- 一般社団法人 粉体工学会
- 粉体工学会誌 (ISSN:03866157)
- vol.54, no.3, pp.172-177, 2017-03-10 (Released:2017-04-22)
Particles of additives that are ingested along with food can either adhere to the intestinal microflora or be absorbed, and these may possibly lead to illnesses caused by changes in the microflora composition. Barely 1% of Fe2O3 particles dissolve in acids present in the stomach. In addition, the direct administration of Fe2O3 particles into the stomach with a probe showed no adverse health effects. However, mixing Fe2O3 particles of a smaller diameter into food and orally administering the dose over a period of more than 2 weeks encouraged the multiplication of the diarrhea-causing Clostridium family amongst intestinal flora, indicating the cause of the diarrhea outbreak. On the other hand, multiplication of the Clostridium species was suppressed by the multiplication of another family within the intestinal flora, namely Lactobacillus. It was confirmed that by analyzing the formation of fermentation products such as hydrogen, acetic acid, and lactic acid, symptoms of diarrhea caused by the alteration of intestinal microflora composition spontaneously recovered.