著者

小出 醇

出版者

公益社団法人日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.29, no.3, 1993-03-01

著者

Pou Kuan Leong Po Yee Chiu Kam Ming Ko

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.4, pp.464-472, 2012-04-01 (Released:2012-04-01)

参考文献数

39

被引用文献数

7 12

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We investigated whether two naturally-occurring prooxidants, namely, schisandrin B (Sch B) and curcumin, and a synthetic prooxidant, menadione, can invariably elicit cyto/hepatoprotective responses against oxidant-induced injury. Results showed that (−)Sch B (a potent enantiomer of Sch B, 15 μM), curcumin (7.5 μM) and menadione (2 μM) induced a similar extent of reactive oxygen species production in AML12 cells. The relative potencies of cytoprotection in vitro were in a descending order of curcumin>menadione>(−)Sch B, which were parallel to the extent of stimulation in cellular reduced glutathione level. We further examined their hepatoprotection in vivo. Pretreatment with Sch B (800 mg/kg) and curcumin (737 mg/kg), but not menadione (344 mg/kg), protected against CCl4 toxicity, with the degree of protection afforded by Sch B being much larger than that of curcumin. The attenuated hepatoprotection afforded by curcumin may be attributed to its low bioavailability in vivo. This postulation is supported by the findings that intraperitoneal injections of Sch B (400 mg/kg) and curcumin (368 mg/kg) and the long term, low dose treatment with Sch B (20 mg/kg/d×15) and curcumin (18 mg/kg/d×15) induced glutathione antioxidant response and hepatoprotection to similar extents in vivo. The inability of menadione to induce hepatoprotection may be related to its extensive intestinal metabolism and/or hepatotoxicity. Taken together, prooxidants can invariably induce the glutathione antioxidant response and confer cytoprotection in vitro. Whether or not the prooxidant can produce a similar response in vivo would depend on its bioavailability and potential toxic effect.

著者

中尾 万三

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.334, pp.1291-1297, 1909-12-26

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皀莢(サイカチ)Gleditschia japonica miqハ本邦ノ各地ニ自生スル喬木ニシテ决明科ニ屬シ其種子ハ古來洗滌料トシテ一般ニ用ヒラレ又民間藥トシテ風疾、梅毒、消渇等ニ應用セラル、著者ハ一キログラム」ノ原料ヲ處理シ之ヨリ一種ノ「サポニン」ヲ淡黄色無晶形ノ粉末トシテ分取セリ該サポニン」ハ一三五度附近ノ温度ニ於テ熔融シ遂ニ分解ス、鑛酸ヲ以テ之ヲ加水分解スルトキハ二七〇-二七五度ニ熔融スル「サポゲニン」ト一種ノ「ペントーゼ」ヲ得ヘシト謂フ

著者

Yu-Ming Chi Motoyuki Nakamura Toyokichi Yoshizawa Xi-Ying Zhao Wen-Mei Yan Fumio Hashimoto Junei Kinjo Toshihiro Nohara Shinobu Sakurada

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.28, no.10, pp.1989-1991, 2005 (Released:2005-10-01)

参考文献数

18

被引用文献数

14 24

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To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), β-funaltrexamine (β-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test. The antinociceptive effect of INCA was antagonized by nor-BNI (κ-receptor antagonist) and β-FNA (μ-receptor antagonist), while NTI (δ-receptor antagonist) did not influence its effect. Furthermore, the antinociceptive effect of INCA was blocked by theophylline (THEO), an adenosine-receptor antagonist. These results suggested that the antinociceptive effect arose from the activation of μ-, κ-receptors and adenosine-receptor.

著者

西崎 弘太郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.344, pp.709-716, 1910-10-26

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著者ハ嘗テ本誌ニ於テ酵素ノ作用ニ由リ生成スヘキ分解生成體ハ毎ニ反作用ヲ行フカ故ニ其相系ヨリ絶エス之レカ消失シ去ルコト精酒ノ釀造ニ就テ見ルカ如クナルニ當テハ酵素ノ作用ハ豫想以上ナリトノ説ヲ公ニシ且ツ「ヂアスターゼ」カ實際臨床的ニ有効ナリトセハ生成スヘキ糖分ノ膓壁ヨリ吸收サルヘキコト之レカ主因ナリトノ意見ヲ有シタリシカ更ニアブテルハルテン氏カ昨年十一月獨逸藥學會ニ於テナシタル講演ヲ引用シテ自説ノ根據ノ益々有力ナルヘキヲ論シ且ツ日本藥局方ニ規定セル其糖化力試驗法ハ寛ニ過クルノ結果適品タルノ程度ニ澱粉ヲ混和スルノ事實アルコトヲ説キ新ニ之レカ試驗法ヲ提案シテ強力ノモノ、ミヲ採用スヘキコトヲ説ケリ

著者

中島 恵美 横川 弘一 市村 藤雄 倉田 孝一 木戸 日出喜 山口 成良 山名 月中

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.2, pp.718-725, 1987-02-25

被引用文献数

4

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The disposition characteristics of biperiden were investigated in rats, rabbits, beagles, and humans, and a physiologically based pharmacokinetic model was established by using the hepatic intrinsic clearance of unbound drug concentration and the tissue-to-plasma unbound concentration ratios. Protein-binding parameters and blood-to-plasma concentration ratios were determined, and linear parameters were obtained in beagles and humans over a wide concentration range. The hepatic intrinsic clearance of humans was predicted from the animal data. The coincidence of each tissue-to-plasma Unbound concentration ratio between rats and rabbits was confirmed in the steady state, and the mean tissue-to-plasma unbound concentration ratios were used for the prediction of the plasma concentration-time courses of beagles and humans. The predicted lines fitted the observed plasma concentrations of beagles and a patient well after a single intravenous injection and repeated intramuscular administrations, respectively.

著者

Kyoko Hayashi Kazuto Narutaki Yasuo Nagaoka Toshimitsu Hayashi Shinichi Uesato

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.33, no.7, pp.1199-1205, 2010-07-01 (Released:2010-07-01)

参考文献数

23

被引用文献数

33 123

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Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir. Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.

著者

Kiichiro Teruya Yuki Myojin-Maekawa Fumio Shimamoto Hiromitsu Watanabe Noboru Nakamichi Koichiro Tokumaru Sennosuke Tokumaru Sanetaka Shirahata

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.3, pp.352-359, 2013-03-01 (Released:2013-03-01)

参考文献数

49

被引用文献数

3 10

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Gastrointestinal damage associated with radiation therapy is currently an inevitable outcome. The protective effect of Kefir was assessed for its usefulness against radiation-induced gastrointestinal damage. A Kefir supernatant was diluted by 2- or 10-fold and administered for 1 week prior to 8 Gray (Gy) X-ray irradiation at a dose rate of 2 Gy/min, with an additional 15 d of administration post-irradiation. The survival rate of control mice with normal drinking water dropped to 70% on days 4 through 9 post-irradiation. On the other hand, 100% of mice in the 10- and 2-fold-diluted Kefir groups survived up to day 9 post-irradiation (p<0.05 and p<0.01, respectively). Examinations for crypt regeneration against 8, 10 and 12 Gy irradiation at a dose rate of 4 Gy/min revealed that the crypt number was significantly increased in the mice administered both diluted Kefir solutions (p<0.01 for each). Histological and immunohistochemical examinations revealed that the diluted Kefir solutions protected the crypts from radiation, and promoted crypt regeneration. In addition, lyophilized Kefir powder was found to significantly recover the testis weights (p<0.05), but had no effects on the body and spleen weights, after 8 Gy irradiation. These findings suggest that Kefir could be a promising candidate as a radiation-protective agent.

著者

朝比奈 泰彦 吉富 英助

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

no.424, pp.489-499, 1917-06-26

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著者等はクソニンジンの揮發油中にチ子オール及一新ケトンC_<10>H_<10>Oを抽出し之をアルテミジアケトンと命名し又左旋樟腦を確定せり

著者

赤田 良信 河野 貞子 山岸 正治 棚瀬 弥一郎

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.100, no.2, pp.212-215, 1980-02-25

被引用文献数

1

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A rapid method for determining paeonol in Moutan Cortex ("Mudanpi"-root bark of Paeonia moutan) was established by high-speed liquid chromatography. Paeonol was separated in a 25 cm column of Zorbax CN, using a Shimadzu-Du Pont Model LC-2 liquid chromatograph, with 50% acetonitrile as the desorption solution. Separation was completed within 7 min. Paeonol in Moutan Cortex was extracted with methanol and the extract was injected directly into the column. Paeonol content was estimated from previously prepared calibration curves based on standard paeonol. At 275 nm, the precision of the determination was about ±1% and the detection limit was about 2 ng (S/N ratio, 3). It was concluded that this method is useful for the evaluation of Moutan Cortex.

著者

崎谷 陽子 赤田 良信 河野 貞子 宮内 芳子

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.27, no.5, pp.1125-1129, 1979-05-25

被引用文献数

9

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A method was established by which glycyrrhizin and glycyrrhetinic acid present in plasma can be extracted with methanol and then separated and determined quantitatively within 10 min by means of high-speed liquid chromatography. Using this method, glycyrrhizin and glycyrrhetinic acid added to the plasma were recovered to satisfactory extents. An in situ recirculating perfusion technique showed that G is absorbed in rat small intestine in an apparent first-order process. There was no detectable amount of glycyrrhetinic acid in the blood after bolus injection of glycyrrhizin into the portal vein, althouth glycyrrhetinic acid was present in a detectable amount in the blood after oral administration. Since it is water-soluble and has a high molecular weight, glycyrrhizin is probably absorbed in the small intestine in the form of glycyrrhetinic acid. With the decline of glycyrrhetinic acid in the blood, there was a rise in the blood level of a substance which exhibited the same chromatographic behavior as glycyrrhizin. This substance appears to be a glucuronic acid conjugate formed as a metabolite of glycyrrhetinic acid, although it is not clear whether it is a mono-or diglucuronic acid conjugate or a mixture of the two. Glycyrrhizin injected into the portal vein was eliminated from the blood only slowly.

著者

金内 美妃 郡 修徳 千本木 要 坂井 英夫 井関 健

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.125, no.2, pp.187-196, 2005-02-01

被引用文献数

3 6

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ケタミンは, 解離性麻酔作用を有する全身性麻酔薬であり, 呼吸抑制などの副作用が少ないことから手術時に繁用されている. 一方, このケタミンは麻酔量より低用量を投与すると, 神経因性疼痛に関与しているといわれるNMDA受容体の非競合的拮抗薬として作用することから, 鎮痛効果も併せ持つ薬剤である.そのため, 非ステロイド性抗炎症薬などに抵抗する難治性疼痛を持つ患者に対し, ケタミンは保険適応外使用ではあるが, 鎮痛薬として静注や筋注以外に経口投与でも用いられている.しかし日本においてケタミンの市販薬は注射液のみであるため, 患者がケタミンによる在宅治療を行う場合, 注射液を経口投与しなければならないが, この注射液は特有の苦味や刺激感を有するため, 患者が服用を拒否する場合もある. そこで臨床現場では, 注射液に単シロップや矯味剤などを添加した液剤やケタミン試薬から調製した錠剤を院内製剤として患者に投与している.

著者

Rampal Rajera Kalpana Nagpal Shailendra Kumar Singh Dina Nath Mishra

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.7, pp.945-953, 2011-07-01 (Released:2011-07-01)

参考文献数

85

被引用文献数

38 212

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During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes play an important role owing to their nonionic properties, in such drug delivery system. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant based multilamellar or unilamellar vesicles in which an aqueous solution of solute is entirely enclosed by a membrane resulting from the organization of surfactant macromolecules as bilayer. Niosomes are formed on hydration of non-ionic surfactant film which eventually hydrates imbibing or encapsulating the hydrating aqueous solution. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site. This paper deals with composition, characterization/evaluation, merits, demerits and applications of niosomes.

著者

浜田 辰夫

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.125, no.1, pp.1-16, 2005-01-01

参考文献数

71

被引用文献数

3

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筆者が学部学生で4年生の卒業実習として北海道大学医学部薬学科の薬品製造学講座に配属されたのは1959年で, 当時は故伴義雄先生が教授で北大薬学部の基礎作りや講座の運営のみならず, 国際学会などで, 世界を股に駆けてのご活躍でした. 幸か不幸か, われわれ新入者は自分で仕事を切り開くしかなく, 苦労の連続でした. しかし, その過程で実験の面白さを体験でき, 研究計画立案, 反応デザインなど化学をより正確にとらえ, 実行する訓練ができたと思います. 当時, 数学と物理が得意だった筆者は将来の計画をどうしようかと迷っていましたが, 物を作る喜び, 自分で計画を立て, 実行する楽しさに将来を決断したことを覚えております. 教育の効率から4年次の卒業研究を危ぶむ声も聞かれますが, 筆者の体験から言わせていただければ, できるだけ早く自分で研究を進める訓練をするほうが効率がいいと思いますので, ぜひ卒業研究は続けてほしいと思います.

著者

Dongliang Wang Maoxuan Liu Jichao Cao Yanna Cheng Chen Zhuo Hongyan Xu Shousheng Tian Yan Zhang Jian Zhang Fengshan Wang

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.12, pp.2128-2132, 2012-12-01 (Released:2012-12-01)

参考文献数

28

被引用文献数

9 48

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Colla corii asini (E’jiao), donkey-hide gelatin prepared by stewing and concentrating from Equus asinus L. donkey hide, is a traditional Chinese medicine preparation widely used in clinical hematic antanemic therapy in China. The aim of the present study was to investigate potential anti-aging effect of Colla corii asini and explore related mechanisms in D-galactose (gal) induced aging model mice. The mice were artificially induced aging by subcutaneously injection with D-gal at the dose of 100 mg/kg·d for 8 weeks. Colla corii asini was simultaneously treated to them once daily by intragastric gavage. Appetite, mental condition, body weight, and organ index were observed. Activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as levels of malondialdehyde (MDA) in serum, brain, and liver were determined by according assay kits. Western blotting analysis was used to detect p16 and p21 expression. Results indicated that Colla corii asini could improve appetite, mental condition, body weight, and organ condition of model mice, improve SOD, CAT, and GSH-Px activities, reduce MDA levels, and modulate age-related genes expression in D-gal induced mice. Therefore, Colla corii asini may have effect to suppress the aging process through enhancing antioxidant activity, scavenging free radicals, and modulating aging-related gene expression.

著者

阿部 俊克 大塚 勝弘 大熊 誠一

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.1, pp.78-81, 1981-01-25

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Rice bran lectin (RBL) agglutinated human erythrocytes regardless of their ABO and MN blood-group systems. The receptor activity of erythrocytes against RBL was completely abolished by treatment with pronase for two hours and partially abolished by treatment with trypsin or α-chymotrypsin for three hours. Sialoglycopeptides released from human erythrocytes by treatment with protease such as pronase, trypsin or α-chymotrypsin inhibited the hemagglutination by RBL. Removal of sialic acid residues of sialoglycopeptides diminished their inhibitory activities. Among sugars tested, only N-acetyl-D-glucosamine showed hemagglutinating inhibition.

著者

Cathérine Gebhard Barbara Elisabeth Stähli Stephanie Largiadèr Erik Walter Holy Alexander Akhmedov Giovanni Guido Camici Thomas Felix Lüscher Felix Christoph Tanner

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.36, no.6, pp.1032-1035, 2013-06-01 (Released:2013-06-01)

参考文献数

16

被引用文献数

4 6

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Caffeic acid phenethyl ester (CAPE) is a component of honeybee hives with various beneficial properties. Tissue factor (TF), the key trigger of thrombosis, is expressed in human endothelial cells. This study was designed to investigate whether CAPE modulates TF expression in human aortic endothelial cells (HAECs). Western blots and real-time polymerase chain reactions were performed. CAPE (10−7–10−5 m) inhibited tumor necrosis factor (TNF)-α induced endothelial TF protein expression by 2.1-fold at 10−5 m (p<0.0001). Similarly, TF surface activity was reduced (p<0.02). In contrast, TF mRNA expression, TF promoter activity, and mitogen-activated protein (MAP) kinase activation remained unaltered. In conclusion, CAPE inhibits TF protein expression and activity at the posttranscriptional level thereby exhibiting anti-thrombotic potential.

著者

伊勢 雄也 恩田 光子 三浦 義彦 島崎 真知子 川田 佳子 萩原 研 片山 志郎 菊池 有道 亀井 美和子 小林 宏司 白神 誠

出版者

公益社団法人日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.6, pp.1021-1025, 2007 (Released:2007-06-01)

参考文献数

9

被引用文献数

2 5

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The contents of pharmacist interventions, which were carried out by the ward pharmacists in their routine pharmacy service activities, were sorted and analyzed to evaluate the contributions of pharmacists. In the ward where pharmacists were stationed, there were a total of 196 cases of pharmacist intervention. The prescription was changed in 170 cases, giving a rate of prescription change of 86.7%. The breakdown of the pharmacist intervention was as follows: “efficacy/safety”, 106 cases, followed by “dosage regimen” (48 cases) and “compliance” (10 cases). Cost savings achieved during the investigation period were calculated to be 440,639 yen, and cost avoidance was valued at 1,941,847-3,883,695 yen using the Diagnosis Procedure Combination (DPC). The results of the present investigation showed that pharmacists contribute to through not only their pharmacy services, but also through the promotion of proper drug use and risk management, thereby contributing to hospital management through cost savings and avoidance.

著者

Jiang Liu Seikou Nakamura Yan Zhuang Masayuki Yoshikawa Ghazi Mohamed Eisa Hussein Kyohei Matsuo Hisashi Matsuda

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.61, no.6, pp.655-661, 2013-06-01 (Released:2013-06-01)

参考文献数

50

被引用文献数

7 22

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Six dihydroisocoumarin glycosides, florahydrosides I and II, thunberginol G 8-O-β-d-glucopyranoside, thunberginol C 8-O-β-d-glucopyranoside, 4-hydroxythunberginol G 3′-O-β-d-glucopyranoside, and thunberginol D 3′-O-β-d-glucopyranoside, have been isolated from the flowers of Hydrangea macrophylla Seringe var. thunbergii Makino (Saxifragaceae) together with 20 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, acylated quinic acid analog, neochlorogenic acid, was shown to substantially inhibit aldose reductase [IC50=5.6 µm]. In addition, the inhibitory effects on aldose reductase of several caffeoylquinic acid analogs were examined for structure–activity relationship study. As the results, 4,5-O-trans-p-dicaffeoyl-d-quinic acid was found to exhibit a potent inhibitory effect [IC50=0.29 µm].

著者

竹本 常松 石黒 敏弘

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.86, no.6, pp.530-533, 1966-06-25

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The terrestrial portion of Euphorbia watanabei MAKINO was found to contain, besides nonacosane (?), tetracosanol, a wax-like, m.p. 59〜60°, and β-sitosterol, five-membered ring triterpenes taraxerol acetate, lupeol acetate, alunusenone (?), taraxerone, luperone, and taraxasterol. It is interesting from botanical aspects that euphane series triterpenes, which would be anticipated from Euphorbia spp., were not obtained.