著者

馬場 駿吉 高坂 知節 稲村 直樹 佐藤 三吉 鈴木 茂 遠藤 里見 石戸谷 雅子 小野寺 亮 山田 公彦 大久 俊和 荒井 英爾 鈴木 雅明 大山 健二 粟田口 敏一 戸川 清 岡本 美孝 松崎 全成 寺田 修久 喜多村 健 石田 孝 馬場 廣太郎 島田 均 森 朗子 池田 聖 金子 敏郎 今野 昭義 山越 隆行 石井 哲夫 窪田 市世 鍋島 みどり 田口 喜一郎 石山 哲也 中野 雄一 中村 英生 五十嵐 文雄 古川 仭 作本 真 山下 公一 久保田 修 宇佐神 篤 伊藤 博隆 鈴木 元彦 間宮 紳一郎 横田 明 加藤 薫 大屋 靖彦 河合 〓 岩田 重信 横山 尚樹 井畑 克朗 瀧本 勲 稲福 繁 坂倉 康夫 鵜飼 幸太郎 雨皿 亮 山田 弘之 坂倉 健二 平田 圭甫 伊藤 由紀子 村上 泰 竹中 洋 山下 敏夫 久保 伸夫 中井 義明 大橋 淑宏 阪本 浩一 村田 清高 平沢 昌子 原田 康夫 森 直樹 白根 誠 多田 渉 小林 優子 竹林 脩文 河野 嘉彦 夜陣 紘治 平田 思 宮脇 修二 津田 哲也 山下 隆司 二階堂 真史 柿 音高 永澤 容 増田 游 後藤 昭一 西岡 慶子 折田 洋造 東川 康彦 武 浩太郎 進 武幹 前山 忠嗣 百田 統洋 堤 昭一郎 茂木 五郎 川内 秀之 松下 太 吉村 弘之 高田 順子 石川 哮 定永 恭明 大山 勝 松崎 勉 坂本 邦彦 廣田 常治 内薗 明裕 鯵坂 孝二 中島 光好

出版者

The Society of Practical Otolaryngology

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.88, no.3, pp.389-405, 1995-03-01

被引用文献数

13 16

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The efficacy and safety of Kampo preparation Sho-seiryu-to were studied in a joint double-blind trial in comparison with a placebo. The study was carried out on 220 patients with perennial nasal allergy at 61 hospitals. Granules in a dose of 3 g were administered 3 times daily for 2 weeks. Moderate to high improvement was recorded in 44.6% of the treated patients and in 18.1% of those receiving placebo. The difference is significant (p <0.001). Side effects were noted in 6.5% of the treated patients and in 6.4% of the controls (not a significant deference). The side effects were mild and had no influence on the daily life of the patients.

著者

山岸 益夫 中村 英生 鈴木 正治 長谷川 聡 中野 雄一

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.83, no.3, pp.383-390, 1990-03-01 (Released:2011-11-04)

参考文献数

12

被引用文献数

1 1

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Morphological and immunohistochemical examinations were performed on the olfactory mucosa of eight patients with olfactory disturbances caused by the common cold (viral infection). The results of olfactory testing and of follow-up examinations were analyzed.H. E. staining revealed three patterns of degeneration. In Group 1 (3 patients) the olfactory epithelium had adequate thickness and a basic arrangement of supporting cells, olfactory receptor cells, and basal cells, but slightly fewer than normal receptor cells. In Group 2 (3 patients) olfactory receptor cells were greatly decreased. Group 3 (2 patients) had olfactory epithelium which was thin and atrophic with no receptor cells or olfactory vesicles, and only the supporting and basal cells remained. Group 1 patients had Grade 2, Group 2 patients Grade 3, and Group 3 patients Grade 4 damage according to our classification of degeneration proposed in 1988.Immunohistochemically, neuron-specific enolase (NSE) immunoreactivity was found in a number of receptor cells in Group 1 with Grade 2 damage and in some in Group 2 with Grade 3 damage. In Group 3 with Grade 4 damage, there was no NSE-immunoreactivity in the epithelium. Glia-specific S-100 protein immunoreactivity was found in Bowman's glands and olfactory nerve bundles in the lamina propria of Group 1 and 2 patients with Grade 2 and 3 damage. Cytokeratin immunoreactivity was found in the basal cells on the basement membrane in all three groups.Seven patients were found to be anosmic with T & T olfactometry, but the three patients in Group 1 responded well to Alinamin- intravenous injection test, and two of them recovered.These results indicate that there is a strong relationship among the appearance of the olfactory epithelium, results of the Alinamin- test and the outcome of olfactory disturbance caused by the common cold. When an olfactory mucosall biopsy performed at the first visit of the patient shows enough functional receptor cells and the Alinamin- test is positive, it is possible that the olfactory disturbance may improve.