著者

Daigo AZAKAMI Eri ONOZAWA Masahiro MIYABE Kazuhiko OCHIAI Masaki MICHISHITA Taichi HIRANO Yutaka MOMOTA Katsumi ISHIOKA Toshinori SAKO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0575, (Released:2016-02-09)

被引用文献数

2

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A 12-year-old female American shorthair cat presented with a one-month history of hematuria and general lethargy. Abdominal ultrasonography revealed complete thickening of the left uterine wall. At a diagnostic laparotomy, a large mass arising from the left uterine horn was discovered, and ovariohysterectomy was performed. Histological diagnosis revealed a T-cell high-grade lymphoma of the uterus. After the ovariohysterectomy, the patient achieved complete remission and maintained by combination chemotherapy from 14 days after surgery. However, relapse occurred in the urinary bladder wall on day 287, and the patient died of postrenal acute renal failure on day 310. This is the first report of a feline case of primary uterine lymphoma that was treated with ovariohysterectomy followed by systemic chemotherapy.

著者

Satoshi NOZAWA Tomoko KIMURA Miyuki KURISHIMA Kana MIMURA Kaori SAEKI Yohei MIKI Hitomi ODA Akihiro MORI Yutaka MOMOTA Daigo AZAKAMI Katsumi ISHIOKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0255, (Released:2015-11-22)

被引用文献数

1 7

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Nesfatin-1 is an anorexic peptide derived from a precursor, nucleobindin-2 (NUCB2), which is distributed in various organs, coexists with ghrelin in the gastric X/A-like cells and closely relates to an appetite control in rodents and humans. Nesfatin-1 may be a significant factor addressing the satiety also in veterinary medicine, however, there are few reports about nesfatin-1 in dogs. In the present study, we detected canine NUCB2/nesfatin-1 mRNA in various tissues, especially abundant in pancreas, gastrointestinal tracts, testis and cerebellum. We examined circulating nesfatin-1 concentrations and NUCB2/nesfatin-1 mRNA expressions in upper gastrointestinal tracts (gastric corpus, pyloric antrum and duodenum) in dogs fed on different types of diets. Plasma nesfatin-1 concentrations in the dogs were approximately 4 ng/ml and they did not change after feeding through the study, however, NUCB2/nesfatin-1 mRNA expressions in pyloric antrum were 1.84-fold higher in the dogs fed on a High fiber/High protein diet (P<0.001), 1.48-fold higher in the dogs fed on a High fat/Low protein diet (P<0.05) and 1.02-fold higher in the dogs fed on a Low fat/High carbohydrate diet (not significant) comparing to those on a control diet. It was concluded that High fiber/High protein and High fat/Low protein diets increased NUCB2/nesfatin-1 production in canine gastrointestinal tracts. These results may set the stage for further investigations of canine NUCB2/nesfatin-1, which may relate to satiety effects in dogs.

著者

Satoshi NOZAWA Hitomi ODA Ran AKIYAMA Kaori UEDA Kaori SAEKI Saori SHONO Natsuki MARUYAMA Atsuki MURATA Hiroyuki TAZAKI Akihiro MORI Yutaka MOMOTA Daigo AZAKAMI Toshinori SAKO Katsumi ISHIOKA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0033, (Released:2014-05-15)

被引用文献数

2 5

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Hyperadrenocorticism (HAC) is a common endocrine disorder in dogs, in which excess glucocorticoid causes insulin resistance. Disturbance of insulin action may be caused by multiple factors, including transcriptional modulation of insulin signal molecules which lie downstream of insulin binding to insulin receptors. In this study, gene expressions of insulin signal molecules were examined using neutrophils of the HAC dogs (the untreated dogs and the dogs which had been treated with trilostane). Insulin receptor substrate (IRS)-1, IRS-2, phosphatidylinositol 3-kinase (PI3-K), protein kinase B/Akt kinase (Akt)-2 and protein kinase C (PKC)-lambda were analyzed in the HAC dogs and compared with those from normal dogs. The IRS-1 gene expressions decreased by 37% and 35% of the control dogs in the untreated and treated groups, respectively. The IRS-2 gene expressions decreased by 61% and 72%, the PI3-K gene expressions decreased by 47% and 55% and the Akt-2 gene expressions decreased by 45% and 56% of the control dogs, similarly. Collectively, gene expressions of insulin signal molecules are suppressed in the HAC dogs, which may partially contribute to the induction of insulin resistance.

著者

Masaki Michishita Tatsuya Uto Ryota Nakazawa Hisashi Yoshimura Kikumi Ogihara Yuko Naya Tsuyoshi Tajima Daigo Azakami Seigo Kishikawa Toshiro Arai Kimimasa Takahashi

出版者

The Japanese Pharmacological Society

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.121, no.4, pp.339-342, 2013-04-20 (Released:2013-04-19)

参考文献数

15

被引用文献数

8 15

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Canine hemangiopericytoma (CHP) is characterized by frequent local recurrence and increased invasiveness. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis in tumors. The aim of the present study was to investigate the effect of a single dose of bevacizumab on a xenograft model of CHP. VEGF protein was secreted from cultured CHP cells and interacted with bevacizumab. Bevacizumab treatment suppressed tumor growth by inhibiting tumor angiogenesis, whereas no significant differences were observed in the proliferation index and apoptosis rates of treated and untreated mice. Thus, bevacizumab had antitumor effects in a xenograft model of CHP.

著者

Yoshifumi Kasuga Miho Iida Yuya Tanaka Masumi Tamagawa Keita Hasegawa Satoru Ikenoue Yasunori Sato Mamoru Tanaka Daigo Ochiai

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.33, no.9, pp.450-455, 2023-09-05 (Released:2023-09-05)

参考文献数

30

被引用文献数

1

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Background: Progress in reducing the global low birthweight (LBW) has been insufficient. Although the focus has been on preventing preterm birth, evidence regarding LBW in term births is limited. Despite its low preterm birth prevalence, Japan has a higher LBW proportion than other developed countries. This study aimed to examine the prevalence of LBW in term singleton births and its associated factors using a national database.Methods: We retrospectively analyzed the data of neonates registered in the Japan Society of Obstetrics and Gynecology Successive Pregnancy Birth Registry System who were born 2013–2017. Exclusion criteria included stillbirths, delivery after 42 gestational weeks, and missing data. Logistic regression analyses were performed to investigate the maternal and perinatal factors associated with LBW in term singletons using the data of 715,414 singleton neonates.Results: The overall prevalence of LBW was 18.3%, and 35.7% of LBWs originated from singleton term pregnancies. Multiple logistic regression analyses indicated that both modifiable and non-modifiable factors were independently associated with LBW in term neonates. The modifiable maternal factors included pre-pregnancy underweight, inadequate gestational weight gain, and smoking during pregnancy, while the non-modifiable factors included younger maternal age, nulliparity, hypertensive disorders of pregnancy, cesarean section delivery, female offspring, and congenital anomalies.Conclusion: Using the Japanese pregnancy birth registry data, more than one-third of LBWs were found to originate from singleton term pregnancies. Both modifiable and non-modifiable factors were independently associated with LBW in term neonates. Prevention strategies on modifiable risk factor control will be effective in reducing LBW worldwide.

著者

Ruochen LIAO Kousuke MORIWAKI Yasushi MAKIHARA Daigo MURAMATSU Noriko TAKEMURA Yasushi YAGI

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E104.D, no.10, pp.1678-1690, 2021-10-01 (Released:2021-10-01)

参考文献数

86

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In this study, we propose a method to estimate body composition-related health indicators (e.g., ratio of body fat, body water, and muscle, etc.) using video-based gait analysis. This method is more efficient than individual measurement using a conventional body composition meter. Specifically, we designed a deep-learning framework with a convolutional neural network (CNN), where the input is a gait energy image (GEI) and the output consists of the health indicators. Although a vast amount of training data is typically required to train network parameters, it is unfeasible to collect sufficient ground-truth data, i.e., pairs consisting of the gait video and the health indicators measured using a body composition meter for each subject. We therefore use a two-step approach to exploit an auxiliary gait dataset that contains a large number of subjects but lacks the ground-truth health indicators. At the first step, we pre-train a backbone network using the auxiliary dataset to output gait primitives such as arm swing, stride, the degree of stoop, and the body width — considered to be relevant to the health indicators. At the second step, we add some layers to the backbone network and fine-tune the entire network to output the health indicators even with a limited number of ground-truth data points of the health indicators. Experimental results show that the proposed method outperforms the other methods when training from scratch as well as when using an auto-encoder-based pre-training and fine-tuning approach; it achieves relatively high estimation accuracy for the body composition-related health indicators except for body fat-relevant ones.

著者

Aritada YOSHIMURA Daigo AZAKAMI Miori KISHIMOTO Takahiro OHMORI Daiki HIRAO Shohei MORITA Shinogu HASEGAWA Tatsushi MORITA Ryuji FUKUSHIMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.85, no.5, pp.541-545, 2023 (Released:2023-05-03)

参考文献数

25

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A 6-year-old castrated male Cavalier King Charles Spaniel was referred to the Animal Medical Center, Tokyo University of Agriculture and Technology, for examination and treatment of recurrent pneumothorax. Chest radiography and computed tomography showed multiple cavitary lesions in the caudal right posterior lobe. These lesions were surgically excised via thoracotomy. Subsequent histopathological examination revealed paragonimiasis. In the postoperative review, we found that the owner had fed raw deer meat to the dog four months earlier. Deer meat has attracted attention as a source of Paragonimus in humans. To our knowledge, this is the first report of Paragonimus infection in a dog due to deer meat consumption.

著者

Daiki FUKUYAMA Keiji SHINODA Daigo TAKAGI Yasuhiro KOBAYASHI

出版者

Japan Association of Mineralogical Sciences

雑誌

Journal of Mineralogical and Petrological Sciences (ISSN:13456296)

巻号頁・発行日

vol.117, no.1, pp.220506, 2022 (Released:2022-10-18)

参考文献数

21

被引用文献数

2

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The compositional dependence of the intensity and electric field gradient (EFG) tensors for Fe2+ at the M1 sites, Fe2+ at the M2 sites, and Fe3+ at the M1 sites in Ca–rich pyroxene were obtained from Mössbauer spectra of crystallographically oriented single–crystal thin sections of four Ca–rich natural pyroxenes. Components of the intensity tensor (IXX, IYY, IXY, and IZZ) for Fe2+ at the M1 sites in Wo50 Ca–rich pyroxene were almost the same; the averages of the IXX, IYY, IXY, and IZZ components were 0.342, 0.477, 0.039, and 0.681, respectively. Intensity tensor for Fe2+ at the M1 sites of Wo40 Ca–rich pyroxene was different from the Wo50. Whereas principal axes of EFG tensors for Fe2+ at the M1 sites of Wo50 pyroxenes had the same direction, principal axes of VXX and VYY of EFG of Wo40 had different directions from that from Wo50. The difference of intensity and EFG tensors between Wo50 and Wo40 suggests that the intensity and EFG tensors for Fe2+ at M1 sites are dependent on the Ca contents and are independent of Fe contents. Some intensity and EFG tensors for Fe2+ at the M2 sites and Fe3+ at the M1 sites in Ca–rich pyroxene were also obtained. However, the compositional dependence of the intensity and EFG tensors has yet to be clarified, because the number of examples is insufficient.

著者

Yoshiaki Seki Kiyoshi Ohishi Yuki Yokokura Toshiki Sano Yuji Ide Daigo Kuraishi Akihiko Takahashi

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Journal of Industry Applications (ISSN:21871094)

巻号頁・発行日

vol.6, no.2, pp.73-82, 2017-03-01 (Released:2017-03-01)

参考文献数

32

被引用文献数

1 5

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In the field of high precision positioning control, the position servo system must be highly robust against disturbance torque. A Permanent Magnet Synchronous Motor (PMSM) has various torque ripple components that degrade control performance. A portion of the torque ripple is caused by the harmonic current. The torque ripple can be suppressed using a highly robust current control system. The remaining torque ripple is defined as the disturbance torque and is compensated for using a Disturbance OBserver (DOB). However, it is very difficult for a DOB to perform the appropriate compensation because it uses a low-pass filter to reduce noise. To obtain highly robust performance, this paper proposes a new position servo system using a disturbance torque hybrid observer and a current control system in the α-β stationary frame. In addition, this paper uses the torque ripple equation instead of a torque ripple table so as to reduce the amount of Digital Signal Processor (DSP) memory. The effectiveness of the proposed position servo system is confirmed using numerical and experimental results.

著者

Nakazawa Daigo Masuda Sakiko Tomaru Utano Ishizu Akihiro

出版者

Springer Nature

雑誌

Nature reviews. Rheumatology (ISSN:17594790)

巻号頁・発行日

vol.15, no.2, pp.91-101, 2019-02

被引用文献数

259

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Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the serum. This disease entity includes microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and drug-induced AAV. Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. The mechanism by which ANCAs cause vasculitis involves ANCA-mediated excessive activation of neutrophils that subsequently release inflammatory cytokines, reactive oxygen species and lytic enzymes. In addition, this excessive activation of neutrophils by ANCAs induces formation of neutrophil extracellular traps (NETs). Although NETs are essential elements in innate immunity, excessive NET formation is harmful to small vessels. Moreover, NETs are involved not only in ANCA-mediated vascular injury but also in the production of ANCAs themselves. Therefore, a vicious cycle of NET formation and ANCA production is considered to be involved in the pathogenesis of AAV. In addition to this role of NETs in AAV, some other important discoveries have been made in the past few years. Incorporating these new insights into our understanding of the pathogenesis of AAV is needed to fully understand and ultimately overcome this disease.

著者

Takanori Honda Yuki Ishida Masaaki Oda Kenichi Noguchi Sanmei Chen Satoko Sakata Emi Oishi Yoshihiko Furuta Daigo Yoshida Yoichiro Hirakawa Jun Hata Takanari Kitazono Toshiharu Ninomiya

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.29, no.2, pp.252-267, 2022-02-01 (Released:2022-02-01)

参考文献数

42

被引用文献数

3 6

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Aim: We investigated the influence of weight change on concurrent changes in predicted cardiovascular disease (CVD) risk and individual CVD risk factors over time. Methods: A total of 2,140 community-dwellers aged 40–74 years participated in both 2002 and 2007 health examinations. Obesity was defined as body mass index ≥ 25 kg/m2. Weight trajectories were classified as: “stable obese” (obese at both examinations), “obese to nonobese” (obese in 2002 but nonobese in 2007), “nonobese to obese” (nonobese in 2002 but obese in 2007), or “stable nonobese” (nonobese at both examinations). We compared changes in the model-predicted risk for CVD and individual CVD risk factors across weight-change categories. Results: The predicted risk for CVD increased during 5 years in all groups; the increment in the predicted risk for CVD was smallest in the obese to nonobese participants and steepest in the nonobese to obese subjects. Compared with the stable obese participants, the obese to nonobese participants had greater favorable changes in waist circumferences, blood pressure, fasting plasma glucose, serum high-density lipoprotein cholesterol, serum triglycerides, and liver enzymes. For all these parameters, opposite trends were observed when comparing the nonobese to obese participants with the stable nonobese group. Conclusions: We demonstrated the favorable association of losing weight in obese people and avoiding excessive weight gain in nonobese people with global risk of future CVD and individual CVD risk factors in a real-world setting. The findings could improve behavioral lifestyle interventions that provide information on the health consequences of weight change at health checkups.

著者

松本 大吾 マツモト ダイゴ Daigo MATSUMOTO

雑誌

千葉商大論叢

巻号頁・発行日

vol.51, no.1, pp.141-158, 2013-09

著者

岩嵜 大悟 Daigo Iwasaki

出版者

基督教研究会

雑誌

基督教研究 = Kirisutokyo Kenkyu (Studies in Christianity) (ISSN:03873080)

巻号頁・発行日

vol.75, no.1, pp.53-64, 2013-06-25

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論文(Article)

著者

Takanori Honda Yuki Ishida Masaaki Oda Kenichi Noguchi Sanmei Chen Satoko Sakata Emi Oishi Yoshihiko Furuta Daigo Yoshida Yoichiro Hirakawa Jun Hata Takanari Kitazono Toshiharu Ninomiya

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.59394, (Released:2021-01-17)

参考文献数

42

被引用文献数

6

---

Aim: We investigated the influence of weight change on concurrent changes in predicted cardiovascular disease (CVD) risk and individual CVD risk factors over time. Methods: A total of 2,140 community-dwellers aged 40–74 years participated in both 2002 and 2007 health examinations. Obesity was defined as body mass index ≥ 25 kg/m2. Weight trajectories were classified as: “stable obese” (obese at both examinations), “obese to nonobese” (obese in 2002 but nonobese in 2007), “nonobese to obese” (nonobese in 2002 but obese in 2007), or “stable nonobese” (nonobese at both examinations). We compared changes in the model-predicted risk for CVD and individual CVD risk factors across weight-change categories. Results: The predicted risk for CVD increased during 5 years in all groups; the increment in the predicted risk for CVD was smallest in the obese to nonobese participants and steepest in the nonobese to obese subjects. Compared with the stable obese participants, the obese to nonobese participants had greater favorable changes in waist circumferences, blood pressure, fasting plasma glucose, serum high-density lipoprotein cholesterol, serum triglycerides, and liver enzymes. For all these parameters, opposite trends were observed when comparing the nonobese to obese participants with the stable nonobese group. Conclusions: We demonstrated the favorable association of losing weight in obese people and avoiding excessive weight gain in nonobese people with global risk of future CVD and individual CVD risk factors in a real-world setting. The findings could improve behavioral lifestyle interventions that provide information on the health consequences of weight change at health checkups.

著者

DaiGo

出版者

文溪堂

雑誌

道徳と特別活動 : 心をはぐくむ

巻号頁・発行日

vol.33, no.1, pp.50-52, 2016-04

著者

中田 大悟 Daigo NAKATA

出版者

創価大学経済学会

雑誌

創価経済論集 (ISSN:09116834)

巻号頁・発行日

vol.47, no.1, pp.67-77, 2018-03-31

著者

神田 大吾 カンダ ダイゴ KANDA Daigo

出版者

茨城大学人文学部

雑誌

人文学科論集 (ISSN:03886875)

巻号頁・発行日

no.43, pp.111-126, 2005-03

著者

Yohei Akiba Kei Miyakoshi Satoru Ikenoue Yoshifumi Saisho Yoshifumi Kasuga Daigo Ochiai Tadashi Matsumoto Mamoru Tanaka

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ18-0575, (Released:2019-04-23)

被引用文献数

11

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A number of data on gestational diabetes mellitus (GDM) in singleton pregnancy is available, however, little is known about the glycemic characteristics of twin pregnancy with GDM. The aim of this study was to compare the severity of dysglycemia between twin and singleton pregnancies with GDM (T-GDM and S-GDM). We retrospectively analyzed pregnancies with GDM defined by the Japan Diabetes Society criteria (T-GDM, n = 20; S-GDM, n = 451) in our hospital. During the study period, women with GDM underwent self-monitoring of blood glucose measurements as well as dietary management. Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal. The glycemic and metabolic characteristics were compared between T-GDM and S-GDM, as follows: gestational week at the diagnosis of GDM, 75 g oral glucose tolerance test (OGTT) results, HbA1c, insulin secretion (i.e. insulinogenic index [IGI] and Insulin Secretion-Sensitivity Index-2 [ISSI-2]), and insulin requirement before delivery. The rate of one abnormal OGTT value in T-GDM was similar to that in S-GDM (60% vs. 71%). There were no significant differences in gestational week and levels of HbA1c at diagnosis, levels of IGI and ISSI-2 between T-GDM and S-GDM (median, 20 weeks vs. 17 weeks, 5.0% vs. 5.2%, 0.58 vs. 0.71, 1.7 vs. 1.8, respectively). The rate of insulin treatment and a median dosage of insulin needed before delivery was comparable between the two groups (T-GDM vs. S-GDM: 45% vs. 32% and 14 vs. 13 unit/day). Our data suggested that the severity of dysglycemia in T-GDM was similar to that in S-GDM during pregnancy.

著者

Shota KAWAKAMI Kazuhiko OCHIAI Yuiko KATO Masaki MICHISHITA Hinako HIRAMA Ryo OBARA Daigo AZAKAMI Masami WATANABE Toshinori OMI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.1, pp.85-91, 2018 (Released:2018-01-27)

参考文献数

23

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Gliomas are common intracranial neoplasias in dogs. However, the underlying pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 2 (IDH2) is often mutated in gliomas. Although almost human IDH2 mutations have been identified at the Arg172 codon, few studies have reported structural, functional or mutational information for canine IDH2. In this study, we cloned the full-length canine IDH2 (cIDH2) cDNA and substituted wild type Arg174 (cIDH2 WT: corresponding to R172 of human IDH2) with Lys (cIDH2 R174K). The cIDH2 WT and R174K proteins were overexpressed in HeLa cells, and their presence was confirmed using an anti-human IDH2-WT mAb (clone: KrMab-3) and an anti-IDH2-R172K mAb (clone: KMab-1). The IDH2 activity between cIDH2 WT and cIDH2 R174K transfectants was compared by measuring the production of NADH and NADPH. NADPH production was lower for cIDH2 R174K than that for cIDH2 WT transfectants. Finally, we detected increased expression of hypoxia inducible factor-1 alpha (HIF-1α) in cIDH2 R174K transfectants. This indicates that mutations at R174 can potentially induce carcinogenesis in canine somatic cells.

著者

犬飼 義明 キマニ ジョン ムンジ メンゲ ダニエル マコリ 槇原 大悟 菊田 真由実 鮫島 啓彰 ワイナイナ コーネリアス ムバティ Inukai Yoshiaki Kimani John Munji Menge Daniel Makori Kikuta Mayumi Samejima Hiroaki Makihara Daigo Wainaina Cornelius Mbathi

出版者

名古屋大学農学国際教育協力研究センター

雑誌

農学国際協力 (ISSN:13475096)

巻号頁・発行日

vol.15, pp.32-41, 2017-03