著者

Keita Noda Bo Zhang Atsushi Iwata Hiroaki Nishikawa Masahiro Ogawa Takashi Nomiyama Shin-ichiro Miura Hideto Sako Kunihiro Matsuo Eiji Yahiro Toshihiko Yanase Keijiro Saku on behalf of the STYLIST Study Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.6, pp.1335-1344, 2012 (Released:2012-05-25)

参考文献数

30

被引用文献数

10 15 4

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Background: Dietary habits are associated with obesity, and both are important contributing factors to lifestyle-related diseases. The STYLIST study examined the effects of dietary counseling by registered dietitians and the delivery of proper calorie-controlled meals (UMIN Registration No: 000006582). Methods and Results: Two-hundred adult patients with hypertension and/or diabetes mellitus were randomly divided into 2 groups with/without dietary counseling and consumed an ordinary diet for 4 weeks. Each group was then subdivided into 2 groups with/without dietary counseling and received calorie-controlled lunch and dinner boxes for the next 4 weeks. The calories in the delivered meals were based on the subject's ideal body weight (BW) and physical activity level. BW, waist circumference, blood pressure, and laboratory data, including glycoalbumin, were measured at 0, 4, and 8 weeks. BW and the other parameters were significantly reduced during the study period in patients who received diet counseling in the ordinary diet period and/or delivered meal period but not in patients without dietary counseling, as assessed by linear mixed models for longitudinal data. Conclusions: The combination of dietary counseling by dietitians and delivery of calorie-controlled meals was effective in reducing BW, as well as blood pressure and glycoalbumin, in patients with hypertension and/or diabetes mellitus. (Circ J 2012; 76: 1335-1344)

著者

Hyun-Ah PARK Ju-Won KIM Hee-Myung PARK

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1233-1236, 2012 (Released:2012-10-01)

参考文献数

12

被引用文献数

2

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A 7-year-old intact female Maltese dog was referred with ptyalism and intermittent vomiting but no regurgitation for over 1 month. Survey radiographs including a contrast study revealed a large circular dilated cavity from the carina to the diaphragm. Additionally, multi-detector computed tomography and three-dimensional reconstruction were performed. These images revealed large idiopathic distal esophageal diverticula. This case report represents the first report using multi-detector computed tomography and three-dimensional reconstruction for evaluation of esophageal diverticula in a dog.

著者

Bandula Kumara WICKRAMASEKARA RAJAPAKSHAGE Masahiro YAMASAKI Shiang-Jyi HWANG Noboru SASAKI Masahiro MURAKAMI Yu TAMURA Sue Yee LIM Kensuke NAKAMURA Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.9, pp.1139-1148, 2012 (Released:2012-10-01)

参考文献数

34

被引用文献数

9 16

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The stability of the characteristics of the diminazene aceturate (DA)-resistant B. gibsoni isolate was initially determined invitro. Part of the DA-resistant B. gibsoni isolate was cultured without DA for 4 weeks, and then newly exposed to 200 ng/ml DA. As a result, this isolate could proliferate the same as the DA-resistant isolate, indicating that the characteristic of DA resistance was stable in the DA-resistant isolate. Additionally, the level of parasitemia in the DA-resistant isolate was comparatively lower than in the wild-type, suggesting that the proliferation potential of the DA-resistant isolate would be lower than that of the wild-type. Subsequently, to investigate the involvement of mitochondrial DNA (mtDNA) in DA resistance in B. gibsoni, the nucleotide sequences and deduced amino acid sequences of mitochondrial genes such as COXI, COXIII, and CYTb genes of the DA-resistant isolate, were compared with those of the wild-type. As a result, these three genes were not altered in the DA-resistant B. gibsoni isolate. Moreover, the transcription levels of COXI, COXIII, and CYTb genes were observed by semi-quantitative RT-PCR. As a result, the gene transcription of those genes in the DA-resistant isolate was not significantly altered. These results indicated that DA did not affect mtDNA directly in DA-resistant B. gibsoni. Thus, it is suggested that mtDNA should not be deeply involved in DA resistance in B. gibsoni.

著者

Eri Segi-Nishida

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.7, pp.939-944, 2011-07-01 (Released:2011-07-01)

参考文献数

58

被引用文献数

16 48

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Electroconvulsive seizure (ECS) therapy is a clinically proven treatment for depression and is often effective even in patients resistant to chemical antidepressants. However, the molecular mechanisms underlying the therapeutic efficacy of ECS are not fully understood. Here, I review studies that show molecular, cellular, and behavioral changes by ECS treatment, and discuss the functions of ECS to underlie the action of antidepressant effects. In hippocampus, these changes cover gene induction, increased adult neurogenesis, and electrophysiological reactivity. Especially, the role of vascular endothelial growth factor (VEGF) in neurogenesis is discussed. Among other gene expression changes in hippocampus, a role of cyclooxygenase (COX)-2, an inducible type of the rate-limiting enzyme of prostanoid synthesis, is focused. ECS-induced changes in other brain regions such as prefrontal cortex and hypothalamus, and ECS-induced behavioral changes are also reviewed. Understanding the molecular, cellular, and behavioral changes by ECS will provide a new view to find potential targets for novel antidepressant design that are highlighted by these findings.

著者

Jeong-Yoo KIM

出版者

Japanese Association For Mathematical Sociology

雑誌

理論と方法 (ISSN:09131442)

巻号頁・発行日

vol.25, no.1, pp.95-106, 2010-03-31 (Released:2010-10-03)

参考文献数

15

被引用文献数

1 4

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I consider the issue of optimal targeting in information diffusion networks. The initial information possessor is to target a single node so as to diffuse the information to all other nodes most effectively. For the purpose, the concept of closeness centrality may be useful, but if the value from delayed information is discounted by a discount factor, the concept should be properly modified. With this respect, I propose a modified concept of closeness centrality which I will call δ-(closeness)-centrality. The δ-centrality of a node is defined by the sum of discounted values generated from information transmission starting from the node given discount factor δ. Some advantages of δ-centrality over the closeness centrality are discussed.

著者

柚木(大家) かおり Kaori YUNOKI-OIE ユノキ(オオイエ) カオリ

出版者

総合研究大学院大学文化科学研究科

雑誌

総研大文化科学研究 = Sokendai review of cultural and social studies (ISSN:1883096X)

巻号頁・発行日

no.1, pp.5-25, 2005-08-10 (Released:2010-07-09)

著者

Tokiko KUSHIRO-BANKER Robert D. KEEGAN Michelle A. DeCOURCEY Tamara L. GRUBB Stephen A. GREENE Robert ARMSTRONG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0062, (Released:2012-09-14)

被引用文献数

2

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The objective of this study was to evaluate glomerular filtration rate (GFR) and the cardiovascular effects of the combination of tepoxalin (TPX) and medetomidine (MED) in dogs. Six healthy dogs of either sex (5 males, 1 female), aged 2.5 ± 2.2 years and weighing 14.7 ± 4.4 kg, were studied. Each dog received four randomized treatments with a minimum of 1 week between treatments: no medication as the control group (C); MED (750 μg/m2, intravenously [IV]); TPX (10 mg/kg orally for 3 days); and MT (TPX 10 mg/kg orally for 3 days plus MED 750 μg/m2, IV). Iohexol (300 mg iodine/kg, IV) was injected in all dogs in each treatment as an indicator of GFR. Blood samples for serum iohexol clearance analysis were collected before and 1, 2, 5, 10, 15, 20, 60, 120, 240, and 360 min after the iohexol administration. Rectal temperature, heart rate, respiratory rate, and direct arterial pressure (AP) were obtained before and 5, 10, 15, 20, 60, 120, 240, and 360 min after the iohexol injection. GFR did not differ between treatments. Heart rate was significantly lower in the MED and MT groups than in C or TPX. Mean AP was significantly higher with MT than TPX, but only at 5 min after the iohexol injection. TPX, MED and the combination of these two drugs do not alter GFR. The combination has minimal effect on cardiovascular variables at these doses in healthy dogs.

著者

Decke-Cornill Albrecht

出版者

大谷学会

雑誌

大谷大学研究年報 (ISSN:02896982)

巻号頁・発行日

vol.63, pp.155-159, 2011-03

著者

Decke-Cornill Albrecht

出版者

大谷学会

雑誌

大谷大学研究年報 (ISSN:02896982)

巻号頁・発行日

vol.63, pp.155-159, 2011-03

著者

藤島 政博 道羅 英夫 GORTZ Hans-Dieter FOKIN Sergei

出版者

山口大学

雑誌

基盤研究(B)

巻号頁・発行日

2005

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繊毛虫Paramecium属とその核内共生細菌Holospora属を野外採集し, 世界分布図に棲息が確認された場所をプロットすることを目的とし, 北欧(フィンランド, スウェーデン, ノルウェー)とその周辺国(エストニア, ロシア), 中国, ブラジル及びオーストラリアで現地協力者の協力を得て採集を行った。その結果, オーストラリアとブラジルで, P. caudatum, P. aurelia species, P. bursaria, 及び, 新種と思われるP. bursaria類似の細胞を採集したが, Holospora維持細胞は採集できなかった

著者

Hye-Young JEOUNG Dae-Sub SONG WooSeog JEONG Won-Ha LEE Jae-Young SONG Dong-Jun AN

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0287, (Released:2012-09-05)

被引用文献数

2 12 3

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A multiplex reverse transcription polymerase chain reaction (mRT-PCR) assay was developed for the simultaneous detection of canine distemper virus (CDV), canine respiratory coronavirus (CRCoV), and canine influenza virus (CIV). These viral pathogens are all causative agents of canine infectious respiratory disease (CIRD). The sensitivity and specificity of the mRT-PCR were determined by comparing it to a rapid antigen test (RAT) or immuno-chromatography test kit and reverse transcription-polymerase chain reaction (RT-PCR) in the detection of CDV, CRCoV, and CIV antigens present in 100 clinical samples (nasal swabs and whole blood samples) from 50 dogs with respiratory disease symptoms. This study revealed that mRT-PCR had almost exactly the same performance or results were almost 100% in agreement with that of RT-PCR and RAT both in terms of the assay sensitivity and specificity which was more highly evident in detecting CIV, CDV, and CRCoV antigens present in canine nasal swab samples. Therefore, this assay could be a better alternative for the definitive and simultaneous ante-mortem detection of the three viral pathogens that cause CIRD by using nasal swabs.

著者

Daisuke KOJIMA Hitoshi HATAI Toshifumi OYAMADA Chun-Ho PARK

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.74, no.8, pp.1045-1049, 2012 (Released:2012-09-03)

参考文献数

25

被引用文献数

2 9

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Extraskeletal myxoid chondrosarcoma was found in a five-month-old male Irish setter dog. At necropsy, the largest mass, measuring 15 × 13 × 13 cm, was found in the right caudal lobe of the lung, and metastatic small masses were observed in multiple organs. Microscopically, the tumor comprised mainly atypical mesenchymal cells and myxoid stroma, which stained positively with Alcian blue. Immunohistochemically, the tumor cells stained positively for vimentin, S-100 protein, neuron-specific enolase, calretinin, and chromogranin A. Ultrastructurally, the cytoplasm of the tumor cells was comprised abundant rough endoplasmic reticulum, mitochondria, Golgi complex, free ribosomes and short irregular microvillous processes extending from the cytoplasm. Based on these pathological findings, this tumor was diagnosed as extraskeletal myxoid chondrosarcoma.

著者

Park So-Young Song Jin-Su Kim Hyoung-Deug Yamane Kenji Son Ki-Cheol

出版者

園芸学会

雑誌

Journal of the Japanese Society for Horticultural Science (ISSN:00137626)

巻号頁・発行日

vol.77, no.4, pp.447-454, 2008-10

被引用文献数

4

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Case studies were performed in two high schools (designated K and J) in Seoul, Korea in order to examine how in-class plantscapes consisting of ornamental plants affected the indoor environment and the stress level of students. Forty-two healthy female students, 16 to 17 years old, were assigned to classrooms with or without plantscapes. Although the differences were small, plants lowered the temperature, raised the relative humidity in the classrooms, and reduced the amount of airborne fine particles. Positive descriptors such as 'clean', 'soft', 'comfortable', and 'fresh' were used by the students to describe the classrooms with plants in both schools after installation of the plants. The stress level of the students was lower in rooms with plants than without in school K and but not in school J; students in control rooms in both schools did not show a significant change in stress. Saliva cortisol content, a physiological indicator of stress, was not reduced by the presence of plants in either school; however, the number of visits to the infirmary was lower for students in rooms with plants than in the control rooms at both schools. The results indicate that the presence of plants improved the physical environment, the general ambience (i.e., appropriate place for classes' and 'relaxed place'), and reduced the level of stress among the students. The role of the interior plantscapes in living spaces is discussed.

著者

メ-ル マ-ガレット

出版者

吉川弘文館

雑誌

日本歴史 (ISSN:03869164)

巻号頁・発行日

no.488, pp.p117-122, 1989-01

著者

-

出版者

琉球大学移民研究センター

雑誌

移民研究 (ISSN:18810829)

巻号頁・発行日

no.5, pp.129-151, 2009-03

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1. ブラジル移民百周年記念シンポジウム 日時:2008年8月25日(月) 場所:マスクードプラザホテル(サンパウロ市) 主催:琉球大学移民研究センター 協力:ブラジル沖縄県人会 2. アルゼンチン移民百周年記念シンポジウム 日時:2008年8月30日(士) 場所:沖縄県人会館(ブエノスアイレス市) 主催:琉球大学移民研究センター 協力:在亜沖縄県人連合会

著者

Wei He Li-Fang Fan Qing Du Bai Xiang Chun-Lei Li Min Bai Yong-Zhen Chang De-Ying Cao

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.57, no.2, pp.122-128, 2009-02-01 (Released:2009-02-01)

参考文献数

31

被引用文献数

7 17 9

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The purpose of the study is to perform the in vitro and in vivo evaluation of multi-layer film coatings for omeprazole. The system consists of drug-layered or drug-containing core pellets coated with salt (sodium chloride and disodium hydrogen phosphate), hydroxypropyl methyl cellulose (HPMC), and enteric film-coating layer, respectively. The drug-layered core pellets were prepared by a coating layer of omeprazole on inert pellet cores in fluidized bed coater. An in vitro/in vivo gastro-resistance study was conducted, and a dissolution study was performed in pH 7.4 phosphate buffer for omeprazole release. The multi-layer coated pellets were stable in gastric pH conditions and upper gastrointestinal (GI) tract in rats. Salt layer improved the drug stability, and its coating levels had little influence on the dissolution profiles of omeprazole. The rate of drug release was significantly delayed by HPMC layer. The salt layer could function as a separated layer, and substitute part of the HPMC layer and decrease the coating levels of HPMC. The bioavailability (AUC) of the multi-layer coated drug-layered and drug-containing pellets was 3.48±0.86 and 2.97±0.57 μg·h/ml, respectively. The drug-layered pellets with multi-layer film coatings not only provided delayed and rapid release of omeprazole, but also could provide a good stable property for omeprazole. It was confirmed that rapid in vitro drug release rate resulted in better absorption.

著者

Xia JIANG Qian REN Shi-Ping CHEN Xiao-Bo TONG Mei DONG Shigeru SUGAYA Takeshi TANAKA Kazuko KITA Nobuo SUZUKI

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.75, no.9, pp.1685-1691, 2011-09-23 (Released:2011-09-23)

参考文献数

37

被引用文献数

6 1

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Little is known about the ability of miso, to modulate mutability in human cells. We have observed increased levels of glucose-regulated protein 78 (GRP78) expression in association with suppression of mutation in human RSa cells irradiated with ultraviolet C (UVC). Here we examined to determine whether miso treatment results in increased GRP78 expression and suppression of UVC mutagenicity in RSa cells. Supernatants of water extracts of miso products and their components were tested. In the sample-treated cells, the amount of GRP78, as estimated by RT-PCR and immunoblotting analysis, increased, and the UVC-induced ouabain resistant mutation (OuaR) and the K-ras codon 12-base substitution mutation frequency decreased. This decrease was not observed in cells with downregulation of GRP78 by GRP78 siRNA transfection. The results suggest that miso suppresses UVC mutagenicity by increasing GRP78 expression in human cells.

著者

Koyabu Daisuke Maier Wolfgang Sánchez-Villagra Marcelo R.

出版者

National Academy of Sciences

雑誌

Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)

巻号頁・発行日

vol.109, no.35, pp.14075-14080, 2012-08-28

被引用文献数

71

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ヒトをはじめとする哺乳類の頭蓋骨の進化的起源を解明. 京都大学プレスリリース. 2012-08-14.

著者

herausgegeben von Eberhard Schmidt-Aßmann und Klaus-Peter Dolde mit Beiträgen von Dirk Ehlers ...

出版者

Verlag Recht und Wirtschaft

巻号頁・発行日

2005

著者

herausgegeben von Theodor Baums Peter Ulmer = Employees' co-determination in the member states of the European Union / edited by Theodor Baums Peter Ulmer

出版者

Recht und Wirtschaft

巻号頁・発行日

2004