著者

Tomoya Yamashita Kazuyuki Kasahara Takuo Emoto Takuya Matsumoto Taiji Mizoguchi Naoki Kitano Naoto Sasaki Ken-ichi Hirata

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.9, pp.1882-1890, 2015-08-25 (Released:2015-08-25)

参考文献数

48

被引用文献数

4 49

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Atherosclerosis is considered a chronic inflammatory disease and an intervention targeting the inflammatory process could be a new therapeutic strategy for preventing atherosclerotic cardiovascular diseases (CVD). We hypothesized that the intestine, which is considered the biggest immune organ in the human body, could be a therapeutic target for preventing CVD. We demonstrated that oral administration of anti-CD3 antibody or an active form of vitamin D3reduced atherosclerosis in mice via induction of regulatory T cells and tolerogenic dendritic cells in the gut-associated lymphoid tissues. Similar to regulatory immune responses achieved by oral tolerance, our method had systemic effects that ultimately contributed towards atherosclerosis reduction. Recently, we have been interested in the gut microbiota, which have been reported as highly associated with intestinal immunity and systemic metabolic disorders, including obesity and diabetes. Notably, the guts of obese individuals are predominantly colonized byFirmicutesoverBacteroidetes. The association between atherosclerosis and microbiota has been attracting increased attention, and gut microbiota have been shown to participate in the metabolism of a proatherogenic compound called trimethylamine-N-oxide (TMAO) and aggravate CVD. Our investigation of the relationship between susceptibility to CVD and the gut microbiota revealed a characteristic flora type. Here, we discuss the evidence for the relationship between the gut microbiota and cardiometabolic diseases, and consider the gut microbiota as new potential therapeutic targets for treating CVD. (Circ J 2015; 79: 1882–1890)

著者

Wu Hsin-Lun Sato Ryota Yamaguchi Atsushi Kimura Masato Haruta Mitsutaka Kurata Hiroki Teranishi Toshiharu

出版者

American Association for the Advancement of Science

雑誌

Science (ISSN:10959203)

巻号頁・発行日

vol.351, no.6279, pp.1306-1310, 2016-03-18

被引用文献数

102

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常温・常圧でのイオン性ナノ結晶の結晶構造制御に成功 -新しい光エネルギー変換材料開発に期待-. 京都大学プレスリリース. 2016-03-18.

著者

On behalf of the J-ROCKET AF Study Investigators Masatsugu Hori Yohei Ohashi Guohua Pan Masaharu Kato Mariko Kajikawa

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0287, (Released:2016-04-22)

参考文献数

4

被引用文献数

2

著者

Jae-Joon RO Ki-Suk SUNG 坂東 栄三 舟橋 明男

出版者

九州産業大学

雑誌

九州産業大学健康・スポーツ科学研究

巻号頁・発行日

vol.9, pp.55-59, 2007-03

著者

LUINTEL Kul B KHAN Mosahid LEON-GONZALEZ Roberto LI Guangjie

出版者

GRIPS Policy Research Center

雑誌

GRIPS Discussion Papers

巻号頁・発行日

vol.15-27, 2016-03

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The existing weight of evidence suggests that financial structure (the classification of a financial system as bank-based versus market-based) is irrelevant for economic growth. This contradicts the common belief that the institutional structure of a financial system matters. We re-examine this issue using a novel dataset covering 69 countries over 1989-2011 in a Bayesian framework. Our results are conformable to the belief - a market-based system is relevant - with sizable economic effects for the high-income but not for the middle-and-low-income countries. Our findings provide a counterexample to the weight of evidence. We also identify a regime shift in 2008.

著者

Yasui Yasuo Hirakawa Hideki Ueno Mariko Matsui Katsuhiro Katsube-Tanaka Tomoyuki Yang Soo Jung Aii Jotaro Sato Shingo Mori Masashi

出版者

Oxford University Press

雑誌

DNA research : an international journal for rapid publication of reports on genes and genomes (ISSN:17561663)

巻号頁・発行日

2016-04-02

被引用文献数

116

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世界初となるソバの全ゲノム解読に成功 -ソバの安全性、高品質性、収量安定性の鍵となる遺伝情報の発見-. 京都大学プレスリリース. 2016-04-13.

著者

Kitayama Shuichi Zhang Rong Liu Tian-Yi Ueda Norihiro Iriguchi Shoichi Yasui Yutaka Kawai Yohei Tatsumi Minako Hirai Norihito Mizoro Yasutaka Iwama Tatsuaki Watanabe Akira Nakanishi Mahito Kuzushima Kiyotaka Uemura Yasushi Kaneko Shin

出版者

Elsevier Inc.

雑誌

Stem cell reports (ISSN:22136711)

巻号頁・発行日

vol.6, no.2, pp.213-227, 2016-02-09

被引用文献数

66

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ヒトiPS細胞から、免疫機能を活性化させる細胞の作製に成功. 京都大学プレスリリース. 2016-03-24.

著者

SU Yuan-Chi YAMADA Koichi

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bulletin of the Agricultural Chemical Society of Japan (ISSN:03758397)

巻号頁・発行日

vol.24, no.2, pp.140-146, 1960

被引用文献数

2

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(1) With regard to the constituents of the fermentation medium, various nitrogen sources, glucose and their optimum concentrations, as well as the additive influences of various growth substances and metals, were examined.<br> Solely considering its worth in industrial application, urea seems to be a satisfactory nitrogen source. Its optimum concentration in the medium containing 5% of glucose was found to lie between 0.67 to 0.9%. The growth of cells should be suppressed when the initial con-centration of glucose exceeds 12.5%; therefore a level of 10% gives a better result. Data show-ed that addition of meat and bran extracts gave an increment of about 26% in acid yield.<br> (2) As for the fermentation condition, after experiments on the incubation temperature, pH and the influence of oxygen supply, etc., reveal that the aerobic condition is favorable for cell growth and accumulation of L-glutamic acid. An oxygen supply around 5 × 10^-6 of K_d is desirable. The optimum incubation temperature was found to lie at 30°C.<br> A reasonable quantity of L-glutamic acid will be produced if the culture is kept neutral or preferably slightly alkaline by feeding a proper amount of urea aqueous solution throughout in-cubation.<br> (3) As a conclusion of the above experimental results, the yield of L-glutamic acid reached 45%, on basis of glucose supplied after 30 hours' in-cubation.<br> (4) By-products such as alanine, α-ketoglutaric acid, pyruvic acid and succinic acid were found at the same time, in the fermentation of L-glu-tamic acid employing <i>Brevibactcrium divaricatum</i> nov. sp.<br> By observing the time of formation, the kind and the amount of these by-products it was presumed that the L-glutamic acid formation with this strain most probably proceeds from glucose to pyruvic acid, and then to α-ketoglu-taric acid via Krebs TCA Cycle. L-Guutamic acid could be considered to be formed from α-keto-glutaric acid. The reductive amination reaction of α-ketoglutaric acid is assumed to be the main pathway of L-glutamic acid synthesis.

著者

Reiner Tillner-Roth ...

出版者

Japan Society of Refrigerating and Air Conditioning Engineers

巻号頁・発行日

1998

著者

岡 恵子 Keong Chin-Huai 斎藤 文雄

出版者

医学書院

雑誌

臨床皮膚科 (ISSN:00214973)

巻号頁・発行日

vol.56, no.6, pp.425-427, 2002-05

被引用文献数

3

著者

Shinya Yuta Kawai Masahiko Niwa Fusako Myowa-Yamakoshi Masako

出版者

Wiley Periodicals, Inc.

雑誌

Developmental psychobiology (ISSN:10982302)

巻号頁・発行日

2016-03-31

被引用文献数

17

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早産児に対する新たな発達評価法の開発に期待. 京都大学プレスリリース. 2016-04-04.

著者

Jung-Sun Kim Hancheol Lee Yongsung Suh Hui-Nam Pak Geu-Ru Hong Chi Young Shim Cheol-Woong Yu Hyun-Jong Lee Woong-Chol Kang Eun-Seok Shin Rak-Kyeong Choi Saibal Kar Jai-Wun Park Do-Sun Lim Yangsoo Jang

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-1134, (Released:2016-03-17)

参考文献数

28

被引用文献数

2 25

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Background:The aim of this study was to evaluate clinical outcome after left atrial appendage (LAA) occlusion in real clinical practice and compare between Amplatzer cardiac plug (ACP) and Watchman.Methods and Results:From October 2010 to February 2015, 96 successful LAA occlusion procedures were performed using either ACP (n=50) or Watchman device (n=46) in non-valvular atrial fibrillation (AF) patients (59 male; age, 65.1±9.4 years; CHADS2, 2.5±1.2; CHA2DS2-VASC, 3.9±1.6; HAS-BLED, 2.7±1.3). The procedure success rate was 96.8%. There were serious complications in 4 patients (4.1%; 2 cardiac tamponade, 1 device embolization, and 1 major bleed). The anticoagulation cessation rate after 6 weeks was 92.7%. During mean 21.9-month follow-up, the incidence of death, stroke, systemic embolization and major bleeding was 5.2%, 4.2%, 0% and 1.0%, respectively. On transesophageal echocardiography of 93 patients within 6 months after the procedure, 24 residual leaks were observed (25.8%; 2 mild, 18 moderate, and 4 major). Clinical outcome was similar for the 2 devices, but peridevice leakage was more frequent with the Watchman than the ACP.Conclusions:LAA occlusion was feasible in non-valvular AF patients with high risk of stroke and hemorrhage. The ACP and Watchman devices were similar in terms of procedural and clinical outcomes.

著者

The 30-Year Company Hisoty Book Committee

出版者

Coca-Cola (Japan)Company, Ltd.

巻号頁・発行日

1987

著者

Tomoya Niki Katsutomo Sasaki Masahito Shikata Takako Kawasaki-Narumi Norihiro Ohtsubo Takaaki Nishijima

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-129, (Released:2016-03-08)

被引用文献数

5

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We isolated a torenia mutant “Begonia” from selfed progeny of the mutable line “Flecked,” in which the ventral petal of the flower was converted into dorsal petal. In normal-type (NT) flowers, dorsal petals were pale violet and limbs of lateral and ventral petals were violet, whereas the ventral petal had a yellow nectar guide. In contrast, the ventral petal of mutant-type (MT) flowers changed to pale violet, and the nectar guide disappeared. These altered pigmentation patterns were observed from the early stage of corolla pigmentation. Expression analyses of the floral symmetry genes CYCLOIDEA (CYC), RADIALIS (RAD), and DIVARICATA (DIV) showed that TfCYC1, TfCYC2, TfCYC3, and TfRAD1 were mainly expressed in dorsal petals of NT flowers, but in the mutant, these genes were expressed in the ventral petal similar to dorsal ones. These results suggest that conversion of ventral to dorsal petal in the “Begonia” mutant is caused by high expression of TfCYC1, TfCYC2, TfCYC3, and TfRAD1 in the ventral petal, comparable to their expression in dorsal petals.

著者

ム-ア チャ-ルズ

出版者

文芸春秋

雑誌

文芸春秋

巻号頁・発行日

vol.72, no.14, pp.p144-156, 1994-11

著者

par Joseph Étienne Kowalewski = Монгольско-русско-французскій словарь / составленный Осипомъ Ковалевскимъ

出版者

Imprimerie de l'université

巻号頁・発行日

1844

著者

SHOHGO ATARASHI SHUICHI YOKOHAMA KEN-ICHI YAMAZAKI KATSU-ICHI SAKANO MASAZUMI IMAMURA ISAO HAYAKAWA

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.5, pp.1896-1902, 1987-05-25 (Released:2009-10-19)

参考文献数

14

被引用文献数

46 99

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Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1) [(±) -ofloxacin; DL-8280; (±) -9-fluoro-2, 3-dihydro-3-methyl-10- (4-methyl-1-piperazinyl) -7-oxo-7H-pyrido [1, 2, 3-de] [1, 4] benzoxazine-6-carboxylic acid] and their fluoromethyl derivatives (14a and 14b) were prepared via their optically active intermediates resolved by use of high-performance liquid chromatography (HPLC). The isomers (13a and 13b) were also obtained efficiently by an alternative route via separation of the diastereoisomers (18, 19) prepared in the reaction of benzoxazine (17) with L-prolinyl chloride.The (-) -isomers of 1 and its fluoromethyl derivative (2) were approximately twice as active as the corresponding racemates, while the (+) -isomers were considerably less active than the racemates.The absolute configuration at the C3 position in the oxazine ring in a series of (-) -compounds (b) was confirmed by X-ray analysis of the hydrochloride of the (-) -benzoxazine derivative (15b) to be S.

著者

Guo-Sheng Li Xu-Han Liu Hua Zhu Lan Huang Ya-Li Liu Chun-Mei Ma Chuan Qin

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.5, pp.644-654, 2011-05-01 (Released:2011-05-01)

参考文献数

41

被引用文献数

10 28

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The diabetic “lipotoxicity” hypothesis presents that fat-induced visceral white adipose tissue insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Berberine, a hypolipidemic agent, has been reported to have antidiabetic activities. The molecular mechanisms for this property are, however, not well clarified. Therefore in this study type 2 diabetic hamsters were induced by high-fat diet with low-dose streptozotocin. Then, we investigated the gene expression alterations and explored the molecular mechanisms underlying the therapeutic effect of berberine on fat-induced visceral white adipose tissue insulin resistance in diabetic hamsters by microarray analysis followed by real-time reverse transcription-polymerase chain reaction (RT-PCR) confirmation. Type 2 diabetic hamsters exhibited hyperglycemia and relative hyperinsulinemia, glucose intolerance, insulin resistance, intra-adipocyte lipid accumulation, significant increase in body weight and visceral white adipose tissue weight, abnormal serum adipokines levels, and deleterious dyslipidemia. Furthermore, they had increased sterol regulatory element-binding proteins (SREBPs) expression and decreased liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs) expression in visceral white adipose tissue. After 9-week berberine treatment, fat-induced insulin resistance and diabetic phenotype in type 2 diabetic hamsters were significantly improved. Compared with diabetic hamsters, expression of LXRs and PPARs significantly increased and SREBPs significantly decreased in visceral white adipose tissue from berberine-treated diabetic hamsters. These results suggest that altered visceral white adipose tissue LXRs, PPARs, and SREBPs transcriptional programs are involved in the therapeutic mechanisms of berberine on fat-induced visceral white adipose tissue insulin resistance in type 2 diabetic hamsters.

著者

Yi-Chou Tsai Chih-Chieh Chang

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.39, no.4, pp.311-311, 2010-04-05 (Released:2010-04-05)

著者

Nomoto Hiroshi Kondo Takuma Miyoshi Hideaki Nakamura Akinobu Hida Yoko Yamashita Ken-ichiro Sharma Arun J. Atsumi Tatsuya

出版者

Endocrine Society

雑誌

Endocrinology (ISSN:00137227)

巻号頁・発行日

vol.156, no.10, pp.3570-3580, 2015-10

被引用文献数

13

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The large-Maf transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) has been found to be crucial for insulin transcription and synthesis and for pancreatic beta-cell function and maturation. However, insights about the effects of small Maf factors on beta-cells are limited. Our goal was to elucidate the function of small-Maf factors on beta-cells using an animal model of endogenous small-Maf dysfunction. Transgenic (Tg) mice with beta-cell-specific expression of dominant-negative MafK (DN-MafK) experiments, which can suppress the function of all endogenous small-Mafs, were fed a high-fat diet, and their in vivo phenotypes were evaluated. Phenotypic analysis, glucose tolerance tests, morphologic examination of beta-cells, and islet experiments were performed. DN-MafK-expressed MIN6 cells were also used for in vitro analysis. The results showed that DN-MafK expression inhibited endogenous small-Maf binding to insulin promoter while increasing MafA binding. DN-MafK Tg mice under high-fat diet conditions showed improved glucose metabolism compared with control mice via incremental insulin secretion, without causing changes in insulin sensitivity or MafA expression. Moreover, up-regulation of insulin and glucokinase gene expression was observed both in vivo and in vitro under DN-MafK expression. We concluded that endogenous small-Maf factors negatively regulates beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function.