著者

Jae Yun Cha Doo Chul Shin Seung Ho Shin Myung Mo Lee Kyoung Jin Lee Chang Ho Song

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.26, no.5, pp.749-751, 2014 (Released:2014-05-29)

参考文献数

22

被引用文献数

1

---

[Purpose] This study examined the relationship between core stability and exercise intensity during a pulley-based shoulder exercise (PBSE) on an unstable support surface. [Subjects] Twenty healthy college students enrolled in this study. [Methods] Surface EMG was carried out in twenty healthy adult men. The electromyographic activities of the rectus abdominis (RA), erector spinae (ES), exercises with 14 kg or 26 kg of resistance and external oblique (EO) muscles during pulley-based shoulder on an unstable support surface (USS) were compared. [Results] The EMG signals of the RA, ES, and EO did not increase with increasing exercise resistance. [Conclusion] Increasing the exercise intensity to increase the core stability during PBSE on a USS may be ineffective.

著者

牧野 眞一 マキノ シンイチ Makino Shin'ichi

出版者

駒澤大学総合教育研究部文化学部門

雑誌

駒沢大学文化 (ISSN:02896613)

巻号頁・発行日

no.30, pp.65-91, 2012-03

著者

Toyotaka SATO Shin-ichi YOKOTA Risa ICHIHASHI Tomoka MIYAUCHI Torahiko OKUBO Masaru USUI Nobuhiro FUJII Yutaka TAMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0144, (Released:2014-03-18)

被引用文献数

7

---

Understanding the prevalence of antimicrobial-resistance and the relationship between emergence of resistant bacteria and clinical treatment can facilitate design of effective treatment strategies. We here examined antimicrobial susceptibilities of Escherichia coli isolated from dogs admitted to a university hospital (University hospital) and companion animal clinics (Community clinics) in the same city, and investigated underlying multidrug-resistance mechanisms. The prevalence of E. coli with intermediate and resistant interpretations to ampicillin (AMP), enrofloxacin (ENR) and chloramphenicol (CHL) was higher in the University hospital than in the Community clinics cases. Use of antimicrobials, including fluoroquinolone, was also significantly higher in the University hospital than in the Community clinics cases. Upon isolation using ENR-supplemented agar plates, all ENR-resistant isolates had 3–4 nucleotide mutations that accompanied by amino acid substitutions in the quinolone-resistance-determining regions of gyrA, parC and parE, and 94.7% of all isolates derived from the University hospital showed AMP and/or CHL resistance, and possessed blaTEM and/or catA1. The average mRNA expression levels of acrA, acrB and tolC, and the prevalence of organic solvent tolerance, in isolates derived from ENR-supplemented agar plates were significantly higher in the University hospital than in the Community clinics isolates. Thus, E. coli derived from the University hospital cases more often showed concomitant decreased susceptibilities to aminopenicillins, fluoroquinolones, and CHL than did those derived from the Community clinics; this was related to an active AcrAB–TolC efflux pump, in addition to acquisition of specific resistance genes and genetic mutations.

著者

Yoshizawa Yuichi Honda Shin-ichiro Shibuya Akira

出版者

Elsevier

雑誌

Molecular immunology (ISSN:01615890)

巻号頁・発行日

vol.57, no.2, pp.216-219, 2014-02

被引用文献数

4

---

Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcα/μR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcα/μR on the background of MRL/MpJ-Faslpr/lpr (Fcamr−/−Faslpr/lpr) mice. Fcamr−/−Faslpr/lpr mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr+/+Faslpr/lpr mice. Moreover, Fcamr−/−Faslpr/lpr mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr+/+Faslpr/lpr mice. These results suggest that Fcα/μR enhances, rather than suppresses, autoantibody production.

著者

SHIMIZU Satoko TSUKADA Toshihiko FUTAMI Hitoyasu UI Kotaro KAMEYA Toru KAWANAKA Masahiro UCHIYAMA Shozo AOKI Akira YASUDA Hiroko KAWANO Shin-ichiro ITO Yukio KANBE Masako OBARA Takao YAMAGUCHI ken

雑誌

Japanese journal of cancer research : gann (ISSN:09105050)

巻号頁・発行日

vol.88, no.11, pp.1029-1032, 1997-11-30

被引用文献数

20 33

著者

Eun-Joo Shin Wan Kyunn Whang Sungun Kim Jae-Hyung Bach Jin-Man Kim Xuan-Khanh Thi Nguyen Thuy-Ty Lan Nguyen Bae Dong Jung Kiyofumi Yamada Toshitaka Nabeshima Hyoung-Chun Kim

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.113, no.4, pp.404-408, 2010 (Released:2010-08-18)

参考文献数

15

被引用文献数

11 25

---

Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT1A–receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A–agonist activity in a 8-OH-DPAT–stimulated [35S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.

著者

Sung Hwun Kang Cheol Woo Kim Young Il Kim Kwi Baek Kim Sung Soo Lee Ki ok Shin

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.25, no.7, pp.895-900, 2013 (Released:2013-08-20)

参考文献数

30

被引用文献数

1 16

---

[Purpose] Balance is generally defined as the ability to maintain the body’s center of gravity within its base of support and may be categorized by either static or dynamic balance. The purpose of the present study was to evaluate the effect of 8 weeks of balance training on strength, and the functional balance ability of elite weightlifters. [Subjects] Thirty-two elite weightlifters were recruited for the present study. They were divided into exercise groups (8 high school students, 8 middle school students) and control groups (8 high school students, 8 middle school students). [Methods] Body compositions were measured by the electrical impedance method, and a Helmas system was used to measure basic physical capacities. The muscular function test was conducted using a Cybex 770. [Results] There were no significant changes in body composition after the training. In contrast, significant changes were found in the number of push-ups, one-leg standing time with eyes closed, and upper body back extension. Interestingly, only the left arm external rotation value after the exercise training program showed a statistically significant difference from the baseline value. [Conclusion] The peak torque values of shoulder internal rotation and knee extension were significantly changed compared to the baseline values, which mean subjects showed balance of their muscular power. Therefore, the results of the present study suggest that an 8-week balance-training program would positively affect elite weightlifters’ balance ability and flexibility. We think that well-balanced muscular functionality may enhance athletes’ sport performance.

著者

Tanaka Shinsuke Kawaguchi Shin-Ya Shioi Go Hirano Tomoo

出版者

The Society for Neuroscience

雑誌

The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:02706474)

巻号頁・発行日

vol.33, no.43, pp.17209-17220, 2013-10-23

被引用文献数

41

---

運動学習の新メカニズム解明に成功. 京都大学プレスリリース. 2013-10-23.

著者

辛 賢 Shin Hyeon

出版者

大阪大学大学院文学研究科

雑誌

待兼山論叢. 哲学篇 (ISSN:03874818)

巻号頁・発行日

vol.38, pp.1-15, 2004-12

著者

Kazuhiko Higashida Izumi Tabata Mitsuru Higuchi Shin Terada

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.2, no.3, pp.355-360, 2013-08-25 (Released:2013-09-08)

参考文献数

42

被引用文献数

1 1

---

Skeletal muscle is the primary site of glucose uptake in humans. Glucose transport activity, which is the rate-limiting step in muscle glucose metabolism, is linearly related to the content of the GLUT-4 isoform of the glucose transporter. Therefore, the level of GLUT-4 in skeletal muscle may be an important determinant of whole-body glucose disposal. It has been well documented that long-term, low- to moderate-intensity endurance exercise training induces an increase in muscle GLUT-4 content. However, emerging evidence suggests that an adaptive increase in GLUT-4 occurs even after a single acute bout of exercise or high-intensity intermittent exercise training. Recent findings also indicate that nutritional status affects GLUT-4 expression in skeletal muscle. This review provides an overview of the effects of exercise and nutritional status on GLUT-4 content in skeletal muscle, and summarizes recent progress in elucidating the molecular regulation of muscle GLUT-4 gene expression by exercise and nutritional stimuli.

著者

Masayuki Takada Yoko Fukuda Shin-ichiro Iwamiya

出版者

一般社団法人 日本音響学会

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.34, no.3, pp.187-196, 2013-03-01 (Released:2013-05-01)

参考文献数

20

被引用文献数

1 4

---

The Japanese Road Traffic Law states that a vehicle horn should be used only in an emergency or in dangerous locations where a horn sign has been installed. However, drivers frequently use their vehicle horn as a signal when passing each other. Furthermore, pedestrians and cyclists are also honked at by drivers. There may be a negative effect of vehicle horn use on people outside the vehicle. Therefore, a questionnaire survey was carried out to ascertain the current circumstances of vehicle horn use. Respondents were asked about the latest or last-remembered instance of horn use in various situations, both when they were driving and when they were pedestrians. With regard to experiences of being honked at by another driver, the questionnaire included questions concerning place, traffic volume, the aim of horn use, the timing pattern of horn use, and the respondent's psychological reaction when honked at by another driver. It was found that drivers briefly honked their horn to express gratitude, or to gain another's attention, in various places. Long honks such as one long honk or two long honks mostly evoked negative psychological reactions in drivers, such as a feeling that the sound of the horn was startling, noisy, or irritating. Furthermore, pedestrians frequently had negative psychological reactions to horns used to gain their attention or to alert them to danger. More than 40% of nondrivers were displeased with the volume and sound quality of horns.

著者

Tsuneo Watanabe Nobuo Terabayashi Bateer Shi Sohee Shin Kosho Kasuga Tamotsu Yabumoto Katsuji Shimizu Toshio Matsuoka

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.2, no.2, pp.243-250, 2013-05-25 (Released:2013-06-21)

参考文献数

24

被引用文献数

1 3

---

The purpose of this study was to investigate the influence of cryotherapy on knee joint position sense (JPS) and intraarticular blood flow volume (IBFV) and evaluate their relationships with cooling time as well as with surface temperature and deep temperature. Ten healthy volunteers were examined. This study consisted of a same-subjects repeated-measures design, with the timeframe of cryotherapy application (no therapy [resting control group], 2-min cooling, or 15-min cooling intervention) after exercise being the independent variable, and IBFV, knee JPS, surface temperature, and deep temperature serving as the dependent variables. Dependent variables were examined before 10-min cycle ergometer exercise (baseline), post-exercise, post-cooling, and 15 min later. In the 15-min cooling group, IBFV immediately after cooling and 15 min later were significantly lower than the post-exercise values (P = 0.048 and 0.016, respectively), and knee JPS at 15 min later was significantly lower than the baseline value (P = 0.037). By contrast, the 2-min cooling group showed no significant changes in either knee JPS or IBFV. Although both surface and deep temperatures after cooling were significantly lower than baseline (P = 0.034 and P < 0.001, respectively) in the 2-min cooling group, 15 min later they were significantly higher than post-cooling values (P = 0.023 and 0.023, respectively). These results suggest that 15-min cooling interventions functionally impair the sensitivity of JPS, although cooling is suitable for reduction of IBFV in deep tissue. Cooling interventions lasting less than 2-min did not affect knee JPS; however no reduction of IBFV occurred during this timeframe.

著者

Abe Shin-ya Shi Youhua Yanagisawa Masao Togawa Nozomu

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Electronics Express (ISSN:13492543)

巻号頁・発行日

vol.9, no.17, pp.1414-1422, 2012

被引用文献数

14

---

In this paper, we propose multiple-supply-voltages aware high-level synthesis algorithm for <i>HDR architectures</i> which realizes high-speed and high-efficient circuits. We propose three new techniques: <i>virtual area estimation</i>, <i>virtual area adaptation</i>, and <i>floor-planning-directed huddling</i>, and integrate them into our HDR architecture synthesis algorithm. Virtual area estimation/adaptation effectively estimates a huddle area by gradually reducing it during iterations, which improves the convergence of our algorithm. Floorplanning-directed huddling determines huddle composition very effectively by performing floorplanning and functional unit assignment inside huddles simultaneously. Experimental results show that our algorithm achieves about 29% run-time-saving compared with the conventional algorithms, and obtains a solution which cannot be obtained by our original algorithm even if a very tight clock constraint is given.

著者

Machida Masanao Takeda Kohei Fujimaki Shin

出版者

Japan Society of Exercise and Sports Physiology

雑誌

Advances in exercise and sports physiology (ISSN:13403141)

巻号頁・発行日

vol.19, no.2, pp.39-46, 2013-07

著者

Hiroto Kinoshita Reiko Kunisaki Hisae Yamamoto Reikei Matsuda Tomohiko Sasaki Hideaki Kimura Katsuaki Tanaka Makoto Naganuma Shin Maeda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.52, no.17, pp.1855-1862, 2013 (Released:2013-09-01)

参考文献数

23

被引用文献数

8 39

---

Objective To investigate the short- and long-term efficacy and safety of infliximab (IFX) in intestinal Behçet's disease (BD) patients in a retrospective cohort study. Methods Among 43 consecutive patients with intestinal BD presenting at the same clinic, 15 with active disease and receiving standard treatment were given IFX infusions (5 mg/kg body weight) every eight weeks. The patients were clinically and endoscopically evaluated before treatment, then assessed after 10 weeks, 12 months and 24 months for a clinical response, defined as a significant improvement in intestinal symptoms and a reduced C-reactive protein (CRP) level. Results At week 10, 12 patients (80%) exhibited a response to IFX, with eight (53%) in remission with no intestinal symptoms and normal CRP levels. A response to IFX was maintained in seven of the 11 patients (64%) available at 12 months and in four of the eight patients (50%) available at 24 months. Of the seven patients receiving prednisolone at entry, five responders had their steroid doses reduced. Fulminant intestinal BD was predictive of an absence of response to IFX. The adverse effects comprised one infusion reaction and one case of fever, most likely related to IFX. Conclusion IFX is effective and safe in patients with refractory intestinal BD.

著者

Min Eun Jung Shin Jun Geun Lee Jae Hwi Yasuno Yoshiaki Lee Byeong Ha

出版者

Optical Society of America

雑誌

Applied optics (ISSN:1559128X)

巻号頁・発行日

vol.52, no.21, pp.5143-5151, 2013-07

---

We propose a single-step method appropriated for a fiber-optic probe-based full-range spectral domain optical coherence tomography (OCT). The fiber-optic probe was scanned over a sample with a magnetically driven actuator. In the reference arm, a phase shift of π/2 was applied during two neighbor axial scanning, from which the complex spectral interferogram was directly reconstructed. Since the complex-conjugate-free OCT image is obtained by doing just one Fourier transform on the complex interferogram, obtaining the full-range image is simple in algorithm and effective in computation time. Some full-range images of biological samples created with the proposed method are presented and the processing time is analyzed.

著者

申 東珪 シン トンギュ Dong kyu Shin

雑誌

史苑

巻号頁・発行日

vol.61, no.1, pp.54-70, 2000-11-08 (Released:2012-11-21)

著者

申 恵豊 Shin Hae Bong

雑誌

青山法学論集 (ISSN:05181208)

巻号頁・発行日

vol.54, no.1, pp.169-225, 0000

著者

Takagaki Kana Satoh Kazuki Honda Shin-ichiro Shibuya Akira

出版者

Elsevier

雑誌

Molecular immunology (ISSN:01615890)

巻号頁・発行日

vol.56, no.1-2, pp.23-27, 2013-11

被引用文献数

4 1

---

Fcα/μR (CD351) is an Fc receptor for both IgA and IgM and forms an atypical dimer that is resistant to reduction by 2-mercaptoethanol or boiling. We previously demonstrated that the cytoplasmic portion of Fcα/μR is required for dimer formation and for its efficient cell-surface expression. However, the biochemical nature of these phenomena has not been determined. By using a BW5147 mouse cell line expressing deletion mutants of the cytoplasmic region of Fcα/μR, we found that the region spanning amino acids 504–523 was required for efficient cell-surface expression, whereas the region spanning amino acids 481–490 was required for dimmer formation. Immunoblotting analyses of transfectants simultaneously expressing Flag-tagged Fcα/μR and hemagglutinin-tagged Fcα/μR suggested that Fcα/μR does not form homodimers. Instead, our data suggest that Fcα/μR forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60–70 kDa.

著者

Nakano Takako Tahara-Hanaoka Satoko Nakahashi Chigusa Can Ismail Totsuka Naoya Honda Shin-ichiro Shibuya Kazuko Shibuya Akira

出版者

Elsevier

雑誌

Molecular immunology (ISSN:01615890)

巻号頁・発行日

vol.45, no.1, pp.289-294, 2008-01

被引用文献数

18 19

---

Neutrophils play a central role in host defenses against infectious microbial pathogens. However, molecular basis for their triggering signals has been incompletely understood. Here, we show molecular and functional characteristics of myeloid-associated immunoglobulin-like receptor (MAIR)-IV. MAIR-IV was preferentially expressed on neutrophils in the peripheral blood, bone marrow, peritoneal cavity and spleen. MAIR-IV physically associates with immunoreceptor tyrosine based activating motif (ITAM)-bearing adaptor FcRγ chain. Cross-linking MAIR-IV with anti-MAIR-IV monoclonal antibody significantly induced secretion of proinflammatory cytokines TNF-α and IL-6 from neutrophils. Thus, MAIR-IV may regulate activation of neutrophils and play an important role for innate immunity.