著者

Pang Alex Soojung-Kim Twiggs Bob

出版者

日経サイエンス

雑誌

日経サイエンス (ISSN:0917009X)

巻号頁・発行日

vol.41, no.9, pp.32-38, 2011-09

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世界初の人工衛星スプートニクは机にのるほどの大きさだった。以降,大型化の一途をたどり,半世紀後にはサッカーグラウンドほどもある国際宇宙ステーションが地球を周回するようになった。

著者

ответственный редактор В.М. Орел составитель и хранитель личного архива академика С.И. Вавилова В.В. Вавилова редактор-составитель Ю.И. Кривоносов

出版者

Наука

巻号頁・発行日

2012

著者

POULAKOU-REBELAKOU Effie KALANTZIS George TSIAMIS Costas PLOUMPIDIS Dimitris

雑誌

Geriatrics & gerontology international (ISSN:14441586)

巻号頁・発行日

vol.12, no.3, pp.405-412, 2012-07-01

著者

Ikeda Atsushi Kawai Koji Ando Satoshi Oikawa Takehiro Inai Hiromu Kimura Tomokazu Takaoka Ei-ichiro Yoshino Takayuki Suetomi Takahiro Kojima Takahiro Miyazaki Jun Nishiyama Hiroyuki

出版者

Oxford University Press.

雑誌

Japanese journal of clinical oncology (ISSN:03682811)

巻号頁・発行日

vol.42, no.8, pp.748-752, 2012-08

被引用文献数

8

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OBJECTIVE:Ureteral obstruction is one of the complications of testicular tumor with retroperitoneal lymph node metastasis that requires ureteral stenting for management. We elucidated the clinical courses of ureteral obstructions and changes in renal functions in patients with indwelling ureteral stenting.METHODS:The medical records of 56 patients who were treated for metastatic testicular tumors by chemotherapy at a single institute between 2002 and 2010 were retrospectively reviewed.RESULTS:Among 56 patients, 12 patients needed ureteral stenting before chemotherapy. The proportion of patients requiring ureteral stenting was significantly higher in seminoma than non-seminoma (47 and 12%, respectively, P < 0.05). The ureteral stent was removed after chemotherapy or retroperitoneal lymph node dissection in all patients, except for one patient who died of cancer during chemotherapy. At retroperitoneal lymph node dissection, ureters were spared in three patients, a partial ureterectomy was needed in one patient, and no case underwent adjunctive nephrectomy. These 11 patients presented no local and distant recurrence at median follow-up of 44 months. Ureteral stenting increased the estimated glomerular filtration rate to more than 60 ml/min before chemotherapy in all patients, but it decreased to <60 ml/min in 6 of 11 patients after chemotherapy.CONCLUSIONS:Ureteral obstruction due to testicular tumor was relieved after chemotherapy or retroperitoneal lymph node dissection. Ureteral stenting was effective to improve renal function before chemotherapy, although we should pay special attention to deterioration of renal function during or after chemotherapy.

著者

edité par Patricia Radelet-de Grave Edoardo Benvenuto avec le soutien de la Faculté des sciences de l'Université catholique de Louvain la Facoltà di Architettura dell'Università degli studi di Genova = Between mechanics and architecture / edited by Patricia Radelet-de Grave Edoardo Benvenuto supported by la Faculté des sciences de l'Université catholique de Louvain la Facoltà di Architettura dell'Università degli studi di Genova

出版者

Birkhaüser Verlag

巻号頁・発行日

1995

著者

Ariane ADAM-POUPART France LABRÈCHE Audrey SMARGIASSI Patrice DUGUAY Marc-Antoine BUSQUE Charles GAGNÉ Hannu RINTAMÄKI Tord KJELLSTROM Joseph ZAYED

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.51, no.1, pp.68-78, 2013 (Released:2013-02-15)

参考文献数

71

被引用文献数

10 38

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The potential impacts of climate change (CC) on Occupational Health and Safety (OHS) have been studied a little in tropical countries, while they received no attention in northern industrialized countries with a temperate climate. This work aimed to establish an overview of the potential links between CC and OHS in those countries and to determine research priorities for Quebec, Canada. A narrative review of the scientific literature (2005–2010) was presented to a working group of international and national experts and stakeholders during a workshop held in 2010. The working group was invited to identify knowledge gaps, and a modified Delphi method helped prioritize research avenues. This process highlighted five categories of hazards that are likely to impact OHS in northern industrialized countries: heat waves/increased temperatures, air pollutants, UV radiation, extreme weather events, vector-borne/zoonotic diseases. These hazards will affect working activities related to natural resources (i.e. agriculture, fishing and forestry) and may influence the socioeconomic context (built environment and green industries), thus indirectly modifying OHS. From this consensus approach, three categories of research were identified: 1) Knowledge acquisition on hazards, target populations and methods of adaptation; 2) Surveillance of diseases/accidents/occupational hazards; and 3) Development of new occupational adaptation strategies.

著者

Cheng-Shu CHUNG Naoki FUJITA Naoya KAWAHARA Sho YUI Eunryel NAM Ryohei NISHIMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0470, (Released:2013-02-19)

被引用文献数

12 39

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Stem cell transplantation is one of the most promising yet enigmatic treatments for spinal cord injury (SCI), a common problem in dogs. As pre-differentiated mesenchymal stem cells (MSCs) can be expanded and differentiated into neurospheres in vitro, before being transplanted back, they may prove to be more beneficial for treating SCI. Therefore, we compared the endogenous differentiation potential, including the neuronal cell differentiation, of neurospheres from canine bone marrow MSCs (cBMMSCs) with that of the adipose tissue-derived MSCs (cADMSCs). Nestin-positive neurospheres were generated from MSCs derived from the bone marrow and adipose tissue. Neuronal cells were differentiated from the neurospheres derived from both these tissues. Gene expression analysis revealed that Nestin, βIII-tubulin, NCAM, OCT4 and SOX2 were expressed in MSCs and the corresponding neurospheres. Notably, cBMMSC-derived neuronal cells expressed higher levels of βIII-tubulin. The mRNA expressions of NANOG, Nestin, OCT4 and SOX2 were upregulated in neurospheres derived from both. Immunofluorescence analysis detected the expression of neuronal markers, namely, βIII-tubulin, GFAP, S100, NF200 and MAP2, in differentiated neuron-like cells. Our findings highlight that both cBMMSCs and cADMSCs could be differentiated into neurospheres and neuron-like cells, and therefore, these cells are suitable candidates for cell transplantation. Further, cADMSCs form a more suitable cell source, as larger number of cells could be harvested from cADMSC-derived neurospheres. Future studies employing in vivo transplantation models to investigate the effectiveness of MSCs for treating SCI are warranted.

著者

Anna KOIKE Rui KANO Masahiko NAGATA Charles CHEN Cheol-Yong HWANG Atsuhiko HASEGAWA Hiroshi KAMATA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0372, (Released:2013-02-14)

被引用文献数

1 6

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Isolates of the yeast Malassezia pachydermatis obtained from skin samples of healthy dogs and of dogs with atopic dermatitis in Japan, Taiwan and Korea were molecularly characterized using intergenic pacer 1 (IGS1) region analysis. The percentage of IGS1 subtype isolates detected in healthy skin was as follows: 1A (6%), 1B (27%), 1C (11%), 2A (6%), 2B (6%), 3A (11%), 3B (6%), 3C (3%) and 3D (24%). In contrast, the most prevalent isolates detected in skin lesions of atopic dermatitis were subtype 3D in Japan and Taiwan and subtype 3C in Korea. All subtype isolates grew well on acidic medium (pH 6). However, subtype 3C and 3D isolates grew better than the other subtype isolates on medium at pH 8.

著者

Sun Lue Moritake Takashi Zheng Yun-Wen Suzuki Kenshi Gerelchuluun Ariungerel Hong Zhengshan Zenkoh Junko Taniguchi Hideki Tsuboi Koji

出版者

Oxford University Press

雑誌

Journal of radiation research (ISSN:04493060)

巻号頁・発行日

vol.54, no.1, pp.61-69, 2013-01

被引用文献数

13

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One-third of patients with medulloblastoma die due to recurrence after various treatments including radiotherapy. Although it has been postulated that cancer stem-like cells are radio-resistant and play an important role in tumor recurrence, the “stemness” of medulloblastoma cells surviving irradiation has not yet been elucidated. Using a medulloblastoma cell line ONS-76, cells that survived gamma irradiation were investigated on their “stemness” in vitro. From 10 500 cells, 20 radio-resistant clones were selected after gamma ray irradiation (5 Gy × two fractions) using the replica micro-well technique. These 20 resistant clones were screened for CD133 positivity by flow cytometry followed by side population assay, tumor sphere formation assay and clonogenic survival assay. Results revealed CD133 fractions were significantly elevated in three clones, which also exhibited significantly increased levels of tumor sphere formation ability and side population fraction. Clonogenic survival assay demonstrated that their radio-resistance was significantly higher than the parental ONS-76. This may support the hypothesis that a small number of cancer stem-like cells (CSCs) are the main culprits in local recurrence after radiotherapy, and disruption of the resistance mechanism of these CSCs is a critical future issue in improving the outcome of patients with medulloblastoma.

著者

story & art by Chica Umino [English translation & adaptation Akemi Wegmuller touch-up art & lettering Sabrina Heep]

出版者

Viz Media

巻号頁・発行日

2008

著者

Hyang-Sook CHOI Masayoshi SAWAMURA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.65, no.1, pp.48-55, 2001 (Released:2002-06-28)

参考文献数

24

被引用文献数

20

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The volatile flavor components of ripe and overripe ki-mikan (Citrus flaviculpus Hort. ex Tanaka) peel oil samples, which had been isolated by cold-pressing, were investigated by capillary GC and GC-MS, and compared with the Hyuganatsu (Citrus tamurana Hort. ex Tanaka) flavor. Limonene (ripe fruit, 82.44%; overripe fruit, 73.10%) was the most abundant compound in the ki-mikan oil, this being followed by γ-terpinene (8.83% and 13.74%), trans-β-farnesene (1.76% and 3.12%) and myrcene (1.54% and 1.13%). The composition of overripe ki-mikan oil was characterized by higher amounts of aliphatic and sesquiterpene hydrocarbons, monoterpene and sesquiterpene alcohols, ketones and esters than that of ripe ki-mikan oil. Monoterpene hydrocarbons, especially limonene (84.78%), were predominant in Hyuganatsu oil. The CPO composition of ki-mikan was qualitatively similar to that of Hyuganatsu, but differed quantitatively. The content of sequiterpene hydrocarbons was higher in the ki-mikan oil samples than in Hyuganatsu oil, while ketones showed the opposite predominance. These differences were more evident in the trans-β-farnesene and l-carvone contents. The ratio of both these compounds could be used to distinguish ki-mikan oil from Hyganatsu oil.

著者

Ignatiev Ivan V. Kozin Igor E. Davydov Valentin G. Nair Selvakumar V. Lee Jeong-Sik Ren Hong-Wen Sugou Shigeo Masumoto Yasuaki

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.63, no.7, pp.075316, 2001-02

被引用文献数

38 48

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Phonon resonances observed in the photoluminescence (PL) spectra of InP and In0.35Ga0.65As self-assembled quantum dots (QD’s) in an external electric field are studied in detail. The resonances are shown to arise from fast phonon-assisted relaxation of hot carriers, and to become observable when the PL is quenched by nonradiative losses from excited states. A simple model is developed that considers tunneling of the carriers from the QD’s into the barrier layer as the main process responsible for PL quenching in the presence of an electric field. From this model, the depth of the potential well for holes is estimated to be 10–20 meV for the InP QD’s. The PL kinetics measurement is performed with a time resolution of 6 ps. Clear evidence of surprisingly fast carrier relaxation with emission of high-energy acoustic phonons is found. Further acceleration of the carrier relaxation is observed under strong optical pumping. We consider this effect to be caused by Auger-like carrier-carrier scattering processes. Acceleration of the relaxation observed at elevated temperatures is ascribed to stimulated phonon emission.

著者

Matsumoto Takahiro Suzuki Jun-ichi Ohnuma Masato Kanemitsu Yoshihiko Masumoto Yasuaki

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.63, no.19, pp.195322, 2001-05

被引用文献数

62

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The optical absorption spectrum in nanocrystalline silicon (n-Si) was determined from both light transmittance and reflectance measurements. We observed that n-Si has a phonon structure in the optical absorption spectrum. This structure originates from momentum-conserving TO phonon absorption and emission, and provides direct evidence that n-Si is an indirect-band-gap semiconductor with quantum size effects. By using small-angle x-ray scattering to measure the nanocrystal size distribution, we found that the band-gap widening varies as (1/L)1.6 with decreasing nanocrystal diameter L.

著者

Kozin I. E. Davydov V. G. Ignatiev I. V. Kavokin A. V. Kavokin K. V. Malpuech G. Ren Hong-Wen Sugisaki M. Sugou S. Masumoto Y.

出版者

American Physical Society

雑誌

Physical review B (ISSN:10980121)

巻号頁・発行日

vol.65, no.24, pp.241312, 2002-06

被引用文献数

61 53

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Spins of resident electrons in charged quantum dots (QD’s) act as local magnets inducing the Zeeman splitting of excitons trapped into dots. This is evidenced by the observation of quantum beats in the linearly polarized time-resolved photoluminescence of a biased array of self-assembled InP QD’s. An external magnetic field is found to shorten the spin beats’ decay time keeping constant the frequency of the beats. A model using the pseudospin formalism allows one to attribute the observed quantum beats to the radiative decay of hot trions having two electrons that occupy different energy levels in a QD.

著者

Goo Moon-Jung Park Jin-Kyu Hong Il-Hwa YANG Hai-Jie YUAN Dong-Wei KI Mi-Ran HAN Jung-Youn JI Ae-Ri KIM Tae-Hwan WILLIAMS Bruce H. JEONG Kyu-Shik

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.70, no.6, pp.633-635, 2008-06-25

被引用文献数

4

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6ヶ月間に渡り胴背部における落屑とび慢性紅斑を特徴とする皮膚病を示した3歳の雌スピッツに治療を施したが,なんら改善がみられないことを理由に当症例が提出された.臨床検査においては,犬は活発で健康であった.皮膚培養では,真菌を確認できなかった.皮膚生検による組織学的検査では,基底層の水腫性変性を伴う界面皮膚炎,真皮における顕著な形質細胞の血管周囲集族と多量の形質細胞集族を伴う界面壁性毛包炎を示した.中程度のCD3陽性リンパ球が真皮表層に浸潤していた.この報告は,異型皮膚病変を伴うまれな犬種に見られた円板状紅斑性狼瘡の稀有な情報を提供するものである.

著者

Francisco J. Pastor-Pérez Sergio Manzano-Fernández Rebeca Goya-Esteban Domingo A. Pascual-Figal Oscar Barquero-Pérez Jose Luis Rojo-Álvarez Estrella Everss Maria Dolores Martinez Martinez-Espejo Mariano Valdés Chavarri Arcadi García-Alberola

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.9, pp.2124-2129, 2012 (Released:2012-08-24)

参考文献数

30

被引用文献数

3

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Background: Abnormalities in autonomic control are a feature of neuroendocrine activation in HF and are responsible for dysregulation of biological rhythms. The purpose was to investigate the presence and the prognostic significance of long-period heart rate (HR) rhythms in heart failure (HF) patients. Methods and Results: In the study, 92 HF patients were enrolled (age 53±14 years and left ventricular ejection fraction [LVEF] 37±10%). A rhythmometric analysis was used to assess the HR rhythms in 7-days (7D) Holter recordings. Rhythms properties were quantified by mesor and amplitude, in beats/min and by acrophase, in hours. Cardiac death or HF decompensation were registered. All patients had 24-h rhythm, 61 patients (77%) had 8-h rhythm, and 66 patients (83%) had 7D rhythm. Twelve patients (15%) experienced events. Among rhythm parameters only 7D median amplitude was different between patients with or without events: 1.1beats/min [0.5–1.5] vs. 2.0beats/min [0.0–3.9], P=0.049 respectively. After multivariate adjustment, LVEF (per 1%, hazard ratio 0.92, 95% confidence interval (CI) 0.87 to 0.98, P=0.01), N-terminal portion of pro-natriuretic hormone type B (per 100pg/ml, hazard ratio 1.036, 95% CI 1.005–1.069, P=0.022), and 7D amplitude of the HR ≤1.71beats/min (hazard ratio 5.4, 95% CI 1.2–34.4, P=0.047) were independent predictors of events. Conclusions: A 7D HR rhythm is present in most patients with HF, and has prognostic significance.  (Circ J 2012; 76: 2124–2129)

著者

Jae-Sik Jang Han-Young Jin Jeong-Sook Seo Tae-Hyun Yang Dae-Kyeong Kim Tae Hee Kim Sang-Hwa Urm Dong-Soo Kim Dong-Kie Kim Sang-Hoon Seol Doo-Il Kim Kyoung-Im Cho Bo-Hyun Kim Yong Hyun Park Hyung-Gon Je Jung-Min Ahn Won-Jang Kim Jong-Young Lee Seung-Whan Lee

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.9, pp.2255-2265, 2012 (Released:2012-08-24)

参考文献数

65

被引用文献数

39 74

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Background: Sodium bicarbonate has been postulated to prevent contrast-induced acute kidney injury (CI-AKI) by various mechanisms, although the reports are conflicting. Methods and Results: We searched MEDLINE, EMBASE, and the Cochrane databases for randomized controlled trials that compared a sodium chloride with a sodium bicarbonate hydration regimen with regard to CI-AKI. Data across 19 clinical trials consisting of 3,609 patients were combined. Preprocedural hydration with sodium bicarbonate was associated with a significant decrease in the rate of CI-AKI (odds ratio [OR] 0.56; 95% confidence interval [CI] 0.36–0.86; P=0.008). Stratified analyses by the type of contrast medium suggested lower odds of CI-AKI with sodium bicarbonate in studies using low-osmolar contrast media (OR 0.40; 95% CI 0.23–0.71, P=0.002) compared with those using the iso-osmolar agents (OR 0.76; 95% CI 0.41–1.43; P=0.40). No significant difference in the rates of postprocedural death (OR 0.49; 95% CI 0.23–1.04; P=0.06) and the requirement for renal replacement therapy (OR 0.94; 95% CI 0.46–1.91; P=0.86) was observed. However, we found significant changes in serum bicarbonate and potassium levels after sodium bicarbonate infusion. Conclusions: This updated meta-analysis demonstrates that sodium bicarbonate-based hydration is superior to sodium chloride in preventing CI-AKI of patients undergoing exposure to iodinated contrast media.  (Circ J 2012; 76: 2255–2265)

著者

Kawano-Furukawa H. Yoshizawa H. Takeya H. Kadowaki K.

出版者

American Physical Society

雑誌

Physical review B (ISSN:01631829)

巻号頁・発行日

vol.66, no.21, pp.212503, 2002-12

被引用文献数

6 7

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An anomalous phonon peak that appears only in the superconducting state has been reported for nonmagnetic intermetallic superconductor RNi211B2C (R=Y, Lu). In the present paper, we shall demonstrate that another rare-earth borocarbide ErNi211B2C seems to show similar phonon anomalies. A spectral weight transfer from the above-lying TA phonon mode to the aforementioned peak was rather small, but it is consistent with the theoretical prediction for the system with smaller 2Δ/Eph ratio. Combining the present results with those observed in the other borocarbide systems, we suggest that such a phonon anomaly might be a common phenomenon for superconductors with a strong nesting feature of the Fermi surface.

著者

Thanida SANANMUANG Nawapen PHUTIKANIT Catherine NGUYEN Sukanya MANEE-IN Mongkol TECHAKUMPHU Theerawat THARASANIT

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2012-116, (Released:2013-01-25)

被引用文献数

4 6 1

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Developmental competence and quality of in vitro produced embryos has been demonstrated to be lower than in vivo derived embryos. This study aimed specifically to determine the effects of in vitro culture of feline embryos using various culture densities on developmental competence and expression of stress- and apoptotic-related genes in terms of heat shock protein 70 (HSP70) and apoptotic-related (BAX and BCL-2) gene expressions. In experiment 1, we characterized the inducible form of a feline-specific HSP70 mRNA sequence, as it has not been previously reported. The primers for feline HSP70 mRNA were synthesized and tested on heat-treated cat fibroblasts. In experiment 2, feline embryos were cultured at different culture densities (embryo:culture volume; 1:1.25, 1:5 and 1:20). The developmental competence was determined along with HSP70, BAX and BCL-2 transcript abundances using quantitative RT-PCR. In vivo derived embryos were used as a control group. A partial cat HSP70 mRNA sequence (190 bp) was characterized and exhibited high nucleotide identity (93 to 96%) with other species. Cleaved embryos cultured at high density (1:1.25) developed to blastocysts at a lower rate than those generated from lower densities. Irrespective of the culture densities used, in vitro cultured blastocysts showed increased levels of HSP70 and BAX transcripts compared with in vivo counterparts. Blastocysts derived from the highest culture density (1:1.25) showed higher levels of upregulation of HSP70 and BAX transcripts than those cultured at lower culture densities (1:5 and 1:20). In conclusion, increased levels of pro-apoptotic (BAX) and stress-response (HSP70) transcripts correlated with developmental incompetence of embryos cultured at high embryonic density, indicating that stress accumulated during in vitro embryo culture affected the fate for embryo development and quality.

著者

Aoki S. Fukugita M. Ishikawa K-I. Ishizuka N. Iwasaki Y. Kanaya K. Kaneko T. Kuramashi Y. Okawa M. Ukawa A. Yamazaki T. Yoshié T.

出版者

American Physical Society

雑誌

Physical review D (ISSN:15507998)

巻号頁・発行日

vol.71, no.9, pp.094504, 2005-05

被引用文献数

68

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We calculate the two-pion wave function in the ground state of the I=2 S-wave system and find the interaction range between two pions, which allows us to examine the validity of the necessary condition for the finite-volume method for the scattering length proposed by Lüscher. We work in the quenched approximation employing a renormalization group improved gauge action for gluons and an improved Wilson action for quarks at 1/a=1.207(12) GeV on 163×80, 203×80, and 243×80 lattices. We conclude that the necessary condition is satisfied within the statistical errors for the lattice sizes L>=24 (3.92 fm) when the quark mass is in the range that corresponds to mpi2=0.273–0.736 GeV2. We obtain the scattering length with a smaller statistical error from the wave function than from the two-pion time correlator.