著者
Rei YAMASHITA Nagako HIKI Fumika KASHIWADA Hideshige TAKADA Kaoruko MIZUKAWA Britta Denise HARDESTY Lauren ROMAN David HYRENBACH Peter G. RYAN Ben J. DILLEY Juan Pablo MUÑOZ-PÉREZ Carlos A. VALLE Christopher K. PHAM João FRIAS Bungo NISHIZAWA Akinori TAKAHASHI Jean-Baptiste THIEBOT Alexis WILL Nobuo KOKUBUN Yuuki Y. WATANABE Takashi YAMAMOTO Kozue SHIOMI Ui SHIMABUKURO Yutaka WATANUKI
出版者
Japan Society for Environmental Chemistry
雑誌
Environmental Monitoring and Contaminants Research (ISSN:24357685)
巻号頁・発行日
vol.1, pp.97-112, 2021 (Released:2021-10-11)
参考文献数
90

Plastic pollution, and its associated impacts on marine fauna due to chemical contamination, is an area of growing global concern. We analyzed 145 preen gland oil samples from 32 seabird species belonging to 8 families with different foraging habits and life history strategies from around the world for plastic additives and legacy persistent organic pollutants. The additives included two brominated flame retardants (decabromodiphenyl ether, BDE209; decabromo diphenyl ethane, DBDPE) and six benzotriazole UV stabilizers (BUVSs; UVP, UV326, UV329, UV328, UV327, and UV234). Polychlorinated biphenyls (PCBs) and organochlorine pesticides (Dichlorodiphenyltrichloroethane and its metabolites: DDTs and hexachlorocyclohexane: HCHs) were detected ubiquitously. High concentrations of PCBs (up to 20,000 ng/g-lipid) were observed in the seabirds from higher-trophic level taxa. These patterns can be attributed to PCB exposure via their diet and associated biomagnification. DDT concentrations showed strong positive correlations with PCB concentrations, suggesting that DDTs in seabirds are also a result of diet and biomagnification. Plastic additives were detected sporadically as BDE209 and DBDPE were detected in 16 seabirds from 10 species (range: 3–379 ng/g-lipid) and BUVSs were detected in 46% (67) of the examined individuals (range: 2–7,055 ng/g-lipid). UV stabilizers were more frequently detected than flame retardants because UV stabilizers are more widely applied to plastic products. None of the plastic additives were correlated to the presence of PCBs, nor were they explained by the foraging area or trophic level. High concentrations of additives were detected in the species with high levels of plastic in their digestive tracts. In some of these species, such as Hawaiian petrels (Pterodroma sandwichensis) from Hawaii and flesh-footed shearwaters (Ardenna carneipes) from Western Australia, plastics were directly observed in the stomach. For other species, including great shearwaters (Ardenna gravis) from Gough Island, blue petrels (Halobaena caerulea) from Marion Island, and black-footed and Laysan albatrosses (Phoebastria nigripes and P. immutabilis) from Hawaii, plastic ingestion has been documented in literature. These patterns can be explained if the additives are mainly from ingested plastics rather than diet. The detection of BFRs and BUVSs demonstrated that a significant proportion of the examined seabirds accumulated chemicals from ingested plastics.
著者
Masahiro Ito Takashi Yamamoto Kenichi Takaku Nanako Tsutsui Mayumi Sasagawa Satoru Hirono Toshiya Suzuki Makoto Kodama
出版者
International Heart Journal Association
雑誌
International Heart Journal (ISSN:13492365)
巻号頁・発行日
vol.53, no.6, pp.394-395, 2012 (Released:2012-12-18)
参考文献数
8
被引用文献数
3 3

There have been only a few reports regarding the relation between snow shoveling and acute heart failure syndromes (AHFS). We present a case series of 5 patients who presented with AHFS, all within 5 days after shoveling snow. Although all patients underwent examination at a regular out-patient clinic, no patient had prior signs or symptoms of heart failure. The condition of all patients had gradually deteriorated, with no abrupt onset of dyspnea after shoveling snow. Four of the 5 patients demonstrated a preserved ejection fraction on echocardiography. Snow shoveling may lead to AHFS in patients who are at risk for developing heart failure.
著者
Kenji Nakatsuma Hiroki Shiomi Takeshi Morimoto Yutaka Furukawa Yoshihisa Nakagawa Kenji Ando Kazushige Kadota Takashi Yamamoto Satoru Suwa Minoru Horie Takeshi Kimura on behalf of the CREDO-Kyoto AMI investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-16-0204, (Released:2016-06-28)
参考文献数
24
被引用文献数
2 16

Background:Inter-facility transfer for primary percutaneous coronary intervention (PCI) from referring facilities to PCI centers causes a significant delay in treatment of ST-segment elevation acute myocardial infarction (STEMI) patients undergoing primary PCI. However, little is known about the clinical outcomes of STEMI patients undergoing inter-facility transfer in Japan.Methods and Results:In the CREDO-Kyoto acute myocardial infarction (AMI) registry that enrolled 5,429 consecutive AMI patients in 26 centers in Japan, the current study population consisted of 3,820 STEMI patients who underwent primary PCI within 24 h of symptom onset. We compared long-term clinical outcomes between inter-facility transfer patients and those directly admitted to PCI centers. The primary outcome measure was a composite of all-cause death or heart failure (HF) hospitalization. There were 1,725 (45.2%) inter-facility transfer patients, and 2,095 patients (54.8%) with direct admission to PCI centers. The cumulative 5-year incidence of death/HF hospitalization was significantly higher in the inter-facility transfer patients than in those with direct admission (26.9% vs. 22.2%; log-rank P<0.001). After adjusting for potential confounders, the risk for death/HF hospitalization was significantly higher (adjusted hazard ratio: 1.22, 95% confidence interval: 1.07–1.40, P<0.001) in the inter-facility transfer patients than in those directly admitted.Conclusions:Inter-facility transfer was associated with significantly worse long-term clinical outcomes for patients with STEMI undergoing primary PCI.
著者
Kenji Nakatsuma Hiroki Shiomi Takeshi Morimoto Kenji Ando Kazushige Kadota Hiroki Watanabe Tomohiko Taniguchi Takashi Yamamoto Yutaka Furukawa Yoshihisa Nakagawa Minoru Horie Takeshi Kimura on behalf of the CREDO-Kyoto AMI investigators
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-15-0870, (Released:2015-12-15)
参考文献数
19
被引用文献数
2 19

Background:In the setting of elective percutaneous coronary intervention (PCI), intravascular ultrasound (IVUS)-guided PCI is associated with a reduction in the incidence of target vessel revascularization (TVR), but the impact of IVUS on long-term clinical outcome in the setting of emergency PCI for ST-segment elevation acute myocardial infarction (STEMI) is still unclear.Methods and Results:The subjects consisted of 3,028 STEMI patients who underwent primary PCI within 24 h of symptom onset in the CREDO-Kyoto acute myocardial infarction registry. Of these, 932 patients (31%) underwent IVUS-guided PCI. Compared with the angiography-guided PCI without IVUS, IVUS-guided PCI was associated with significantly lower incidences of TVR (primary outcome measure; 22% vs. 27%, log-rank P<0.001) and definite stent thrombosis (ST; 1.2% vs. 3.1%, log-rank P=0.003). The cumulative incidence of all-cause death was not significantly different between the 2 groups. After adjusting for confounders, however, there were no significant differences between the 2 groups in risk for TVR (adjusted HR, 1.14; 95% CI: 0.86–1.51, P=0.38) and definite ST (adjusted HR, 0.58; 95% CI: 0.19–1.72, P=0.33).Conclusions:IVUS-guided PCI was not associated with a lower risk for TVR or ST in STEMI patients undergoing primary PCI.
著者
Masahiro Natsuaki Takeshi Morimoto Hiroki Shiomi Ko Yamamoto Kyohei Yamaji Hirotoshi Watanabe Takashi Uegaito Mitsuo Matsuda Toshihiro Tamura Ryoji Taniguchi Moriaki Inoko Hiroshi Mabuchi Teruki Takeda Takenori Domei Manabu Shirotani Natsuhiko Ehara Hiroshi Eizawa Katsuhisa Ishii Masaru Tanaka Tsukasa Inada Tomoya Onodera Ryuzo Nawada Eiji Shinoda Miho Yamada Takashi Yamamoto Hiroshi Sakai Mamoru Toyofuku Takashi Tamura Mamoru Takahashi Tomohisa Tada Hiroki Sakamoto Takeshi Tada Kazuhisa Kaneda Shinji Miki Takeshi Aoyama Satoru Suwa Yukihito Sato Kenji Ando Yutaka Furukawa Yoshihisa Nakagawa Kazushige Kadota Takeshi Kimura on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-Investigators
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
pp.CJ-21-0526, (Released:2021-09-16)
参考文献数
27

Background:Optimal intensity is unclear for P2Y12receptor blocker therapy after percutaneous coronary intervention (PCI) in real-world clinical practice.Methods and Results:From the CREDO-Kyoto Registry, the current study population consisted of 25,419 patients (Cohort-2: n=12,161 and Cohort-3: n=13,258) who underwent their first PCI. P2Y12receptor blocker therapies were reduced dose of ticlopidine (200 mg/day), and global dose of clopidogrel (75 mg/day) in 87.7% and 94.8% of patients in Cohort-2 and Cohort-3, respectively. Cumulative 3-year incidence of GUSTO moderate/severe bleeding was significantly higher in Cohort-3 than in Cohort-2 (12.1% and 9.0%, P<0.0001). After adjusting 17 demographic factors and 9 management factors potentially related to the bleeding events other than the type of P2Y12receptor blocker, the higher bleeding risk in Cohort-3 relative to Cohort-2 remained significant (hazard ratio (HR): 1.52 95% confidence interval (CI) 1.37–1.68, P<0.0001). Cohort-3 compared with Cohort-2 was not associated with lower adjusted risk for myocardial infarction/ischemic stroke (HR: 0.96, 95% CI: 0.87–1.06, P=0.44).Conclusions:In this historical comparative study, Cohort-3 compared with Cohort-2 was associated with excess bleeding risk, which might be at least partly explained by the difference in P2Y12receptor blockers.
著者
Noriko HAYASHI Tetsuo IIDA Takako YAMADA Kazuhiro OKUMA Isao TAKEHARA Takashi YAMAMOTO Koji YAMADA Masaaki TOKUDA
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
雑誌
Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
巻号頁・発行日
vol.74, no.3, pp.510-519, 2010-03-23 (Released:2010-03-23)
参考文献数
36
被引用文献数
100

This clinical study was conducted to investigate the safety and effect of D-psicose on postprandial blood glucose levels in adult men and women, including borderline diabetes patients. A randomized double-blind placebo-controlled crossover experiment of single ingestion was conducted on 26 subjects who consumed zero or 5 g of D-psicose in tea with a standard meal. The blood glucose levels at fasting and 30, 60, 90, and 120 min after the meal were compared. The blood glucose level was significantly lower 30 and 60 min after the meal with D-psicose (p<0.01, p<0.05), and a significant decrease was also shown in the area under the curve (p<0.01). The results suggest that D-psicose had an effect to suppress the postprandial blood glucose elevation mainly in borderline diabetes cases. A randomized double-blind placebo-controlled parallel-group experiment of long-term ingestion was conducted on 17 normal subjects who took 5 g of D-psicose or D-glucose with meals three times a day for 12 continuous weeks. Neither any abnormal effects nor clinical problems caused by the continuous ingestion of D-psicose were found.
著者
Hideo Matsumura Katsunori Kojima Shigeru Mio Takashi Yamamoto Akihisa Kodaira Hiroyasu Koizumi
出版者
Nihon University School of Dentistry
雑誌
Journal of Oral Science (ISSN:13434934)
巻号頁・発行日
pp.19-0005, (Released:2020-05-15)
参考文献数
16
被引用文献数
2

The purpose of the current study was to synthesize a methacrylate monomer with a thiohydantoin structure. In a flask, (2-thiohydantoin-4-yl) propionic acid, 10-hyroxydecyl methacrylate, 4-dimethylaminopyridine, and tetrahydrofuran (THF) were placed in a nitrogen atmosphere. A THF solution of N,N’-dicyclohexylcarbodiimide was added and stirred at room temperature. Ethyl acetate and n-hexane were then added to the reaction mixture. The reacted slurry was purified by chromatography with silica gel and hexane-ethyl acetate gradient elution solvent. The structure of the compound was assigned with proton nuclear magnetic resonance spectrum analysis, infrared spectroscopy, and high-resolution mass spectral analysis. The colorless viscous liquid obtained in yield of 49% was characterized as 10-methacryloyloxydecyl-(2-thiohydantoin-4-yl)propionate (MDTHP) or 10-((3-(5-oxo-2-thioxysoimidazolidin-4-yl)propanoyl)oxy)decyl methacrylate (2-THPDM). The MDTHP was soluble to acetone, isopropanol, and methyl methacrylate up to 2.6% or more. This compound could be potentially applicable as a functional monomer for bonding metals and alloys.
著者
Takashi Yamamoto Hiroyoshi Kohno Akira Mizutani Hanako Sato Hiroki Yamagishi Yutaka Fujii Miku Murakoshi Ken Yoda
出版者
The Ornithological Society of Japan
雑誌
ORNITHOLOGICAL SCIENCE (ISSN:13470558)
巻号頁・発行日
vol.16, no.1, pp.17-22, 2017 (Released:2017-03-01)
参考文献数
42
被引用文献数
6

There is increasing evidence showing that wind velocity affects the flight and foraging behavior of seabirds; however, few studies have examined these effects on seabirds inhabiting tropical oceans where lighter wind conditions usually prevail. The Brown Booby Sula leucogaster is an example of a tropical seabird with relatively low wing loading; strong wind conditions may be expected to impede the stability of their flight. We examined how different wind conditions affected the duration and flying behavior of Brown Booby fledglings during foraging trips by means of direct observation of nest attendance and by attaching video loggers to birds. The duration of foraging trips by fledglings decreased with increasing wind speed, and during flight, the body rotation of fledglings became greater with increasing wind speed. As expected, fledglings were buffeted by strong winds due to their relative inexperience in flight combined with their low wing loading. Fledglings were probably forced to flap against strong winds in order to adjust the stability of their bodies, offsetting the efficient use of wind for gliding. Furthermore, the height at which fledglings flew fluctuated more at higher wind velocities, which may have constrained their detection and capture of prey. In conclusion, our results indicate that the aerodynamic performance of Brown Booby fledglings is impaired by strong wind conditions, leading to poor flight stability and potentially reduced prey detection.