著者
Hirotaka IGARASHI Koichi OHNO Aki FUJIWARA-IGARASHI Hideyuki KANEMOTO Kenjiro FUKUSHIMA Yuko GOTO-KOSHINO Kazuyuki UCHIDA Hajime TSUJIMOTO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0505, (Released:2014-12-20)
被引用文献数
3 12

Inflammatory colorectal polyps (ICRPs) frequently occur in miniature dachshunds (MDs) in Japan. MDs with ICRPs develop multiple polyps with severe neutrophil infiltration that respond to immunosuppressive therapy. Therefore, ICRPs are thought to constitute a novel, breed-specific form of canine inflammatory bowel disease (IBD). Pattern recognition receptors (PRRs) play a key role in the distinction of pathogens from commensal bacteria and food antigens. Dysfunction resulting from genetic disorders of PRRs have been linked to human and canine IBD. Therefore, we analyzed the reactivity of PRRs in MDs with ICRPs. Twenty-six MDs with ICRPs and 16 control MDs were recruited. Peripheral blood-derived monocytes were obtained from each dog and then stimulated with PRR ligands for 6 and 24 hr; subsequently, messenger RNA (mRNA) expression levels and protein secretion of IL-1β were quantified using quantitative real-time PCR and ELISA, respectively. The levels of IL-1β mRNA and protein secretion after stimulation with a nucleotide-binding oligomerization domain 2 (NOD2) ligand were significantly greater in monocytes from ICRP-affected MDs than in those from control MDs. In addition, IL-1β protein secretion induced by toll-like receptor (TLR) 1/2, TLR2 and TLR2/6 stimulation was also significantly greater in ICRP-affected MDs. These results suggest that reactivity against NOD2, TLR1/2, TLR2 and TLR2/6 signals is enhanced in ICRP-affected MDs and may play a role in the pathogenesis of ICRPs in MDs. Additional studies of the genetic background of these PRRs should be performed.
著者
神宮字 寛 上田 哲行 五箇 公一 日鷹 一雅 松良 俊明
出版者
公益社団法人 農業農村工学会
雑誌
農業農村工学会論文集 (ISSN:18822789)
巻号頁・発行日
vol.77, no.1, pp.35-41, 2009 (Released:2010-10-15)
参考文献数
20

フィプロニルやイミダクロプリドを成分とする育苗箱施用殺虫剤は,稲の吸汁性害虫を対象とした殺虫剤であり,育苗箱に用いる.本研究では,本薬剤がアキアカネ幼虫の死亡率,羽化数,羽化行動に及ぼす影響を小型ライシメータにより検証した.各ライシメータは,フィプロニル区,イミダクロプリド区および無処理区とし,それぞれ3反復で実験を行った.アキアカネ卵は,それぞれのライシメータに300卵散布した.そして,各ライシメータ中のアキアカネ幼虫の死亡率,羽化数を求めた.アキアカネ幼虫の死亡率が最も大きい値を示したのはフィプロニル区となり,羽化個体が観察されなかった.イミダクロプリド区では,フィプロニル区に比べて死亡率は低い値を示したが,幼虫の平均成長率および成虫の後翅長が無処理区よりも低下した.また,羽化異常を示す個体が無処理区に比べて高い割合で発現した.フィプロニルやイミダクロプリドを成分とする育苗箱施用殺虫剤の使用は,アキアカネ幼虫の大きな減少を招くことが示唆された.
著者
植村 恒三郎
出版者
日本森林学会
雑誌
林學會雑誌 (ISSN:21858187)
巻号頁・発行日
vol.16, no.1, pp.10-11, 1934-01-10 (Released:2009-02-13)
著者
植村 恒三郎
出版者
日本森林学会
雑誌
林學會雑誌 (ISSN:21858187)
巻号頁・発行日
vol.13, no.5, pp.293-308, 1931-05-10 (Released:2009-02-13)
参考文献数
4
著者
Tadahisa MASHITA Hiroaki KAMISHINA Yuya NAKAMOTO Yosuke AKAGI Ataru NAKANISHI Yusuke HARASAKI Tsuyoshi OZAWA Takashi UEMURA Yui KOBATAKE Shunsuke SHIMAMURA Naoki KITAMURA Sadatoshi MAEDA Yuji UZUKA Gerry SHAW Jun YASUDA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0582, (Released:2014-12-19)
被引用文献数
4

The aim of this study was to evaluate the prognostic value of concurrent measurement of serum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullary T2W hyperintensity in parapalegic to paraplegic dogs. Our hypothesis was that concurrent measurement of these would provide a more accurate prediction of functional outcome in dogs with thoracolumbar intervertebral disc herniation (IVDH). A prospective case-control clinical study was designed using 94 dogs with acute onset of thoracolumbar IVDH. The association of serum pNF-H concentration, T2W hyperintensity on sagittal MRI (T2H/L2), deep pain perception and surgical outcome were evaluated with logistic regression analysis after three months for all 94 surgically treated dogs. Sensitivity to predict non-ambulatory outcome was compared among pNF-H and T2H/L2 and combination of both. Logistic regression analysis indicated that serum pNF-H concentration and T2H/L2 were significantly correlated with surgical outcome (P<0.05); however, deep pain perception was not (P=0.41). The results of logistic regression analysis indicated that the odds ratios of unsuccessful long-term outcome were 2.6 for serum pNF-H concentration, 1.9 for T2H/L2 and 2.3 for deep pain sensation. The sensitivity and specificity to predict non-ambulatory outcome for using serum parameter pNF-H>2.6 ng/ml, using T2H/L2 value of >0.84 and using both serum pNF-H and T2H/L2, were 95% and 75.7%, 65% and 86.5%, and 90.0% and 97.5%, respectively. Therefore, combined measurements of serum pNF-H and T2H/L2 might be useful for predicting long-term outcome in dogs with thoracolumbar IVDH.
著者
Yoshiki YAMAYA Toshihiro WATARI
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.14-0338, (Released:2014-12-19)
被引用文献数
4

Canine chronic rhinitis (CR) and bronchitis (CB) are suspected to be allergic diseases. The present study tested whether dogs diagnosed with CR or CB present an atopic predisposition based on the serum levels of allergen-specific IgE antibodies and the ratio of CC chemokine receptor 4 (CCR4)-positive cells among peripheral blood CD4-positive cells (CCR4/CD4). We found that most dogs with CR and CB have a possibility of atopic predisposition, and macrolide therapy constitutes an alternative to corticosteroid therapy in controlling the clinical signs.
著者
黒木 竜馬 坂本 眞人 古谷 博史
出版者
電気・情報関係学会九州支部連合大会委員会
雑誌
電気関係学会九州支部連合大会講演論文集 平成24年度電気関係学会九州支部連合大会(第65回連合大会)講演論文集
巻号頁・発行日
pp.154, 2012-09-14 (Released:2014-12-17)

エンターテインメントの分野では正確さよりも速度やリアルタイム性が重要である場合が多い。一方、物理シミュレーションでは精度が要求される。すると、計算精度を上げるために数値計算法のタイムステップを小さくし、質点を増やさなければならない。その結果、計算量が膨大になり、リアルタイムシミュレーションは現実的ではない。さらに、実行速度はハードウェアに依存するため時間軸とのずれが懸念される。そこで、本論文では、時間軸を一致させた非リアルタイムシミュレーションを提案し、難しいとされる布を対象とした3DCGアニメーションを試みた。
著者
多田 堯 橋本 学
出版者
公益社団法人 日本地震学会
雑誌
地震 第2輯 (ISSN:00371114)
巻号頁・発行日
vol.41, no.2, pp.259-262, 1988-06-25 (Released:2010-03-11)
参考文献数
13

A fault of the 1918 Omachi earthquake (M=6.5) have been estimated based on the vertical crustal movement associated with the earthquake. The 1918 Omachi earthquake was the largest earthquake which had ever occurred near the northern part of the Itoigawa-Shizuoka Tectonic Line (ISTL). The estimated fault is a high dip angle reverse fault with left lateral strike slip component. The fault plane strikes to the N-S and dips to the east. The fault model suggests a possibility that the Chikuma Mountains (Northeastern Japan) thrust against the Matsumoto Basin (Southwestern Japan).