著者
今村 博臣 安東 友美 藤川 誠
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.53, no.1, pp.020-023, 2013 (Released:2013-01-29)
参考文献数
8

ATP is indispensable for all living organisms. Despite its importance, however, distribution and dynamics of ATP level inside living cells still remained unclear. We have developed FRET-based ATP biosensors, “ATeam” and “GO-ATeam”, which enabled us to visualize intracellular ATP level. Using these biosensors, we have successfully evaluated the effect of IF1 protein and Ca2+ on regulation of ATP level. Also, we found that replication of hepatitis C virus genome resulted in the declination of cytosolic ATP level of host cells and the formation of putative virus replication sites with high ATP levels.
著者
田崎 明 喜多 英治 大塚 仁也
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.15, no.3, pp.125-132, 1975-05-25 (Released:2009-05-25)
参考文献数
12
被引用文献数
2 3

In the last decade, SQUID "Superconducting Quantum Interference Device" has been developed in low temperature physics area. The SQUID is a device to which quantum effect in superconductivity is applied, and is used as a high sensitive magnetometer, low level current detector etc.. In this report, basic concepts and applications of this device are reviewed, and then our development on this device for biological measurements is presented. Possibilities of kinetic measurements of some reaction systems are also discussed.
著者
堀 沢子 西田 宏記
出版者
一般社団法人 日本生物物理学会
雑誌
生物物理 (ISSN:05824052)
巻号頁・発行日
vol.36, no.3, pp.139-143, 1996-05-25 (Released:2009-07-09)
参考文献数
19

The cell fate determination in ascidian embryos is mediated by various cell interactions. Two sensory pigment cell precursors constitute an equivalence group, in which the ocellus (eye) pathway is the dominant fate. It is suggested that the unique cell interaction, which is called lateral inhibition, is involved in determination events of these equivalent cells. It is likely that the mode of specification which utilizes the lateral inhibition within equivalent cells plays a fundamental role during early embryogenesis in both invertebrates and vertebrates.