著者
高橋 夏子 小林 正紀 板垣 史郎 平野 剛 武隈 洋 菅原 満 井関 健
出版者
日本薬学会
雑誌
Yakugaku Zasshi (ISSN:00316903)
巻号頁・発行日
vol.132, no.6, pp.777-783, 2012-06-01

The most effective drugs based on the type of cancer are chosen for chemotherapy. Tumor cells can be targeted at the DNA, RNA or protein level, and most of the classical anticancer drugs interact with tumor DNA in a time-dependent manner or a concentration-dependent manner. However, it has been unclear to date whether a combination therapy is carried out by using exact classification. Thus it is necessary to reclassify a great number of anticancer drugs. We propose a new classification system based on pharmacological effects of anticancer drugs. Classification of four anticancer drugs (cisplatin, carboplatin, paclitaxel and gemcitabine) was performed by the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The four anticancer drugs were grouped by IC50 values (inhibitory concentration, 50%) in a time-dependent manner and a concentration-dependent manner. The present approach may be combined to enhance the chemosensitivity, improve the dose of cytotoxic drugs and evaluate the effects of novel anticancer drugs.
著者
小山 顕 Ken Oyama
雑誌
聖和論集 (ISSN:21850232)
巻号頁・発行日
no.39, pp.15-21, 2011-12-22

1 0 0 0 OA 訃報

著者
國分 征
出版者
東京大学理学部
雑誌
東京大学理学部廣報
巻号頁・発行日
vol.23, no.1, pp.32-33, 1991-06
著者
尾谷 昌則
出版者
京都大学
巻号頁・発行日
2005-03-23

新制・課程博士
著者
山田 祐子
出版者
Waseda University
巻号頁・発行日
2004-01

制度:新 ; 文部省報告番号:乙1849号 ; 学位の種類:博士(人間科学) ; 授与年月日:2004/1/21 ; 早大学位記番号:新3689
著者
Sakamoto Hiroaki
出版者
Kyoto University
巻号頁・発行日
2012-05-23

新制・課程博士
著者
森 雅秀
出版者
東京大学東洋文化研究所
雑誌
東洋文化研究所紀要 (ISSN:05638089)
巻号頁・発行日
vol.142, pp.130-86, 2003-03

The vāstunāga, literally means “a serpent of site”, is the nāga drawn on the surface of the ground where a building is to be constructed. It was performed as a part of the traditional architectural ritual in India. In the period when Tantric Buddhism flourished, the vāstunāga ritual was applied to the procedure of mandala construction. For the mandala stands for the dwelling palace of the deities depicted in it, the Buddhists of this period followed the method of the architectural ritual for its construction. The following ritual compendiums of Tantric Buddhism explain the vāstunaga ritual: the Vajrāvalī by Abhāyakaragupta, the Ācāryakriyāsamuccaya by Jagaddarpana, and the Kriyāsamgrahapañjikā by Kuladatta. It is also mentioned in the ritual manuals written by Tathāgatavajra, Divākaracandra, Ratnaraksita, Prajñāraksita and Durjayacandra. The architectural texts of Hindu tradition, such as the Śilpaprakāśa, the Vastuvidyā also provide the information of this ritual. In addition, some manuscripts in which the vāstunaga is depicted are available in Nepal and Tibet. According to these information sources, I introduce the details of the vāstunaga ritual in this article. I, then, indicate the variety of this ritual found in them, especially the difference of the ritual purpose between Hindu architectural ritual and the mandala construction of Buddhism should be distinguished.