出版者

写

巻号頁・発行日

vol.[26] 十二ノ下 隠売女之部,

出版者

写

巻号頁・発行日

vol.[25] 十二ノ中 御仕置之部 下(一座評儀者),

出版者

写

巻号頁・発行日

vol.[24] 十二ノ上 御仕置之部 下(一座評儀者),

著者

滝澤 みか

出版者

中世文学会

雑誌

中世文学 (ISSN:05782376)

巻号頁・発行日

vol.62, pp.94-103, 2017 (Released:2018-06-20)

出版者

写

巻号頁・発行日

vol.[23] 十一ノ下 御仕置之部 上,

出版者

写

巻号頁・発行日

vol.[22] 十一ノ中 御仕置之部 上,

著者

岸田 真 Shin KISHIDA

雑誌

桜美林論考. 人文研究 = The journal of J. F. Oberlin University. Studies in humanities (ISSN:21850690)

巻号頁・発行日

vol.4, pp.143-157, 2013-03-01

出版者

写

巻号頁・発行日

vol.[21] 十一ノ上 御仕置之部 上,

出版者

写

巻号頁・発行日

vol.[20] 九ノ下 書物之部,

出版者

写

巻号頁・発行日

vol.[19] 九ノ上 薬種之部,

出版者

写

巻号頁・発行日

vol.[17] 八ノ上 金銀銭両替之部,

出版者

写

巻号頁・発行日

vol.[15] 七ノ中 米穀之部,

著者

Takao YASUHARA Satoshi MURAI Nobuhiro MIKUNI Susumu MIYAMOTO Isao DATE

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.60, no.7, pp.337-350, 2020 (Released:2020-07-15)

参考文献数

14

被引用文献数

4 5

---

Cranial implants are commonly used throughout the world, yet the data on complications remain partly clarified. The aim of this study was to gather real data in 2018 on complications related to cranial implants in neurosurgery. The survey population consisted of 1103 institutes supplying neurosurgical treatment. The survey consisted of two-stage questionnaire. First the incidence of complications was investigated, then the secondary questionnaire was e-mailed to the respondents about the detailed of the complications. As the result, the annual incidence of complications related to cranial implants was 0.558% in Japan. Titanium plate and mesh were used predominantly in craniotomy and cranioplasty, respectively. The second survey collected data on 449 cases with complications (infection: 63%, implant exposure: 46%, multiple answer). Postoperative infection was associated with male sex, brain tumor, short interval between surgery and complication, usage of ceramics, hydroxyapatite, resin, and artificial dura, hyponutrition, multiple surgeries, dirty wound, and sinusitis as patient factors, and CSF leakage, ruptured sutures, and sinus maltreatment as surgery factors. Meanwhile, long hospital stay was associated with age, male sex, mRS 3–5 before complication, short interval between initial surgery and complication, large craniotomy, long operative time, usage of ceramics and artificial dura, multiple surgeries and dirty wound as patient factors, ruptured suture as a surgical factor, and bacterial infection, especially MRSA infection, as the complication and treatment consisting of removal as complication factors. In conclusion, this is the first Japanese national survey on complications related to cranial implants in neurosurgery. It is important to recall that complications may arise years after surgery and to be aware of the risk factors associated with complications.

出版者

写

巻号頁・発行日

vol.[14] 七ノ上 米穀之部,

著者

Azliza Mad Anuar Akira Minami Hiroshi Matsushita Kanako Ogino Kosei Fujita Hatsune Nakao Shota Kimura Vikineswary Sabaratnam Kaoru Umehara Yuuki Kurebayashi Tadanobu Takahashi Hiroaki Kanazawa Akihiko Wakatsuki Takashi Suzuki Hideyuki Takeuchi

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.10, pp.1438-1443, 2022-10-01 (Released:2022-10-01)

参考文献数

59

---

Estrogen deficiency during menopause causes a variety of neurological symptoms, including depression. The edible Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (HE), is a medicinal mushroom that has the potential for a neuroprotective effect and ameliorating neurological diseases, such as depression, anxiety, and neurodegenerative diseases. HE contains phytoestrogens, including daidzein and genistein. However, the ameliorating effect of HE on menopausal symptoms is not well understood. Here we investigated the impact of methanol extract of the HE fruiting body on depressive-like behavior in postmenopausal model rats. The activation of estrogen receptor alpha (ERα) causes body weight loss and uterine weight gain. Body weight gain and uterine weight loss by estrogen deficiency in ovariectomized (OVX) rats were reversed with 17β-estradiol (E2) but not with HE. Thus, the phytoestrogens in HE may hardly activate ERα. Estrogen receptor beta (ERβ) is expressed in the brain, and activation of ERβ ameliorates menopausal depressive symptoms. Notably, depressive-like behavior in OVX rats evaluated in forced swim test was reduced by administration of not only E2 but also HE for 92 d. Long-term activation of ERα increases the risk of breast and uterine cancers. HE, therefore, may be effective in treating menopausal depression without the risk of carcinogenesis caused by ERα activation.

出版者

日本鉄道技術協会

巻号頁・発行日

vol.30, no.3, 1987-03

出版者

写

巻号頁・発行日

vol.[13] 六ノ下 高札之部、日雇座之部、旅人宿之部、奉公人宿之部,

出版者

写

巻号頁・発行日

vol.[12] 六ノ上 御成之部、江戸川神田川之部,

著者

和田 弘名 ワダ コウメイ Koumei Wada

雑誌

帝塚山大学短期大学部紀要

巻号頁・発行日

vol.41, pp.74-81, 2004-02-02