13 0 0 0 OA 疥癬診療ガイドライン(第3版追補)
10 0 0 0 OA 疥癬診療ガイドライン(第3版)
- 著者
- 日本皮膚科学会疥癬診療ガイドライン策定委員会 石井 則久 浅井 俊弥 朝比奈 昭彦 石河 晃 今村 英一 加藤 豊範 金澤 伸雄 久保田 由美子 黒須 一見 幸野 健 小茂田 昌代 関根 万里 田中 勝 谷口 裕子 常深 祐一郎 夏秋 優 廣田 孝司 牧上 久仁子 松田 知子 吉住 順子 四津 里英 和田 康夫
- 出版者
- 公益社団法人 日本皮膚科学会
- 雑誌
- 日本皮膚科学会雑誌 (ISSN:0021499X)
- 巻号頁・発行日
- vol.125, no.11, pp.2023-2048, 2015-10-20 (Released:2015-10-22)
- 参考文献数
- 185
Here, we present our new guideline for the diagnosis and treatment of scabies which we, the executive committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 has contributed to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. For making proper diagnosis of scabies, following three points should be taken into consideration: clinical findings, detection of the mite(s) (Sarcoptes scabiei var. hominis), and epidemiological findings. The diagnosis is confirmed when the mites or their eggs are identified by microscopy or by dermoscopy. As we now have a choice of phenothrin, the first line therapy for classical scabies is either topical phenothrin lotion or oral ivermectin. Second line for topical treatment is sulfur-containing ointments, crotamiton cream, or benzyl benzoate lotion. Gamma-BHC ointment is no more provided for clinical use. If the patient is immunosuppressed, the treatment option is still the same, but he or she should be followed up closely. If the symptoms persist, diagnosis and treatment must be reassessed. For hyperkeratotic (crusted) scabies and nail scabies, removal of thick scabs, cutting of nails, and occlusive dressing are required along with topical and/or oral treatments. It is important to apply topical anti-scabietic lotion/cream/ointment below the neck for classical scabies or to the whole body for hyperkeratotic scabies, including the hands, fingers and genitals. For children and elderlies, it is recommended to apply treatment to the whole body even in classical scabies. The dosage for ivermectin is a single oral administration of approximately 200 μg/kg body weight. It should be taken on an empty stomach with water. Administration of a second dose should be considered at one-week with new lesions and/or with detection of mites. Safety and effectiveness of combined treatment with topical and oral medications are not yet confirmed. Further assessment is needed. Taking preventative measures is as important as treating those infected. It is essential to educate patients and healthcare workers and conduct epidemiological studies to prevent further spread of the disease through effectively utilizing available resources including manpower, finance, logistics, and time. (Jpn J Dermatol 125: 2023-, 2015)
- 著者
- 大槻 マミ太郎 照井 正 小澤 明 森田 明理 佐野 栄紀 髙橋 英俊 小宮根 真弓 江藤 隆史 鳥居 秀嗣 朝比奈 昭彦 根本 治 中川 秀己
- 出版者
- 公益社団法人 日本皮膚科学会
- 雑誌
- 日本皮膚科学会雑誌 (ISSN:0021499X)
- 巻号頁・発行日
- vol.121, no.8, pp.1561-1572, 2011-07-20 (Released:2014-11-13)
Clinical use of TNFα (tumor necrosis factor α) inhibitors, adalimumab and infliximab, for psoriasis began in January 2010 when an additional indication for this disease was approved. In January 2011, an interleukin-12/23 p40 (IL-12/23 p40) inhibitor, ustekinumab, was newly approved as the third biologic agent with an indication for psoriasis. All of these biologic agents are expected to exhibit excellent efficacy against not only psoriasis but also psoriatic arthritis, and to contribute to the improvement of quality of life (QOL) of psoriatic patients. At the same time, however, they require safety measures to prevent adverse drug reactions such as serious infections. We therefore decided to prepare this Guideline/Safety Manual for the Use of Biologic Agents in Psoriasis (The 2011 Version) by revising that for the use of TNFα Inhibitors prepared by the Biologics Review Committee of the Japanese Dermatological Association in February 2010. In this new unified version for all three biologic agents including ustekinumab, requirements for clinical facilities for the use of biologic agents, contents of safety measures against reactivation of tuberculosis and hepatitis B, and recommendable combination therapies with biologic agents, have been renewed and added. This guideline/safety manual has been prepared to assist dermatology specialists experienced in clinical practice of psoriasis to use biologic agents safely and properly.
3 0 0 0 OA JAK キナーゼ
- 著者
- 朝比奈 昭彦
- 出版者
- 一般社団法人 日本アレルギー学会
- 雑誌
- アレルギー (ISSN:00214884)
- 巻号頁・発行日
- vol.67, no.2, pp.157-158, 2018 (Released:2018-03-16)
- 参考文献数
- 8
2 0 0 0 OA 乾癬における生物学的製剤の使用ガイダンス(2022年版)
1 0 0 0 OA 可変式ロングパルスダイレーザー(Vビーム®)の臨床的有用性
- 著者
- 服部 尚子 朝比奈 昭彦 渡辺 孝宏 白井 明 鑑 慎司 渡辺 玲 岸 晶子 大原 國章
- 出版者
- 特定非営利活動法人 日本レーザー医学会
- 雑誌
- 日本レーザー医学会誌 (ISSN:02886200)
- 巻号頁・発行日
- vol.27, no.4, pp.270-279, 2007-01-15 (Released:2008-01-15)
- 参考文献数
- 26
可変式ロングパルスダイレーザー(Vビーム®,595nm-long pulsed dye laser with adjustable pulse duration (ALPDL))は波長595nm,最大出力40 J/cm2のパルスダイレーザーであるが,パルス幅が可変(0.45ms~40ms)で,ダイナミック・クーリング・デバイス®とよばれるテトラフルオロエタンガス(-26.1℃)による皮膚冷却装置を付属していると言う特徴を有する.従来型の機種より波長の長いことから,より深くまでレーザー光が到達し,長いパルス幅,大きい出力により,より少ない副作用で,より大きな血管をターゲットとできる.ALPDLは5種類の円形のハンドピースと3x10mmの矩形のハンドピースを装着することができる.色素斑用ハンドピースは,患部の血管を障害することなく,老人性色素斑等の色素性病変を治療可能としている.ALPDLは,単純性血管腫,苺状血管腫,毛細血管拡張症,老人性色素斑,ウイルス性疣贅, 瘡,肥厚性瘢痕/ケロイド,乾癬,光老化等,様々な病変の治療に利用され,有効であるとの報告が示されている.ALPDLのこれらの疾患への治療可能性について報告する.