著者
越智 英輔 中里 浩一 石井 直方
出版者
明治学院大学
雑誌
若手研究(B)
巻号頁・発行日
2009

本研究では、スポーツ現場において頻発する肉離れ損傷のメカニズムを解明することを目的とした。ラットエキセントリック筋収縮装置を用いて様々な条件下で筋損傷を誘発した結果、骨格筋萎縮を伴う比較的重度の肉離れ損傷モデルを作成することができた。さらに、タンパク質・遺伝子発現を検討した結果、修復に伴いミオスタチン・タンパク質分解系シグナル発現が増加し、骨格筋萎縮・結合組織瘢痕化への関与が示唆された。
著者
石井 直方 中里 浩一 越智 英輔 禰屋 光男
出版者
東京大学
雑誌
基盤研究(B)
巻号頁・発行日
2009

筋肥大を引き起こさない低負荷強度での上腕筋群のレジスタンストレーニングを、筋血流制限下での大腿筋のレジスタンストレーニングと組み合わせると、上腕筋群にも筋肥大が生じる(筋肥大の「交叉転移」: Madarame et al., 2008)。本研究では、この交叉転移における循環因子の役割を調べるために、ヒトおよびラットトレーニングモデルを用いて実験を行った。ヒトを対象としたトレーニング実験から、この交叉転移は、一般的な高負荷強度トレーニングによっても起こることが分かった。さらに、運動前後の血清をプロテオーム解析によって比較し、量的に差異のある複数の成長因子を同定した。一方、高強度トレーニングを負荷したラットの血清を培養筋芽細胞に添加したところ、筋タンパク質合成に関与するシグナル伝達系の活性化が見られた。これらの結果は、何らかの成長因子が循環因子として筋肥大の交叉転移に関わっていることを示唆する。
著者
石井 直方 中里 浩一 佐々木 一茂 小笠原 理紀 田村 優樹 越智 英輔
出版者
東京大学
雑誌
基盤研究(A)
巻号頁・発行日
2019-04-01

加齢性筋減弱症 (サルコペニア)に伴う速筋線維特異的萎縮と線維数減少、結合組織増生などの質的変化の機序はいまだ不明である。本研究では、サルコペニア動物モデル、およびヒトを対象とし、筋線維タイプ、ミトコンドリア、筋サテライト細胞、運動神経、結合組織における質的変化とその要因に関する知見を得るとともに、それらに対するレジスタンス運動の効果を検証する。
著者
津山 薫 藤城 仁音 中嶋 耕平 中里 浩一 中嶋 寛之
出版者
The Japanese Society of Physical Fitness and Sports Medicine
雑誌
体力科学 (ISSN:0039906X)
巻号頁・発行日
vol.48, no.2, pp.251-263, 1999-04-01 (Released:2010-09-30)
参考文献数
19

A study was conducted to evaluate and compare neck muscle strength between two levels of college American football players with the aim of preventing neck injuries. The subjects were American football players at N University (n=52) belonging to the first level league and American football players at G University (n=14) belonging to the third level league. The findings were as follows.1. The neck muscle strength of freshman players at N University tended to be lower than that of senior players.2. It was shown that the neck muscle strength/body weight of experienced American football players was 10-30% higher than that of inexperienced players.3. There was a significant difference in neck muscle strength/body weight between N University and G University in 1997. However, there was no significant difference between them in 1998, because neck muscle strength/body weight of G University players increased by 13-30% after neck muscle training for about nine months. It was suggested that coaching staff must evaluate the neck muscle strength of each player, especially in freshmen who have had no experience of American football, in order to prevent neck injuries because mismatch of performance level may cause catastrophic neck injury.
著者
齋藤 義信 岩井 一師 中里 浩一 入江 一憲 水野 増彦 中嶋 寛之
出版者
日本体力医学会
雑誌
体力科學 (ISSN:0039906X)
巻号頁・発行日
vol.58, no.1, pp.99-108, 2009-02-01
被引用文献数
1 1

The purpose of this study was to clarify physical characteristics related to low back pain (LBP) in collegiate track and field athletes. We particularly focused on the nature of the track and field. The subjects were 21 male collegiate track and field athletes including only sprinters, hurdlers, long jumpers and triple jumpers. The examined parameters were physical characteristics, isokinetic flexor and extensor strength in the knee and trunk regions. The evaluation of LBP was estimated by a questionnaire test and orthopedic surgeons' diagnosis. According to these evaluations, we divided all track and field athletes into two groups ; LBP group (n=11, 52.4%) and no LBP group (n=10, 47.6%). As a result, a take-off leg of knee flexor/extensor strength ratio in the LBP group was significantly lower than that in the no LBP group (P<0.05). The LBP group showed a significant difference between a take-off leg and a lead leg in knee flexor strength compared with the no LBP group (P<0.05). The LBP group has been short engaged in the track and field than the no LBP group (P<0.05). In the trunk flexor and extensor strength, there was no significant difference between the LBP and the no LBP group in this study. These results suggest that the imbalanced knee muscle strength may be one of some factors related to chronic low back pain in collegiate track and field athletes.
著者
津山 薫 山本 洋祐 中里 浩一 中嶋 寛之
出版者
日本体力医学会
雑誌
体力科學 (ISSN:0039906X)
巻号頁・発行日
vol.54, no.3, pp.249-258, 2005-06-01
被引用文献数
3 2

The purpose of this study was to examine the effects of dynamic neck muscle training using a cervical extension machine (CEM) on isometric cervical extension strength (ICES) and a cross-sectional area of neck extensor muscles. Subjects were 18 male college judo athletes divided into a control group (n=10) and training group (n=8), respectively. In the training group, dynamic neck muscle training was performed for a 6 week training period, followed by a 10 week training period. There was a detraining period of 12 weeks between the first training period and the second. The ICES was measured at eight angles using a CEM, and the neck muscle cross-sectional area was determined using magnetic resonance imaging. The ICES and cross-sectional area of neck extensor muscles in the training group showed significant increases after the second training period. In particular, the increase in the cross-sectional area was greater in the deepest layer of the neck extensor muscles (rotator, multifidus and semispinaris cervicis muscles) than in the superficial layer (trapezius muscle). In the control group, no significant changes in ICES or cross-sectional area were observed. In conclusion, it was shown that dynamic neck muscle training using a CEM was effective in developing both ICES and the cross-sectional area of neck extensor muscles, especially in the deepest layer.