著者
兒島 峰 Kojima Mine
出版者
神奈川大学人文学会
雑誌
人文研究 (ISSN:02877074)
巻号頁・発行日
no.178, pp.81-129, 2012

This paper analyzes how movies can showcase experiences during historical moments and evoke the consciousness of people throughfeature films such as "Even the Rain" (Icíar Bollaín, 2010), inspired by the "Water War" that broke out in Cochabamba, Bolivia in 2000. First, I elaborate on the film's story and indicate the different reception it received in Spain, where the film was made, and Bolivia,where it was shot. It was well received in Spain because it depicted the parallelism in history between the Conquest era and present day,and the resistance of a united people against oppression. In contrast,in Bolivia, it was received with a polemic because it was considered to be plagiarized from the Bolivian film "To Hear the Birds Singing"(Jorge Sanjinés, 1995)and accused of having a colonial view of the film.Second, to clarify the bases of such contrasting critiques, I attempt to examine the historical and social visions of both societies, one suzerain and the other colonized. Third, I explain the historical process, politicoeconomic background, and the impact of ochabamba's "Water War" on Bolivian and international societies, and clarify how this crucial historical subject is reconstructed and what message is conveyed through the film. Finally, I suggest how we can learn the history and facts through the films.
著者
檜山 英三 原田 隆範 兒島 正人
出版者
一般社団法人 日本質量分析学会
雑誌
Journal of the Mass Spectrometry Society of Japan (ISSN:13408097)
巻号頁・発行日
vol.68, no.2, pp.33-37, 2020-04-01 (Released:2020-04-15)
参考文献数
2

Circulating tumor cell (CTC) has improved the study of cancer disease as it represents a noninvasive biopsy that can be used as prognostic and prediction biomarkers as well as for future molecular diagnosis as an accurate selection of molecular targets and effective drugs. As tumor heterogeneity exists in neuroblastoma (NBL), we aimed to evaluate lipid-metabolomic molecular profile as well as genetic profiles at the single cell level of CTC for better understanding the heterogeneity and malignant grade of NBL. For attempt of CTC analysis in NBL patients, we have isolated single-CTCs and then performed direct trapping of a single cell within a nanospray tip followed by super-sonication after the addition of ionization solvent for metabolomics analysis. And we also performed genomic aberrations and expressions using next-generation sequencing after whole genome/transcriptome amplifications (WGA/WTA). In the NBL-CTCs, metabolomic analysis detected catechol amine metabolites, which are specific to NBL, and drugs included in the patient’s course of therapy in addition to vital molecules such as amino acids. In genomic analysis, the average amount of amplified DNA was 19.0 µg, and the percentage of reads mapped to any targeted region relative to all reads mapped to the reference was 66.5–98.9%. The concordance rates of CTC and tumor mutations were 49–80%. The genomic expression analysis in CTC showed the activation of cancer metastatic, neurogenic, stem cell signaling pathway genes. This “direct single-cell analysis method” seems to be useful for direct and wide range genomic and molecular marker detection in NBL-CTC, for evaluating heterogeneity of NBL tumor at diagnosis as well as during treatments. This method will be applicable for selection of effective drugs and evaluation of treatment efficacy in future.
著者
五月女 さき子 鳴瀬 智史 六反田 賢 澤田 俊輔 河岡 有美 兒島 由佳 柳本 惣市 梅田 正博
出版者
一般社団法人 日本老年歯科医学会
雑誌
老年歯科医学 (ISSN:09143866)
巻号頁・発行日
vol.34, no.1, pp.94-100, 2019-06-30 (Released:2019-07-24)
参考文献数
10

骨粗鬆症や悪性腫瘍の骨転移などに対してビスフォスフォネート製剤やデノスマブ製剤などの骨吸収抑制薬が広く使用されているが,薬剤関連顎骨壊死(MRONJ)を発症することがある。MRONJに対して最近では外科療法の有効性が報告されるようになった。今回80歳以上の高齢者に発生したMRONJに対する治療法と予後について後ろ向きに検討した。3施設で加療を行ったMRONJ180例(80歳以上66例,80歳未満114例)の背景因子や治療法の差,予後の差,および治癒率に影響する因子について,Fisherの正確検定,One-way ANOVA,Kaplan-Meier法,Log rank検定,Cox比例ハザードモデルにより解析を行った。80歳以上の高齢者では骨粗鬆症で長期間骨吸収抑制薬が投与されている患者が多かった。治療法は年齢にかかわらずほとんどの患者で外科療法が選択されており,年齢による治癒率の差はなかった。治癒率に関連する因子として,原疾患(骨粗鬆症/悪性腫瘍),治療法(外科療法/保存療法),術前CTにおける骨膜反応の有無の3変数が独立した因子となっていたが,年齢は治癒率とは関連性はみられなかった。これらのことから,MRONJは年齢よりも原疾患やCT所見を主眼において治療法を選択することが望ましく,また若年者と同程度の予後が期待できるものと思われた。
著者
望月 隆弘 衣笠 えり子 草野 英二 大和田 滋 久野 勉 兒島 憲一郎 小林 修三 佐藤 稔 島田 憲明 中尾 一志 中澤 了一 西村 英樹 野入 英世 重松 隆 友 雅司 佐中 孜 前田 貞亮
出版者
一般社団法人 日本透析医学会
雑誌
日本透析医学会雑誌 (ISSN:13403451)
巻号頁・発行日
vol.45, no.9, pp.853-862, 2012-09-28 (Released:2012-10-05)
参考文献数
23

【目的】ビタミンE固定化ポリスルフォン膜ダイアライザ(VPS-HA)が,血液透析患者の貧血や,貧血治療薬(ESA)の投与量に影響を与えるか否かを検討した.【方法】主要なエントリー基準は,機能分類IV型ポリスルフォン(PS)膜を3か月以上使用し,直近3か月はTSAT 20%以上で,ESA製剤の変更がなく,ヘモグロビン(Hb)値は10.0g/dL以上12.0g/dL未満を満たす患者とした.研究参加は48施設で,305症例がエントリーされた.エントリー患者を,VPS-HAに変更する群(151名)と,従来のIV型PS膜を継続する群(154名)の2群に分け(中央登録方式),研究開始時のHb値を維持(10.0≦Hb<11.0g/dLおよび11.0≦Hb<12.0g/dL)するESA投与量を主要評価項目とした.その評価指標としてエリスロポエチン抵抗性指数(erythropoietic resistance index:ERI)を用いた.【結果】研究は1年間実施された.目標Hb値10.0≦Hb<11.0g/dLの範囲では差はなかったが,目標Hb値11.0≦Hb<12.0g/dLの範囲で,VPS-HA群はIV型PS膜群に比して良好なESA反応性を示した.とくにVPS-HA群のDarbepoetin alfa(DA)投与例では,8か月以降で開始時と比較して統計的有意差をもってERIが減少していた.またIV型PS膜群のrHuEPO投与症例では,統計的に5,7,10か月で,開始時と比較してERIが増加していた.VPS-HAとIV型PS膜の群間比較では,11か月目でVPS-HA群のDA投与例でIV型PS膜群に比して,ERIが有意に減少していた.【結語】目標Hb値11.0≦Hb<12.0g/dLの範囲で,ビタミンE固定化膜は,IV型PS膜に比べてDA投与量が減少しており,ESA投与量軽減効果が期待できる(UMIN試験ID:UMIN000001285).
著者
兒島 洋一 岸元 努 辻川 茂男
出版者
Japan Society of Corrosion Engineering
雑誌
Zairyo-to-Kankyo (ISSN:09170480)
巻号頁・発行日
vol.45, no.5, pp.305-314, 1996-05-15 (Released:2009-11-25)
参考文献数
25
被引用文献数
1

The rate of uniform corrosion, the likelihood of pitting and crevice corrosion for aluminum, Al, in white wine were investigated in this paper. In commercial wines, the K2S2O5 is commonly added to induce free-SO2 which reduces the dissolved oxygen and acts as a fungicide in the wine. The spontaneous electrode potential of Al, ESP, in a deaerated wine containing less than 1ppm of free-SO2, at 25°C was measured to be about -600mV vs. SCE. Since the K2S2O5 is an oxidizing agent for the Al, the ESP was ennobled with the addition of K2S2O5 reaching -520mV with a concentration of 1000ppm K2S2O5. The uniform corrosion rate was measured to be 13μm/y at 25°C and this rate was found to depend on the temperature with an activation energy of 42kJ/mol. However, this rate was found to have no dependency on the electrode potential within the ESP range. The critical pitting potential, VC, PIT, measured in the wine containing 25ppm of Cl- was -370mV which was more noble than the ESP, and the pitting corrosion can not occur. The repassivation potential for the growing crevice corrosion, ER, CREV, was measured to be -530mV. It was also found that this potential does not depend on either the temperature or the concentration of K2S2O5. It was observed that the ESP became more noble than the ER, CREV with the addition of 800ppm K2S2O5 at 25°C. At a lower temperature, however, the ESP became more noble than the ER, CREV when a lesser amount of K2S2O5 were added. An effective method to decrease the rate of uniform corrosion is to reduce the holding temperature; however, to effectively prevent the crevice corrosion at these lower temperatures, the K2S2O5 concentration must be kept below 100ppm.

1 0 0 0 OA 鹿兒島市史

著者
鹿兒島市 編纂
出版者
鹿兒島市
巻号頁・発行日
1916
著者
兒島 峰
出版者
筑波大学
巻号頁・発行日
2011

筑波大学博士 (学術) 学位論文・平成23年11月30日授与 (乙第2566号)
著者
兒島
出版者
公益社団法人日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
no.155, pp.21-22, 1895-01-26