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この論文はM&Aが企業に与えるパフォーマンス効果を明らかにするものである。分析の対象とした企業は製造業(機械、電気機器業界)と非製造業(サービス、ソフト・情報、運輸倉庫業界)に属する日本の企業である。分析の結果、M&A実施企業は実施翌年度において非実施企業よりROAやROEなどが高いことが分かった。さらに、この分析ではM&Aを行う企業が元々優れた業績を残す属性がある可能性を排除しきれないため、M&A実施企業において実施前と実施後の業績を比較し業績改善効果を分析した。その際、分析結果が業界によって異なることから、製造業と非製造業のそれぞれにおけるM&Aのパフォーマンス効果の特性を分析することとなった。この分析から、 (1) 製造業では1、2年という期間では業績の改善結果が見られず、業績改善を長期間に見据えている可能性があること (2) 非製造業ではROAや売上高増加率が改善する一方、販管費率が悪化することが明らかになった。

2012-11-15 04:10:23
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http://hdl.handle.net/2433/141340

1 0 0 0 OA 構文構造を用いた感情極性分類の精度向上

著者: 中山貴樹
巻号頁・発行日: 2012-03

Supervisor:東条敏

2012-11-14 22:55:00
1 はてなブックマーク

http://hdl.handle.net/10119/10421

1 0 0 0 OA 東京における「させていただく」

著者: 松本修
出版者: 関西大学国文学会
雑誌: 国文学 (ISSN:03898628)
巻号頁・発行日: vol.92, pp.355-367, 2008-03

2012-11-14 22:29:00
1 はてなブックマーク

http://hdl.handle.net/10112/1194

1 0 0 0 OA 看護教育機関における学生の感染予防対策に関する調査(第2報) : B型肝炎について

著者: 平塚志保佐藤洋子森下節子良村貞子
出版者: 北海道大学医療技術短期大学部
雑誌: 北海道大学医療技術短期大学部紀要 (ISSN:09152083)
巻号頁・発行日: vol.12, pp.65-74, 1999-12

2012-11-14 18:37:17
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http://hdl.handle.net/2115/37648

1 0 0 0 OA On the existence of indiscernible trees

著者: Takeuchi Kota Tsuboi Akito
出版者: Elsevier
雑誌: Annals of pure and applied logic (ISSN:01680072)
巻号頁・発行日: vol.163, no.12, pp.1891-1902, 2012-12
被引用文献数: 11 5

We introduce several concepts concerning the indiscernibility of trees. A tree is by definition an ordered set (O,<) such that, for any a∈O, the initial segment {b∈O:b<a} determined by a is a linearly ordered set. A typical example of a tree is the set ω<ω of finite ω-sequences with the order relation <ini, where η<iniν means that η is a proper initial segment of ν. In this paper, we consider some structure M in the language L and are interested in sets A of the form (aη)η∈O, where O is a tree, and aη labeled by η is an element in M. Such a set A is also called a tree in this paper. We study the indiscernibility of trees A in general settings and apply the obtained results to the study of unstable theories.

2012-11-14 08:31:04
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1 0 0 0 OA An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

著者: Vong Long Binh Tomita Tsutomu Yoshitomi Toru Matsui Hirofumi Nagasaki Yukio
出版者: Elsevier
雑誌: Gastroenterology (ISSN:00165085)
巻号頁・発行日: vol.143, no.4, pp.1027-1036.e3, 2012-10
被引用文献数: 155 22

Background & AimsDrugs used to treat patients with ulcerative colitis are not always effective because of nonspecific distribution, metabolism in the gastrointestinal tract, and side effects. We designed a nitroxide radical-containing nanoparticle (RNPO) that accumulates specifically in the colon to suppress inflammation and reduce the undesirable side effects of nitroxide radicals.MethodsRNPO was synthesized by assembly of an amphiphilic block copolymer that contains stable nitroxide radicals in an ether-linked hydrophobic side chain. Biodistribution of RNPO in mice was determined from radioisotope and electron spin resonance measurements. The effects of RNPO were determined in mice with dextran sodium sulfate (DSS)-induced colitis and compared with those of low-molecular-weight drugs (4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl [TEMPOL] or mesalamine).ResultsRNPO, with a diameter of 40 nm and a shell of poly(ethylene glycol), had a significantly greater level of accumulation in the colonic mucosa than low-molecular-weight TEMPOL or polystyrene latex particles. RNPO was not absorbed into the bloodstream through the intestinal wall, despite its long-term retention in the colon, which prevented its distribution to other parts of the body. Mice with DSS-induced colitis had significantly lower disease activity index and less inflammation following 7 days of oral administration of RNPO compared with mice with DSS-induced colitis or mice given low-molecular-weight TEMPOL or mesalamine.ConclusionsWe designed an orally administered RNPO that accumulates specifically in the colons of mice with colitis and is more effective in reducing inflammation than low-molecular-weight TEMPOL or mesalamine. RNPO might be developed for treatment of patients with ulcerative colitis.

2012-11-14 08:30:58
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1 0 0 0 OA Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

著者: Hayakawa Ichiro Ikedo Akiyuki Chinen Takumi Usui Takeo Kigoshi Hideo
出版者: Elsevier
雑誌: Bioorganic & medicinal chemistry (ISSN:09680896)
巻号頁・発行日: vol.20, no.19, pp.5745-5756, 2012-10
被引用文献数: 17 3

Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.

2012-11-14 08:30:53
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1 0 0 0 OA Visualization study of ignition modes behind bifurcated-reflected shock waves

著者: Yamashita Hiroki Kasahara Jiro Sugiyama Yuta Matsuo Akiko
出版者: Elsevier Inc.
雑誌: Combustion and flame (ISSN:00102180)
巻号頁・発行日: vol.159, no.9, pp.2954-2966, 2012-09
被引用文献数: 47 1

This study was a numerical and experimental investigation of low-temperature auto-ignitions behindreflected shock waves in which a shock tube was employed as the experimental system. We used ahigh-speed video camera and the Schlieren method to visualize the ignition phenomena. Experimentswere performed over a temperature range from 549 ± 10 to 1349 ± 11 K and a pressure range from56 ± 2 to 203 ± 13 kPa, and a non-diluted stoichiometric acetylene–oxygen mixture was chosen as thecombustible gas. We introduced a numerical simulation to help us understand the disturbed temperaturedistribution behind bifurcated shock waves due to interference between reflected shock waves and theboundary layer developed behind incident shock waves. Additionally, we experimentally observed andevaluated quantitatively a tendency for ignition positions to be located farther from the reflecting wallas the temperature decreased behind reflected shock waves. To focus our attention on the ignition positions,we classified the ignition types behind reflected shock waves as near-wall ignition and far-wallignition by 4.7 mm distance from reflecting wall. The criterion for these ignition types was estimatedto be -1.0≦(∂ti/∂T5t)p5t≦-0.5. As a main object in this manuscript, we proposed an ignition modelin which local ignition is induced at some distance from reflecting wall based on the numerical simulationand results; the local ignitions at a point distant from the reflecting wall are induced by the temperaturerise, with the distance from the reflecting wall, immediately behind concave reflected shock wavesdue to developing of bifurcated shock waves. We confirmed that there is no discrepancy between the proposedmodel and experimental results.

2012-11-14 08:30:47
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1 0 0 0 OA Effect of plasma lipids, hypertension and APOE genotype on cognitive decline

著者: Yasuno Fumihiko Tanimukai Satoshi Sasaki Megumi Ikejima Chiaki Yamashita Fumio Kodama Chiine Hidaka Shin Mizukami Katsuyoshi Asada Takashi
出版者: Elsevier Inc.
雑誌: Neurobiology of aging (ISSN:01974580)
巻号頁・発行日: vol.33, no.11, pp.2633-2640, 2012-11
被引用文献数: 28

We examined the combined effect of plasma lipids/hypertension and apolipoprotein E (APOE) genotype on cognitive function in elderly individuals. Plasma concentrations of high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), APOE, and history of hypertension were evaluated in 622 community-dwelling individuals aged 65 years and older. We investigated the associations between plasma lipids/hypertension and cognitive function in apolipoprotein E4 allele (APOE4) carrier (E4+) and APOE4 noncarrier (E4–) groups using 3-year longitudinal data. At baseline and 3 years later, cognitive scores were correlated with plasma APOE levels in both E4– and E4+, and HDL level in E4–. The combination of hypertension and E4+, but not E4–, was associated with a significant deterioration in cognitive function during the 3-year follow-up. Our findings suggest that an interaction between APOE and HDL is facilitated by APOE4, and is possibly linked with a protective effect on cognitive decline in later life. The findings also indicate a synergistic effect of an APOE4 allele and hypertension on the acceleration of cognitive decline.

2012-11-14 08:30:42
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1 0 0 0 OA The New Japanese Postgraduate Medical Education and Quality of Emergency Medical Care

著者: Tokuda Yasuharu Goto Eiji Otaki Junji Omata Fumio Shapiro Mina Soejima Kumiko Ishida Yasushi Ohde Sachiko Takahashi Osamu Fukui Tsuguya
出版者: Elsevier Inc.
雑誌: The Journal of emergency medicine (ISSN:07364679)
巻号頁・発行日: vol.43, no.3, pp.494-501, 2012-09
被引用文献数: 4

BackgroundThe new postgraduate medical education (PGME) was recently introduced to improve quality of emergency care in Japan.ObjectivesTo compare the quality of care and confidence in provision of emergency medicine between physicians who completed the old and new PGME programs.MethodsA cross-sectional survey was sent to 279 physicians of postgraduate years 4–9, and 208 responses (75%) were received. Quality of care in emergency medicine was measured using 26 questions on treatment choices for various clinical conditions. Each question had six responses, including a single correct choice. Effect size was obtained by dividing the total difference in score by the standard deviation of the score distribution. Confidence in emergency medicine was rated using four self-reported items on the level of confidence in treating acute illnesses in various emergency medicine settings.ResultsThe mean score for quality of care was significantly higher in the new PGME group (15.3) compared to the old PGME group (12.8). The difference in scores was 2.5 (p < 0.01) and the effect size (0.47) indicated a moderate difference. Linear regression of total scores adjusted for physician covariates produced similar results of an adjusted score difference of 2.5 (p < 0.01) and an adjusted effect size of 0.47. The new PGME group also had significantly greater confidence in provision of emergency medicine based on significant differences between the groups for all four self-reported items (all p < 0.05).ConclusionsJapanese physicians who complete the new PGME program are likely to provide higher quality of care and have greater confidence in emergency medicine compared to those who completed the old PGME program.

2012-11-14 08:30:25
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1 0 0 0 OA 国の安定性の量的評価に関する研究

著者: 恒吉隆郎
巻号頁・発行日: 2012

筑波大学博士 (社会工学) 学位論文・平成24年3月23日授与 (甲第6051号)

2012-11-14 08:30:14
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http://hdl.handle.net/2241/117835

1 0 0 0 OA Aerobic oxidative dehydrogenations of benzyl alcohols to benzaldehydes by using a cyclometalated ruthenium catalyst

著者: Taketoshi Ayako Beh Xin Ning Kuwabara Junpei Koizumi Take-aki Kanbara Takaki
出版者: Elsevier Ltd.
雑誌: Tetrahedron letters (ISSN:00404039)
巻号頁・発行日: vol.53, no.28, pp.3573-3576, 2012-07
被引用文献数: 23

The ruthenium(III) complex bearing phenylpyridine as acyclometalated ligand serves as an efficient catalyst for the aerobicoxidativedehydrogenation of benzylalcohols to the corresponding benzaldehydes under mild conditions and for the one-pot synthesis of benzonitriles from benzylalcohols with ammonia.

2012-11-13 08:30:12
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