文献一覧: 一般社団法人日本医療薬学会 (出版者)

Accuracy of dividing weight of 11 drugs (5 powders, 3 fine glanules and 3 glanules) were tested on a automatic pre-packing machine, TOSHO BL-4W. The mean coefficient of variation (C. V.) was 3.9% for 30 subpacks of 1g in theoretical weight and sufficient accuracy of dividing weight was obtained. However, fine lactose, corn starch, and precipitated calcium carbonate showed relatively large C. V. values. The mean C. V. of 3 drugs (Gastropylore, heavy magnesium oxide and Marzulene S) were 3.0 and 5.5% obtained on 0.3 and 0.6g in theoretical weight, respectively, and these mean C.V. were regarded as sufficient. However, on 0.3g in theoretical weight, Gastropylore gave relatively large C. V., 8.5%. Gastropylore also gave relatively large C. V. on total weight of 30 subpacks. Angles of fall were highly correlated to C. V. values. It is suggested that angles of fall are especially useful for predict accuracy of dividing weight on a pre-packing machine.

2020-09-04 19:57:22
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1 0 0 0 OA カルシウム拮抗薬の血中濃度および降圧効果に及ぼす食事の影響

著者: 清水孝子西原カズヨ澤田康文伊賀立二
出版者: 一般社団法人日本医療薬学会
雑誌: 病院薬学 (ISSN:03899098)
巻号頁・発行日: vol.19, no.6, pp.534-541, 1993 (Released:2011-08-11)
参考文献数: 22
被引用文献数: 1 1

Food ingestion does not affect the bioavailability of the nifedipine capsule, a calcium channel antagonist, but delays its absorption rate in healthy subjects. On the other hand, in two different sustained-release preparations of nifedipine, both the bioavailability and anti-hypertensive efficacy in one of them increases, whereas the other is not so much affected by meals. Furthermore, the food induces a reduction in the bioavailability of nicardipine sustained-release preparation, while those of nisordipine, benidipine and manidipine increase conversely.Such a change in the bioavailability based on food intake may influence the anti-hypertensive efficacy after the initial dosing of the medicine but not so after multiple dosing.In each medicine or dosage form, there are some differences in the change in the blood level and anti-hypertensive efficacy brought on by food ingestion among the drugs. In general, however, in order to improve patient compliance, we recommend that calcium channel antagonists should be taken after meals following the directions given for this medication.

2020-09-03 06:42:03
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1 0 0 0 センシティブ(避妊・性交渉)な内容を含む患者コミュニケーション

著者: 林昌洋遠藤一司
出版者: 一般社団法人日本医療薬学会
雑誌: 日本医療薬学会年会講演要旨集
巻号頁・発行日: vol.28, pp.495-499, 2018

2020-01-02 21:34:43
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1 0 0 0 OA シンポジウム37 経皮吸収型製剤の適正使用と今後の展開

著者: 北河修治大谷道輝
出版者: 一般社団法人日本医療薬学会
雑誌: 日本医療薬学会年会講演要旨集第26回日本医療薬学会年会 (ISSN:24242470)
巻号頁・発行日: pp.18-13-S37, 2016-09-17 (Released:2019-01-18)

2019-12-19 19:52:27
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1 0 0 0 OA 粒子径等により物性を変えた医薬品に対する軽質無水ケイ酸め添加効果

著者: 林弘祐笠野俊彦須原清治
出版者: 一般社団法人日本医療薬学会
雑誌: 病院薬学 (ISSN:03899098)
巻号頁・発行日: vol.7, no.2, pp.108-117, 1981 (Released:2011-08-11)
参考文献数: 6

Pharmaceutical preparations such as sodium bicarbonate, lactose and potato starch show 2 different physical properties depending on their crystal diameters and moisture contents. Light anhydrous silicic acid (LASA) was added in several levels to 2 forms of the above preparations in order to investigate how these amounts of addition cause differences in their physical properties. Results are as follows:1) The angle of repose was minimized when LASA was added to powdered sodium bicarbonate in a proportion ranging from 0.1 to 0.25% and became greater in proportions exceeding 0.25%. Both the angle of repose and apparent specific volume of crystalline sodium bicarbonate were minimized by addition of LASA 0.01% and became greater in proportions exceeding 0.5%.2) In the case of powdered lactose, addition of LASA 0.01%resulted in negligible improvement in the physical properties. The effect was maximum in the proportion of 0.25%. In the case of crystalline lactose, addition of LASA even in 0.01% improved the physical properties. The effect was slightly enhanced by addition of LASA up to 0.1%. However, the addition of LASA in the proportion ranging from 0.25 to 0.5% deteriorated the effect.3) The degree of improvement in the physical properties of wet and dry potato starch reached maximum by addition of LASA 0.25 and 0.05%, respectively. The effect on wet stacrch by addition of LASA was greater.4) Scanning electron microscopy for observing the mixed conditions revealed that larger number of LASA particles attached to particles of the preparations when the physical properties were improved to a greater extent, and further increased proportions of addition resulted in the tendency to deteriorate physical properties by generation of aggregated particles of LASA attached particles of the preparations.

2019-11-13 20:02:12
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1 0 0 0 OA アンプルカット時に生じるガラス片のIVH調製者顔面への飛散

著者: 藤山悳正仙田隆一遠山裕子菊地加代子瀧沢武雄城武昇一
出版者: 一般社団法人日本医療薬学会
雑誌: 病院薬学 (ISSN:03899098)
巻号頁・発行日: vol.21, no.1, pp.22-28, 1995-02-10 (Released:2011-08-11)
参考文献数: 8

Intravenous hyperalimentation (IVH) treatment has been used in Japan since 1970, many hospitals applying this treatment to patients and receiving good results. Since the introduction of IVH treatment, its prescription and technique of this treatment have improved as a result of the many experiments and clinical reasearch conducted.In this study on the pharmacist's safety while adjusting IVH, it was forcused mainly on the amount and the size of the scattering glass fragments and the distance they traveled when an ampoule is opened.The results of the experiment were follows.(1) The number of glass fragments for those larger than 30μm only Scattered was from a minimum of 2 to a maximum of 33. The largest glass fragment found in each of the three samples used was 182.7μm, 238.3μm, and 126.1μm for Ohtsuka MV® Sohvita®, and distilled water, respectively.(2) Many fragment were from 30μm to 40μm in size, with fragments of this size were contained in each sample as follows: 53.50%, 46.30%, and 57.95% in Ohtsuka MV®, SohvitaR, and distilled water, respectively.(3) It was found that glass fragments could scatter up to 80cm in distance away from the ampoule.

2019-09-17 21:13:15
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1 0 0 0 OA イヌリン注射液中のエンドトキシン濃度の測定と除去方法の検討

著者: 青山隆夫松元美香中山紀美子中島克佳渋谷文則小滝一澤田康文伊賀立二
出版者: 一般社団法人日本医療薬学会
雑誌: 病院薬学 (ISSN:03899098)
巻号頁・発行日: vol.23, no.2, pp.108-114, 1997-04-10 (Released:2011-08-11)
参考文献数: 16
被引用文献数: 1 1

The pyrogenic activity of 10% inulin injections prepared at a hospital pharmacy was measured using the Pyrogen test in Japanese Pharmacopeia (JP), while the endotoxin concentration in the injections was determined by the, Limulus test, which were JP Endotoxin test and a turbidmetric kinetic assay. After the intravenous administration of 30 ml of inulin injections to a rabbit, the rectal temperature rose to 1.5° compared with that before administration. As a result, the endotoxin was found in all lots of the inulin injections tested, and their values were markedly beyond the limit of Water For Injections prescribed in JP (0.25 EU/ml). In addition, the endotoxin content varied between the various lots of inulin powder, and also between the manufacturers. The endotoxin in inulin injection was removed (less than the quantitative limit of 0.031 EU/ml) by adding activated carbon black to the injection or the filtration using a Posidyne® Nylon 66 filter. No pyrogenic activity was observed in the inulin injections after the removal of endotoxin.Based on these results, the adverse effects induced by inulin injections may thus be caused by endotoxin derived from inulin. This method using either adsorption or filtration is thus considered to be useful for the removal of endotoxin when preparing inulin injections.

2019-05-17 16:53:02
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1 0 0 0 OA アルファカルシドール製剤成分含量に及ぼす保存環境の影響

著者: 中村裕義木村真春山形眞一中村均大森栄北田光一
出版者: 一般社団法人日本医療薬学会
雑誌: 病院薬学 (ISSN:03899098)
巻号頁・発行日: vol.23, no.5, pp.437-444, 1997-10-10 (Released:2011-08-11)
参考文献数: 3

In the present study, we examined the effects of light, temperature and humidity on the residual rate of alfacalcidol in four commercially available preparations of alfacalcidol (Alfarol® capsules, Alfarol® powder, Warkmin® capsules and Onealfa® tablets). The tests were performed for up to 10 weeks with PTP seals, or without PTP seals. The changes in residual rate of alfacalcidol in Alfarol® powder packaged with cellophane-laminate paper, and Onealfa® tablets packaged with cellophane-laminate paper after crushing were also examined.The residual rate of alfacalcidol decreased in Alfarol® capsules packaged with PTP seals under fluorescent lighting (1000 lux) and in Alfarol® powder without an aluminum seal under all conditions. There were no changes in the contents of alfacalcidol in Alfarol® capsules with PTP seals and Alfarol® powder packaged by aluminum seal. A slight decrease in the residual rate of alfacalcidol in Warkmin® capsules was found under fluorescent lighting. The residual rate of alfacalcidol decreased in Onealfa® tablets under high temperature and/or high humidity. Alfarol® powder packaged with cellophane-laminate paper and Onealfa® tablets packaged with cellophane-laminete paper after crushing were found to be unstable, indicating that long-term storage should be avoided when these formulations are prepared.

2019-05-07 19:49:36
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