著者

大杉 順一 伊藤 直也 鈴木 朗 尾崎 行男 上床 正 渡部 真司 鷹津 文麿 石川 宏靖 長屋 昭夫

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.48, pp.255-256, 1985-04-10

著者

清水 政彦 平山 篤志 上松 正朗 松田 伸一 金銅 伸彦 足立 孝好 奥山 裕司 山元 博義 樋口 義治 水野 裕八 山口 修 柏瀬 一路 児玉 和久

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.63, no.3, 1999-10-20

著者

斎藤 雅彦

出版者

社団法人日本循環器学会

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.39, no.12, pp.1345-1355, 1976

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1.食用ガエル心房筋の摘出標本について,膜興奮から張力発生に至る過程への温度1の効果を2重隔絶膜電位固定法を用いて検討した.2.心房筋を高温(3℃)から(4℃)に冷却するとき,膜のわずかな脱分極,活動電位の振巾の増大とその持続時間の顕著な延一長にともない,静止張力の減少と,単収縮張力の著しい増大が出現し,加温すればいずれにおいても可逆的な復元が認められた.3.膜電位を静止電位レベルに維持し,数秒おきに1秒間の矩形波脱分極固定を行った場合にも,冷却により単収縮張力は増大し,静止張力は減少した.この所見は低温による単収縮張力の増強が活動電位の.単なる延長のみによるものでない事を示す.4.このさい,矩形波脱分極固定に対する終末電流ならびに容量性電流は減少し,また,活性内向き電流の経過は遅延し,外向き遅延電流は著しく抑制された.5.TTX(10<SUP>-7</SUP>g/ml)存在下でも低温により単収縮は増大し,静.上張力は減少した.また遅い内向き電流の増強ないし遅延電流の抑制も認められた.6.正常リンゲル液中の膜電位一電流特性から,冷却による遅い内向き電流の増強と,遅延電流の抑制は別個に出現する現象であることが推測された.また冷却により活動電位の振巾は増大し,内向き電流の逆転電位は上昇するが,さらに収縮の立上り速度の上昇,頂点時間の延長などの変化の所見から低一温ではI<SUB>Ca</SUB>による張力発生が主役を果すと考えられた.7.また矩形波脱分極と発生張力の関係から,冷却は膜電位一張力曲線を過分極側に移行せしめるとともに.収縮張力発生の閾値,張力飽和の飽和電位も過分極側へ移行することが認められた.8.以上の所見から,低温はおそらく膜結合のCaを増加し,これが膜抵抗, I<SUB>Ca</SUB>の増大をもたらし, I<SUB>Ca</SUB>の増大は単収縮張力を増強するという変力機構の存在に加えて,他方,膜抵枕の増大,外向きのI<SUB>K1</SUB>,I<SUB>X1</SUB>電流の抑制はいずれも活動電位の持続を延一長し,さらに収縮張力の増強をもたらすという2重の変力機構があることが結論された.

著者

HAKUO TAKAHASHI TOSHIHIDE YOSHIDA MASATO NISHIMURA TADASHI NAKANISHI MOTOHARU KONDO MANABU YOSHIMURA

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.56, no.9, pp.936-942, 1992-09-20 (Released:2008-04-14)

参考文献数

15

被引用文献数

17 18

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Regional vascular effects of some adrenergic agents, focussing on brown adipose tissue (BAT), were investigated using tracer microspheres with a reference sample method in the anesthetized rat. Intravenous injections of 0.5 mg/kg BRL-26830A, a β3-adrenergic agonist, increased heart rate, but changes in blood pressure and cardiac output were not significant. The drug decreased blood flow in the brain, the spleen and the kidneys, but markedly increased it in BAT. At 2 mg/kg, arotinolol, an α/β-adrenergic blocker, decreased blood pressure by 20 mmHg and increased cardiac output by 95 ml/min/kg. It slightly but significantly decreased blood flow in the liver and the spleen, but markedly increased the flow in BAT. Acebutolol, a β1-adrenergic blocker, decreased blood flow in the liver, the spleen, the pancreas, the kidneys, the adrenals, the skeletal muscle and the skin. Bunazosin, an α1-adrenergic blocker, decreased it in all organs and tissue expect the brain and BAT. The pattern of redistribution of blood flow by arotinolol was very similar to that caused by BRL-26830A. Acebutolol and bunazosin rather decreased the blood flow in the BAT. These results indicate that stimulation of β3-adrenergic receptors, in BAT results in vasodilation, and that arotinolol may bind to those β3-adrenergic receptors.

著者

寺西 純一 三神 大世 斉藤 尚孝 西原 馨子 山田 聡 小野塚 久夫 高辻 浩也 北畠 顕

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.61, 1997-03-05

著者

阿部 信一

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.35, no.8, pp.1035-1048, 1971 (Released:2008-04-14)

参考文献数

50

被引用文献数

4 2

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The aim of the present report is to investigate the pathogenesis of the shoulder-hand syndrome (SHS) coming after myocardial infarction and frequent anginal attacks. Methods The incidence, onset, sex difference, age and the site of infarction were observed as for the cases of myocardial infarction and coronary insufficiency accompanied by SHS, admitted to The 2nd Tokyo National Hospital during past 5 years. EMG were recorded in 14 myocardial infarction and 2 coronary insufficiency cases followed by SHS concerning the following muscles ; Mm. trapezius, deltoideus, biceps brach., triceps brach., brachioradialis, flexor carpi radialis, extensor digitorum communis, abductor digiti quinti, flexor pollicis brev., and extensor pollicis brev.. Moreover, complement fixation reaction (CFR) for the antigen of necrotic heart muscle and cervical cord died from myocardial infarction, electrophoresis and immuno-electrophoresis were attempted in 15 SHS cases. On the other had, to clarify the pathogenesis, animal experiments were performed. Myocardial infarction was artificially made by ligation of the branch of coronary arteries in 55 rabbits. ECG, EMG, evoked EMG, gel diffusion test (Ouchterlony's method) and CFR against the antigen of necrotic heart muscle and involved cervical cord were followed up in these rabbits before and every 2 weeks after the infarction. Then, they were exsanguinated from 4 to 8 weeks after the infarction and pathological studies and immunological studies with fluorescent antibody technique were attempted in these excised section preparation of ischemic heart muscle and cervical cord. Anti-rabbit γ-globulin goat serum conjugated with Fluorescein isothiocyanate was used in that technique and blocking test was simultaneously carried out with unlabelled anti-rabbit γ-globulin goat serum.

著者

YUKIO YAMORI MASAHIRO KIHARA JUN FUJIKAWA YASUNARI SOH YASUO NARA MICHIYA OHTAKA RYOICHI HORIE TOKUGORO TSUNEMATSU SHlNYA NOTE MASAICHI FUKASE

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.46, no.9, pp.933-938, 1982-09-20 (Released:2008-04-14)

参考文献数

20

被引用文献数

15 18

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In our attempt to design a method which would be more reliable than dietary survey interviews when estimating salt and protein intakes in a population survey, a urinalysis-related study was done on volunteers. Urinary sodium (Na), urea nitrogen (UN) and inorganic sulfate (SO4), all indices of dietary salt, protein and sulfoamino acids, respectively, were confirmed to reflect the nutritional condition. Interaction between salt and protein was not observed at least at the dietary levels used in the present study (for salt, 0.33 and 0.1 g/kg body weight/day; for protein, 1.6 and 0.7 g/kg body weight/day). Excretion of components was delayed several days or more after dietary ingestion, and nutritional estimation by urinalysis, therefore, may not be so much affected by daily variables in the diet intake. Further, partial urine samples proved to have a highly significant correlation with 24-hour (hr) urine, as for urinary Na, potassium (K), SO4, UN and their creatinine (Cr) ratios, thus indicating the availability of partial urine samples as substitutes for 24-hr urine specimens. Thus, urinalysis is a more readily facilitated, more scientific and more quantitative method for epidemiological nutritional surveys.

著者

Noriko Inoue Tomoko Ohkusa Tomoko Nitta Masahiko Harada Kazuya Murata Masunori Matsuzaki

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.65, no.11, pp.1001-1003, 2001 (Released:2001-10-25)

参考文献数

5

被引用文献数

1

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A 26-year-old man had a loss consciousness for a few minutes while smoking in the standing position, and was referred to hospital. No abnormalities were found in a computed tomography examination of his head, in a 24-h electrocardiogram or in an exercise tolerance test. The head-up tilt test (HUT) while tobacco smoking elicited a positive response in the tilted position, but the HUT without tobacco smoking was negative. The most noteworthy effect of tobacco smoking during the HUT was the high level of plasma epinephrine compared to the levels seen during supine smoking or the HUT alone. Syncope induced by tobacco smoking in the standing position is rare and the mechanism may be the same as that underlying neurally mediated syncope. (Jpn Circ J 2001; 65: 1001 - 1003)

著者

竹越 襄

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.32, no.9, pp.1331-1346, 1968-10-20 (Released:2008-04-14)

参考文献数

14

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In recent years the hemodynamics in hypertensive subjects have become a focus of interest to many cardiologists. However, the relation of acid-base equilibrium to the regulation of hemodynamics in hypertensives has not received much attention. Some investigators have studied about the hemodynamics in respiratory acidosis and alkalosis, but none in metabolic acid-base disturbances. This study therefore was carried out to elucidate the influences of metabolic acidosis and alkalosis on the hemodynamics in normotensive and hypertensive subjects. Materials and Methods Three hundred ml of 0.01 N hydrochloric acid solution was injected intravenously in 10 normotensive and 6 hypertensive subjects to induce metabolic acidosis and one hundred and fifty ml of 7 per cent sodium bicarbonate solution was injected intravenously in 7 normotensive and S hypertensive subjects to induce metabolic alkalosis. Pulse rate and blood pressure were measured before and every 5 minutes after the infusion of acidotic and alkalotic solution, for 45 minutes in the former and 30 minutes in the latter. Arterial pH, plasma volume, cardiac output, stroke volume and total peripheral resistance were measured before and after the infusion. Results Changes in metabolic acidosis : Arterial blood pH fell after the intravenous infusion of 0.01 N hydrochloric acid solution. Pulse rate showed a slight fall both in normotensive and hypertensive subjects, but to an insignificant extent. Systolic, diastolic and mean blood pressures indicated no significant changes after the in-fusion in normotensive and hypertensive subjects. Extracellular plasma volume did not show any changes in both groups. Cardiac output showed a slight increase in both groups after the infusion. Total peripheral resistance indicated no significant elevation after the infusion in normotensive subjects, while it showed a moderate increase in hypertensive ones, but the difference between both groups were not significant.

著者

吉田 忠正

出版者

社団法人日本循環器学会

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.28, no.9, pp.704-711, 1964

被引用文献数

1

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Recently, the hepatic circulation in hemorrhagic shock has been investigated by HEINEMANN, BRADLEY, SELKURT, FRANK and others. However, the opinions among the authors have not yet been in agreement but rather controversial, par icularly, as to the relationship between hepatic blood flow and cardiac output. HEINEMANN reported that hepatic blood flow fell sharply following hemorrhage and then returned spontaneously the control level in absence of the restoration of blood pressure. While, the others reported that hepatic blood flow did not recovered and remained in decreased level, having the same trend in blood pressure change. It seems likely that such a controversy will be partly due to the difference of the methods employed in measuring hepatic blood flow and partly to the confusion in recognizing the stage of shock, because the sequence of respective hemodynamic phenomenon is considerably different at the period of observation in this condition. The purpose of the present paper is to classify the relationship of hepatic blood flow and cardiac output throughout the entire course of hemorrhagic shock and its bearing on the irreversibility of shock. Oxygen utilization in the splanchnic viscera was also studied. The Relationship between Hepatic Blood Flow and Cardiac Output 1) Methods : Hepatic blood flow was measured by modified Frank's method. Twenty-two dogs ranging in weight from 8 to 20 kg were used and anesthetized with intravenous pentobarbital sodium of 25 mg/kg. A polyethylene catheter was passed through a right external jugular vein into the hepatic vein and then wedged into one of hepatic lobar veins. The outer end of the catheter in the hepatic vein was fixed at the level of the vena cava and allowed to drain continuously. The rate of hepatic outflow was measured by a graduated cylinder and stop watch. The blood collected was returned by transfer to an elevated burette draining into a left external jugular vein. Heparin (3-5 mg/kg) was given intravenously during the experiments. Cardiac output was calculated from indicator dilution curves according to the STEWART-HAMILTON principle. Two different procedures were used. In one method <SUP>32</SUP>P labelled red cells were used as an indicator and injected intravenously. Blood samples were collected successively from the femoral artery. In another cases, radio-iodinated serum albumin (RISA) was injected as an indicator. Cardiac output was calculated from radio-cardiograms by using a scintillation detector at the heart region and a rate-meter. 2) Results : We could distinguish the following two stages in hemorrhagic shock in relation to hepatic blood flow and cardiac output. a) The first stage : In the early stage of shock, hepatic blood flow decreases in parallel with the changes in cardiac output. b) The second stage : After same delay from the initial bleeding, hepatic blood flow decreases progressively without marked reduction in cardiac output. Consequently, a difference or "gap" appears in percentile changes of hepatic blood flow and cardiac output. c) Effects of transfusion : Complete recovery of arterial pressure, cardiac output and hepatic blood flow can be obtained by a transfusion performed in the first stage. Whereas, the transfusion made in the second stage give rise only transient recovery of arterial pressure and cardiac output.

著者

田邊 聖子 志野原 睦 安谷屋 均 沢登 徹 平岡 昌和

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.61, 1997-03-05

著者

Haruhiko Sakurai Miyazaki Kei Kenichirou Matsubara Kazuhiko Yokouchi Kazuki Hattori Ryoichi Ichihashi Yoshihiro Hirakawa Hideto Tsukamoto Yoshihiro Saburi

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.64, no.11, pp.893-896, 2000 (Released:2001-05-31)

参考文献数

23

被引用文献数

6 8

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Cardiogenic shock developed in a 72-year-old Japanese woman during combination therapy with verapamil and atenolol for recurrent supraventricular arrhythmia. She had coronary atherosclerosis, liver cirrhosis and brady-cardia-tachycardia syndrome. Despite of the high-dose catecholamines and counterpulsation, she progressively deteriorated. Bolus administration of intravenous calcium chloride(CaCl2) immediately resolved her hemodynamic collapse.

著者

仲嶋 秀文 黒田 敏男 西永 正典 山澤 正則 加倉井 章 金 承範 渡辺 慎太郎 島田 和幸 布施 勝生

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.58, 1994-03-01

著者

内藤 博昭 有沢 淳 滝沢 伊津夫 大久保 敏雄 植原 敏男 林田 孝平 太田 光重 西村 坦彦 菅原 徹雄 前田 宏文 小塚 隆弘 中島 克彦 松久茂 久雄 小柳 仁 藤田 毅 川副 浩平 林 研二

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.45, 1981-12-31

著者

川村 修 北中 秀法 中野 誠 鏑木 恒男 池田 文武 内田 三千彦 横山 正一

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.40, no.11, 1976-11

著者

Matsumori Akira Ohashi Naohiro Nishio Ryosuke Kakio Tadashi Hara Masatake Furukawa Yutaka Ono Koh Shioi Tetsuo Hasegawa Koji Sasayama Shigetake

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.63, no.6, pp.433-438, 1999-05-20

被引用文献数

2 23

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The familial of hypertrophic cardiomyopathy(HCM)is attributed to mutations in the genes for contractile proteins, but the etiology of non-familial form remains unknown. This study was designed to examine the clinical features, histopathologic changes, and hepatitis C virus(HCV)genomes in patients with HCM associated with HCV infection. Anti-HCV antibody was present in the sera of 9 of 65 patients(13.8%)with HCM versus 2.41% in a control population of voluntary blood donors in Japan, a statistically significant difference (p<0.0001). Among these 9 patients, 6 had ace-of-spades-spaped deformities of the left ventricle with apical hypertrophy. Myocardial fibrosis was found in all patients, and mild cellular infiltration was observed in 5patients. Type 1b HCV RNA was present in the sera of 5 of the 9 patients. The copy number of HCV was 5.5×10^3-8.6×10^5 genomes/ml serum, and multiple clones of HCV were detected in the sera of each patient by an analysis of the hypervariable regions using fluorescent single-strand conformation polymorphism. Positive strands of HCV were found in the hearts of 5 patients, and negative strands in the hearts of 2 patients. A high prevalence of HCV infection was found in patients with HCM, particularly of the apical variety, suggesting that HCV is an important causal agent in the pathogenesis of the disease.

著者

前田 雅人 中尾 正一郎 宮里 浩高 瀬戸口 学 有馬 新一 田中 弘允 樋口 逸郎 納 光弘

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.58, 1994-04-20

著者

Kinji Ishikawa Ken Kanamasa Iwao Ogawa Toshihiko Takenaka Takeo Naito Noriaki Kamata Tadahiko Yamamoto Shoji Nakai Junkichi Hama Miki Oyaizu Akio Kimura Kentaro Yamamoto Naoko Aso Miyuki Arai Hiroshi Yabushita Ryo Katori on behalf of the Secondary Prevention Group

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.60, no.10, pp.779-788, 1996 (Released:2001-12-25)

参考文献数

27

被引用文献数

50 63

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Background Nitrates dilate coronary arteries, ameliorate myocardial ischemia, minimize left ventricular remodeling, and reduce mortality in patients with acute myocardial infarction. However, the effects of long-term treatment with nitrates on cardiac events in patients with healed myocardial infarction are not known. Methods and Results A total of 1,002 patients with healed myocardial infarction (789 male and 213 female) were randomly divided into 2 groups: treatment with nitrates or nontreatment. The mean observation period was 18.0 ±19.9 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics of the 2 groups were also compared to determine any effects on outcome. Among the 621 cases treated with nitrates, 41 cases (6.6%) experienced cardiac events during the observation period, whereas only 12 of the 381 cases that were not treated with nitrates (3.1%) had cardiac events. This difference was statistically significant (p<0.05; odds ratio 2.17; 95% confidence interval 1.13-4.19). There were no differences in the incidence of noncardiac death or being lost to follow-up between the 2 groups. Although the precise mechanism of this increase in the occurrence of cardiac events by long-term treatment with nitrates is not clear, nitrate tolerance with possible rebound and neurohormonal effects may be involved. Conclusion Long-term treatment with nitrates increased cardiac events in patients with healed myocardial infarction. (Jpn Circ J 1996; 60: 779 - 788)

著者

向原 直木 安部 行弘 武田 光 藤井 章伸

出版者

社団法人日本循環器学会

雑誌

Japanese circulation journal (ISSN:00471828)

巻号頁・発行日

vol.51, 1988-02-10

著者

Shozo Sueda Takaaki Ochi Kazuo Yano Kazuaki Mineoi Tadashi Kondou Naoto Ochi Yutaka Hayashi Hitoshi Kukita Shouzou Matsuda Hiroyuki Kawada Takashi Tsuruoka Tadao Uraoka

出版者

日本循環器学会

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.64, no.8, pp.559-565, 0001-01-01 (Released:2001-05-31)

参考文献数

30

被引用文献数

16 24

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The incidence of provoked coronary spasm with the standard single spasm provocation test has been relatively low in patients with rest angina. The present study examined the clinical usefulness of a newly designed spasm provocation test, an intracoronary injection of acetylcholine (ACh) following an ergonovine (ER) test, in patients with rest angina who demonstrated low disease activity and atypical chest pain. Triple sequential spasm provocation tests were performed in 24 patients with atypical chest pain who had no ischemia and in 40 patients with rest angina who had distinct ischemia. Initially, an ACh test (20-100μg) and then an ER test (40-64μg) were performed and then, if no spasm was provoked, an intracoronary injection of ACh was given after the ER test to evaluate coronary spasm. Coronary spasm was defined as total or subtotal occlusion. In the 24 patients with atypical chest pain, no spasm was provoked by intracoronary injection of either ACh or ER, but coronary spasms were induced in 2 patients using the new method, with the remaining 22 not experiencing spasm (specificity of new method, 92%). In the 40 patients with rest angina, intracoronary injection of ACh induced coronary spasm in 22 patients (group I) and 6 (group II) demonstrated spasm with intracoronary injection of ER. Coronary spasm was not induced by either the ACh test or the ER test in 12 patients (group III). The intracoronary administration of ACh after the ER test provoked spasm in 11 of 12 patients. Diffuse spasms were provoked in 10 of 11 patients. In patients with rest angina, the frequency of chest pain attacks in 1 month experienced by patients in group III (0.8±0.8) was significantly lower than that of patients in group I (7.0±5.3, p<0.01) or II (3.5±2.3, p<0.05). No serious or irreversible complications related to this new combined method were observed. In conclusion, this method was safe and reliable for the induction of coronary spasm in patients with rest angina who may have low disease activity.