著者

長水 正也 岡本 有紀子 奥村 拓也 佐藤 由美子 森下 修行

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.3, pp.115-122, 2021-11-30 (Released:2021-12-14)

参考文献数

10

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Objective: The use of direct oral anticoagulants (DOACs) has increased because they have some advantages over warfarin, such as fewer interactions and no requirement for coagulation monitoring in principle. DOACs have dose adjustment requirement based on renal function and other complex criteria that differ depending on specific DOAC preparations and indications. At the Nagoya City East Medical Center, DOAC dose‒related decisions previously depended on the knowledge and discretion of individual pharmacists. However, a dose checking sheet for DOACs (the Checking Sheet) was prepared and used on our electronic medical record system since September 2016 to increase the reliability of prescription checking, eliminate improper prescriptions, and ensure electronic documentation of pharmaceutical inquiries. In this study, we compared percentages of proper prescriptions before and after the introduction of the Checking Sheet to assess the effectiveness of its use, which has not been reported previously.Method: The percentage of proper DOAC prescriptions was used as a measure to assess the effectiveness of the Checking Sheet. We investigated DOAC prescriptions from March 2017, when the Checking Sheet system had been established, and compared those with prescriptions from March 2016 (before the Checking Sheet was introduced). Prescriptions of rivaroxaban, apixaban, edoxaban, and dabigatran for nonvalvular atrial fibrillation or venous thromboembolism were included; prescriptions dispensed outside the hospital were excluded.Result: DOAC prescriptions before and after the Checking Sheet introduction were similar in number. The percentage of proper prescriptions increased significantly from 82.4 to 94.3%. Among specific DOAC preparations, the number of improper prescriptions decreased significantly for apixaban and showed a tendency to decrease for rivaroxaban.Conclusion: The increases in the number of proper DOAC prescriptions observed after introducing the Checking Sheet showed that the Checking Sheet helped ensure a certain level of prescription checking, suggesting its usefulness for promoting proper DOAC use.

著者

大津 史子 山田 安彦 岩澤 真紀子 後藤 伸之 武隈 洋 冨田 隆志

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.2, pp.N1-N9, 2021-08-31 (Released:2021-09-25)

著者

向原 里佳 岩本 卓也 奥田 真弘

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.20, no.3, pp.N1_2-N3, 2018

著者

酒井 隆全 大津 史子 後藤 伸之

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.13, no.4, pp.183-188, 2012 (Released:2012-03-15)

参考文献数

8

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Objective: The purposes of this study were to verify the actual state and to identify the problems associated with research activities by pharmacists.Methods: The abstracts presented at the 42nd and the 37th Japan Pharmaceutical Association (JPA) Congress of Pharmacy and Pharmaceutical Science were investigated.  They were categorized into six research types: “Outcome research”; “Intervention research”; “Observational study”; “Status report”; “Case report”; and “Other”.  They were then ranked according to evidence level, with “Outcome research” ranked the highest.  In addition, “Outcome research”, “Intervention research” and “Observational studies” were checked for whether they had structured abstracts, and form scores were awarded.Results: We found that only 0.8% of abstracts were “Outcome research”.  but the level was higher at the 42nd Congress than the 37th (p=0.03).  Structured abstracts were also more common at the 42nd Congress than at the 37th (p<0.01).  However, the form scores were not significantly different between the 42nd and 37th Congresses.Conclusions: Our findings suggest that pharmacist research activities are improving, but that there is still room for further development.  The referee system and the guidelines for research design are useful methods to encourage more activity.  The target of this study was community pharmacy, and further studies are necessary for hospital pharmacy.

著者

赤沢 学 今井 志乃ぶ

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.1, pp.N1-N4, 2015-05-30 (Released:2015-06-28)

参考文献数

2

著者

岡本 有紀子 中村 康夫 工藤 正治

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.2, pp.82-93, 2021-08-31 (Released:2021-09-25)

参考文献数

14

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Objective: The guidance on “what to do when patients missed a dose” is an important item of medication instructions; however, only a small number of prescription drugs contain it. The “Drug Guide for Patients” and “Kusuri-no-Shiori” are documents designed to facilitate medication instructions for patients, having a section on “what to do when patients missed a dose.” Specific descriptions under it differ among medication instruction documents for some drugs, including those containing the same active pharmaceutical ingredients; however, the actual status of such discrepancies has not been clarified. In this study, we conducted a fact-finding survey to clarify such discrepancies using two medication instruction documents for drugs containing the same active pharmaceutical ingredients.Methods: The medication instructions of “Drug Guides for Patients” and “Kusuri-no-Shiori” for 532 active pharmaceutical ingredients used in oral drugs were included in the survey. After reading the descriptions under the “what to do when patients missed a dose” section, we divided them into six groups and determined whether the descriptions for the same ingredient in the documents fell in the same group.Results: For 186 ingredients (35.0%), we identified discrepancies between the documents. Among these, the instructions for 61 ingredients (11.5%) contained contradicting descriptions, such as “take the missed dose as soon as you remember” in one document and “always let go of the missed dose” in another document.Conclusions: A substantial number of discrepancies in descriptions about “what to do when patients missed a dose” were found between the two documents, raising concerns of confusion in medication instructions when the documents used were different. Therefore, the descriptions should be improved to resolve the discrepancies among medication instruction documents. Moreover, it is important for pharmacists or other healthcare professionals to review the descriptions thoroughly before using the document to provide appropriate medication instructions without confusion.

著者

丸山 加名 近藤 悠希 山門 慎一郎 加治屋 忠一 山本 健 古川 綾 石塚 洋一 岩元 正義 山本 美智子 入江 徹美

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.2, pp.99-108, 2021-08-31 (Released:2021-09-25)

参考文献数

12

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Objectives: It is important for patients to make correct use of drug information (DI) to promote the proper use of medicines. Many patients use the Internet to find DI, but awareness about the websites of public institutions that provide DI is low. This study aimed to identify the actual use of the Internet for DI and associated problems to inform development of a comprehensive DI website for patients.Method: Patients with diabetes were set as a model case for patients who take medicines and need DI. A questionnaire survey was conducted among patients with diabetes who visited community pharmacies in Kagoshima City from March 2019 to October 2019. The survey covered Internet use, DI needs, methods of sourcing DI, and problems obtaining DI via the Internet.Results: There were 349 valid respondents (median age 64 years), of which 52.1% used the Internet at least once a week. Around half of the Internet users searched for DI on the Internet. More than half of these respondents chose a DI acquisition site because it “appeared at the top of search results” and was “easy to understand.” However, around half of these respondents felt that “there is too much information on the internet and I don’t know what is correct.”Conclusion: This study suggests that older patients with a long history of diabetes use the Internet to obtain DI. However, patients face various problems accessing DI via the Internet. It may be necessary to construct a comprehensive website that is easy to use and enhance public health literacy to support the proper use of medicines by patients.

著者

合田 幸広 袴塚 高志

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.11, no.4, pp.210-216, 2010-03-31 (Released:2010-08-10)

参考文献数

4

著者

柴田 壮一 伊藤 千裕 小室 治孝 増渕 幸二 宮下 博幸 薄井 健介 貝沼 潤 厚田 幸一郎

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.11, no.3, pp.173-179, 2010-02-28 (Released:2010-08-10)

参考文献数

7

被引用文献数

2

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Objective: In the Drug Informatics in Department of Pharmacy, Kitasato Institute Hospital (hereinafter “the hospital”), we have had question-and-answer sessions regarding doping agents (banned drugs) among doctors and other workers and prepared an Anti-doping Quick Reference List (hereinafter “the list”), facing an urgent need to provide precise information quickly.Methods: The list consists of drugs adopted by the hospital and over-the-counter drugs according to package inserts, interview forms, and other sources of information.Results: In the list, hospital and over-the-counter drugs are classified into three categories in terms of a doping test: (1) “Non-banned” (drugs that can be used), (2) “Banned” (drugs that cannot be used), and (3) “Suspected” (unclear drugs) with their half lives for elimination as an indicator of the disappearance time from the body and divided by medicinal effect.  In addition, we indicated any drug for which the Therapeutic Use Exemption (TUE) application (hereinafter, TUE application) is required before use.Conclusion: The list prepared in this investigation offers many benefits, including precise and quickly available information on banned and non-banned drugs, ease in suggesting alternatives, and avoidance of failure in TUE application.

著者

望月 眞弓

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.12, no.3, pp.105-107, 2011-02-28 (Released:2011-06-29)

著者

後藤 伸之 山田 成樹 藤森 研司

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.15, no.4, pp.165-168, 2014-02-28 (Released:2014-04-02)

参考文献数

5

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Objective: The purpose of this study was to clarify the importance of therapeutic drug monitoring (TDM) at acute care hospitals using Diagnosis Procedure Combination (DPC) data.Methods: We used DPC data from about 3,500,000 inpatients at about 950 acute care hospitals.  The investigation period was from July 2010 to December 2010.  Patients were divided into 2 groups: TDM intervention (n=22,012); and non-TDM intervention (n=26,400).  We compared the clinical indicators (length of hospital stay, payment based on performance and drug costs) and use of antimicrobials.Results: TDM intervention was carried out in 45.5% patients for whom an anti-MRSA agent was prescribed.  The duration of anti-MRSA agent administration was significantly longer in the TDM intervention group than in the non-TDM intervention group.  The total daily cost of anti-MRSA agents was significantly lower in the TDM intervention group than in the non-TDM intervention group.Conclusion: Our results suggest that TDM intervention is often performed for seriously ill patients who require continuous treatment.  TDM intervention may prevent adverse reactions as a result of adjusting the dosage of the anti-MRSA agent.

著者

荒牧 英治

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.20, no.1, pp.N5-N7, 2018 (Released:2018-06-16)

参考文献数

3

著者

森次 幸男 水野 裕久 柴 英幸 今野 浩一 岩崎 幸司

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.20, no.3, pp.156-172, 2018-11-30 (Released:2018-12-08)

参考文献数

5

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Objective:The purpose of this survey was to identify the roles,responsibilities and skills of medical science liaisons(MSLs) in Japan. In addition,we compared to the prior survey results in 2011,2013 and 2015.Method:We contacted 47 pharmaceutical companies with a questionnaire survey on MSLs which included 22 items and analyzed the anonymized results using a web response system.Results:The total number of MSLs increased compared to prior surveys(ranged from 0 to 110). Many companies need MSLs with medical professional qualifications and sophisticated medical expertise. The roles and responsibilities MSLs were expected to perform included managing thought leaders(TL)and/or key opinion leaders (KOL)and implementing medical strategies. On the other hand, issues reported included management of MSLs and cooperation with other stakeholders in the company,and a still low level of recognition of MSLs.Conclusion:The roles of MSL are diverse,and while their activities and status are becoming established they are not yet unified across companies. It is recommended that at the earliest opportunity the roles,responsibilities and key performance indicators(KPI)of MSLs are defined,and educational programs established so that they can act as effective liaisons with medical professionals.

著者

永田 健一郎 辻 敏和 村岡 香代子 米滿 紘子 久光 莉瑛 舞 彩華 橋本 昂介 月野木 祥子 渡邊 裕之 金谷 朗子 江頭 伸昭

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.22, no.2, pp.83-90, 2020-08-31 (Released:2020-09-18)

参考文献数

10

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Objective: In this study, we aimed to develop a new system that can centrally manage and share drug information, and also evaluated its usefulness.Methods: Using PHP v5.3.3 as the programming language and MySQL v5.1.73 as the database, we built a web application that constantly runs on the server. Various drug information was registered in this system, and its usage status was analyzed based on the access log.Results: The system was accessed 31,678 times during the survey period (October 1 to December 31, 2019). The information sought included: basic drug information (ordering category of drugs, dosage forms and strengths, drug price, etc.) (13,962 times, 44.1%),question and answer records (7,221 times, 22.8%), pharmaceutical documents (package inserts, interview forms, documents regarding compatibility of injections, etc.) (7,172 times, 22.6%), notifications regarding new and discontinued drugs (727 times, 2.3%), websites (676 times, 2.1%), PreAVOID reports (663 times, 2.1%), pharmaceutical safety information (525 times, 1.7%), information regarding off-label drug use (409 times, 1.3%), and bibliographic information and guidelines (323 times, 1.0%). Among the users (62 pharmacists), 59.7% accessed the system only via a personal computer (PC), 38.7% via a PC and smart device (smartphone or tablet),and 1.6% via only a smart device. The median number of accesses to this system was significantly higher in pharmacists in charge of wards (190 [9-1,435]) or drug information (3,750 [2,957-5,548]) than dispensing pharmacists (68.5 [3-193]) (p<0.001).Conclusion: This system allowed the central management and sharing of various drug information on the web, permitting access regardless of device type. Since this system was frequently used by pharmacists in charge of wards or drug information, this system was considered particularly useful in hospital pharmacist ward services and drug information services.

著者

秋山 滋男 土井 信幸 淺野 未代子 福澄 重泰 高橋 真吾 鈴木 勝俊 小川 憲治 宮本 悦子

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.22, no.2, pp.101-107, 2020-08-31 (Released:2020-09-18)

参考文献数

9

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Objectives: “Adverse Drug Reaction Relief System” (hereinafter called the Relief System) has been established to provide prompt relief to patients experiencing health damage caused by adverse drug reactions. Since 2018, the Relief System has required community pharmacies that acquire additional points as local support system to actively report adverse drug reactions. Here, we investigated the recognition and utilization of the relief system among community pharmacists.Method: A questionnaire survey was conducted among community pharmacists between August 1 and September 30, 2019.Results: The survey achieved a response rate of 58.1%. The recognition rates of the relief system and Pharmaceuticals and Medical Devices Agency (PMDA) as its application destination were 98.9 and 74.5%, respectively. Of the community pharmacists, 2.6% had experience in utilizing the relief system; and 8.8% did not want to recommend the utilization of the relief system for patients mainly because of the “low recognition of the system” and “the complicated and troublesome preparation of the necessary documents such as medical certificates.” The community pharmacists who acquire additional points as local support system, compared with those who do not, achieved significantly higher rates in two items, including that for preparation of the documented procedures pertaining to adverse drug reactions.Conclusion: Despite the high recognition of the relief system among community pharmacists, the percentage of pharmacists with experience in actually utilizing the relief system and applying to the PMDA was low. One reason that the use of the relief system was not widespread was the low recognition particularly of the destination and procedures of reports on adverse drug reactions. In the future, educational campaigns to improve pharmacists’ comprehension of the relief system will be needed. Moreover, pharmacists must play a central role in enhancing the recognition of the public relief system and promoting medical safety.

著者

細見 光一 朴 ピナウル 豕瀬 諒 藤本 麻依 高田 充隆

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.17, no.3, pp.125-132, 2015 (Released:2015-12-18)

参考文献数

39

被引用文献数

2

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Objective: To examine the association between atypical and typical antipsychotics and extrapyramidal symptoms (EPS), we analyzed the US Food and Drug Administration Adverse Event Reporting System (FAERS) and the Japanese Adverse Drug Event Report database (JADER) from the Pharmaceuticals and Medical Devices Agency (PMDA).Methods: A reporting odds ratio was calculated and used to detect spontaneous report signals, with detection defined as a lower limit >1 in a 95% confidence interval.  In addition, time to onset and age at onset of EPS were investigated.Results: Drug-reaction pairs were identified in both FAERS (n=29,017,485) and JADER (n=2,079,653).  In analyses of both databases, significant associations were found between atypical and typical antipsychotics and EPS.  Atypical antipsychotics cause EPS with a longer duration of therapy compared to typical ones.  EPS in patients treated with atypical antipsychotics was observed at a broad range of ages compared to the patients treated with typical ones.Conclusion: Atypical antipsychotics, like typical ones, may increase the risk of EPS.  Because of the longer latency of onset, it may be difficult to find EPS associated with atypical antipsychotics.  Therefore, the severe symptom may be developed in patients treated with atypical antipsychotics.  The attention should be paid to the EPS in patients of all ages treated with atypical antipsychotics.

著者

大荒 政志 増田 博也 久岡 清子 名徳 倫明

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.22, no.1, pp.17-23, 2020-05-29 (Released:2020-06-13)

参考文献数

10

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Objective: The number of pharmacists regularly working at geriatric health service facilities is limited, but many users of such facilities have multiple chronic conditions and receive continuous pharmacotherapy, simultaneously using numerous different types of oral drugs. We examined the outcomes of pharmacotherapeutic intervention provided by hospital pharmacists for geriatric health service facility users.Methods: We examinedthe outcomes of active pharmacotherapeutic intervention providedby hospital pharmacists for 154 facility users.Results: After the intervention, there were significant decreases in the mean number of types and price of drugs used, as they decreased from 7.38 to 6.17 and 368.3 to 309.2 yen/day, respectively. The number of prescription drugs changed was 300, and 206 of these changes were proposedby the pharmacists. The efficacy-basedcategories that these drugs belongedto widely ranged. The most frequent reasons for change were the “disappearance of symptoms”, “based on indications”, and “suspected adverse events”. Adverse events variedfrom mildto those that may leadto severe conditions.Conclusion: Pharmacotherapeutic interventions by pharmacists may optimize pharmacotherapy, reduce polypharmacy, and reduce the financial burden on geriatric health service facilities.

著者

Keiko Naganuma Mitsuhiro Someya Ryoo Taniguchi Fumio Nakajima

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.21, no.4, pp.159-171, 2020-02-28 (Released:2020-03-17)

参考文献数

21

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Objective: This study aims to clarify the current attitude status of community pharmacists toward pharmacies and the roles of family pharmacists.Methods: A questionnaire survey was administered to 196 community pharmacists involved in 52 community pharmacies.Results: Overall, 189 pharmacists responded to the survey. More than 80% of the pharmacists responded to “Pharmacists supervise all the medicines for patients, even if they were prescribed from various medical institutions, and check the acceptability of taking medicines together to prevent duplicate medications and drug interactions,” and 91.5% responded to “The pharmacy is close to medical institutions and convenient” as the reason for selecting a specific pharmacy. In terms of the reasons for patients to select a couple of pharmacies, 95.8% of the pharmacists responded to “The pharmacies are close to hospitals and clinics respectively, and convenient.”Relatively high percentages of the pharmacists responded to the following four roles of a family pharmacists: “A family pharmacist explains medicines to the patients in a way they can easily understand” (62.4%), “A family pharmacist provides consultations for medicines” (79.4%), “A family pharmacist exactly understands all the medicines the patients take” (62.4%), and “A family pharmacist checks duplicate medications and drug interactions prescribed in various medical institutions” (78.8%). However, only 15.3% of the pharmacists responded to “A family pharmacist shares information with prescribing doctors and medical institutions enough.”Conclusion: Although community pharmacists were conscious of several interpersonal activities, they believed that patients did not select a pharmacy on the basis of the qualities of the pharmacist but rather on the location of the pharmacy. Community pharmacists are facing challenges to become a true family pharmacist meeting the requirements of “Pharmacy Vision” and need to further improve their attitudes to play an important role in regional comprehensive healthcare with other medical professionals and institutions.

著者

藤田(濱邊) 和歌子 赤井 那実香 徳山 尚吾

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.11, no.3, pp.149-155, 2010-02-28 (Released:2010-08-10)

参考文献数

20

被引用文献数

2

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Objective: It is well known that opioids are the dominant medication for the palliative care of cancer pain.  Although the enhancement of palliative care has been shown as the social issue in Japan, our opioid consumption is 1/7-7/8 of its global average.  These actual conditions of “low consumption of opioid” may affect the enrichment of palliative care in Japan.  In this study, we performed attitude surveys on the current situation of opioid usage for the palliative care in Japan by questionnaire method intended for hospital pharmacists.  Design and Methods: The questionnaire was mailed to pharmacists in randomly selected 100 hospitals among the general clinics involved in palliative care (October 10-16, 2006).  The collection rate was 63% (63 person/100 hospitals).  Results: About 94% of respondents recognized that the palliative care is poor in Japan, of which about 78% considered that there are relationship between the amount of opioid usage and enrichment of palliative care.  Furthermore, the problem of medical staff was considered as the most important factor contributing to the current status of palliative care in Japan.  In addition, in the order, legal barrier (8%)>problems in regard to patients (7%)>problems in regard to medical agents are considered to affect the current status of palliative care in Japan.  Specifically, it is considered that some problems such as deficiency of education (57%), deficiency of number of specialized staff (21%), and lack of experience of opioid usage (10%) or viased view of opioid (5%) are included in the problems of medical staff in Japan.  Conclusions: As the specific issue to achieve advanced palliative care and to improve quality of life in cancer patients, the improvement of curriculum and the training of medical staff for clinical opioid usage in the palliative care seems to be the most important in Japan.  In addition, the improvement of information provision by pharmacists toward the medical staff may be important for the promotion of palliative care using opioid in the future in Japan.

著者

保坂 茂 山本 碧 斉藤 竜也 大島 新司 大嶋 繁 大島 公恵 久津間 信明 本間 精一 小林 大介

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.15, no.2, pp.64-70, 2013 (Released:2013-09-05)

参考文献数

14

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Objective: In this study, we evaluated distinctive types of physical predisposition in patients with common side effects.Method: We selected 500 and 1,200 individuals with and without a previous diagnosis of side effects, respectively, through web-based research.  Then, we conducted a decision tree analysis for investigating the status of 100 types of physical predisposition in these individuals.Results and Conclusion: The individuals who had suffered from hepatic disorder and answered “relevant” for “predisposition to swelling” (likelihood ratio of a positive result [LR+] 2.17; p=0.004) and “very relevant” for “predisposition to skin dryness” (LR+ 3.52; p<0.001) enhanced the probability of extracting individuals who developed side effects.  The individuals who had suffered from skin disorder and answered “relevant” for “predisposition to eczema and inflammation” and “not relevant” for “predisposition to higher temperature” had an LR+ of 2.22 (p<0.001).  The individuals with “predisposition to worsening of physical condition on a rainy or high-humidity day” are more likely to develop side effects with the use of antibiotics and NSAIDs, compared to those without this predisposition (antibiotics: LR+ 2.33; NSAIDs: LR+ 2.51).  The results of this study indicate that we can identify patients with a high risk of side effects through an interview on predisposition.