著者

今浦 将治 山谷 武司 上原 望 眞野 匠智 永瀬 怜司 木村 耕二 菅野 浩 山田 安彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.6, pp.767-774, 2017 (Released:2017-06-01)

参考文献数

15

被引用文献数

4

---

We evaluated the effects of pharmacist intervention for adverse drug reaction detection and exacerbation avoidance, as well as the severity and outcome of reactions based on analyses of pharmacist involvement in a collaborative approach to medicine. Of 5436 cases with pharmacist involvement, adverse drug reaction prevention was seen in 440, accounting for 8.1%, and exacerbation avoidance in 213, accounting for 3.9%. We concluded that pharmacist involvement contributes to detect adverse drug reactions and avoid exacerbation, and improves pharmacotherapy safety. We also analyzed 131 cases in which the course after intervention was followed. When categorized by adverse drug reaction severity, Grade 1 and 2 were the same at 45.8%, Grade 3 at 8.4%, respectively. Those findings suggested that pharmacist intervention contributes to early detection of an adverse drug reaction. Also, the relationship between clues for detecting adverse drug reactions by a pharmacist and their severity showed that objective evaluations such as clinical laboratory test results, physical assessments and medication history were important for detecting reactions that became more serious. Patients recovered or recovering from an adverse reaction comprised 76.4%, indicating that pharmacist intervention contributed to exacerbation avoidance and improvement. Our findings revealed the effects of pharmacist intervention for adverse drug reaction detection and exacerbation avoidance, and for safety improvement of pharmacotherapy. Additionally, we considered it necessary for the future pharmacist intervention to improve skills of assessing an adverse drug reaction objectively.

著者

山田 安彦

出版者

The Human Geographical Society of Japan

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.24, no.4, pp.369-403, 1972-08-28 (Released:2009-04-28)

参考文献数

157

---

At its extention to the North-eastern part of Japan, the Japanese Ancient State came into contact with the power of Ezo (a tribe in the ancient history of Japan). The auther would like to call the region, where both powers met with, as the transitional zone of the Ritsuryô State or the State ruled by the Code. The purpose of this treatise is to analyse the regional structure at the transitional zone, related to the Shinto shrine and the settlement.Before the Ritsuryô State started to wield its authority to promote reclamation, the Yaoi culture, which was based on paddy farming in Western Japan, had already penetrated into the northern part of North-eastern Japan; the Kofun (the ancient tomb) culture, which originally had its central domain in Kinai provinces (Yamato, Yamashiro, Kawachi and Izumi), had propagated to the Sendai plain.In examing the Kofun cultural sphere in the Sendai plain, it turned out that Takatsuka Kofun (the great tomb of ancient mould) culture had attained to the basins of the River Naruse and the River Eai. Its succeeding Gunshufun (ancient gathered tomb) culture had been at a standstill in the lower reaches of the River Abukuma. But the Yokoana-kofun (the tunnel tomb of ancient mould) culture had advanced to the basin of the River Hazama, which runs through the northern fringe of the Sempoku zone (northern half part of the Sendai plain). Some Yokoana-Kofun culture were still for a while to be seen in this zone even in the Nara Era.The author has an intention to analyse the regional structure of the Sendai plain which located in the transitional zone of the Rtisuryô State, in following after the integrating process of the Ezo district into its organization. At the same time he would like to grasp the shifting aspects of regional structure at the Sendai plain from the Pre-Nara Era to the Nara Era at the angle of the authoritative penetration from the Ancient State's side.Geographical feature of the Sempoku plain is its alternative range of hill and plain. At the plain there were found a lot of low and damp spots which infiltrated from the coast to the innermost of the land. At the places where are above more than 10m. of contour line, their abrupt and sharp inclination often brought deluge to the low land at rainfalls. Thus there were supposed to be confirmed flood areas. Promotion of developing policy of the Ancient State had been greatly affected by this natural condition.In consideration of village organization, now, it is to be pointed out that administrative villages, which were incorporated in the provincial system of the Ritsuryô State, were far more fully established in the Sen'nan zone (southern part of Sendai plain) than in the Sempoku zone.In ancient times a Shinto shrine was usually built at each village, so it is natural to suppose that there should had been more Shinto shrines in the Sen'nan zone than in the Sempoku zone. On the contrary, in fact there were more of Shikinai shrines in the Sempoku zone than in the sen'nan zone, in taking note of the village organization ratio. To confirm the Shinto shrines of ancient times, it seems there is no other way but studying of the Shikinai Shinto shrines: i.e. the legalized ones in the Ancient Japanese Law “Engishiki”. They had been usually set up around the forts at the frontiers or along the relaying route linking them with each other.Most of Shikinai Shinto shrines were ordinarily located at the position above more than 10m. contour line, facing down the low lying land or low marshy ground. Broad spread of Grey soil were to be found at such low plains.

著者

中村 浩規 横山 晴子 矢口 武廣 鈴木 優司 徳岡 健太郎 渡邊 昌之 北川 泰久 山田 安彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.3, pp.445-452, 2011-03-01 (Released:2011-03-01)

参考文献数

15

被引用文献数

4 4

---

In this study, we investigated the effect of histamin H2 receptor antagonist (H2RA) or proton pump inhibitor (PPI) for the prevention of upper gastrointestinal lesions associated with low-dose aspirin. We carried out a retrospective study of 2811 patients who had been prescribed low-dose aspirin (Bayaspirin® 100 mg) for more than 30 days at Tokai University Hachioji Hospital from 2006 to 2008. We classified them into three groups: aspirin alone group (n=1103), aspirin with H2RA group (n=844) and aspirin with PPI group (n=864). Patients who developed upper gastrointestinal lesions were diagnosed with gastric ulcer, duodenal ulcer, gastritis or duodenitis by gastroscopy. We then compared the incidence of upper gastrointestinal lesions among the groups. The incidence in aspirin alone group, aspirin with H2RA group and aspirin with PPI group was 2.54%, 1.54% and 1.04%, respectively; that of aspirin with PPI group being significantly lower (p<0.05). Additively, the odds ratio (OR) of aspirin with H2RA group and aspirin with PPI group was 0.60 (95% confidence interval [95%CI]: 0.31-1.17) and 0.40 (95% CI: 0.19-0.86) as compared with aspirin alone group, respectively. The upper gastrointestinal lesions were developed within two years in all groups. Our results suggest that the combined administration of low-dose aspirin and PPI is effective for the prevention of upper gastrointestinal lesions associated with low-dose aspirin. Also, the pharmacists should be especially careful for upper gastrointestinal lesions development within two years after administration of low-dose aspirin, regardless of combined whether H2RA or PPI.

著者

鈴木 優司 横山 晴子 添田 真司 徳岡 健太郎 渡邊 昌之 北川 泰久 山田 安彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

pp.13-00193, (Released:2014-01-18)

参考文献数

11

---

Low-dose aspirin-induced gastrointestinal lesions are becoming an important problem in clinical practice. In our investigation of such adverse effects, we obtained 4 important findings considered useful for physicians, as follows; 1) even when aspirin was given at a dose, the incidence rate of gastrointestinal lesions was higher than with other NSAIDs, 2) the odds ratios for gastrointestinal lesions induced by aspirin with a histamine H2 receptor antagonist and proton pump inhibitor were 0.6 and 0.4, respectively, as compared with aspirin alone, 3) it is difficult to administer aspirin, which exerts an antiplatelet effect, without inducing gastrointestinal lesions, and 4) these gastrointestinal lesions appears early, especially within 2 years after administration. We distributed a questionnaire to 41 physicians to confirm our findings, and compared high (n=20) and low (n=21) frequency aspirin prescription groups. The recognition rate of points 1 and 3 noted above in the high group was significantly elevated as compared to the low group, whereas there no significant difference in regard to the information in point 4 between the groups and the rate of recognition was low. Moreover, only 27% of the surveyed physicians were familiar with all 4 points. Prior to receiving this information, 17% of the physicians gave no related instructions their patients, which was reduced to 0% after receiving this information. Furthermore, 98% of those surveyed found the information to be useful. Our results suggest that these 4 points of information regarding potential adverse gastrointestinal effects of low-dose aspirin are useful for physicians.

著者

山田 安彦 伊藤 清美 中村 幸一 澤田 康文 伊賀 立二

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.16, no.12, pp.1251-1259, 1993-12-15 (Released:2008-04-10)

参考文献数

29

被引用文献数

22 21

---

The usual therapeutic doses for the treatment of both angina pectoris and cardiac arrhythmia vary widely among beta-blocking agents, with a maximum of about a 200-fold difference, despite subjects' same clinical improvement at the varying doses. In order to clarify the mechanism of this difference, we analyzed retrospectively the cardiac pharmacological activities of beta-blocking agents based on the receptor occupancy theory by using both their unbound concentrations in plasma at steady state (Cssf), as well as dissociation constants (KB and KI, which were determined by in vitro binding experiments and by in vitro pharmacological experiments, respectively) for a beta 1 receptor. A significant log-linear relationship between Cssf and the KB values was obtained with a slope of regression line of 0.91 (r=0.83, p<0.01). On the other hand, the correlation coefficient of the relationship between Cssf and the KI values was low, with a slope of about 0.5 (r=0.80, p<0.01). The beta 1 receptor occupancies calculated from KB values at the steady state condition after the oral administration of usual doses were almost constant (80.5±16.8%), regardless of the wide variation of usual doses of the drugs. This result indicated that the receptor occupancy may be an appropriate indicator for the pharmacological activity of the drug. Furtheremore, there were significant relationships between the primary pharmacokinetic parameters : Cb/Cf, CLtot/F, and Vdssf, and the octanol/water partition coefficient (PC), with correlation coefficients of 0.80, 0.50 and 0.85, respectively. Accordingly, it is suggested that the prediction of a ususal dose of a new beta-blocking agent can be carried out by using the KB and PC values based on quantitative structure-Pharmacokinetic/pharmacodynamic relationships. This methodology should be very useful for estimating the rational usual dose of a new beta-blocking agent from the animal experimental and physicochemical data in the preclinical study.

著者

山田 安彦

出版者

一般社団法人 人文地理学会

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.11, no.1, pp.72-76, 1959-02-28 (Released:2009-04-28)

参考文献数

3

著者

山田 安彦 櫻井 和子 中村 幸一 澤田 康文 伊賀 立二

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.3, pp.283-293, 1993-06-30 (Released:2007-03-29)

参考文献数

46

---

It is well known that change in drug distribution occur in association with hepatic disease. The prediction of the variation in the volume of distribution of drugs at steady-state (Vdss) in hepatic disease is very useful for the planning of drug dosage regimens. In the present study, we tried to develop methodology for estimating Vdss in hepatic disease based on physiological pharmacokinetics. The following two methods were utilized to predict Vdss in hepatic disease (hepatic cirrhosis and hapatitis). Method 1 : Vdss in hepatic disease was predicted assuming that Vdss in hepatic disease is not different from that in the normal condition. Method 2 : it is assumed that hepatic disease could not lead to alterations in the tissue binding but in the plasma binding, Vdss in hepatic disease was calculated according to the mass balance equation (Vdss=7.2+7.8·fP+27·fp/fT ; where fP and fT are plasma and tissue unbound fraction, respectively) by using the data of Vdss and fp in normal condition and that in hepatic disease. In hapatic cirrhosis, a significant correlation between the observed and predicted values according to Method 1 was obtained with a slope of regression line of 0.79 (p<0.001). On the other hand, a significant linear correlation between the observed and predicted values according to Method 2 was obtained with a slope of 1.03 (p<0.001). Furthermore, a significant difference in percent errors between the two methods was observed (p<0.05). In hepatitis, same resuls were also obtained. In conclusion, it is suggested that the extent of intrinsic tissue binding of various drugs is little altered in hepatic disease. The prediction of the apparent volume of distribution in hepatic disease according to Method 2 was successful for most drugs studied and very useful for clinical use.

著者

横山 晴子 山田 安彦 山村 喜一 中村 均 伊賀 立二

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.121, no.3, pp.233-237, 2001-03-01 (Released:2002-09-27)

参考文献数

7

被引用文献数

13 11

---

The effect of mouth wash on the removal of drug residues in both mouth and pharynx after the use of fluticasone propionate dry powder inhaler (FP-DPI) was studied. The concentration of FP in mouth wash after sprinkle and inhalation of Flutide® 50, 100, 200 Rotadisk® was determined by HPLC-UV. The total amount of the removed FP was measured by the sum of the concentration of FP in 5 times of mouth washes. The mouth wash procedures removed totally 79.3±4.4% (50 μg), 68.5±3.6% (100 μg), 69.3±3.4% (200 μg) of sprinkled amount of FP and 29.5±11.1% (50 μg), 35.6±6.6% (100 μg), 31.6±8.3% (200 μg) of inhaled, respectively. It was required for the removal of 90% of the totally recovered FP to do two times of mouth washes in each case. These data suggest that the mouth wash is an effective precaution for candidiasis induced by FP delivered by DPI.

著者

大津 史子 山田 安彦 岩澤 真紀子 後藤 伸之 武隈 洋 冨田 隆志

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.2, pp.N1-N9, 2021-08-31 (Released:2021-09-25)

著者

谷岡 武雄 山田 安彦

出版者

公益社団法人 日本地理学会

雑誌

地理学評論 (ISSN:00167444)

巻号頁・発行日

vol.27, no.7, pp.275-286, 1954

---

We have investigated the distribution of the &ldquo;Jori&rdquo;-type pattern in the paddy fields, with an intention of examining historically exploitation and reclamation in the eastern Harima Plain, southern part of Hyogo Prefecture. And also this treatise is aimed at the reconstruction of the &ldquo;Jori&rdquo;-system as a system of agricultural village planning in ancient times. In this region, a vast area is occupied by the hills of Miocene Series and the uplands of the Plio-Pleistocene Series, the alluvial plain is relatively narrow. Consequently, the development of the exploitation in the plain is not very old and the process was rather slow. In this plain, the &ldquo;Jori&rdquo;-type system is not universal and is discontinuous, as seen in Fig. 1-3.<br> The &ldquo;Jori&rdquo;-system was a system established in 652 to divide the cultivated land in a mesh of 6-cho squares, (a 6-cho square is equal to about 650 metres square in area.) These squares were called &ldquo;Sato&rdquo;. A &ldquo;Sato&rdquo;, in turn, was divide dinto 36 equal parts, a part being 1-cho square, this was called a &ldquo;Tsu.bo&rdquo;. The allotments of the paddy fields based on the &ldquo;Jori&rdquo;-system in Kato -gun (county) have a direction of N 43&deg;E (Fig. 3) along the lengthwise lines. But, in many other areas, the lengthwise lines of the allotments of the paddy fields run about N 18&deg;E or N 22&deg;E, and resemble those in the Shikama-gun (Himeji district), In Taka-gun which is situated along the upper stream of the Kakogawa, the lengthwise lines of the &ldquo;Jori&rdquo; pattern run nearly N-S, or approximately N 6&deg;W; the latter is similar to those of the &ldquo;Jori&rdquo; pattern in Tajima and Tamba areas (northern part of Hyogo Prefecture).<br> In the eastern Harima plain, the distribution of the &ldquo;Jori&rdquo;-type pattern is limited to the valleys which have had no recent inundation or to the older deltas. In the valley plains, the older settlements have been located at the foot of the uplands. But, the &ldquo;Jori&rdquo; pattern is not found in mountainous districts, hilly lands, uplands flood plains and the newer deltas.<br> On the delta of the Kakogawa, the &ldquo;Jori&rdquo; -system exists in the areas more than 2 kilometers inland from the coast line. But, on the delta of the Akashigawa, it is found also in the areas near the coast line.<br> We have tried to reconstruct the site of the &ldquo;Joel&rdquo;-system, the ancient administrative system, in Kako-gun (Fig. 2.) and Akashi-gun (Fig. 3.), basing the reconstruction on the lots, place names, cadastral maps and ancient documents. In these two counties, the east-west line of &ldquo;Sato&rdquo; of the &ldquo;Jori&rdquo; pattern which divided the cultivated lands into 6-cho squares was called the &ldquo;Bo&rdquo;, and the north-south line was called the &ldquo;Jo&rdquo;, the former counting from the southern border line to the northern, the latter counting from the western border line to the eastern. This system, in this province, was called the &ldquo;Jobo&rdquo;, but in other provinces, was called the &ldquo;Jori&rdquo;.<br> In these areas, the cadastral number in the &ldquo;Jori&rdquo;-system makes a continuous series, that is, from the south-eastern corner to the south-western corner, next, from the west to the east and so on, thus to arrive at the north-eastern corner.

著者

添田 真司 高柳 理早 渡邊 昌之 山田 安彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.5, pp.589-593, 2017 (Released:2017-05-01)

参考文献数

13

被引用文献数

1

---

In this study, we established a methodology to calculate the rate of overlooking a dispensing error (inspecting error rate) as a new index for the purpose of determining dispensing error and malpractice rates. Using data obtained from analyses of these error rates at our and two other hospitals, an inspecting error rate was calculated for each institution. Our results showed that inspecting errors occurred at a frequency 3-5 times greater as compared to dispensing errors at each of the examined hospitals. We concluded that construction of a higher quality safety management system would be enabled by incorporation of an inspecting error rate as a new index to evaluate medical safety in regard to dispensing of medicines and managing inspection accuracy.

著者

高柳 理早 山田 安彦 河野 真理子 中村 均 佐藤 均 伊賀 立二

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.5, pp.489-494, 2002-10-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

1 1

---

The new Good Clinical Practice (GCP) guidelines, which were based on ICH-GCP, were enforced in Japan in April 1997. These guidelines recommend that pharmacists play the role of managers of investigational drugs and also as cooperators (clinical research coordinator) in the performance of clinical trials. In this study, we carried out a survey of the attitude of the new graduate pharmacists (the group of graduates in the 1998 fiscal year and a group of graduates in the 1999 fiscal year) on clinical trials. After the first questionnaire, we lectured the students on GCP and performed clinical trials, and then the second questionnaire was conducted two months later. The group of graduates in the 1999 fiscal year had more opportunities to come in contact with information on clinical trials than the group in the 1998 fiscal year. Both groups knew that new GCP guidelines had been established, but they did not understand the details. Some of them had a negative impression concerning clinical trials. The lectures improved their knowledge and impression on the practice of clinical trials. After the lecture, over 90% of them thought that pharmacists should manage investigational drugs and provide information on these drugs for the rational practice of clinical trials. Furthermore, in 60% or more of the students, an improvement in the consciousness of evaluating the safety and efficacy of investigational drugs regarding the pharmacist's role was found.

著者

渡部 恵 杉浦 宗敏 清野 敏一 光永 義治 中村 均 山田 安彦 土屋 文人 大江 和彦 伊賀 立二

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 = Journal of the Pharmaceutical Society of Japan (ISSN:00316903)

巻号頁・発行日

vol.122, no.10, pp.841-847, 2002-10-01

参考文献数

4

被引用文献数

4 4

---

In the computerized prescription order entry system, it has been pointed out that a physician's input mischoice for medicine is one of the causes of medication errors. We therefore investigated the input mischoices by physicians at the time of writing prescriptions. Subsequently, the number of input characters in a prescription order was changed to three characters from two characters. Furthermore, 105 items of high-alert medications, which are likely to result in injury if errors occur, were established. A warning screen display system that requests reconfirmation of the effect, name, usage, and dosage of those medicines was also built. It was found that 70% of input mistakes were caused by choosing the medicine displayed immediately above or below the desired drug. By changing the number of input characters of a prescription order to three characters from two characters, the rate of specification of a trademark improved sharply from 36% to 85%. Consequently, the rate of choice of a drug with another trademark decreased significantly from 0.028% to 0.0047%. In 5% of cases when the warning screen was displayed for a high-alert medicine, the prescription was stopped, and 25% were changed to other medicines. The above results show that the system that requires the input of three or more characters for the physician order entry and displays a warning screen for high-alert medicines is useful in preventing mischoices at the time of prescription input.<br>

著者

山田 安彦

出版者

歴史地理学会

雑誌

歴史地理学紀要 (ISSN:04863461)

巻号頁・発行日

no.24, pp.p145-181, 1982-03

著者

山下 佳子 小滝 一 山田 安彦 中村 幸一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.19, no.3, pp.184-190, 1993-06-20 (Released:2011-08-11)

参考文献数

18

---

Drug informations on a suitable insertion duration of suppositories and on a deal with the problem of the loss from rectal are essential for the proper therapy of patients. In the present study, we collected the data on drug disposition after administration of commercially available suppositories which had systemic pharmacological effects, and then analized pharmacokinetically on the problems of the insertion duration of them and the loss from rectal. The rectal absorption rate and the cumulative absorption ratio of drugs from commercially available suppositories were estimated by the deconvolution analysis. The plasma concentration data after rectal and intravenous administration were obtained in nine kinds of drugs, which were ampicilline, ketoprophene, indomethacine, acetoaminophene, phenobarbital, donperidone, bromazepam, buprenorphine and morphine. It was shown that the completion time of the absorption of drug from the suppositories varied largely from 50 min for ampicilline to 8 hours for donperidone. Comparing the time periods required to reach to 50% in the cumulative absorption ratio in those drugs, the fastest time was found in ampicilline (15 min), and the slowest was in aminophylline (90 min). These findings make it possible to the persue counseling for the patients on the proper insertion duration of each suppositories. The simulation of the time course of blood drug concentration after the loss of suppositories from rectal and the supplement of them was successfully performed, suggesting that the optimal drug concentration could be controled by the rational supplemental dose. In conclusion, the drug information based on the deconvolution analysis can be useful to instruct a rational use of suppositories to the pharmacist and/ or the patients.

著者

山田 純一 高柳 理早 横山 晴子 鈴木 康弘 篠原 智美 山田 安彦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.134, no.12, pp.1331-1345, 2014 (Released:2014-12-01)

参考文献数

10

---

We evaluated the effectiveness of small group discussion (SGD) in association with a drug abuse prevention program for junior high school students. The students first received a lecture about drug abuse prevention, then participated in SGD. The discussion focused on how to take action when tempted to abuse drugs. We gave a questionnaire 3 times; before and after the lecture (before SGD), and after SGD. Seventy-seven students replied to these questionnaires. After the lecture, knowledge about drug abuse was improved and all students answered that they had never abused drugs. However, in answer to a different question, a few students noted that they might use drugs in some situations. We consider it necessary to give more consideration to this problem. After the lecture, 35.5% of the students felt that they had definitely acquired skills for drug abuse prevention, whereas after the SGD this was increased to 73.7%. In addition, more than 75% of the students answered that the SGD program was useful since the opinions of other students could be heard. These results suggest that more students acquired skills to prevent drug abuse by participation in SGD. Our findings showed that SGD was useful and that the students were able to more effectively understand important concepts related to drug abuse prevention.

著者

国分 秀也 的場 元弘 山田 安彦 矢後 和夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.131, no.1, pp.113-127, 2011-01-01 (Released:2011-01-01)

参考文献数

89

被引用文献数

1 1

---

The pain experienced by cancer patients can be managed in 70-90% of cases by the World Health Organisation protocol for cancer pain. However, cancer pain treatment in Japan is not sufficiently effective. To use medicine safely and effectively, various problems must be solved. Therefore, in this study, appropriate usage of cancer pain treatment was examined. We were able to use acetaminophen suppositories (800 mg each) in cancer pain patients. It was suggested that high serum concentrations of oxycodone and hydrocotarnine might be observed in geriatric patients or in the state of decreased hepatic blood flow, making dose adjustment is necessary for such patients. We also clarified that the conversion ratio from oral oxycodone to intravenous ocycodone/hydrocotarnine was 0.71±0.12. In addition, we clarified the pharmacokinetics of controlled-release oxycodone in patients with cancer pain. Moreover, the findings of our study indicate that in the steady state, the serum concentrations of fentanyl are not maintained at a constant level for 3 days following the use of transdermal fentanyl. We established a method of appropriately passing a nasal duct for sustained release of fine granules of morphine sulfate. Resolution of the clinical problems associated with cancer pain treatments is anticipated to allow the proper use of cancer pain treatments in Japan.