remarkably improved in glaucoma patients after consultation regarding “the 5min interval of instillation” .Based on these results, our consultation method for the rational use on ophthalmic solutions was thus evaluated. However, since some patients who still did not appreciate the need for the rational use of such medication still presented, further improvements in the consultation method requires for the rational use.

著者

山下 佳子 小滝 一 山田 安彦 中村 幸一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.19, no.3, pp.184-190, 1993-06-20 (Released:2011-08-11)

参考文献数

18

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Drug informations on a suitable insertion duration of suppositories and on a deal with the problem of the loss from rectal are essential for the proper therapy of patients. In the present study, we collected the data on drug disposition after administration of commercially available suppositories which had systemic pharmacological effects, and then analized pharmacokinetically on the problems of the insertion duration of them and the loss from rectal. The rectal absorption rate and the cumulative absorption ratio of drugs from commercially available suppositories were estimated by the deconvolution analysis. The plasma concentration data after rectal and intravenous administration were obtained in nine kinds of drugs, which were ampicilline, ketoprophene, indomethacine, acetoaminophene, phenobarbital, donperidone, bromazepam, buprenorphine and morphine. It was shown that the completion time of the absorption of drug from the suppositories varied largely from 50 min for ampicilline to 8 hours for donperidone. Comparing the time periods required to reach to 50% in the cumulative absorption ratio in those drugs, the fastest time was found in ampicilline (15 min), and the slowest was in aminophylline (90 min). These findings make it possible to the persue counseling for the patients on the proper insertion duration of each suppositories. The simulation of the time course of blood drug concentration after the loss of suppositories from rectal and the supplement of them was successfully performed, suggesting that the optimal drug concentration could be controled by the rational supplemental dose. In conclusion, the drug information based on the deconvolution analysis can be useful to instruct a rational use of suppositories to the pharmacist and/ or the patients.

著者

小滝 一彦

出版者

日本大学

雑誌

挑戦的萌芽研究

巻号頁・発行日

2014-04-01

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ベッカーによる人的資本論では、若い時は賃金が生産性より高く、訓練後は賃金より生産性が高いと考えている。一方、ラジアーらは賃金を後払いにすることで、若い労働者の賃金は生産性より低く、退職間近の労働者では賃金のほうが生産性より高いと考えた。この研究では標準的な生産関数を用い、賃金や生産性などの人的資本も標準的なミンサー型の関数を用い、両者を企業単位で線形関数として統合し、パネル固定効果分析を行える関数型を確立した。データ分析の結果、若い労働者の賃金は生産性よりも高いがまもなく逆転する。一方、賃金と生産性は中高年期の労働者で再び逆転し、退職間近の労働者では再び賃金が生産性よりも高くなる。

著者

保坂 恵玲 高柳 理早 鈴木 あやな 折井 孝男 清野 敏一 清水 秀行 山村 喜一 中村 幸一 小滝 一 澤田 康文 伊賀 立二

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.4, pp.342-347, 1997-08-10

被引用文献数

8

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We conducted a survey to evaluate a system adopted by the Pharmacy Department of Tokyo University Hospital to address the problem of drug compliance under this system, patients are provided with a "Drug History Handbook", or drug notebook. This survey attempted to determine the extent to which a "Drug History Handbook" helped patients understand the drug they were taking, and the extent to which it was utilized during visits to other institutions. Based on the results of the survey we evaluated the efficacy of "Drug History Handbook" as a means to enable patients themselves to perform comprehensive drug information management. Out of 288 patients respondmg to the survey 149 (52%) had a "Drug History Hand-book"149out of 286 respondents or 40% had been diagnosed at other institutions. The respondents who said they had shown their "Drug History Handbook" to phamacists or physicians at other pharmacies, hospitals, or medical institutions were numbered 7 1 out of 149 (48%), including duplicate responses. At community pharmacies conducted at the same time, responses were obtained from 48 pharmacies. Of the 48 responding pharmacies, 21 (44%) said that patients had presented either "Drug History Handbook"or "prescription cards" From these results, it is clear that the patients thus realized the importance of keeping a complete record of the drugs they had taken, and that presenting information about drug history can be a very valuable aid in both prescribing and preparing appropriate medications. From thus survey, it was found that the use of a "Drug History Handbook" can help prevent the dispersal of information about purchase of over the counter drugs as well as prescription drugs. As a means of patient education, it can also be extremely effective for avoiding the duplicated administration of medications and drug-drug interactions.

著者

倉本 加代 青山 隆夫 中島 克佳 中村 幸一 小滝 一 伊賀 立二

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.6, pp.491-496, 1997-12-10

被引用文献数

2

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We studied the effects of various infusion containers materials on the fluid volumes, different infusion fluids and fluid concentrations of nartograstim (NT), a recombinant human granulocyte colony stimulating factor, on the adsorption of NT to containers, after adding NT preparations (Neu-up^&ltss;[O!R}> for injection 100) into infusion fluids. The NT concentrations in the infusion fluids after adding NT to containers were determined by a high-performance liquid chromatographic method or bioassay. When 1000 ng of NT was added to 500 ml physiological saline in glass containers (final concentration : 200 ng/ml), the residual rates in the fluids was to 89.5% immediately after addition, and thereafter decreased 73.3% at 6 hr and 59.1% at 24 hr. Similarly, when NT was added to the same solution in polypropylene containers, the residual rates was 74.2% immediately after adding, and 37.5% at 6 hr, and 27.8% at 24 hr. The results in the ethylenvinyl acetate and polyethylene containers were also similar to those in the polypropylene containers. No influence of the volumes (100 and 250 ml) or the kinds of fluids (physiological saline, 5% glucose solution and ringer lactate solution) on the residual rates of NT in fluids was observed. As the fluid concentrations of NT were higher, the residual rates were found to be larger within the range of 100- 1200 ng/ml. These decreases in the NT concentrations in the infusion fluids could be prevented almost completely by adding commercially available total-vitamin injections containing polysorbate surfactants.