著者
元木 泰雄
出版者
京都大学 (Kyoto University)
巻号頁・発行日
1995-01-23

新制・論文博士
著者
成田 健太郞
出版者
中國文學會
雑誌
中國文學報 (ISSN:05780934)
巻号頁・発行日
vol.72, pp.54-86, 2006-10
著者
大津 博義
出版者
[出版者不明]
巻号頁・発行日
2011-10

制度:新 ; 報告番号:甲3453号 ; 学位の種類:博士(理学) ; 授与年月日:2011/10/27 ; 早大学位記番号:新5778
著者
水野 将樹
出版者
東京大学大学院教育学研究科
雑誌
東京大学大学院教育学研究科紀要 (ISSN:13421050)
巻号頁・発行日
vol.43, pp.185-195, 2004-03-10

Trust is mentioned as one of the most desired qualities in many relationships. However, there has not been enough researches on trust. As first, this paper provided an overview of psychological studies on trust and then suggested classification of these studies into 2 major groups (one with 3 sub-groups) based on a type of trust; trust as a personal trait and trust as a trait of relationships. Having reviewed Japanese researches on trust according to this classification, the integration of studies was found to be important. In addition, a multi-dimensional approach and a distinction between trust and security are thought to be useful.
著者
Nomoto Hiroshi Kondo Takuma Miyoshi Hideaki Nakamura Akinobu Hida Yoko Yamashita Ken-ichiro Sharma Arun J. Atsumi Tatsuya
出版者
Endocrine Society
雑誌
Endocrinology (ISSN:00137227)
巻号頁・発行日
vol.156, no.10, pp.3570-3580, 2015-10
被引用文献数
11

The large-Maf transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) has been found to be crucial for insulin transcription and synthesis and for pancreatic beta-cell function and maturation. However, insights about the effects of small Maf factors on beta-cells are limited. Our goal was to elucidate the function of small-Maf factors on beta-cells using an animal model of endogenous small-Maf dysfunction. Transgenic (Tg) mice with beta-cell-specific expression of dominant-negative MafK (DN-MafK) experiments, which can suppress the function of all endogenous small-Mafs, were fed a high-fat diet, and their in vivo phenotypes were evaluated. Phenotypic analysis, glucose tolerance tests, morphologic examination of beta-cells, and islet experiments were performed. DN-MafK-expressed MIN6 cells were also used for in vitro analysis. The results showed that DN-MafK expression inhibited endogenous small-Maf binding to insulin promoter while increasing MafA binding. DN-MafK Tg mice under high-fat diet conditions showed improved glucose metabolism compared with control mice via incremental insulin secretion, without causing changes in insulin sensitivity or MafA expression. Moreover, up-regulation of insulin and glucokinase gene expression was observed both in vivo and in vitro under DN-MafK expression. We concluded that endogenous small-Maf factors negatively regulates beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function.