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1 0 0 0 OA Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

著者: Mito Takayuki Kikkawa Yoshiaki Shimizu Akinori Hashizume Osamu Katada Shun Imanishi Hirotake Ota Azusa Kato Yukina Nakada Kazuto Hayashi Jun-Ichi
出版者: Public Library of Science
雑誌: PLoS ONE (ISSN:19326203)
巻号頁・発行日: vol.8, no.2, pp.e55789, 2013-02
被引用文献数: 26 5

Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting in expression of respiration defects. On the contrary, transmitochondrial mito-miceΔ carrying mtDNA with a large-scale deletion mutation (ΔmtDNA) also express respiration defects, but not express premature aging phenotypes. Here, we resolved this discrepancy by generating mtDNA mutator mice sharing the same C57BL/6J (B6J) nuclear background with that of mito-miceΔ. Expression patterns of premature aging phenotypes are very close, when we compared between homozygous mtDNA mutator mice carrying a B6J nuclear background and selected mito-miceΔ only carrying predominant amounts of ΔmtDNA, in their expression of significant respiration defects, kyphosis, and a short lifespan, but not the alopecia. Therefore, the apparent discrepancy in the presence and absence of premature aging phenotypes in mtDNA mutator mice and mito-miceΔ, respectively, is partly the result of differences in the nuclear background of mtDNA mutator mice and of the broad range of ΔmtDNA proportions of mito-miceΔ used in previous studies. We also provided direct evidence that mtDNA abnormalities in homozygous mtDNA mutator mice are responsible for respiration defects by demonstrating the co-transfer of mtDNA and respiration defects from mtDNA mutator mice into mtDNA-less (ρ0) mouse cells. Moreover, heterozygous mtDNA mutator mice had a normal lifespan, but frequently developed B-cell lymphoma, suggesting that the mtDNA abnormalities in heterozygous mutator mice are not sufficient to induce a short lifespan and aging phenotypes, but are able to contribute to the B-cell lymphoma development during their prolonged lifespan.

2013-05-14 08:30:57
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1 0 0 0 OA Goal orientation, evaluative fear, and perceived coach behavior among competitive youth swimmers in Germany and Japan

著者: Alfermann Dorothee Geisler Guido Okade Yoshinori
出版者: ELSEVIER
雑誌: Psychology of sport and exercise (ISSN:14690292)
巻号頁・発行日: vol.14, no.3, pp.307-315, 2013-03
被引用文献数: 14

AbstractObjectivesThe primary objective of this study was to compare youth athletes from two culturally distinct nations (Germany and Japan) on key aspects of their psychological make-up (goal orientation, fear of evaluation) and perceived coach support.DesignData were obtained with questionnaires distributed during a training session and analyzed with regression as well as multivariate and univariate analyses of variance.MethodThere were 56 German (30 female, 26 male) and 117 Japanese (60 female, 57 male) swimmers with a mean age of 13.2 (SD = 2.0) and 14.1 (SD = 1.8) years, respectively. All of the athletes participated regularly in high-level competitions.ResultsAs hypothesized, the German athletes were more task than ego oriented and more task focused than the Japanese, whereas the latter group had higher ego orientation scores than the German swimmers and put similar emphasis on both task and ego concerns. Contrary to expectations, however, there were no differences between the national cohorts in evaluative fear. The Japanese swimmers perceived their training climates to be more competition oriented than did the German participants. In terms of coach–athlete interactions, the German athletes reported significantly more instruction, positive feedback, and social support than the Japanese. Coach variables contributed significantly to the Japanese participants' feelings of satisfaction, with no such correlations in the German sample.ConclusionsResults are interpreted through cultural traditions and may be partly explained by differences in individualism. Practical recommendations for coaches and consultants are offered in light of the research findings.

2013-05-14 08:30:52
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1 0 0 0 OA 幻の Forestry Sociology : GHQ 下の構想と民俗学者の参与

著者: 中野泰
出版者: 筑波大学大学院人文社会科学研究科歴史・人類学専攻
雑誌: 歴史人類 (ISSN:03854795)
巻号頁・発行日: no.41, pp.63-118, 2013-03

2013-05-14 08:30:36
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http://hdl.handle.net/2241/118982

1 0 0 0 OA 応用電気研究所. 一沿革. 二創設期の思い出(初代所長簑島高). 三研究の進展. あとがき. 年表

出版者: 北海道大学
雑誌: 北大百年史
巻号頁・発行日: vol.部局史, pp.1207-1250, 1980-03-20

2013-05-14 06:29:00
1 はてなブックマーク

http://hdl.handle.net/2115/29991

1 0 0 0 OA 宗教の計量的分析 : 真如苑を事例として

著者: 川端亮カワバタアキラ Kawabata Akira

18137

2013-05-13 23:50:34
1 + 3 Twitter

http://hdl.handle.net/11094/1397

1 0 0 0 OA The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

著者: Kimura Ikuo Ozawa Kentaro Inoue Daisuke Imamura Takeshi Kimura Kumi Maeda Takeshi Terasawa Kazuya Kashihara Daiji Hirano Kanako Tani Taeko Takahashi Tomoyuki Miyauchi Satoshi Shioi Go Inoue Hiroshi Tsujimoto Gozoh
出版者: Nature Publishing Group
雑誌: Nature communications (ISSN:20411723)
巻号頁・発行日: vol.4, 2013-05-07
被引用文献数: 1034

腸内細菌による宿主のエネルギー恒常性維持機構の解明 : 短鎖脂肪酸受容体GPR43活性化は脂肪の蓄積を抑制し肥満を防ぐ. 京都大学プレスリリース. 2013-05-08.

2013-05-13 15:17:29
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1 0 0 0 OA 1982年浦河沖地震による津波

著者: 羽鳥徳太郎
出版者: 東京大学地震研究所
雑誌: 東京大学地震研究所彙報 (ISSN:00408972)
巻号頁・発行日: vol.57, no.3, pp.525-535, 1983-01-17

A small tsunami was generated by the Urakawa-oki earthquake (M=7.1) near Cape Erimo, southern Hokkaido, on March 21, 1982. At Urakawa, the initial disturbance of the present tsunami began with an upward motion simultaneous with the earthquake occurrence. The first wave period was 16min and the third wave was the highest with a semi-amplitude of 80 cm. According to the author's method based on the attenuation of wave-amplitude with distance, the tsunami magnitude (Imamura-Iida scale) are estimated to be m = 0. This rank is average for an earthquake having a magnitude of M=7.1. The source area of the present tsunami which inferred from an inverse refraction diagram is located along the coast from Urakawa to Shizunai. The length of the tsunami source is 40 km and the width 20 km. The tsunami source area agrees with the aftershock area. From the analysis of the initial tsunami motion on the records, an average uplift of 14 cm may have occurred at the sea-bottom of the source area.

2013-05-13 14:49:41
1 + 1 Wikipedia

http://hdl.handle.net/2261/12856

1 0 0 0 OA 1982年浦河沖地震による被害

著者: 伯野元彦大谷圭一
出版者: 東京大学地震研究所
雑誌: 東京大学地震研究所彙報 (ISSN:00408972)
巻号頁・発行日: vol.57, no.3, pp.581-608, 1983-01-17

The Urakawa-Oki earthquake of M=7.1 occurred on March 21, 1982 and consequently cause some damage to small towns in the south part of Hokkaido. This report describes the earthquake-induced damage to the various types of structures and life lines: Houses and buildings, Roads, Railways. Water supply systems, Electric power and communication systems, Landslides and land failures. The following characteristic features of the damage due to the earthquake are recognized, 1. Wooden houses on soft peat ground suffered damage owing to the destruction of the peat ground itself. On the other hand, reinforced concrete buildings on soft peat ground always have a deep pile foundation and suffered almost no damage. Authors suppose the peat layer to be so soft that it acts like a high cut filter and high frequency components of the incident ground motion which are the main components of high acceleration, is reduced. 2. Most lifeline systems such as water, electric supply systems, and traffic, lost their functions due to the earthquake, and people were subjected to inconveniences. For example, it took 30 days to rehabilitate the railway traffic in this area.

2013-05-13 14:49:41
1 + 1 Wikipedia

http://hdl.handle.net/2261/12859

1 0 0 0 OA 自立と依存 : 「自立した個人」の虚実

著者: 浜野研三 Kenzo Hamano
雑誌: 人文論究 (ISSN:02866773)
巻号頁・発行日: vol.54, no.1, pp.1-13, 2004-05-25

2013-05-12 23:13:29
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http://hdl.handle.net/10236/6220

1 0 0 0 OA 非正規雇用概念の適用過程からみる韓国労働市場の「格差」 : 日本との比較を通じて(<特集>「労働」と「格差」)

著者: 有田伸
出版者: 東京大学社会科学研究所
雑誌: 社會科學研究 (ISSN:03873307)
巻号頁・発行日: vol.62, no.3/4, pp.77-97, 2011-03-15

非正規雇用という概念の具体的な意味内容は, 社会によって大きく異なり得る. 本稿は, 韓国社会にこの概念がどのように適用され, 何が「非正規雇用」とされてきたのかを現実の雇用構造と照らし合わせながら検討することで, 韓国労働市場における「格差」の性格を明らかにしていく. 韓国においてこれまで非正規雇用として読み替えられることが多かった経済活動人口調査の臨時・日雇カテゴリーは, 確かに労働市場における雇用の安定性や報酬等の格差をすくいとっているが, 分類基準の「土着化」故に, これらの格差は韓国に根強く存在する企業規模間格差の反映ともなってしまっている. これらを考慮すれば, 韓国では正規/非正規雇用の区分が日本ほどには自明でなく, その影響もそこまで独立的なものではない可能性が高い. 以上の韓国の事例と比較すると, 日本の非正規雇用は自明性/標準性と独立性が強く, それが非正規雇用の認識・分析枠組にも影響を及ぼしているという点で特徴的といえる.