著者

Masahiro Kawahara Keiko Konoha Tetusya Nagata Yutaka Sadakane

出版者

Japan Society for Biomedical Research on Trace Elements

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.18, no.3, pp.211-220, 2007-10-01 (Released:2008-04-04)

参考文献数

56

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Aluminum is the most abundant metal in the earth's crust. However, it is not essential for life. Owing to its specific chemical properties, aluminum inhibits more than 200 biologically important functions and causes various adverse effects. It is suggested that the exposure to aluminum has a relationship with neurodegenerative diseases including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease. However, these relationships still remain elusive. Furthermore, the complexity of bioavailability has difficulty in evaluation of aluminum toxicity. In this paper, we review the detailed characteristics of aluminum neurotoxicity and bioavailability based on the recent literatures, and discuss its biological fate and effects to human health. Considering its long half-life in the body, unnecessary exposure to aluminum should be avoided for human health.

著者

西邑 泰広 松倉 武文

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.11, no.4, pp.347-348, 2000-12-31

参考文献数

1

著者

篠原 厚子 千葉 百子 中埜 拓 稲葉 裕

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.15, no.1, pp.49-53, 2004 (Released:2005-04-08)

参考文献数

5

---

The concentrations of 48 kinds of major and trace elements in dry milk were determined by microwave-induced plasma mass spectrometry, atomic absorption spectrometry, or colorimetry. The order of the element concentrations in dry milk was K > Ca, P > Na > Mg >> Zn > Rb > Fe > Sr > Cu, Ba, Ni, Mo, Mn, As > Se, Co, Cr. Other elements determined were much lower or under detection limit. Element concentrations in fractions of milk (skim milk, butter milk, acidic casein, whey, whey protein concentrate (WPC), and milk mineral) were also determined. The concentrations of each element in these powdered samples were dependent on the fractions. Concentrations of Ca and Mg in skim milk, butter milk, whey and WPC were similar to those in dry milk, but those in acidic casein fraction were very low and those in milk mineral fraction were extremely high. The concentrations of P in milk mineral fraction were about twice of dry milk, and Na was almost the same, and K was lower than those in dry milk. The present study indicates that the milk mineral fraction is a good source of Ca and Mg.

著者

Munehiro Yoshida Ayumi Mukama Ryota Hosomi Kenji Fukunaga

出版者

Japan Society for Biomedical Research on Trace Elements

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.28, no.1, pp.28-34, 2017-05-22 (Released:2017-06-01)

参考文献数

22

---

Although high dietary iodine intake due to consumption of edible kelp (kombu) is observed, there are few health problems associated with iodine in Japan. Since several kinds of isoflavones contained in soybeans act as goitrogens, the consumption of soybean may modify the adverse effects of excess iodine derived from kombu. In the present study, to clarify the effects of eating soybean meal on thyroid function and tissue distribution of iodine, we measured iodine content of serum and several organs in rats fed casein diet or soybean meal diet with or without kombu powder. Four types of experimental diet (casein diet, casein diet with 5% kombu, soybean meal diet, soybean meal diet with 5% kombu) were prepared using dried kombu powder (Saccharina diabolica; iodine content, 7.18 mg/g). Twenty-four male 4-week-old Wistar rats were divided into four groups and fed these four diets for four weeks each. No significant differences were observed in animal growth, thyroid weights, serum total thyroxine, triiodothyronine and thyroid stimulating hormone concentrations among the four groups. Irrespective of dietary protein (casein or soybean), the iodine content in thyroid gland of all four groups was significantly increased to a similar level by the administration of kombu. Iodine concentrations in serum, liver and kidney were also increased by the kombu, but the increases of iodine in these tissues were significantly lower in rats fed soybean than in those fed casein indicating that soybean meal reduced the content of iodine in serum, liver and kidney. These results suggest that the consumption of soybean products could prevent the manifestation of adverse effects due to an excess iodine intake from kombu.

著者

松田 晃彦 武田 隆久 木村 美恵子

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.19, no.4, pp.297-307, 2008-12-31 (Released:2009-07-01)

参考文献数

32

被引用文献数

1

---

Selenium (Se) is an essential trace element and component of glutathione peroxidase known to be involved in the reduction of free radicals. Reduction of body Se is easily induced by the external Se-deficient environment, but the symptoms of Se deficiency such as cardiomyopathy, weakness of muscle strength, muscle pain, anemia, and white nail are rarely seen in human. In this review paper, we describe that the appearance of functional disorders following Se deficiency in rats is not easily appeared, and that Se deficiency in rats reduces toxic threshold of anticancer drug “adriamycin”. And also, we consider the significance of prevention of Se deficiency based on the results of these animal studies.

著者

Manfred Anke Mario Müller Christine Hoppe

出版者

Japan Society for Biomedical Research on Trace Elements

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.3, pp.183-187, 2005 (Released:2006-04-20)

参考文献数

22

---

Nine generations of goats receiving 2.5 to 6.5 mg Al/kg feed dry matter (DM) developed significantly increased mortality, impaired success of first insemination, an increased rate of abortions and, in the fourth generation, a distinct weakness of the hindlegs. Aluminum-poor nutrition led to significant variations of Al contents of aorta, spleen and bones. This effect of aluminum-poor nutrition was also evident in chickens. The normative requirement of animals is < 10 mg Al/kg diet DM. A potential daily normative aluminum requirement - if it should exist - is < 2000 μg, on the average of a week. The aluminum requirement of animals and man is satisfied by the natural aluminum offer.

著者

柳澤 裕之 山内 博

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.20, no.1, pp.1-2, 2009-04-01 (Released:2009-07-01)

著者

圓谷 奈保美 本間 謙吾 西頭 英起 一條 秀憲

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.23, no.1, pp.14-23, 2012 (Released:2013-09-09)

参考文献数

79

---

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the selective loss of upper and lower motoneurons. Approximately 10% of all ALS cases are genetically inherited, and a mutation in the Cu, Zn superoxide dismutase (SOD1) gene is thought to be a cause of motoneuron dysfunction. Importantly, the motoneuron toxicity appears to result from a toxic gain-of-function mutation in SOD1 and not from the loss of superoxide dismutase activity. Transgenic mice overexpressing several types of SOD1 mutant show the ALS-like phenotype and are widely accepted as animal models of ALS. However, no common toxic mechanism has been identified among these SOD1 mutants. Studies using autopsies of ALS patients or model mouse have suggested multiple causes of ALS including oxidative stress, mitochondrial dysfunction, excitotoxicity, neurofilaments abnormality and protein aggregation. Endoplasmic reticulum (ER) stress mediated motoneuron death is also suggested to be included in the pathogenesis of ALS. ALS-related mutant SOD1 evokes ER stress through the specific interaction with Derlin-1, a component of ER associated degradation (ERAD) machinery, leading to the subsequent motoneuron death. Zinc plays an important role in the function of nervous system and its dyshomeostasis is also thought to be one of the causes of ALS. In fact, zinc accumulation is observed in the brains and the spinal cords of mutant SOD1 transgenic mice. Moreover, zinc chelation extends the life span of these mise. There seems to be relationships between zinc dysregulation and several pathogenic processes of ALS. In this review, we will focus on the pathological role of ER stress and zinc in ALS.

著者

渋市 郁雄 安江 正明 加藤 克彦 渡邉 泰雄

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.17, no.1, pp.11-16, 2006 (Released:2006-09-13)

参考文献数

24

被引用文献数

1

---

This paper argues the possible effects of natural vanadium-containing Mt. Fuji ground water on the hyperglycemia based on our previously reported animal and clinical studies. In the animal studies, we documented that the activities of liver insulin receptors, particularly β subunit, and primary insulin-like growth factor-1 β were recovered to the normal levels by the daily forced oral treatment with Mt. Fuji ground water containing natural vanadium in Goto-Kakisaki (GK) rat which is the genetic model of Type II diabetes. Furthermore the increased levels of blood glucose and serum hemoglobin A1C (HbA1C) of GK rats were significantly blocked by the consecutive treatment of natural vanadium water. It is interesting that the other genetic model of Type II diabetes, KKAy mice, were likely to be shown the inhibitory effects of the consecutive treatment of natural vanadium water on increases of blood glucose but not significant. In these animals, however, the significant improvements of Glut 4 transporter and receptor activities in the adipose and muscle were detected. In the clinical studies, the levels of blood glucose and serum HbA1C of hyperglycemic patients were significantly reduced by three month consecutive treatment of this Mt. Fuji ground water, and also the QOL of these patients were completely improved, although these effects were clearly affected by the changes in each life style. Thus both animal and human studies suggest that the daily treatment with Mt. Fuji ground water containing natural vanadium is useful for the regulation of blood glucose levels and the improvement of QOL to the hyperglycemia patients due to the improvements of glucose transporter and the insulin receptor and so on. However it might be little difficult to expect the significant improvement of the severe conditions of diabetes mellitus by the consecutive treatment of natural vanadium water, since this ground water is good as a supplement.

著者

川原 正博

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.12, no.3, pp.207-216, 2001-09-30

参考文献数

65

被引用文献数

6

著者

水野 佑紀 藤森 英治 吉永 淳

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.28, no.4, pp.154-161, 2018-02-28 (Released:2018-04-10)

参考文献数

9

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Urinary cadmium (Cd) concentration has been used as a biomarker of long-term exposure to this metal in the previous researches. ICP mass spectrometry (ICP-MS) has become a method of choice for measuring urinary Cd concentrations, however, spectral interference from molybdenum oxide (MoO) has to be removed/corrected for accurate analysis. This study evaluated (1) MoO spectral interference in urinary Cd determination by ICP-MS, and (2) the performance of chelate-resin solid phase extraction (SPE) for removal of the interference. Cadmium concentrations in human urine certified reference materials and human urine samples from a male subject were determined by ICP-MS with mathematical MoO interference correction and ICP-MS preceded by SPE, as well as those by electrothermal atomic absorption spectrometry (ETAAS). The sensitivity and accuracy of the determination of urinary Cd was generally satisfactory for all the 3 methods; however, ICP-MS without SPE was found to give a deviated Cd concentrations for urine samples with higher Mo/Cd ratio due to uncertainty in interference correction. It was concluded that ICP-MS with mathematical interference correction is suitable as a routine method for measuring urinary Cd concentrations, but ICP-MS with SPE can be a method of choice for urine with high Mo/Cd ratio and for highly sensitive and accurate urinary Cd analysis.

著者

深田 俊幸

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.1, pp.1-6, 2015-05-08 (Released:2015-05-28)

参考文献数

26

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Zinc is an essential trance element, and its homeostasis is controlled by zinc transporter family members. Various approaches have revealed the important roles of zinc homeostasis by zinc transporters in cellular functions, and manifested a role for zinc as a signaling factor: zinc signaling. This short review introduces the zinc biology and zinc signaling with their basic and historical backgrounds.

著者

野本 昭三 山内 一由 中林 徹雄

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.14, no.4, pp.335-337, 2003-12-30

参考文献数

4

被引用文献数

5

著者

植村 雅子 米田 誠治

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.26, no.4, pp.157-165, 2016-03-22 (Released:2016-04-14)

参考文献数

43

---

Platinum-based anticancer drugs, represented by cisplatin, play important roles in present cancer chemotherapy. Although three or five platinum-based drugs have been approved for clinical use worldwide or in Japan, many active researches are still ongoing to seek next generation platinum-based drugs with less side effect and higher efficacy. Tetrazolato-bridged dinuclear platinum(II) complexes (tetrazolato-bridged complex) are distinctively different from existing platinum-based drugs in cytotoxicity spectra, DNA interactions, and cellular uptake profiles, probably due to their unique structures. Tetrazolato-bridged complexes provide high in vivo antitumor activity toward pancreatic cancer which is difficult to cure. In this review, we introduce the recent drug development researches on platinum-based drugs and update the latest findings of tetrazolato-bridged complex.

著者

Manfred Anke Wolfram Dorn Mario Müller Mathias Seifert

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.3, pp.198-202, 2005 (Released:2006-04-20)

参考文献数

19

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Cadmium-poor nutrition (< 15 μg Cd/kg feed dry matter (DM)) did not affect feed intake and growth rate, while it affected reproduction performance. Intrauterinally cadmium-depleted kids were often phlegmatic, too lazy to eat and drink, and died of muscle weakness. With oral application of the control feed (300 μg Cd/kg DM), they slowly regained their mobility. Feeding them 65 μg Cd/kg feed DM prevented myasthenia. The normative cadmium requirement of goats (and animals in general) amounts to < 20 μg/kg diet DM. The daily requirement of humans might be < 3 μg.

著者

Hiroshi Yasuda Toshie Yonashiro Kazuya Yoshida Tomiko Ishii Toyoharu Tsutsui

出版者

日本微量元素学会

雑誌

Biomedical Research on Trace Elements (ISSN:0916717X)

巻号頁・発行日

vol.16, no.4, pp.285-292, 2005 (Released:2006-07-19)

参考文献数

35

被引用文献数

4

---

In order to investigate any role of minerals in autistic disorders, we measured 24 mineral contents in scalp hair samples of 360 autistic children and compared with those of healthy controls. In the male autistic group aged 4-9 years (N=200), the geometric means of many element levels, namely not only essential minerals such as cobalt, chromium, iodine, molybdenum and phosphorus, but also nickel, boron, cadmium and lead were significantly lower than those in the control group (p<0.001). In contrast, selenium level was significantly higher in the autistic group. On the mercury levels, no significant difference was observed between the two groups, though with a tendency of low concentration in the autistic group. Similar mineral imbalance profiles with a global mineral deficiency were observed in the other autistic groups aged 0-3 and 10-15 years (N=85 and 20) and also in the female autistic groups. In addition, high accumulation of a few elements such as iron, manganese, chromium, copper, sodium, aluminum, cadmium, lead, or mercury was observed in some autistic individuals. These findings indicate that autistic children are suffered from a global mineral deficiency in various trace elements, with some individuals being exposed to a marked accumulation of several elements. Autistic children may be classified to sub-groups, based on their mineral imbalance profile in hair.

著者

大村 実

出版者

日本微量元素学会

雑誌

Biomedical research on trace elements (ISSN:0916717X)

巻号頁・発行日

vol.13, no.3, pp.149-157, 2002-09-30