著者

柳 奈津代 佐藤 宏樹 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.141, no.9, pp.1095-1107, 2021-09-01 (Released:2021-09-01)

参考文献数

24

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The difficulty and anxiety of nursery staff in administering medication to children at nursery schools has been reported, and its reduction is desired. However, the attitudes of mothers in requesting medication and the factors related to a high frequency of requests are not clear. We conducted an online survey of 600 mothers from April to May 2019 regarding the administration of medication at nursery school, and 301 mothers who had previously made such requests were analyzed. The results showed that 100.0% and 76.4% of the mothers felt gratitude and were apologetic for requesting medicine administration, respectively. In total, 47.5% of mothers expected pharmacists to support nursery staff in administering medication. Mothers' attitude of “I think the nursery staff should administer medication to my child more often” was significantly positively associated with a high frequency of the request in adjusted Model [adjusted odds ratio (AOR) 2.75, 95% confidence interval (CI) 1.36-5.55, p=0.005], while “I think the parents should manage so that the children do not have to take medicine in the nursery school so often” showed a negative association (AOR 0.33, 95% CI 0.17-0.66, p=0.002). Factors related to the involvement of community pharmacists were not significant. It is suggested that a change in mothers' attitudes could decrease the frequency of requests and consequently reduce the burden on nursery staff. Community pharmacists may support nursery staff to contribute to changing mothers' attitudes through medication consultations at the pharmacy.

著者

石坂 優奈 柳 奈津代 佐藤 宏樹 三木 晶子 馬来 秀行 小西 ゆかり 雨宮 潤美 澤田 康文

出版者

一般社団法人 日本老年薬学会

雑誌

日本老年薬学会雑誌 (ISSN:24334065)

巻号頁・発行日

vol.5, no.3, pp.24-31, 2022-09-30 (Released:2022-11-10)

参考文献数

10

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Pharmacists attended an interprofessional team meeting that included nurses and care workers at fee-based homes for the elderly to assess the association between medication, health status, and living conditions provided by care workers. A visually based comparative worksheet on a timeline was used. This study aimed to clarify the role of pharmacists in interprofessional collaboration. A total of 47 residents at 13 facilities were assessed, and drug deprescription or prescription changes were provided in 39 cases. The cases were classified according to the reason for the change, e.g., discontinuation of unnecessary medication, the possibility of a harmful event, examination of therapeutic effect, and improving drug adherence. The participation of pharmacists helped clarify information about medication and health status and contributed to reducing drug-related problems in many cases.

著者

朝比奈 泰子 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.2, pp.271-275, 2010-02-01 (Released:2010-02-01)

参考文献数

25

被引用文献数

1

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Hyperkalemia is common in patients with renal disease, and is sometimes caused by dietary potassium intake. We aimed to determine and compare the content of potassium in nine brands of glucosamine supplements sold in the Japanese market and via the Internet. The potassium content was 0.165-3 mg per daily dose in Japanese products, which contained glucosamine hydrochloride or N-acetylglucosamine, while the content in foreign products, in which glucosamine was sulfated, was 197-280 mg. Our results show that the potassium content in glucosamine sulfate supplements can correspond to 20% of the maximum daily intake of potassium by patients on hemodialysis, because the products sometimes contain glucosamine as glucosamine sulfate potassium chloride for stabilization. Although it is not permitted to sell glucosamine sulfate as food in Japan, consumers can easily buy foreign products that contain glucosamine sulfate via the Internet, and those products rarely indicate the potassium content. Health professionals should pay attention to patients' use of glucosamine supplements, especially when patients' dietary potassium intake needs to be restricted.

著者

山田 安彦 櫻井 和子 中村 幸一 澤田 康文 伊賀 立二

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.3, pp.283-293, 1993-06-30 (Released:2007-03-29)

参考文献数

46

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It is well known that change in drug distribution occur in association with hepatic disease. The prediction of the variation in the volume of distribution of drugs at steady-state (Vdss) in hepatic disease is very useful for the planning of drug dosage regimens. In the present study, we tried to develop methodology for estimating Vdss in hepatic disease based on physiological pharmacokinetics. The following two methods were utilized to predict Vdss in hepatic disease (hepatic cirrhosis and hapatitis). Method 1 : Vdss in hepatic disease was predicted assuming that Vdss in hepatic disease is not different from that in the normal condition. Method 2 : it is assumed that hepatic disease could not lead to alterations in the tissue binding but in the plasma binding, Vdss in hepatic disease was calculated according to the mass balance equation (Vdss=7.2+7.8·fP+27·fp/fT ; where fP and fT are plasma and tissue unbound fraction, respectively) by using the data of Vdss and fp in normal condition and that in hepatic disease. In hapatic cirrhosis, a significant correlation between the observed and predicted values according to Method 1 was obtained with a slope of regression line of 0.79 (p<0.001). On the other hand, a significant linear correlation between the observed and predicted values according to Method 2 was obtained with a slope of 1.03 (p<0.001). Furthermore, a significant difference in percent errors between the two methods was observed (p<0.05). In hepatitis, same resuls were also obtained. In conclusion, it is suggested that the extent of intrinsic tissue binding of various drugs is little altered in hepatic disease. The prediction of the apparent volume of distribution in hepatic disease according to Method 2 was successful for most drugs studied and very useful for clinical use.

著者

柳 奈津代 佐藤 宏樹 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

pp.21-00001, (Released:2021-05-24)

参考文献数

11

被引用文献数

1

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Previous studies have reported the inappropriate administration of medication at nursery schools by the staff and a lack of drug-related information from caregivers at the time of request. However, the situation concerning medication administration at nursery schools from the mothers’ perspective is unknown and it is not clear what information the mothers provided to nursery staff at the request. We conducted an online survey between April and May 2019 regarding the administration of medication at the nursery school with input from 600 mothers. Overall, 510 (85%) individuals replied that the requests to administer medication were acceptable for all or some of the medications. Application forms for medications were used by 91% of the 301 mothers who had previously made such requests. Although information including the child’s name, medication times, illness of the child, parent’s name, and dosage form was specified by over 70% of mothers, drug-related information such as effectiveness, side effects, and drug interactions was insufficient. In total, 41 instances of inappropriate medication administration by staff were reported by 35 mothers. It is suggested that the drug information sheets provided by community pharmacies should make up for inadequate drug-related information on application forms for medications to avoid the risk of adverse events and reduce staff burden. Toward this end, it is necessary to provide easily understandable information sheets for nursery staff, as the medication is usually administered by nursery staff, not a nurse. Community pharmacists should support these measures as pharmaceutical professionals.

著者

澤田 康文

出版者

日経BP社

雑誌

日経ドラッグインフォメーションpremium

巻号頁・発行日

no.205, pp.PE29-32, 2014-11

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患者の母親は、インフルエンザには2種類の治療薬があり、患者の父親にも処方されたリレンザは治癒までに5日間かかるが、患者の妹に処方されたイナビルは1日で済むと判断してしまった。 また患者の母親は、インフルエンザによる出席停止は、患者の体調回復の…

著者

馬来 秀行 白石 朗 三木 晶子 佐藤 宏樹 小西 ゆかり 浅井 康平 舟橋 健一 臼井 順信 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.137, no.8, pp.1041-1049, 2017-08-01 (Released:2017-08-01)

参考文献数

4

被引用文献数

2 4

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In our previous research, there was no collaboration between care workers and pharmacists, for the most part. As a result, it was discovered that in some cases, problems concerning medication of nursing home residents had not been resolved. To solve this issue, we brought together care workers and pharmacists for a workshop we conducted. We assigned 12 care workers with at least two years of experience and 12 pharmacists to four mixed groups and guided them in the management of in-home long-term medical care and conducted small group discussions (SGD) using the KJ method. In the pre-survey before the workshop, all 12 care workers replied “yes” to having experienced “concerns over medication” and nine (75%) replied “no” to having experienced “discussions (consultations) with pharmacists regarding the medication of residents”. As a result of the SGD, “information sharing among professionals” was revealed as a problem common to all groups. Furthermore, common countermeasures for this issue included communication notes and holding collaborative meetings. In the post-survey after the workshop, 67% of the participants replied that their thoughts concerning countermeasures were “coherent”, and everyone replied that their “awareness was increased”. In a follow-up survey after the workshop, 82% of the participants replied that they were using some form of what they had learned and discovered in the workshop in their actual work.

著者

玉木 啓文 佐藤 宏樹 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.10, pp.1305-1312, 2018-10-01 (Released:2018-10-01)

参考文献数

17

被引用文献数

1 1

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Similar-appearing press-through package (PTP) sheets (also known as blister packs) that contain different medicines may result in incorrect medication due to confusion errors. To evaluate the significance of this problem and to identify the factors that may lead to such errors, we conducted a questionnaire survey for pharmacists. Three hundred and eighty-two pairs of PTP sheets with similar appearance were included in the questionnaire. Factors related to color (sheet color at the front of the sheet 90.9%, color of tablet/capsule 57.1%, print color at the front of the sheet 45.9%) were most frequently selected as influencing the perceived similarity of the reported pairs, followed by tablet/capsule shape (46.2%), sheet size (32.4%), and mark and character positioning on sheets (6.8%). In the pairs of similar PTP sheets, pairs manufactured by the same pharmaceutical company accounted for 15%. The frequency of confusion errors or near-errors due to similar appearance of PTP sheets was highest at the time of collecting PTP sheets from the medicine shelf and returning the sheets to the medicine shelf, followed by the time of inspection of prepared medicines and medication instructions. The questionnaire results also indicate that patients themselves can confuse similar PTP sheets and take the wrong medicine. Further quantitative studies are needed to clarify the key factors that cause confusion errors due to similar appearance and to identify potential remedial measures.

著者

清水 孝子 西原 カズヨ 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.19, no.6, pp.534-541, 1993 (Released:2011-08-11)

参考文献数

22

被引用文献数

1 1

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Food ingestion does not affect the bioavailability of the nifedipine capsule, a calcium channel antagonist, but delays its absorption rate in healthy subjects. On the other hand, in two different sustained-release preparations of nifedipine, both the bioavailability and anti-hypertensive efficacy in one of them increases, whereas the other is not so much affected by meals. Furthermore, the food induces a reduction in the bioavailability of nicardipine sustained-release preparation, while those of nisordipine, benidipine and manidipine increase conversely.Such a change in the bioavailability based on food intake may influence the anti-hypertensive efficacy after the initial dosing of the medicine but not so after multiple dosing.In each medicine or dosage form, there are some differences in the change in the blood level and anti-hypertensive efficacy brought on by food ingestion among the drugs. In general, however, in order to improve patient compliance, we recommend that calcium channel antagonists should be taken after meals following the directions given for this medication.

著者

壁矢 健司 佐藤 宏樹 堀 里子 三木 晶子 三浦 康正 澤田 康文

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.21, no.2, pp.49-56, 2019-08-31 (Released:2019-10-10)

参考文献数

12

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Objective:Marketing specialists (MSs) from pharmaceutical wholesalers might shore up post-marketing surveillance (PMS) by pharmaceutical manufacturers. The purposes of this study were as follows: to research problems in PMS found by market specialists, to find solutions for these problems, and motivating MSs to work on PMS. Methods: We conducted a workshop with 12 MSs, who were already working on PMS operations. Participants were divided into three groups. Each group discussed problems with their PMS operations using the KJ method, discussed the potential solutions for the problems, and finally presented them in a plenary debate session. Questionnaire surveys were conducted for the participants before, immediately after, and 6 months after the workshop. Results: This workshop revealed two crucial and urgent problems on PMS faced by MSs: lack of feedbacks to clinical site and lack of publicity of the significance of PMS by MSs. Several solutions were suggested: browsing system of collected information, publication of the stages of improvement in pharmaceutical preparations and packaging, and distributing leaflets about PMS by MSs. In addition, this workshop conferred a positive influence on the participants: in the post-workshop questionnaires, most of the participants answered that they could well understand the problems (92%) and the solutions (75%) on PMS, and that they could improve their attitudes toward PMS operations (83%). . Conclusion: This workshop was quite effective for most of the participants in searching the problems, considering the solutions, and improving their attitudes. Organization of several such workshops might result in better PMS by MSs.

著者

青山 隆夫 松元 美香 中山 紀美子 中島 克佳 渋谷 文則 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.2, pp.108-114, 1997-04-10 (Released:2011-08-11)

参考文献数

16

被引用文献数

1 1

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The pyrogenic activity of 10% inulin injections prepared at a hospital pharmacy was measured using the Pyrogen test in Japanese Pharmacopeia (JP), while the endotoxin concentration in the injections was determined by the, Limulus test, which were JP Endotoxin test and a turbidmetric kinetic assay. After the intravenous administration of 30 ml of inulin injections to a rabbit, the rectal temperature rose to 1.5° compared with that before administration. As a result, the endotoxin was found in all lots of the inulin injections tested, and their values were markedly beyond the limit of Water For Injections prescribed in JP (0.25 EU/ml). In addition, the endotoxin content varied between the various lots of inulin powder, and also between the manufacturers. The endotoxin in inulin injection was removed (less than the quantitative limit of 0.031 EU/ml) by adding activated carbon black to the injection or the filtration using a Posidyne® Nylon 66 filter. No pyrogenic activity was observed in the inulin injections after the removal of endotoxin.Based on these results, the adverse effects induced by inulin injections may thus be caused by endotoxin derived from inulin. This method using either adsorption or filtration is thus considered to be useful for the removal of endotoxin when preparing inulin injections.

著者

大塚 亮子 青山 隆夫 高柳 理早 清野 敏一 清水 秀行 中村 幸一 小滝 一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.3, pp.269-277, 1997-06-10 (Released:2011-08-11)

参考文献数

15

被引用文献数

1 2

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We studied the effect of advising outpatients on the rational use of ophthalmic solutions and compliance by a questionnaire (n=158), in order to establish the optimal consultation method. A total of 41.8% of the patients answered the questionnaire. In compairing the actual use of ophthalmic solutions before and after consultation, the rates of rational use increased for all items except for “applications per day”, which decreased slightly from 93.4% before the consultation to 90.2% after that. In particular, “eyelid closure” and “nasolacrimal occlusion” after instillation, and “the 5 min interval of instillation in the case of plural medication”, considerably increased from 34.8% before the consultation to 60.6% after that, from 9.5% to 50.8% and from 45.9% to 73.8%, respectively. The compliance remarkably improved in glaucoma patients after consultation regarding “the 5min interval of instillation” .Based on these results, our consultation method for the rational use on ophthalmic solutions was thus evaluated. However, since some patients who still did not appreciate the need for the rational use of such medication still presented, further improvements in the consultation method requires for the rational use.

著者

澤田 康文 佐藤 宏樹

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.48, no.11, pp.1062-1066, 2012-11-01 (Released:2016-12-16)

著者

山口 智子 向井 志乃 魚谷 茂雄 大谷 壽一 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.122, no.5, pp.331-338, 2002 (Released:2003-02-18)

参考文献数

10

被引用文献数

1

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Phenytoin (PHT) exhibits nonlinear pharmacokinetics in the therapeutic range. Therefore a slight increase in dose may lead to considerable elevation of the serum PHT level. Although its bioavailability is dependent on the formulation, bioequivalence is considered to be preserved between the three major formulations, of tablet, 97% fine granules, and 10% powder. However, we experienced many cases of increases serum PHT concentration after changes in formulation from 97% fine granules to 97/4% hospital-made fine granules, and from the latter to 10% powder. Retrospective analysis revealed that these alterations were accompanied by 55% and 16% increases in the serum concentration-to-dose ratio of PHT, respectively. We investigated the factors of this increase by analyzing the weight of remaining powder in a package and the PHT content of each formulation. Each package of PHT formulation prepared with 97% fine granules and 10% powder was unsealed, and the contents were weighed to calculate the rate of recovery. The rate of ingestion was estimated by correcting the rate of recovery by PHT strength (i. e., 1.0 for 10% powder and 0.97 for fine granules). The rates of recovery and ingestion for 10% powder were 13% and 16% higher than those for 97% fine granules, respectively (p<0.01). In conclusion, Changing the PHT formulation from 97% fine granules to 10% powder may lead to a considerable increase in the serum PHT concentration and possibly induce PHT toxicity.

著者

平山 匡彦 鈴木 慎太郎 井上 広平 作元 誠司 井手 陽一 北原 敏弘 中野 正治 宮崎 長一郎 嵩下 賢 出口 法隆 佐藤 宏樹 三木 晶子 澤田 康文

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.2, pp.87-94, 2016 (Released:2016-09-27)

参考文献数

3

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Objectives: First steps to promote the proper use of medicines in remote islands and rural areas are as follows: (1) recognition of the profession of “pharmacist” from secondary-remote-island residents who do not have a pharmacy or drugstore or the opportunity for pharmacist contact and (2) an understanding by remote-island residents of the advantages of having a “family pharmacist.”Methods: Repeated “medicine information and consultation sessions” for secondary-remote-island residents of Japan’s Nagasaki Prefecture were held.  Residents were then surveyed for changes in awareness of or demand for pharmacists and the nature of such changes.Results: Before the information sessions, 29.7% of residents did not recognize the profession of pharmacy, but the extent of their recognition increased after information sessions were concluded.  They were asked “Who explains medicines in a way that is easy to understand ?”; more than half responded “doctors” before the information session, but after information sessions were concluded, those who said “pharmacists” increased.Conclusion: Conducting “medicine information and consultation sessions” for residents of secondary-remote islands and rural areas enabled them to understand the profession of pharmacy.  The initiatives in the present study are first steps toward promoting proper use of medicines by residents of remote islands and rural areas who use “family pharmacies/pharmacists.”

著者

中嶋 瞳 三木 晶子 佐藤 宏樹 堀 里子 澤田 康文

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.6, pp.360-368, 2014-06-10 (Released:2015-06-10)

参考文献数

14

被引用文献数

1

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Among the adverse effects of anticancer drugs, critical effects have attracted the most attention. However, non-critical adverse effects that lower the quality of life of cancer patients have been gaining recognition. For example, the package insert of tegafur・gimeracil・oteracil potassium (S-1) was modified and lacrimal duct obstruction was added to the list of critical adverse effects on September 25, 2012. In a similar vein, this study aimed to examine the awareness of healthcare professionals regarding the adverse effects of anticancer drugs on the eyes. A web-based questionnaire survey was administered to medical doctors and pharmacists. We received responses from 38 doctors and 123 pharmacists. Only 39.5% (15) of the doctors and 33.3% (41) of the pharmacists were aware of the adverse effects of anticancer drugs on the eyes. Among respondents who had observed these adverse effects, only 12.5% (1/8) of doctors and 11.1% (2/18) of pharmacists reported them to the authorities or the pharmaceutical companies. The results suggest that the adverse effects of anticancer drugs on the eyes should gain more recognition among healthcare professionals. Therefore, we would like to encourage them in obtaining information concerning the safety of medicines and to report all observed adverse effects regardless of their severity.

著者

玉木 啓文 佐藤 宏樹 堀 里子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.4, pp.525-529, 2012 (Released:2012-04-01)

参考文献数

4

被引用文献数

1 2

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Confusion of drug names is one of the most common causes of drug-related medical errors. A similarity measure of drug names, “vwhtfrag”, was developed to discriminate whether drug name pairs are likely to cause confusion errors, and to provide information that would be helpful to avoid errors. The aim of the present study was to evaluate and improve vwhtfrag. Firstly, we evaluated the correlation of vwhtfrag with subjective similarity or error rate of drug name pairs in psychological experiments. Vwhtfrag showed a higher correlation to subjective similarity (college students: r=0.84) or error rate than did other conventional similarity measures (htco, cos1, edit). Moreover, name pairs that showed coincidences of the initial character strings had a higher subjective similarity than those which had coincidences of the end character strings and had the same vwhtfrag. Therefore, we developed a new similarity measure (vwhtfrag+), in which coincidence of initial character strings in name pairs is weighted by 1.53 times over coincidence of end character strings. Vwhtfrag+ showed a higher correlation to subjective similarity than did unmodified vwhtfrag. Further studies appear warranted to examine in detail whether vwhtfrag+ has superior ability to discriminate drug name pairs likely to cause confusion errors.

著者

山下 佳子 小滝 一 山田 安彦 中村 幸一 澤田 康文 伊賀 立二

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.19, no.3, pp.184-190, 1993-06-20 (Released:2011-08-11)

参考文献数

18

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Drug informations on a suitable insertion duration of suppositories and on a deal with the problem of the loss from rectal are essential for the proper therapy of patients. In the present study, we collected the data on drug disposition after administration of commercially available suppositories which had systemic pharmacological effects, and then analized pharmacokinetically on the problems of the insertion duration of them and the loss from rectal. The rectal absorption rate and the cumulative absorption ratio of drugs from commercially available suppositories were estimated by the deconvolution analysis. The plasma concentration data after rectal and intravenous administration were obtained in nine kinds of drugs, which were ampicilline, ketoprophene, indomethacine, acetoaminophene, phenobarbital, donperidone, bromazepam, buprenorphine and morphine. It was shown that the completion time of the absorption of drug from the suppositories varied largely from 50 min for ampicilline to 8 hours for donperidone. Comparing the time periods required to reach to 50% in the cumulative absorption ratio in those drugs, the fastest time was found in ampicilline (15 min), and the slowest was in aminophylline (90 min). These findings make it possible to the persue counseling for the patients on the proper insertion duration of each suppositories. The simulation of the time course of blood drug concentration after the loss of suppositories from rectal and the supplement of them was successfully performed, suggesting that the optimal drug concentration could be controled by the rational supplemental dose. In conclusion, the drug information based on the deconvolution analysis can be useful to instruct a rational use of suppositories to the pharmacist and/ or the patients.

著者

澤田 康文

出版者

じほう

雑誌

調剤と情報 = Rx info (ISSN:13415212)

巻号頁・発行日

vol.19, no.9, pp.1203-1208, 2013-09

著者

保坂 恵玲 高柳 理早 鈴木 あやな 折井 孝男 清野 敏一 清水 秀行 山村 喜一 中村 幸一 小滝 一 澤田 康文 伊賀 立二

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.23, no.4, pp.342-347, 1997-08-10

被引用文献数

8

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We conducted a survey to evaluate a system adopted by the Pharmacy Department of Tokyo University Hospital to address the problem of drug compliance under this system, patients are provided with a "Drug History Handbook", or drug notebook. This survey attempted to determine the extent to which a "Drug History Handbook" helped patients understand the drug they were taking, and the extent to which it was utilized during visits to other institutions. Based on the results of the survey we evaluated the efficacy of "Drug History Handbook" as a means to enable patients themselves to perform comprehensive drug information management. Out of 288 patients respondmg to the survey 149 (52%) had a "Drug History Hand-book"149out of 286 respondents or 40% had been diagnosed at other institutions. The respondents who said they had shown their "Drug History Handbook" to phamacists or physicians at other pharmacies, hospitals, or medical institutions were numbered 7 1 out of 149 (48%), including duplicate responses. At community pharmacies conducted at the same time, responses were obtained from 48 pharmacies. Of the 48 responding pharmacies, 21 (44%) said that patients had presented either "Drug History Handbook"or "prescription cards" From these results, it is clear that the patients thus realized the importance of keeping a complete record of the drugs they had taken, and that presenting information about drug history can be a very valuable aid in both prescribing and preparing appropriate medications. From thus survey, it was found that the use of a "Drug History Handbook" can help prevent the dispersal of information about purchase of over the counter drugs as well as prescription drugs. As a means of patient education, it can also be extremely effective for avoiding the duplicated administration of medications and drug-drug interactions.