著者
村田 雄二郎
出版者
アジア経済研究所
雑誌
アジア経済 (ISSN:00022942)
巻号頁・発行日
vol.38, no.3, pp.91-96, 1997-03
著者
生田 勝義
出版者
立命館大学法学会
雑誌
立命館法学
巻号頁・発行日
vol.337, pp.1201-1237, 2011
著者
Tokizane Sanae
巻号頁・発行日
1994

Thesis (Ph.D. in Literature)--University of Tsukuba, (B), no. 958, 1994.3.25

1 0 0 0 OA 須彌山儀考

著者
的場 健一郎
出版者
東亞天文協會
雑誌
天界 = The heavens
巻号頁・発行日
vol.15, no.174, pp.472-474, 1935-09-25
著者
Othman Mahmoud Ben Han Junkyu Omri Abdelfatteh El Ksouri Riadh Neffati Mohamed Isoda Hiroko
出版者
Hindawi Publishing Corporation
雑誌
Evidence-based complementary and alternative medicine (ISSN:1741427X)
巻号頁・発行日
vol.2013, pp.737401, 2013
被引用文献数
10

This study aimed to investigate the antistress properties of the ethanol extract of Cymbopogon schoenanthus (CSEE), growing wild in the southern part of Tunisia. The effect of extracts on H2O2-induced cytotoxicity and stress in human neuroblastoma SH-SY5Y cells. Its effect on stress-induced in ICR mice was exposed to force swim and tail suspension, in concordance with heat shock protein expression (HSP27 and HSP90), corticosterone, and catecholamine neurotransmitters level. Our results demonstrated that pretreatment of SH-SY5Y cells with CSEE at 1/2000, 1/1000, and 1/500 v/v dilutions significantly inversed H2O2-induced neurotoxicity. Moreover, CSEE treatments significantly reversed heat shock protein expression in heat-stressed HSP47-transformed cells (42°C, for 90 min) and mRNA expression of HSP27 and HSP90 in H2O2-treated SH-SY5Y. Daily oral administration of 100 mg/kg and 200 mg/kg CSEE was conducted to ICR mice for 2 weeks. It was resulted in a significant decrease of immobility time in forced swimming and tail suspension tests. The effect of CSEE on animal behavior was concordant with a significant regulation of blood serum corticosterone and cerebral cortex levels of catecholamine (dopamine, adrenaline, and noradrenaline). Therefore, this study was attempted to demonstrate the preventive potential of CSEE against stress disorders at in vitro and in vivo levels.
著者
Tamura Masato Matsui Hirofumi Kaneko Tsuyoshi Hyodo Ichinosuke
出版者
Society for Free Radical Research Japan
雑誌
Journal of clinical biochemistry and nutrition (ISSN:09120009)
巻号頁・発行日
vol.53, no.2, pp.75-80, 2013-08
被引用文献数
45 4

Alcohol/ethanol has been reported to derived necrosis and apoptosis with an oxidative stress in gastric mucosal cells. However the clear evidence for reactive oxygen species (ROS) generation by alcohol in gastric cells in vitro is none. In this study, we elucidated ethanol is an oxidative stress inducer on rat gastric epithelial cells by electron paramagnetic resonance measurement in living cells. We also confirmed whether ethanol-induced cellular ROS was derived from mitochondria or not. The results of cellular ROS determination showed that an increment of cellular ROS was shown for 15 min from exposing 1% (v/v) ethanol. Lipid peroxidation in cellular membrane also induced by 1% ethanol and the tendency is same in the results of cellular ROS determination. JC-1 stained showed the decrement of mitochondrial membrane potential. Additionally the localization of cellular ROS coincided with mitochondria. These results indicated that ethanol is not merely a necrotizing factor for gastric epithelial cells, but also an oxidative stress inducer via injured mitochondria.