著者

藤田 利治

出版者

一般社団法人 日本薬剤疫学会

雑誌

薬剤疫学 (ISSN:13420445)

巻号頁・発行日

vol.14, no.1, pp.27-36, 2009 (Released:2009-09-30)

参考文献数

11

被引用文献数

53 47

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During the post-approval period, hypotheses about potentially new adverse drug reactions (ADR) have traditionally emerged from passive surveillance systems that collect large volumes of spontaneous case reports of suspected adverse drug reactions. With signal detection by traditional (or conventional, or manual) methods, quantitative (or statistical, or automated) methods for spontaneous reporting system (SRS) databases were introduced in the late 1990’s in order to detect serious ADR as early as possible. Most quantitative methods rely on comparisons of relative reporting frequencies, also known as disproportionality analyses. In FY 2009, the Pharmaceuticals and Medical Device Agency (PMDA) plans to introduce the quantitative methods (data mining method) used on Japanese SRS database. This paper introduces the recent situation on signal detection and signal management of adverse drug reactions.

著者

成田 友代 藤田 利治 松本 まり 中橋 猛 森 亨

出版者

日本公衆衛生学会

雑誌

日本公衆衛生雑誌 (ISSN:05461766)

巻号頁・発行日

vol.47, no.3, pp.245-263, 2000-03-15

参考文献数

23

被引用文献数

1

著者

中井 義勝 久保木 富房 野添 新一 藤田 利治 久保 千春 吉政 康直 稲葉 裕 中尾 一和

出版者

一般社団法人 日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.42, no.11, pp.729-737, 2002-11-01 (Released:2017-08-01)

参考文献数

8

被引用文献数

6

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1999年の1年間に全国23施設を受診した摂食障害女性患者975人について,臨床背景,身体症状,精神症状と食行動異常,本人の状態と家族の状態,誘発因子につき調査し,神経性食欲不振症制限型(AN-R),同むちゃ食い/排出型(AN-BP),神経性大食症排出型(BN-P),同非排出型,特定不能の摂食障害の5群で比較した.各病型に持徴的な身体症状(AN-Rのうぶ毛密生,柑皮症,AN-BPとBN-Pの唾液腺腫脹や歯牙侵食等)があった.精神症状は各群に共通して出現率が多い項目(過剰適応,強迫傾向)と群間で有意差のある項目(肥満恐怖,対人関係不良,抑うつ等)があった.誘発因子はストレスとダイエットが2大因子であった.この資料は,摂食障害を専門としない人にもその診断に役立つと思われる.

著者

藤田 利治 藤井 陽介 渡辺 好宏 小坂 仁 和田 敬仁 森 雅亮 横田 俊平

出版者

一般社団法人 日本薬剤疫学会

雑誌

薬剤疫学 (ISSN:13420445)

巻号頁・発行日

vol.15, no.2, pp.73-95, 2010 (Released:2011-03-22)

参考文献数

14

被引用文献数

15 17

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Objective: The mechanism underlying the development of neuropsychiatric symptoms such as unconsciousness, abnormal behavior, delirium, hallucinations, and convulsions in influenza has not been thoroughly investigated. The relationship between drug administration and neuropsychiatric symptoms during influenza is also poorly understood. This study is the first pharmacoepidemiologic study focused on investigating the relationship between drug administration and neuropsychiatric symptoms.Design: Cohort studyMethods: Study subjects were patients under 18 years old who had influenza during the 2006/07 season. We prepared two kinds of questionnaires for doctor and for patient's family, and carried out the survey between January and March, 2007. Using data from 9,389 patients, we analyzed the relationship between neuropsychiatric symptoms, such as delirium, unconsciousness and convulsion, and drug administration of acetaminophen and oseltamivir.Results: Analysis of the relationship between delirium and drug administration provided hazard ratios of 1.55(p=0.061)for acetaminophen and 1.51(p=0.084)for oseltamivir. These hazard ratios, which were adjusted for risk factors by multivariate analysis of the proportional hazard model, showed an increasing tendency of delirium after administration of each drug. In patients who received oseltamivir, a high incidence of delirium was observed between 6 and 12 hours after onset of fever. Furthermore, delirium was found to develop in a shorter time following oseltamivir use than it did after acetaminophen use. There was no relationship between unconsciousness and acetaminophen administration, as demonstrated by a hazard ratio of 1.06(p=0.839). The incidence of unconsciousness increased significantly with oseltamivir use with a hazard ratio of 1.79(p=0.0389), and unconsciousness was found to occur in a short time after oseltamivir use.Conclusion: The results obtained from this study suggest that there are increased risks of delirium and unconsciousness with drug administration. Further pharmacoepidemiologic studies for hypothesis testing are required to study the relationship between abnormal behavior and drug administration.

著者

北川 源四郎 椿 広計 藤田 利治 津田 博史 西山 慶彦 川﨑 能典 佐藤 整尚 土屋 隆裕 久保田 貴文 藤田 晴啓 奥原 浩之 村上 政勝 片桐 英樹 宮本 道子 曽根原 登 冨田 誠 笛田 薫 蓮池 隆 宮原 孝夫 安藤 雅和

出版者

大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイ

雑誌

基盤研究(A)

巻号頁・発行日

2010-04-01

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本研究では,科学的情報収集に基づく社会価値選択,価値を決定する構造モデル導出,価値のモデル上での最適化,最適化された価値の社会への還元からなる情報循環設計を科学的政策決定の統計数理科学的枠組みと位置づけ,政策の科学的決定に資する統計数理体系構築を目的とした.本研究を通じて,公的ミクロ情報分析統計基盤の確立,情報循環加速ツールの開発,時空間可視化ツールの開発を達成し,同成果を自殺予防対策研究,観光政策研究,産業環境政策研究に応用し,それぞれの政策立案に資する新たな知見を得るとともに,データに基づく政策を提言した.