- 著者
- Marie Ito Kayoko Terada Zuisei Hayashi Shunji Suzuki
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.81, no.4, pp.289-291, 2014 (Released:2014-09-03)
- 参考文献数
- 6
- 被引用文献数
- 2
We examined differences in delivery modes between deliveries managed by female obstetricians and gynecologists (OB/GYNs) and those managed by male OB/GYNs at our hospital. The rate of vacuum extraction/forceps delivery was significantly lower when deliveries were managed by female OB/GYNs. Logistic regression analysis showed that the lower rate of vacuum extraction/forceps delivery was associated with a lower rate of diagnosis of nonreassuring fetal status during the second stage of labor by female OB/GYNs. The rate of cesarean delivery and obstetric outcomes did not differ with the gender of the managing OB/GYN. The increasing number of female OB/GYNs may help increase the rate of maternal satisfaction associated with the decreased rate of instrumental delivery.
- 著者
- Sakae Kumasaka Atsushi Takagi Kentaro Kuwabara Makoto Migita
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.80, no.6, pp.456-459, 2013 (Released:2014-01-10)
- 参考文献数
- 6
- 被引用文献数
- 1
A case of herpes simplex virus (HSV) encephalitis in a neonate after delivery from a woman whose genital HSV infection had been treated with acyclovir is reported. The main approach to prevent genital HSV infection in the neonate is interruption of transmission at the time of delivery. Guidelines for prophylactic therapy with acyclovir have been established, but the risk of neonatal infection remains. A fever began to develop in a male neonate delivered vaginally from a 35-year-old woman. Treatment with intravenous acyclovir was started on the basis of a diagnosis of HSV encephalitis, because polymerase chain reaction was positive for HSV in the cerebrospinal fluid. The mother had had a first genital HSV infection during the second trimester, but treatment with injected acyclovir had caused the blisters and erosion to resolve by the time of delivery. Important steps for preventing neonatal HSV infection are the appropriate treatment of mothers with a history of genital HSV infection, the assessment of delivery methods, and the appropriate treatment of neonates.
- 著者
- Kentaro Asayama Hiroshi Yamadera Takao Ito Hideaki Suzuki Yoshihisa Kudo Shunkichi Endo
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.70, no.4, pp.334-341, 2003 (Released:2003-08-29)
- 参考文献数
- 29
- 被引用文献数
- 73 173
Previously, we reported that morning bright light therapy improved sleep time and cognitive function in Alzheimer type of dementia. We conducted a double blind study to examine the effects of melatonin on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type of dementia. The subjects were 9 persons given a placebo (PLA), and 11 given melatonin (3 mg)(MLT). The mean age was 79.2±6.4 (17 females and 3 males). The drugs were given at 20: 30 each day for 4 weeks. We checked sleep time and activity by Actigraph through one week before and the 4th week after drug administration. Cognitive and non-cognitive functions were evaluated with the clinical dementia rating scale (CDR), and Mini Mental State Examination (MMSE), and the Alzheimer's Disease Assessment Scale (ADAS). We successfully recorded Actigraph data from 18 patients (PLA8, MLT10). The mean sleep time change ratio and SD of the administration of PLA in the night was-0.2±13.7%, and MLT was 33.2±37.6%. The mean activity counts and SD of the administration of PLA in the night was 29.8±77.0%; in MLT it was-44.9±21.9%. Melatonin significantly prolonged the sleep time (p=0.017) and decreased activity (p=0.014) in the night (21: 00∼6: 00) in the MLT group, although no significant difference in sleep time or activity in the daytime (6: 00∼21: 00) was recognized between the two groups. In comparison with ADAS cognition score changes, the mean change and SD in the PLA was 0.3±3.7; in MLT it was-4.3±3.6 points. In comparison with ADAS non-cognition score, the mean change and SD in the PLA group was-0.8±1.0, in the MLT group it was-4.1±2.2 points. There were also significant differences between the PLA and the MLT groups in the comparison with the score improvement of ADAS cognition (p=0.017) and non-cognition (p=0.002), otherwise there was no significant difference in improvement of MMSE between both groups.Melatonin administration had effect to improve sleep time and night activity, but no significant effect to improve daytime naps and activity. Although melatonin administration might has less strong effect on circadian rhythm than morning bright light therapy we previously reported, cognitive and non-cognitive functions were improved. Melatonin seemed to be useful for care of the Alzheimer type of dementia patients.
2 0 0 0 OA 柿胃石の2例
- 著者
- 木下 博
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学雑誌 (ISSN:00480444)
- 巻号頁・発行日
- vol.19, no.3, pp.452-456, 1952-03-15 (Released:2010-10-14)
- 参考文献数
- 22
2 0 0 0 OA 北海道アイヌの皮膚・毛髪並に虹彩色調
- 著者
- 原 正春
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学雑誌 (ISSN:00480444)
- 巻号頁・発行日
- vol.20, no.11, pp.925-930, 1953 (Released:2010-10-14)
- 参考文献数
- 14
2 0 0 0 OA “こり”に対する磁場の治療効果について
2 0 0 0 OA ケロイドの病態と治療
- 著者
- 土佐 眞美子 小川 令
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.16, no.1, pp.8-17, 2020-02-15 (Released:2020-03-11)
- 参考文献数
- 99
- 被引用文献数
- 1
Keloids are chronic inflammatory fibrous tumors that cause excessive production of such extracellular macromolecules as collagen, due to the overexpression of various growth factors and cytokines. The etiology of keloids is unknown. They cause pain and itching, which together with the red mass leads to physical and mental stress in patients. No definitive treatment for keloids has been established, although various treatment methods have been reported, and the current consensus is that the recurrence of keloids cannot be completely suppressed. Elucidation is awaited of the pathologic mechanism of keloid development and identification of signal transduction pathways that will help establish a molecular targeted therapy for keloids.
2 0 0 0 OA ロジスティック回帰
- 著者
- 中澤 秀夫
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.10, no.4, pp.186-191, 2014-10-15 (Released:2014-11-17)
- 参考文献数
- 13
- 被引用文献数
- 1 2
This paper explains logistic regression analysis, which is a commonly used technique in medical statistics. In particular, the basic ideas and methods of interval estimation and hypothesis testing with the software package SPSS are explained.
2 0 0 0 OA 動脈硬化と脂質異常症 ~脂質異常症治療薬の最新情報~
- 著者
- 寺本 民生
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.13, no.4, pp.199-204, 2017-10-15 (Released:2017-11-20)
- 参考文献数
- 9
2 0 0 0 OA 遺伝子医療の倫理的課題
- 著者
- 島田 隆
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.68, no.5, pp.430-434, 2001 (Released:2001-12-28)
2 0 0 0 OA 「医学を選んだ君に問う」を読んで
- 著者
- 水野 杏一
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.7, no.3, pp.109, 2011 (Released:2012-10-19)
2 0 0 0 OA 腹痛が持続した横川吸虫症の1例
- 著者
- 折本 瑞恵 早川 潤 藤野 修 福永 慶隆
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.69, no.1, pp.71-73, 2002 (Released:2002-03-01)
- 参考文献数
- 8
- 被引用文献数
- 2 2
2 0 0 0 OA 蛍光染料の食品衛生学的研究(その1)
2 0 0 0 OA 2.組織細胞化学シリーズ(若手研究者へのヒント) 最近の免疫組織化学賦活法(6)
- 著者
- 並松 茂樹 杉崎 祐一 土屋 眞一
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.6, no.4, pp.178-184, 2010 (Released:2010-11-09)
- 参考文献数
- 15
Current antigen retrieval techniques include the use of citrate buffer, Tris-HCl containing 5% urea, and EDTA solutions combined with heating in a microwave oven or autoclave. These methods must be adjusted for a given tissue or antigen. To improve the efficiency of antigen retrieval for immunohistochemical staining, we developed a new method using citraconic anhydride. We describe this new antigen retrieval method using 0.05% citraconic anhydride solution of pH 7.4 and heat. This antigen retrieval method produced satisfactory staining results for a wide variety of antigens.
2 0 0 0 OA インフルエンザによる死亡について
2 0 0 0 OA 妊婦スポーツの安全管理指針
- 著者
- 越野 立夫
- 出版者
- 日本医科大学医学会
- 雑誌
- Journal of Nippon Medical School (ISSN:13454676)
- 巻号頁・発行日
- vol.70, no.2, pp.124-128, 2003 (Released:2003-04-22)
- 参考文献数
- 23
- 被引用文献数
- 4 5
In recent years with ever-increasing numbers of pregnant women wanting to participate in sport activities, the question as to how safe maternal exercise is for mother and fetus has become more important. The effects of pregnancy on maternal cardio-respiratory system include increases in oxygen consumption, cardiac output, heart rate, stroke volume, and plasma volume. The increase in oxygen reserve seen in early pregnancy is reduced later, suggesting that maternal exercise may present a greater physiological stress in the third trimester. The aims of this article are 1) to comment on the evidence relating to the health risks and benefits of physical activity for pregnant women and their unborn fetuses and 2) to realize guidelines for management of maternal exercise. In the absence of either obstetric or medical complications, pregnant women can continue to exercise and derive related benefits. The type, intensity, frequency, and duration of the exercise seem to be important determinants of its beneficial effects. Evidence suggests that weight-bearing exercise produces a greater decrease in oxygen reserve than non weight-bearing exercise. Furthermore, to maintain a heart rate below 150 beats per minute during pregnancy, the intensity of weight-bearing exercise must be reduced. In addition, depending on the individual's needs and the physiologic changes associated with pregnancy, women may have to modify their specific exercise regimens. Although increases in the frequency of uterine contractions have been observed during physical activities, changes are often minimal. In response to moderate exercise, the increase in frequency of uterine contractions is gestation dependent and significant in the third but not in the second trimester. The physiological adaptations to exercise during pregnancy appear to protect the fetus from potential harm and, while an upper level of safe activity has not been established, the benefits of continuing to be active during pregnancy appear to outweigh any potential risks. All decisions about participation in physical activity during pregnancy should however be made by women in consultation with their medical advisers.
2 0 0 0 OA 高グリシン血症 (グリシン脳症) の病因と発症機構
- 著者
- 多田 啓也
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学雑誌 (ISSN:00480444)
- 巻号頁・発行日
- vol.60, no.6, pp.375-380, 1993-12-15 (Released:2010-03-01)
- 参考文献数
- 24
2 0 0 0 OA 記憶力低下とうつ病の予防に対する運動の効果を海馬の神経新生から考察する
- 著者
- 三上 俊夫
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学医学会雑誌 (ISSN:13498975)
- 巻号頁・発行日
- vol.8, no.2, pp.168-173, 2012 (Released:2012-05-30)
- 参考文献数
- 28
Regular exercise plays an important role in preventing metabolic diseases, the impairment of cognitive function, and the onset of depression. Regular exercise enhances adult neurogenesis in the dentate gyrus of the hippocampus, and the exercise-derived prevention of cognitive deficits and depression is closely related to adult hippocampal neurogenesis. Both blood-derived factors and brain-derived factors are thought to contribute to the exercise-induced enhancement of adult hippocampal neurogenesis. Blood-derived factors include insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF) . Exercise increases the transport of these substances from the blood to the brain and increases adult hippocampal neurogenesis. In contrast the exercise-induced enhancement of adult hippocampal neurogenesis can be blocked by inhibiting the binding of IGF-1 or VEGF to its receptor. On the other hand, brain-derived factors include brain-derived neurotrophic factor (BDNF) or Wnt3. In particular, BDNF plays a wide range of roles in neuronal development and survival, and the exercise-induced enhancement of hippocampal BDNF contributes to the increase in hippocampal neurogenesis. Aging and chronic stress impairs cognitive function, whereas regular exercise prevents age- or stress-induced impairment of cognitive function, the improvement of which is attributed to the action of IGF-1 or BDNF. In addition, the preventive effect of exercise on the onset of depression is also dependent on the improvement of hippocampal neurogenesis via BDNF or VEGF. These findings demonstrate that regular exercise helps maintain cognitive function and prevents depression in the elderly and the stressed; however, the mechanism of the exercise-induced improvement of cognition or depression remains unclear. Clarifying the mechanism via neuroscientific and molecular biological studies is needed to promote the usefulness of exercise for preventing cognitive deficits and depression.
- 著者
- 杉本 元祐
- 出版者
- 日本医科大学医学会
- 雑誌
- 日本医科大学雑誌 (ISSN:00480444)
- 巻号頁・発行日
- vol.28, no.6, pp.1342-1355, 1961
