著者

Julien Ternacle Romain Gallet Armand Mekontso-Dessap Guy Meyer Bernard Maitre Alexandre Bensaid Priscille Jurzak Pascal Gueret Jean-Luc Dubois Randé Pascal Lim

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.10, pp.2612-2618, 2013 (Released:2013-09-25)

参考文献数

22

被引用文献数

4 19

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Background: The benefit of load expansion is controversial in acute pulmonary embolism (PE). The aim of this study was to evaluate the benefit of furosemide in cases of normotensive acute PE. Methods and Results: We retrospectively included 70 consecutive normotensive patients (systolic blood pressure ≥90mmHg) admitted for acute PE with right ventricular dilation. Overall, 40 patients were treated during the first 24h by repeated bolus of furosemide (78±42mg, range 40–160mg) and 30 patients received isotonic saline solution (1.6±0.9L). Severity of hemodynamic status was similar in both groups, but patients in the furosemide group were older and had a greater creatinine level. At 24h, only the furosemide group had a decreased shock index (0.82±0.22 vs. 0.63±0.16, P<0.0001) with improved systolic blood pressure (118±18 vs. 133±17mmHg, P<0.0001), and creatinine levels. After treatment, there were fewer patients with simplified pulmonary embolism severity index ≥1 in the diuretic group (45% vs. 55%, P=0.03) than in the fluid expansion group (47% vs. 40%, P<0.0001). Finally, oxygen requirement at 24h decreased only in the diuretic group (75% to 47%, P=0.0004), and in-hospital survival without death and PE-related shock were similar between the 2 groups. Conclusions: In normotensive PE with RV dilatation, diuretics may improve hemodynamics and oxygenation requirement.  (Circ J 2013; 77: 2612–2618)

著者

小山田 明 権 容聖 鈴木 孝 糟谷 忠雄 Rossat-Mignod J.

出版者

一般社団法人日本物理学会

雑誌

年会講演予稿集

巻号頁・発行日

vol.45, no.3, 1990-03-16

著者

菊地 哲夫 Tetsuo KIKUCHI 東京農業大学生物産業学部産業経営学科 Department of Business Science Faculty of Bio-Industry Tokyo University of Agriculture

出版者

東京農業大学

雑誌

東京農業大学農学集報 (ISSN:03759202)

巻号頁・発行日

vol.55, no.2, pp.140-149,

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本稿の目的は,仲卸業者の財務状況を把握して,仲卸業者が抱えている経営課題を考察することである。事例として東京都中央卸売市場の仲卸業者を対象とした。財務分析は,収益性,生産性,安定性の3つの視点より行い,さらに総合評価を加えた。その結果,収益性や生産性が他の卸売業(中小企業)に比較して低い点が明らかとなった。現在,仲卸業者の定数制がとられている。経営効率の高い仲卸業者による市場運営を形成してもらうためには,規制を撤廃して参入・脱退を自由にするべきである。また,卸売市場法の改正(2004)により,これまでの業務上の規制が大分緩和された。規制緩和をビジネスチャンスとして,積極的に業務の拡大を図っていくことが望まれる。これらの課題に対処し,経営基盤の強化を図っていくことが重要である。The present paper aims to ascertain the financial situation of intermediate wholesalers and examine business problems that these wholesalers face. As a case study, the present study focuses on intermediate wholesalers in the Tokyo Metropolitan Central Wholesale Market. Financial analysis was performed from the perspectives of profitability, productivity, and stability and an overall assessment was made. The results revealed that the intermediate wholesalers studied had low profitability and productivity compared with other wholesalers (small businesses). Currently, the system for ensuring a constant number of intermediate wholesalers is in place in Tokyo. To ensure high management efficiency in market operations by intermediate wholesalers, the present regulations should be abolished and entry to and withdrawal from the market should be liberalized. In 2004, operating regulations were substantially relaxed following the revision of the Wholesale Market Law. Intermediate Wholesalers should seize the business opportunities liberalized by such deregulation by actively seeking to expand operations. These issues must be addressed and the business framework must be strengthened in order to improve the profitability and productivity of intermediate wholesalers.

著者

クラウス ホフマン-ホラント マティアス ジモニス[著] 滝沢 誠[訳]

出版者

日本大学

雑誌

日本法學 (ISSN:02874601)

巻号頁・発行日

vol.77, no.4, pp.1-24, 2012-03-10

著者

Wilawan PUMIDONMING Doaa SALMAN Dulyatad GRONSANG Abdelbaset E. ABDELBASET Khamphon SANGKAEO Shin-ichiro KAWAZU Makoto IGARASHI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0293, (Released:2016-08-27)

被引用文献数

29

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Gastrointestinal zoonotic helminths of dogs and cats have a public health concern worldwide. We investigated the prevalence of gastrointestinal helminths of zoonotic significance in dogs and cats in lower Northern Thailand and utilized molecular tools for species identification of hookworms and Opisthorchis viverrini. Fecal samples of 197 dogs and 180 cats were collected. Overall prevalence of infection using microscopy was 40.1% in dogs and 33.9% in cats. Helminth infection found in both dogs and cats included hookworms, Spirometra spp., Taenia spp., Toxocara spp., O. viverrini, Strongyloides spp. and Trichuris spp. Hookworms were the most common helminth in dogs, while Spirometra spp. was the most prevalent in cats. Among hookworm infection in dogs and cats, Ancylostoma ceylanicum was the most prevalent hookworm, being 82.1% in hookworm infected dogs and 95.8% in hookworm infected cats. Mixed-infection due to hookworms and Spirometra spp. was the most dominant in both dogs and cats. Our finding showed that zoonotic helminth infection is highly prevalent in dogs and cats in the lower Northern area of Thailand.

著者

Shiraishi Kouya Okada Yukinori Takahashi Atsushi Kamatani Yoichiro Momozawa Yukihide Ashikawa Kyota Kunitoh Hideo Matsumoto Shingo Takano Atsushi Shimizu Kimihiro Goto Akiteru Tsuta Koji Watanabe Shun-Ichi Ohe Yuichiro Watanabe Yukio Goto Yasushi Nokihara Hiroshi Furuta Koh Yoshida Akihiko Goto Koichi Hishida Tomoyuki Tsuboi Masahiro Tsuchihara Katsuya Miyagi Yohei Nakayama Haruhiko Yokose Tomoyuki Tanaka Kazumi Nagashima Toshiteru Ohtaki Yoichi Maeda Daichi Imai Kazuhiro Minamiya Yoshihiro Sakamoto Hiromi Saito Akira Shimada Yoko Sunami Kuniko Saito Motonobu Inazawa Johji Nakamura Yusuke Yoshida Teruhiko Yokota Jun Matsuda Fumihiko Matsuo Keitaro Daigo Yataro Kubo Michiaki Kohno Takashi

出版者

Springer Nature

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.7, 2016-08-09

被引用文献数

47

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日本人に多いEGFR変異を持つ肺腺がんの罹りやすさを決める遺伝子領域発見-免疫を司るHLA遺伝子など6遺伝子領域が関与-. 京都大学プレスリリース. 2016-08-25.

著者

HUYNH J-R.

雑誌

Curr. Biol.

巻号頁・発行日

vol.11, pp.901-906, 2001

被引用文献数

1 69

著者

Ryo Nishio Toshiro Shinke Hiromasa Otake Takahiro Sawada Yoko Haraguchi Masakazu Shinohara Ryuji Toh Tatsuro Ishida Masayuki Nakagawa Ryoji Nagoshi Amane Kozuki Takumi Inoue Hirotoshi Hariki Tsuyoshi Osue Yu Taniguchi Masamichi Iwasaki Noritoshi Hiranuma Akihide Konishi Hiroto Kinutani Junya Shite Ken-ichi Hirata

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.76, no.10, pp.2348-2355, 2012 (Released:2012-09-25)

参考文献数

32

被引用文献数

15 37

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Background: Cytochrome P450 (CYP) 2C19 polymorphism is associated with reduced responsiveness to clopidogrel and poor clinical outcome after drug-eluting stent (DES) implantation, but its contribution to lesion outcome after DES implantation is unclear. Methods and Results: The study included 160 Japanese patients who received clopidogrel and underwent DES implantation with follow-up angiography. Patients were divided into 3 groups by CYP2C19 polymorphism: extensive metabolizers (EM), intermediate metabolizers (IM), and poor metabolizers (PM). The incidence of major adverse cardiac events (MACE) and target lesion revascularization (TLR) were compared among the 3 groups. Optical coherence tomography (OCT) was performed for 120 patients to evaluate the incidence of intra-stent thrombi. Of the 160 patients, the proportion of EM, IM, and PM was 37.5%, 48.1%, and 14.4%, respectively. The incidence of TLR and MACE was more frequent in IM and PM than EM (TLR: 18.2% and 26.1% vs. 3.3%, P=0.008, MACE: 22.1% and 30.4% vs. 5.0%, P=0.005). Among the 120 patients who underwent follow-up OCT, intra-stent thrombi were more frequently detected in IM and PM than in EM (45.6% and 63.2% vs. 20.5%, P=0.005). The incidence of TLR was significantly higher in patients with than in those without intra-stent thrombi (27.7% vs. 6.8%, P=0.003). Conclusions: CYP2C19 loss-of-function polymorphism might be associated with the incidence of MACE and TLR in association with intra-stent thrombi.  (Circ J 2012; 76: 2348–2355)

著者

Brigitte Basdevant-Gaudemet

出版者

Pulim

巻号頁・発行日

2006

著者

Rieko Kubo Masato Akagi Reiko Akahane-Yamada

出版者

一般社団法人 日本音響学会

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.36, no.5, pp.397-407, 2015 (Released:2015-09-01)

参考文献数

15

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This study investigated the differences in first-language-based (L1-based) phonetic processing for second language (L2) phonemes among different age groups of adults. A speech-in-speech masking paradigm was utilized to examine the contribution of the L1-based processing. A phoneme identification task in one language was conducted in the presence or absence of an interferer of a masker of the same or a different language. The degree of interference (i.e., the decrease in identification performance) was postulated to increase as the similarity of underlying processes for the target and masker increases. Experiment 1 was conducted to test the effectiveness of the paradigm. As expected, the interference increased as the similarity of underlying processes for the target and masker increased. Experiment 2 examined the perception of English /r/–/l/ and other phonetic contrasts by Japanese listeners in various adult age groups, to examine whether the degree of interference differs depending on the putative degrees of L1-based processing and on age. The results demonstrated such differences and showed that the L1-based processing can be estimated from the decrease in the identification performance. They also suggested that the perception of /r/–/l/ in the initial singleton and initial cluster positions was high L1-based in older adults.

著者

Yun-Fan Hwang Hideo Suzuki

出版者

一般社団法人 日本音響学会

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.37, no.3, pp.115-122, 2016-05-01 (Released:2016-05-01)

参考文献数

6

被引用文献数

2

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This paper presents a finite-element analysis on the free vibration of Japanese drum wood barrels under insufficient material property data. Unlike isotropic material such as steel, wood behaves like an orthotropic composite material, whose elastodynamic characterization in a cylindrical shell needs Young’s modulus in the longitudinal (in-grain) and circumferential (cross-grain) directions, shear modulus, and Poisson ratios. Due to measurement difficulty encountered during the process of testing, only the longitudinal Young’s modulus and the specific gravity of the wood were measured. In the analysis, the finite-element models of the drum were constructed using conical shell elements. The required unknown elastic constants were estimated consecutively by a try-and-error approach, and the estimated values were reached when the computed resonance frequencies matched simultaneously with those of the seven lower modes measured in experiments. In order to accomplish this, both the estimated constants and the finite-element analysis must be within acceptable range of accuracy. It was found that the values of the circumferential (cross-grain) Young’s modulus, which was unknown at the beginning of the study, turns out to be crucial in determining the lower mode resonance frequencies. The usefulness of this analysis is that the estimated elastic constants can now be used for updating the finite-element model. The updated model can then be used calculating the higher order modes which cannot be practically obtained through measurements.

著者

Shuzo ORIKASA Kazumi NABESHIMA Noriyuki IWABUCHI Jin-Zhong XIAO

出版者

BMFH出版会

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.35, no.3, pp.141-145, 2016 (Released:2016-07-28)

参考文献数

28

被引用文献数

7

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Schizophrenia is a chronic psychiatric illness. Disruption of the dopaminergic system has been suggested to be the pathogenic cause of this disease. The effect of Bifidobacterium longum BB536 (BB536) on schizophrenic behavior was investigated in an animal model. Daily administration of BB536 (109 CFU/mouse, p.o. for 2 weeks) was found to reduce rearing behavior augmented by the dopamine receptor agonist apomorphine and to decrease the resting level of plasma corticosterone and the ratio of kynurenine to tryptophan. These results suggest the potential of BB536 for supplemental treatment of the symptoms of schizophrenia.

著者

Tanaka Takashi Kanatsu-Shinohara Mito Lei Zhenmin Rao C.V. Shinohara Takashi

出版者

Elsevier Inc.

雑誌

Stem Cell Reports (ISSN:22136711)

巻号頁・発行日

vol.7, no.2, pp.279-291, 2016-08-09

被引用文献数

52

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精子幹細胞の自己複製を促す新規遺伝子の発見. 京都大学プレスリリース. 2016-08-10.

著者

Myoung-Kwon Kim

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.7, pp.2144-2147, 2016 (Released:2016-07-29)

参考文献数

16

被引用文献数

2

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[Purpose] This study was undertaken to investigate the effects of the balance exercises with a Swiss ball on static and dynamic balance abilities in elderly (≥65 years) subjects. [Subjects and Methods] Twenty elderly subjects with no relevant orthopedic history of a back condition were selected for trunk stabilization exercises with a Swiss ball (Thera-Band, USA). The subjects performed these trunk stabilization exercises for 20 minutes, five times per week for 4 weeks. The experimental group (n=10) was blindfolded during these balance exercises, while the control group control group (n=10) was not. [Results] The experimental group showed significant improvements in velocity in the evaluation of static balance and in time, total distance, and left/right movement distance in the evaluation of dynamic balance after the intervention, whereas the control group showed significant improvements in time in the evaluation of dynamic balance. A significant intergroup difference was observed after the intervention for velocity gain. [Conclusion] Exercising with a blindfold stimulates other senses by blocking visual information, and hence it enhances improvements in balance ability.

著者

Myung-Mo Lee Doo-Chul Shin Chang-Ho Song

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.7, pp.2019-2024, 2016 (Released:2016-07-29)

参考文献数

31

被引用文献数

36

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[Purpose] This study was aimed at investigating the preliminary therapeutic efficacy and usefulness of canoe game-based virtual reality training for stroke patients. [Subjects and Methods] Ten stroke patients were randomly assigned to an experimental group (EG; n=5) or a control group (CG; n=5). Patients in both groups participated in a conventional rehabilitation program, but those in the EG additionally participated in a 30-min canoe game-based virtual reality training program 3 days a week for 4 weeks. Therapeutic efficacy was assessed based on trunk postural stability, balance, and upper limb motor function. In addition, the usefulness of canoe game-based virtual reality training was assessed in the EG and therapist group (TG; n=20), which consisted of physical and occupational therapists, by using the System Usability Scale (SUS). [Results] Improvements in trunk postural stability, balance, and upper limb motor function were observed in the EG and CG, but were greater in the EG. The mean SUS scores in the EG and TG were 71 ± 5.2 and 74.2 ± 4.8, respectively. [Conclusion] Canoe game-based virtual reality training is an acceptable and effective intervention for improving trunk postural stability, balance, and upper limb motor function in stroke patients.

著者

Yoshihisa UENOYAMA Vutha PHENG Hiroko TSUKAMURA Kei-ichiro MAEDA

出版者

日本繁殖生物学会

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2016-083, (Released:2016-07-29)

被引用文献数

44

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Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of reproductive functions in mammals owing to its involvement in the direct activation of gonadotropin-releasing hormone (GnRH) neurons after binding to its cognate receptor, GPR54. Ever since the discovery of kisspeptin, intensive studies on hypothalamic expression of KISS1/Kiss1 and on physiological roles of hypothalamic kisspeptin neurons have provided clues as to how the brain controls sexual maturation at the onset of puberty and subsequent reproductive performance in mammals. Additionally, emerging evidence indicates the potential involvement of extra-hypothalamic kisspeptin in reproductive functions. Here, we summarize data regarding kisspeptin inside and outside the hypothalamus and revisit the physiological roles of central and peripheral kisspeptins in the reproductive functions of mammals.

著者

VENS-CAPPELL B.

雑誌

Aquaculture Engineering

巻号頁・発行日

vol.3, pp.71-89, 1984

被引用文献数

1 29

著者

VENS-CAPPELL B.

雑誌

Aquacult. Eng.

巻号頁・発行日

vol.4, pp.33-49, 1985

被引用文献数

1 31

著者

Hiroo Imai Nami Suzuki-Hashido Yoshiro Ishimaru Takanobu Sakurai Lijie Yin Wenshi Pan Masaji Ishiguro Katsuyoshi Masuda Keiko Abe Takumi Misaka Hirohisa Hirai

出版者

一般社団法人 日本生物物理学会

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.13, pp.165-171, 2016 (Released:2016-07-14)

参考文献数

14

被引用文献数

1 5

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In mammals, bitter taste is mediated by TAS2Rs, which belong to the family of seven transmembrane G protein-coupled receptors. Since TAS2Rs are directly involved in the interaction between mammals and their dietary sources, it is likely that these genes evolved to reflect species-specific diets during mammalian evolution. Here, we analyzed the amino acids responsible for the difference in sensitivities of TAS2R16s of various primates using a cultured cell expression system. We found that the sensitivity of TAS2R16 varied due to several amino acid residues. Mutation of amino acid residues at E86T, L247M, and V260F in human and langur TAS2R16 for mimicking the macaque TAS2R16 decreased the sensitivity of the receptor in an additive manner, which suggests its contribution to the potency of salicin, possibly via direct interaction. However, mutation of amino acid residues 125 and 133 in human TAS2R16, which are situated in helix 4, to the macaque sequence increased the sensitivity of the receptor. These results suggest the possibility that bitter taste sensitivities evolved independently by replacing specific amino acid residues of TAS2Rs in different primate species to adapt to species-specific food.

著者

Jung-Sub Shin Hee-Won Park Gyo In Hyun Kyu Seo Tae Hyung Won Kyoung Hwa Jang Byung-Goo Cho Chang Kyun Han Jongheon Shin

出版者

公益社団法人日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c16-00240, (Released:2016-07-05)

参考文献数

17

被引用文献数

14

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Panax ginseng C.A. Meyer is one of the most popular medicinal herbs in Asia and the chemical constituents are changed by processing methods such as steaming or sun drying. Metabolomic analysis was performed to distinguish age discrimination of four- and six-year-old red ginseng using ultra-performance liquid chromatography quadruple time of flight mass spectrometry (UPLC-QToF-MS) with multivariate statistical analysis. Principal component analysis (PCA) showed clear discrimination between extracts of red ginseng of different ages and suggest totally six discrimination markers (two for four-year-old and four for six-year-old red ginseng). Among these, one marker was isolated and the structure determined by NMR spectroscopic analysis was 13-cis-docosenamide (marker 6-1) from six-year-old red ginseng. This is the first report of a metabolomic study regarding the age differentiation of red ginseng using UPLC-QToF-MS and determination of the structure of the marker. These results will contribute to the quality control and standardization as well as provide a scientific basis for pharmacological research on red ginseng.