著者
Ryugo S. HAYANO Masaharu TSUBOKURA Makoto MIYAZAKI Hideo SATOU Katsumi SATO Shin MASAKI Yu SAKUMA
出版者
日本学士院
雑誌
Proceedings of the Japan Academy, Series B (ISSN:03862208)
巻号頁・発行日
vol.89, no.4, pp.157-163, 2013-04-11 (Released:2013-04-11)
参考文献数
14
被引用文献数
46 73

The Fukushima Dai-ichi NPP accident contaminated the soil of densely-populated regions in Fukushima Prefecture with radioactive cesium, which poses significant risks of internal and external exposure to the residents. If we apply the knowledge of post-Chernobyl accident studies, internal exposures in excess of a few mSv/y would be expected to be frequent in Fukushima.Extensive whole-body-counter surveys (n = 32,811) carried out at the Hirata Central Hospital between October, 2011 and November, 2012, however show that the internal exposure levels of residents are much lower than estimated. In particular, the first sampling-bias-free assessment of the internal exposure of children in the town of Miharu, Fukushima, shows that the 137Cs body burdens of all children (n = 1,383, ages 6–15, covering 95% of children enrolled in town-operated schools) were below the detection limit of 300 Bq/body in the fall of 2012. These results are not conclusive for the prefecture as a whole, but are consistent with results obtained from other municipalities in the prefecture, and with prefectural data.(Communicated by Toshimitsu YAMAZAKI, M.J.A.)
著者
Ryugo S. HAYANO Masaharu TSUBOKURA Makoto MIYAZAKI Hideo SATOU Katsumi SATO Shin MASAKI Yu SAKUMA
出版者
日本学士院
雑誌
Proceedings of the Japan Academy, Series B (ISSN:03862208)
巻号頁・発行日
vol.91, no.3, pp.92-98, 2015-03-11 (Released:2015-03-11)
参考文献数
17
被引用文献数
3 4

Comprehensive whole-body counter surveys of Miharu-town school children have been conducted for four consecutive years, in 2011–2014. This represents the only long-term sampling-bias-free study of its type conducted after the Fukushima Dai-ichi accident. For the first time in 2014, a new device called the Babyscan, which has a low 134/137Cs MDA of <50 Bq/body, was used to screen the children shorter than 130 cm. No child in this group was found to have detectable level of radiocesium. Using the MDAs, upper limits of daily intake of radiocesium were estimated for each child. For those screened with the Babyscan, the upper intake limits were found to be ≲1 Bq/day for 137Cs. Analysis of a questionnaire filled out by the children’s parents regarding their food and water consumption shows that the majority of Miharu children regularly consume local and/or home-grown rice and vegetables. This however does not increase the body burden.
著者
Ryugo S. HAYANO Masaharu TSUBOKURA Makoto MIYAZAKI Hideo SATOU Katsumi SATO Shin MASAKI Yu SAKUMA
出版者
日本学士院
雑誌
Proceedings of the Japan Academy, Series B (ISSN:03862208)
巻号頁・発行日
vol.90, no.6, pp.211-213, 2014-06-11 (Released:2014-06-11)
参考文献数
9
被引用文献数
3 4

Comprehensive whole-body counter surveys covering over 93% of the school children between the ages of 6 and 15 in Miharu town, Fukushima Prefecture, have been conducted for three consecutive years, in 2011, 2012 and 2013. Although the results of a questionnaire indicate that approximately 60% of the children have been regularly eating local or home-grown rice, in 2012 and 2013 no child was found to exceed the 137Cs detection limit of 300 Bq/body.
著者
Shin Kawasoe Takuro Kubozono Shiro Yoshifuku Satoko Ojima Naoya Oketani Masaaki Miyata Hironori Miyahara Shigeho Maenohara Mitsuru Ohishi
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-16-0766, (Released:2016-11-03)
参考文献数
48
被引用文献数
7

Background:The association between serum uric acid (UA) levels and atrial fibrillation (AF) in the general population in Japan is not well known.Methods and Results:In total, 285,882 consecutive subjects (men, 130,897; women, 154,985; age, 58±15 years) not receiving treatment for hyperuricemia who underwent health checkups were enrolled. Subjects were stratified into deciles according to age, body mass index, estimated glomerular filtration rate, systolic blood pressure, and UA level. AF prevalence was calculated for each decile. The odds ratio that defined the decile with the lowest AF prevalence as reference was calculated in each sex. In men, the mean UA was 6.0±1.4 mg/dl; AF prevalence was 1.8% and was lowest in the decile with UA 4.4–4.9 mg/dl. Deciles with both high and low UA (5.4–5.6 mg/dl to >7.8 mg/dl and <4.3 mg/dl) were associated with significantly higher AF prevalence. In women, the mean UA was 4.5±1.1 mg/dl; AF prevalence was 0.7% and was lowest in the decile with UA 3.6–3.8 mg/dl. Deciles with highest UA (5.0–5.2 mg/dl to >5.9 mg/dl) were associated with significantly higher AF prevalence. The analysis adjusted for other clinical covariates demonstrated an independent association between UA and AF in both sexes.Conclusions:In a representative Japanese general population, UA level was significantly associated with AF, independently of other cardiovascular risk factors.
著者
Takuya MAKI Miho INOUE-MURAYAMA Kyung-Won HONG Eiji INOUE Masami MAEJIMA Norio KANSAKU Yuichi TANABE Shin'ichi ITO
出版者
Japanese Society of Animal Breeding and Genetics
雑誌
The Journal of Animal Genetics (ISSN:13459961)
巻号頁・発行日
vol.36, no.2, pp.95-104, 2008-12-01 (Released:2010-03-18)
参考文献数
20
被引用文献数
1 1

日本犬標準6品種 (柴犬、紀州犬、四国犬、北海道犬、甲斐犬、秋田犬) の中で、柴犬は飼育数も多く最も馴染み深い。柴犬には、信州柴犬 (日保系・柴保系) 、山陰柴犬、美濃柴犬の3内種が存在し、形態や性格が異なる。先行する日本犬研究の多くは、柴犬の3内種を区分けしないで扱ってきたため、各内種内の遺伝的多様性や、内種間の遺伝的分化の程度は明らかでない。本研究では、柴犬3内種 (信州柴犬/日保系、信州柴犬/柴保系、山陰柴犬、美濃柴犬の4集団) に、比較として加えた7品種 (北海道犬、秋田犬、四国犬、薩摩犬、琉球犬、日本スピッツ、ラブラドール・レトリーバーの7集団) の計11集団、合計430頭に対して、マイクロサテライト17座位を用いて、解析した。用いた17座位による柴犬3内種 (4集団) の期待ヘテロ接合度の平均は、信州柴犬/日保系が0.641、信州柴犬/柴保系が0.480、山陰柴犬が0.508、美濃柴犬が0.588であり、他の7犬種の平均0.603と、大きく異ならない値を示した。また、柴犬3内種 (4集団) 問の遺伝的分化の程度は高度に有意であった (P<0.Ol) 。11集団間の枝分れ図では、柴犬の3内種 (4集団) は相互に近い位置関係を示したが、山陰柴犬は、他の2内種 (3集団) からはやや離れた位置関係にあった。この結果から、山陰柴犬は、信州柴犬 (日保系・柴保系) や美濃柴犬と異なる可能性が考えられた。また、柴犬3内種 (4集団) に属する個体問の枝分れ図では、個々の内種内は遺伝的に密にまとまっており、 (社) 日本犬保存会【日保】と天然記念物柴犬保存会【柴保】両系の問にも明確な差が認められた。このことから、各内種を保存・育成する会で、独自に血統が保持されてきたことが示唆された。今回の結果から、柴犬3内種 (4集団) 問は統計的に高度に有意な遺伝的分化を示しており、今後の研究では、柴犬は3内種 (4集団) 別に区分けして取り扱う必要がある、と考えられる。
著者
Kei Fujiwara Miho Yanagisawa Shin-ichiro M. Nomura
出版者
日本生物物理学会
雑誌
BIOPHYSICS (ISSN:13492942)
巻号頁・発行日
vol.10, pp.43-48, 2014 (Released:2014-08-07)
参考文献数
38
被引用文献数
1 6

Toward reconstitution of living cells by artificial cells technology, it is critical process to understand the differences between mixtures of biomolecules and living cells. For the aim, we have developed procedures for preparation of an additive-free cell extract (AFCE) and for concentrating biomacromolecules in artificial cells. In this review, we introduce our recent progress to reconstitute intracellular environments in vitro and in artificial cells.
著者
Yamada Seitaro Fukumoto Shin-ichiro
出版者
Graduate School of Veterinary Medicine, Hokkaido University
雑誌
Japanese Journal of Vetrinary Research (ISSN:00471917)
巻号頁・発行日
vol.59, no.2, pp.101-104, 2011-08

Green- or brown-striped trematode sporocyst broodsacs typical of Leucochloridium infecting the ocular tentacles of a land snail, Succinea lauta, were collected in Abashiri, Hokkaido in northern Japan (N43° 59´, E144° 14´) in June of 2000 and 2001. The metacercariae isolated from the sporocyst broodsac were morphologically identified as Leucochloridium spp. (Leucoclhoridiidae Poche). This report is the first to describe evidential specimens of the sporocyst broodsac of the genus Leucochloridium Carus, 1835, infecting the intermediate host in Japan, suggesting that Leucochloridium spp. completes Their life cycle in Hokkaido, Japan.
著者
辛 在卿 J.K. Shin 京都創成大学
雑誌
京都創成大学紀要 = Kyoto Sosei University review
巻号頁・発行日
vol.7, pp.15-28, 2007-01-01

朝鮮半島が植民地であった当時、鉄道省管轄下の指定航路で、日本と朝鮮半島および満州を結ぶ日本の基幹路線であった、関釜連絡船以外の主要な連絡船としては、済州道と大阪を結ぶ<君が代丸>しかなかった。本論文では、<君が代丸>という船が、どのような船なのか、その歴史的実像を明らかにしたい。
著者
Moono SHIN Tomijiro KUBOTA Koji HAMADA Tadayoshi HITOMI Takeshi OTA
出版者
日本水環境学会
雑誌
Journal of Water and Environment Technology (ISSN:13482165)
巻号頁・発行日
vol.13, no.5, pp.383-394, 2015 (Released:2015-10-10)
参考文献数
16

Radioactive contamination resulting from the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Station disaster following the Great East Japan earthquake and tsunami on March 11, 2011, has affected large areas of land in Fukushima, Japan. At present, agriculture has been limited to some areas, and there are concerns that radioactive substances carried by rainwater might contaminate water bodies such as ponds and rivers. In order to resume safe agricultural activities, evaluating the dynamics of radioactive substances in agricultural water is essential. In this study, we measured the concentration and analyzed the impact of radioactive cesium in irrigation water on rice in five districts having limited residential population. Further, we analyzed the radioactive cesium balance and soil samples from decontaminated paddy fields. The main findings of the study are (1) radioactive cesium in agricultural water was mainly in suspended form at the experimental locations within the 40 km zone; (2) most of the radioactive cesium in the irrigation water was accumulated in the paddy field, but radioactive cesium in irrigation water had limited impact on brown rice cultivation; and (3) continual monitoring of areas with radiation levels higher than those recorded in this study is recommended.
著者
Kohei Takata Satoshi Imaizumi Emi Kawachi Yasunori Suematsu Tomohiko Shimizu Satomi Abe Yoshino Matsuo Hitomi Tsukahara Keita Noda Eiji Yahiro Bo Zhang Yoshinari Uehara Shin-ichiro Miura Keijiro Saku
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-14-0638, (Released:2014-10-16)
参考文献数
47
被引用文献数
8 22

Background:Smoking cessation reduces the risk of cardiovascular disease (CVD) and improves clinical outcomes in public health. We studied the effect of smoking cessation on high-density lipoprotein (HDL) functionality.Methods and Results:We randomly treated 32 smokers with varenicline or a transdermal nicotine patch as part of a 12-week smoking cessation program (The VN-SEESAW Study). The plasma lipid profiles, plasma and HDL malondialdehyde (MDA) levels, HDL subfractions as analyzed by capillary isotachophoresis, cholesterol efflux capacity, and antiinflammatory activity of HDL were measured before and after the anti-smoking intervention. After smoking cessation, HDL-C, apoA-I levels and HDL subfractions were not significantly different from the respective baseline values. However, cholesterol efflux capacity and the HDL inflammatory index (HII) were significantly improved after smoking cessation. The changes in both parameters (%∆ cholesterol efflux capacity and ∆HII) were also significantly improved in the successful smoking cessation group compared with the unsuccessful group. The changes in cholesterol efflux capacity and HII also correlated with those in end-expiratory CO concentration and MDA in HDL, respectively.Conclusions:Our findings indicate that smoking cessation leads to improved HDL functionality, increased cholesterol efflux capacity and decreased HII, without changing HDL-C or apoA-I levels or HDL subfractions. This may be one of the mechanisms by which smoking cessation improves the risk of CVD.
著者
Yusuke Matsui Yusuke Uchida Hervé Jégou Shin'ichi Satoh
出版者
The Institute of Image Information and Television Engineers
雑誌
ITE Transactions on Media Technology and Applications (ISSN:21867364)
巻号頁・発行日
vol.6, no.1, pp.2-10, 2018 (Released:2018-01-01)
参考文献数
53

Product Quantization (PQ) search and its derivatives are popular and successful methods for large-scale approximated nearest neighbor search. In this paper, we review the fundamental algorithm of this class of algorithms and provide executable sample codes. We then provide a comprehensive survey of the recent PQ-based methods.
著者
Yumiko Takahashi Yutaka Matsunaga Yuki Tamura Eiki Urushibata Shin Terada Hideo Hatta
出版者
一般社団法人日本体力医学会
雑誌
The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
巻号頁・発行日
vol.3, no.5, pp.531-537, 2014-11-25 (Released:2014-12-05)
参考文献数
26
被引用文献数
1 5

Previous studies suggested that taurine (2-aminoethanesulfonic acid) administration enhances glucose uptake, one of the rate-limiting factors for glycogen synthesis. In this study, we investigated the effects of post-exercise taurine administration on glycogen repletion in skeletal muscle in ICR mice. In experiment 1, we orally administered either taurine (0.5 mg/g body weight) solution or physiological saline immediately after treadmill running at 25 m/min for 90 min. The serum free fatty acid (FFA) concentration at 60 min after the exercise was significantly higher in the taurine-treated group compared with the control group (p < 0.05). At 120 min after the exercise, the tibialis anterior muscle glycogen concentration in the taurine-treated group was significantly higher than that in the control group (p < 0.05). In experiment 2, we orally administered either glucose (1 mg/g body weight) solution or glucose solution containing taurine immediately after and at 60 min after the exercise. The area under the curve (AUC) for blood glucose concentration from 0 to 60 min after the exercise was significantly smaller in the taurine-treated group compared with the control group (p < 0.01). Our results show that post-exercise taurine administration enhances glycogen repletion in skeletal muscle. Higher skeletal muscle glycogen concentration by taurine administration may be partly due to the acceleration of glucose uptake. In addition, as the elevation of blood FFA level leads to an increase in fat oxidation, it is possible that a higher serum FFA concentration by taurine treatment is related to the sparing of carbohydrate for glycogen repletion.
著者
Masatsugu Hori Masayasu Matsumoto Norio Tanahashi Shin-ichi Momomura Shinichiro Uchiyama Shinya Goto Tohru Izumi Yukihiro Koretsune Mariko Kajikawa Masaharu Kato Hitoshi Ueda Kazuya Iwamoto Masahiro Tajiri on behalf of the J-ROCKET AF study investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-12-0454, (Released:2012-06-05)
参考文献数
13
被引用文献数
164 241

Background: The global ROCKET AF study evaluated once-daily rivaroxaban vs. warfarin for stroke and systemic embolism prevention in patients with atrial fibrillation (AF). A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF. Methods and Results: J-ROCKET AF was a prospective, randomized, double-blind, phase III trial. Patients (n=1,280) with non-valvular AF at increased risk for stroke were randomized to receive 15mg once-daily rivaroxaban or warfarin dose-adjusted according to Japanese guidelines. The primary objective was to determine non-inferiority of rivaroxaban against warfarin for the principal safety outcome of major and non-major clinically relevant bleeding, in the on-treatment safety population. The primary efficacy endpoint was the composite of stroke and systemic embolism. Non-inferiority of rivaroxaban to warfarin was confirmed; the rate of the principal safety outcome was 18.04% per year in rivaroxaban-treated patients and 16.42% per year in warfarin-treated patients (hazard ratio [HR] 1.11; 95% confidence interval 0.87–1.42; P<0.001 [non-inferiority]). Intracranial hemorrhage rates were 0.8% with rivaroxaban and 1.6% with warfarin. There was a strong trend for a reduction in the rate of stroke/systemic embolism with rivaroxaban vs. warfarin (HR, 0.49; P=0.050). Conclusions: J-ROCKET AF demonstrated the safety of a Japan-specific rivaroxaban dose and supports bridging the global ROCKET AF results into Japanese clinical practice.
著者
Ikeda Kaori Fujimoto Shimpei Morling Beth Ayano-Takahara Shiho Carroll Andrew E. Harashima Shin-ichi Uchida Yukiko Inagaki Nobuya
出版者
Public Library of Science
雑誌
PLOS ONE (ISSN:19326203)
巻号頁・発行日
vol.9, no.10, 2014-10-15
被引用文献数
7

糖尿病患者の心の負担に日本人特有の要因の存在 -協調性を重視する文化の影響-. 京都大学プレスリリース. 2014-10-16.
著者
Sookyoung Park Seunghoon Lee Yunkyung Hong Youngjeon Lee Kanghui Park Dongkwang Shin Sang-Rae Lee Kyu-Tae Chang Yonggeun Hong
出版者
Japan Society of Physical Education, Health and Sport Sciences
雑誌
International Journal of Sport and Health Science (ISSN:13481509)
巻号頁・発行日
vol.10, pp.50-57, 2012 (Released:2012-09-13)
参考文献数
35

This study compared the range of hallux valgus angle (HVA) deformity between basketball players and same aged non-basketball players as controls. The participants included 21 basketball players (9 males, 12 females, mean age 18 years) and 36 age-matched college students (19 males, 17 females, mean age 20 years) who served as controls. After direct palpation of the first metatarsal and proximal phalange, we measured the HVA deformity using a photographic approach in the women basketball players and a goniometer for the men basketball players and all controls. The HVA was greater in basketball players than in the controls. Among female basketball players, the HVA was significantly greater in guards compared with forwards and centers. In conclusion, playing basketball may increase the HVA. The greater increase in HVA among guards might arise because they are required to make diagonal and horizontal movements that increase the burden on the foot. In general insole or ergonomic shoes could reduce pain, improved walking ability, and hallux valgus angle for prophylactic or therapeutic approaches. Therefore, an appropriate preventive interventional program should be developed.
著者
Takashi Okubo Takahiro Tsukui Hiroko Maita Shinobu Okamoto Kenshiro Oshima Takatomo Fujisawa Akihiro Saito Hiroyuki Futamata Reiko Hattori Yumi Shimomura Shin Haruta Sho Morimoto Yong Wang Yoriko Sakai Masahira Hattori Shin-ichi Aizawa Kenji V. P. Nagashima Sachiko Masuda Tsutomu Hattori Akifumi Yamashita Zhihua Bao Masahito Hayatsu Hiromi Kajiya-Kanegae Ikuo Yoshinaga Kazunori Sakamoto Koki Toyota Mitsuteru Nakao Mitsuyo Kohara Mizue Anda Rieko Niwa Park Jung-Hwan Reiko Sameshima-Saito Shin-ichi Tokuda Sumiko Yamamoto Syuji Yamamoto Tadashi Yokoyama Tomoko Akutsu Yasukazu Nakamura Yuka Nakahira-Yanaka Yuko Takada Hoshino Hideki Hirakawa Hisayuki Mitsui Kimihiro Terasawa Manabu Itakura Shusei Sato Wakako Ikeda-Ohtsubo Natsuko Sakakura Eli Kaminuma Kiwamu Minamisawa
出版者
日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会
雑誌
Microbes and Environments (ISSN:13426311)
巻号頁・発行日
pp.1203230372-1203230372, (Released:2012-03-28)
参考文献数
1
被引用文献数
14 27

Bradyrhizobium sp. S23321 is an oligotrophic bacterium isolated from paddy field soil. Although S23321 is phylogenetically close to Bradyrhizobium japonicum USDA110, a legume symbiont, it is unable to induce root nodules in siratro, a legume often used for testing Nod factor-dependent nodulation. The genome of S23321 is a single circular chromosome, 7,231,841 bp in length, with an average GC content of 64.3%. The genome contains 6,898 potential protein-encoding genes, one set of rRNA genes, and 45 tRNA genes. Comparison of the genome structure between S23321 and USDA110 showed strong colinearity; however, the symbiosis islands present in USDA110 were absent in S23321, whose genome lacked a chaperonin gene cluster (groELS3) for symbiosis regulation found in USDA110. A comparison of sequences around the tRNA-Val gene strongly suggested that S23321 contains an ancestral-type genome that precedes the acquisition of a symbiosis island by horizontal gene transfer. Although S23321 contains a nif (nitrogen fixation) gene cluster, the organization, homology, and phylogeny of the genes in this cluster were more similar to those of photosynthetic bradyrhizobia ORS278 and BTAi1 than to those on the symbiosis island of USDA110. In addition, we found genes encoding a complete photosynthetic system, many ABC transporters for amino acids and oligopeptides, two types (polar and lateral) of flagella, multiple respiratory chains, and a system for lignin monomer catabolism in the S23321 genome. These features suggest that S23321 is able to adapt to a wide range of environments, probably including low-nutrient conditions, with multiple survival strategies in soil and rhizosphere.
著者
Yamasaki Chisato Murakami Katsuhiko Fujii Yasuyuki Sato Yoshiharu Harada Erimi Takeda Jun-ichi Taniya Takayuki Satake Ryuichi Kikugawa Shingo Shimada Makoto Tanino Motohiko Halligan Brian Shimoyama Mary Twigger Simon Yura Kei Kimura Kouichi Yasuda Tomohiro Nishikawa Tetsuo Akiyama Yutaka Motono Chie Mukai Yuri Shionyu Masafumi Nagasaki Hideki Suwa Makiko Horton Paul Kikuno Reiko Ohara Osamu Lancet Doron Eveno Eric Graudens Esther Imbeaud Sandrine Debily Marie Anne Jia Libin Hayashizaki Yoshihide Amid Clara Han Michael Osanger Andreas Endo Toshinori Thomas Michael A. Hirakawa Mika Makalowski Wojciech Nakao Mitsuteru Kim Nam-Soon Thierry-Mieg Danielle Yoo Hyang-Sook De Souza Sandro J. Bonaldo Maria de Fatima Niimura Yoshihito Kuryshev Vladimir Schupp Ingo Wiemann Stefan Bellgard Matthew Thierry-Mieg Jean Wagner Lukas Zhang Qinghua Go Mitiko Minoshima Shinsei Ohtsubo Masafumi Hanada Kousuke Koyanagi Kanako O. Tonellato Peter Isogai Takao Zhang Ji Lenhard Boris Kim Sangsoo Chen Zhu Hinz Ursula Estreicher Anne Nakai Kenta Makalowska Izabela Barrero Roberto A. Hide Winston Tiffin Nicola Wilming Laurens Chakraborty Ranajit Soares Marcelo Bento Chiusano Maria Luisa Suzuki Yutaka Auffray Charles Yamaguchi-Kabata Yumi Itoh Takeshi Gough Craig Hishiki Teruyoshi Fukuchi Satoshi Nishikawa Ken Sugano Sumio Nomura Nobuo Tateno Yoshio Imanishi Tadashi Gojobori Takashi Chun Hong-Woo Habara Takuya Hanaoka Hideki Hayakawa Yosuke Hilton Philip B. Kaneko Yayoi Kanno Masako Kawahara Yoshihiro Kawamura Toshiyuki Matsuya Akihiro Nagata Naoki Nishikata Kensaku Ogura Noda Akiko Nurimoto Shin Saichi Naomi Sakai Hiroaki Sanbonmatsu Ryoko Shiba Rie Suzuki Mami Takabayashi Kazuhiko Takahashi Aiko Tamura Takuro Tanaka Masayuki Tanaka Susumu Todokoro Fusano Yamaguchi Kaori Yamamoto Naoyuki Okido Toshihisa Mashima Jun Hashizume Aki Jin Lihua Lee Kyung-Bum Lin Yi-Chueh Nozaki Asami Sakai Katsunaga Tada Masahito Miyazaki Satoru Makino Takashi Ohyanagi Hajime Osato Naoki Tanaka Nobuhiko Suzuki Yoshiyuki Ikeo Kazuho Saitou Naruya Sugawara Hideaki O'Donovan Claire Kulikova Tamara Whitfield Eleanor
出版者
Oxford University Press
雑誌
Nucleic Acids Research (ISSN:03051048)
巻号頁・発行日
vol.36, no.1, pp.D793-D799, 2008-01
被引用文献数
10

Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of full-length cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB_4.6. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 (98.1%) protein-coding and 642 (1.9%) non-protein-coding loci; 858 (2.5%) transcribed loci overlapped with predicted pseudogenes. For all these transcripts and genes, we provide comprehensive annotation including gene structures, gene functions, alternative splicing variants, functional non-protein-coding RNAs, functional domains, predicted sub cellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, orthologous genes, protein–protein interactions (PPI) and annotation for gene families. The current H-InvDB annotation resources consist of two main views: Transcript view and Locus view and eight sub-databases: the DiseaseInfo Viewer, H-ANGEL, the Clustering Viewer, G-integra, the TOPO Viewer, Evola, the PPI view and the Gene family/group.