著者

Kensuke ORITO Asako KAWARAI-SHIMAMURA Atsushi OGAWA Atsushi NAKAMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0463, (Released:2017-10-31)

被引用文献数

8

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A prospective observational study was performed in canine clinical medicine to evaluate the emetic action and adverse effects of tranexamic acid. Veterinarians treated 137 dogs with a single dose of tranexamic acid (50 mg/kg, IV) after accidental ingestion of foreign substances. If needed, a second (median, 50 mg/kg; range, 20–50 mg/kg, IV) or third dose (median, 50 mg/kg; range, 25–50 mg/kg, IV) was administered. Tranexamic acid induced emesis in 116 of 137 (84.7%) dogs. Median time to onset of emesis was 116.5 sec (range, 26–370 sec), median duration of emesis was 151.5 sec (range, 30–780 sec), and median number of emesis episodes was 2 (range, 1–8). Second and third administrations of tranexamic acid induced emesis in 64.7% and 66.7% of dogs, respectively. In total, IV administration of tranexamic acid successfully induced emesis in 129 of 137 (94.2%) dogs. Adverse effects included a tonic-clonic convulsion and hemostatic disorder in two different dogs, both of which recovered after receiving medical care. Tranexamic acid induced emesis in most dogs following a single-dose. When a single dose was not sufficient, an additional dosage effectively induced emesis. Overall, adverse effects were considered low and self-limiting.

著者

Ken Okumura Hiroshi Inoue Hirotsugu Atarashi Takeshi Yamashita Hirofumi Tomita Hideki Origasa for the J-RHYTHM Registry Investigators.

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.78, no.7, pp.1593-1599, 2014 (Released:2014-06-25)

参考文献数

21

被引用文献数

32 83

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Background: Recent European guidelines recommended the CHA2DS2-VASc score for thromboembolic and the HAS-BLED score for bleeding risk stratifications. We validated these scores in 7,384 Japanese patients with nonvalvular atrial fibrillation (NVAF) enrolled in the J-RHYTHM Registry. Methods and Results: Of the study cohort, 6,387 patients taking warfarin and the other 997 not taking warfarin were prospectively examined for 2 years. Thromboembolic and major bleeding risks were stratified by modified CHA2DS2-VASc (mCHA2DS2-VASc) and HAS-BLED (mHAS-BLED) scores, respectively. Of the patients with mCHA2DS2-VASc score 0, 1, and ≥2, thromboembolism occurred in 2/141 (0.7%/year), 4/233 (0.9%/year), and 24/623 (1.9%/year), respectively, in the non-warfarin group, and in 1/346 (0.1%/year, P=0.19 vs. non-warfarin), 4/912 (0.2%/year, P=0.05), and 92/5,129 (0.9%/year, P=0.0005), respectively, in the warfarin group. When female sex was excluded from the score, thromboembolism occurred in 2/180 patients (0.6%/year), 5/245 (1.0%/year), and 23/572 (1.6%/year), respectively, in the non-warfarin group, and in 1/422 (0.1%/year, P=0.20 vs. non-warfarin), 5/1,096 (0.2%/year, P=0.02), and 91/4,869 (0.9%/year, P=0.0005), respectively, in the warfarin group. Patients with mHAS-BLED scores ≥3 were at high risk for major bleeding irrespective of warfarin treatment (1.3 and 2.6%/year in the non-warfarin and warfarin groups, respectively). Conclusions: In Japanese NVAF patients, the mCHA2DS2-VASc score is useful for identifying patients at truly low risk of thromboembolism. Female sex may be excluded as a risk from the score. mHAS-BLED score ≥3 is useful for identifying patients at high risk of major bleeding.  (Circ J 2014; 78: 1593–1599)

著者

Hisashi Ogawa Yasuhiro Hamatani Kosuke Doi Yuji Tezuka Yoshimori An Mitsuru Ishii Moritake Iguchi Nobutoyo Masunaga Masahiro Esato Yeong-Hwa Chun Hikari Tsuji Hiromichi Wada Koji Hasegawa Mitsuru Abe Gregory YH Lip Masaharu Akao on behalf of the Fushimi AF Registry Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.10, pp.1403-1410, 2017-09-25 (Released:2017-09-25)

参考文献数

33

被引用文献数

14

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Background:Female sex is considered a risk factor for thromboembolism in patients with atrial fibrillation (AF), and is included in the risk stratification scheme, CHA2DS2-VASc score. The purpose of the present study was to investigate the clinical outcomes of female Japanese AF patients.Methods and Results:The Fushimi AF Registry is a community-based prospective survey of the AF patients in Fushimi-ku, Kyoto. Follow-up data were available for 3,878 patients. Female AF patients (n=1,551, 40.0%) were older (77.0 vs. 71.4 years; P<0.001) than male patients (n=2,327, 60.0%). Female patients were more likely to have heart failure (31.1% vs. 23.7%; P<0.001). Previous stroke incidence (19.2% vs. 21.4%; P=0.083) was comparable between male and female patients. During the median follow-up period of 1,102 days, Cox regression analysis demonstrated that female sex was not independently associated with a risk of stroke or systemic embolism (adjusted hazard ratio [HR] 0.74; 95% confidence interval [CI]: 0.54–1.00, P=0.051). However, female sex showed an association with a lower risk of intracranial hemorrhage (adjusted HR 0.54; 95% CI: 0.30–0.95, P=0.032) and all-cause death (adjusted HR 0.56; 95% CI: 0.46–0.68, P<0.001).Conclusions:We demonstrated that female sex is not independently associated with an increased risk of thromboembolism, but is associated with a decreased risk of intracranial hemorrhage and all-cause death in Japanese AF patients enrolled in the Fushimi AF Registry.

著者

Jung-Hyun Choi

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.9, pp.1514-1517, 2017 (Released:2017-09-15)

参考文献数

19

被引用文献数

6

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[Purpose] This study aimed to evaluate the effects of taping and hot packs on premenstrual syndrome, in an attempt to generate basic data for physical therapy intervention for premenstrual syndrome. [Subjects and Methods] Thirty-two females in their 20s with premenstrual syndrome were randomly assigned to a taping group (n=10), hot pack group (n=11), and taping with hot pack group (n=11). Premenstrual syndrome was assessed using the Menstrual Distress Questionnaire in each participant prior to intervention and was re-assessed after applying kinesio taping and/or hot pack from 10 days before the estimated date of menstruation until the first day of menstruation. [Results] Data revealed that the taping and taping with hot pack groups showed significantly reduced premenstrual syndrome following intervention. In terms of the differences in the Menstrual Distress Questionnaire total score among the groups, the taping with hot pack and hot pack groups showed a significant difference. [Conclusion] These findings indicate that kinesio taping is an easy, non-drug intervention for female college students with premenstrual syndrome.

著者

Thanda Aye Tsugumi Kuramoto-Ahuja Heonsoo Han Hitoshi Maruyama

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.9, pp.1518-1521, 2017 (Released:2017-09-15)

参考文献数

29

被引用文献数

2

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[Purpose] The aim of this study was to compare immediate effects between new medical stretching (NMS) and conventional medical stretching (CMS) techniques on Hamstrings flexibility. [Subjects and Methods] Thirteen healthy adult males, with finger floor distance (FFD) less than zero centimeter, without known musculoskeletal and neurological impairment in spine or lower extremities, were included. The subjects were randomly allocated to two groups. The subjects were instructed to perform NMS and CMS (hold for 30 seconds once, twice for each side of lower extremity) for both sides (total two minutes, only one session for one day). The interval between the two techniques was one week. FFD was measured with digital standing trunk flexion meter at the pre-intervention and post-intervention of both techniques. [Results] The mean values of FFD improved at the post-interventions of both techniques. The tests of within subject effects indicated that the main effect of treatment was not significant but the main effect of time was significant and the interaction of treatment and time was also significant. [Conclusion] The results of this study indicated that both medical stretching techniques were effective on Hamstrings flexibility immediately after the intervention and NMS technique was more effective on improving flexibility.

著者

マ-トン ロバ-ト・K. 中野 正大

出版者

京都工芸繊維大学工芸学部

雑誌

京都工芸繊維大学工芸学部研究報告 人文 (ISSN:03895076)

巻号頁・発行日

no.43, pp.p93-103, 1994

著者

Léo Cuenin Sophie Lamoureux Mathieu Schaaf Thomas Bochaton Jean-Pierre Monassier Marc J. Claeys Gilles Rioufol Gérard Finet David Garcia-Dorado Denis Angoulvant Meyer Elbaz Nicolas Delarche Pierre Coste Marc Metge Thibault Perret Pascal Motreff Eric Bonnefoy-Cudraz Gérald Vanzetto Olivier Morel Inesse Boussaha Michel Ovize Nathan Mewton

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0671, (Released:2017-09-23)

参考文献数

38

被引用文献数

8

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Background:Up to 25% of patients with ST elevation myocardial infarction (STEMI) have ST segment re-elevation after initial regression post-reperfusion and there are few data regarding its prognostic significance.Methods and Results:A standard 12-lead electrocardiogram (ECG) was recorded in 662 patients with anterior STEMI referred for primary percutaneous coronary intervention (PPCI). ECGs were recorded 60–90 min after PPCI and at discharge. ST segment re-elevation was defined as a ≥0.1-mV increase in STMax between the post-PPCI and discharge ECGs. Infarct size (assessed as creatine kinase [CK] peak), echocardiography at baseline and follow-up, and all-cause death and heart failure events at 1 year were assessed. In all, 128 patients (19%) had ST segment re-elevation. There was no difference between patients with and without re-elevation in infarct size (CK peak [mean±SD] 4,231±2,656 vs. 3,993±2,819 IU/L; P=0.402), left ventricular (LV) ejection fraction (50.7±11.6% vs. 52.2±10.8%; P=0.186), LV adverse remodeling (20.1±38.9% vs. 18.3±30.9%; P=0.631), or all-cause mortality and heart failure events (22 [19.8%] vs. 106 [19.2%]; P=0.887) at 1 year.Conclusions:Among anterior STEMI patients treated by PPCI, ST segment re-elevation was present in 19% and was not associated with increased infarct size or major adverse events at 1 year.

著者

Kim Hyun-tae Kim Tae-woo Hong Won-hwa Tanabe Shin-ichi

出版者

日本建築学会、大韓建築学会、中国建築学会

雑誌

Journal of Asian Architecture and Building Engineering (ISSN:13467581)

巻号頁・発行日

vol.16, no.3, pp.633-639, 2017-09-15 (Released:2017-09-15)

参考文献数

45

被引用文献数

6

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The authors evaluate indoor air quality in apartments built according to the South Korean Clean-Healthy House construction standard. The evaluation includes three types of residential units with differing gross floor areas. Indoor air was analyzed for formaldehyde (observed range 52.0–99.2 ug/m3), acetaldehyde (14.6–61.0 ug/m3), benzene (0.6–1.3 ug/m3), toluene (161.8–371.0 ug/m3) ethylbenzene (6.5–17.0 ug/m3), xylene (14.7–45.0 ug/m3), and styrene (37.7–112.5 ug/m3). The concentrations of all analyzed substances were within the South Korean guidelines. The findings confirm that the Clean-Healthy Homes initiative has led to a greatly improved indoor air environment compared to existing newly built apartment blocks in South Korea. However, this construction standard is applied only to large apartment developments comprising 1,000 or more units, and it seems that further effort should be made to extend the standard to stand-alone residences and small-scale apartment blocks in order to ensure that indoor air quality is maintained more widely.

著者

Kim Hyun-tae Tanabe Shin-ichi

出版者

日本建築学会、大韓建築学会、中国建築学会

雑誌

Journal of Asian Architecture and Building Engineering (ISSN:13467581)

巻号頁・発行日

vol.16, no.3, pp.661-668, 2017-09-15 (Released:2017-09-15)

参考文献数

56

被引用文献数

1

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PVC floor material is widely used in Korean homes, and people customarily sit or lie on the floor surface. This could potentially put residents of such homes at high risk of exposure to semi-volatile organic compounds (SVOCs). However, there is a current lack of information regarding the degree of SVOC contamination in Korean homes. Therefore, this study was implemented to measure SVOC concentration in the air and house dust in homes and kindergartens, places where children spend long periods of time. The substances analyzed were 2E1H, D6, DEP, TBP, TCEP, DBP, TPP, DOA, and DEHP. Amounts of 2E1H, D6, DEP, DBP, and DEHP were detected in the air of the homes included in the study, and the average air concentrations of DBP and DEHP were 0.53 μg/m3 and 0.28 μg/m3, respectively. The average dust DEHP concentrations in the rooms of homes and kindergartens were 2,800 μg/g and 4,350 μg/g, respectively, showing that higher values were measured in kindergartens. The measured DEHP concentrations in the dust of both homes and kindergartens where PVC floor materials are used were high.

著者

CHEN Siyu OGURA Shin-ichiro

出版者

Field Science Center, Graduate School of Agricultural Science, Tohoku University

雑誌

Journal of Integrated Field Science

巻号頁・発行日

vol.14, pp.55-59, 2017-03

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Symposium mini review

著者

Ángel SOTO-BUSTOS Alicia CARO-VADILLO Elena MARTÍNEZ-DE-MERLO Elisa González ALONSO-ALEGRE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0049, (Released:2017-08-28)

被引用文献数

5

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The purpose of this research was to compare the accuracy of newly described P wave-related parameters (P wave area, Macrux index and mean electrical axis) with classical P wave-related parameters (voltage and duration of P wave) for the assessment of left atrial (LA) size in dogs with degenerative mitral valve disease. One hundred forty-six dogs (37 healthy control dogs and 109 dogs with degenerative mitral valve disease) were prospectively studied. Two-dimensional echocardiography examinations and a 6-lead ECG were performed prospectively in all dogs. Echocardiography parameters, including determination of the ratios LA diameter/aortic root diameter and LA area/aortic root area, were compared to P wave-related parameters: P wave area, Macrux index, mean electrical axis voltage and duration of P wave. The results showed that P wave-related parameters (classical and newly described) had low sensitivity (range=52.3% to 77%; median=60%) and low to moderate specificity (range=47.2% to 82.5%; median 56.3%) for the prediction of left atrial enlargement. The areas under the curve of P wave-related parameters were moderate to low due to poor sensitivity. In conclusion, newly P wave-related parameters do not increase the diagnostic capacity of ECG as a predictor of left atrial enlargement in dogs with degenerative mitral valve disease.

著者

Yumi YUASA Yi-Lun TSAI Chao-Chin CHANG Tien-Huan HSU Chi-Chung CHOU

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0224, (Released:2017-08-06)

被引用文献数

19

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Canine anaplasmosis is regarded as an infection by Anaplasma platys rather than zoonotic Anaplasma phagocytophilum in subtropical areas based on the assumption that the common dog tick species is Rhipicephalus sanguineus, which transmits E. canis and presumably A. platys. We investigated asymptomatic dogs and dog ticks from 16 communities in Nantou County, Taiwan to identify common dog tick species and to determine the prevalence of Anaplasma and Ehrlichia spp. Of total 175 canine blood samples and 315 ticks, including 306 R. sanguineus and 9 Haemaphysalis hystricis, 15 dogs and 3 R. sanguineus ticks were positive for E. canis, while 47 dogs and 71 R. sanguineus ticks were positive for A. platys, via nested PCR for 16S rDNA and DNA sequencing of selected positive amplicons. However, among the dogs and ticks that were positive to A. platys 16S rDNA, only 20 dogs and 11 ticks were positive to nested PCR for A. platys groEL gene. These results revealed the importance of searching for novel Anaplasma spp. closely related to A. platys in dogs and ticks. Seropositivity to a commercial immunochromatographic test SNAP 4Dx Anaplasma sp. was not significantly associated with PCR positivity for A. platys but with infestation by ticks carrying A. platys (P<0.05). Accordingly, R. sanguineus may be involved in transmission of A. platys but may not act as a reservoir of E. canis and PCR results for 16S rDNA could be a problematic diagnostic index for A. platys infection.

著者

蔡 龍保 サイ リュウホ Lung-Pao Tsai

出版者

立教大学経済学研究会

雑誌

立教経済学研究 (ISSN:00355356)

巻号頁・発行日

vol.69, no.5, pp.1-24, 2016-03

著者

Hans-Rudolf Weiss

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.12, pp.3483-3486, 2016 (Released:2016-12-27)

参考文献数

25

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[Purpose] Untreated early-onset scoliosis may eventually progress to more than 90° after growth, cause severe health problems, and increase chance of mortality. Therefore, surgical intervention is often indicated prior to the development of a life-threatening deformity. This case report aims to reveal how a 76-year-old male patient with curves exceeding 110° is functioning with minimal difficulty. [Subject and Methods] The patient, who has never had surgical intervention for scoliosis, can perform his everyday activities. His curves were 111° thoracic and 118° lumbar when he presented at the author’s office in January 2015. [Results] The patient reported that he rarely needs a physician and participates in endurance sports like jogging. Despite this, the patient recognizes his restrictive ventilation disorder (shortness of breath) when he is inactive. The patient complained of shortness of breath and cosmetic concerns. [Conclusion] The current guidelines indicate that early-onset scoliosis should be operated at a young age; however, this protocol is not supported by high-quality evidence. Notably, patients with curvatures exceeding 100° after puberty may have a reasonable quality of life when they lead an active life with regular participation in endurance sports and physical rehabilitation.

著者

Hirohisa Takano Ken-ichiro Inoue

出版者

日本毒性病理学会

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.30, no.3, pp.193-199, 2017 (Released:2017-07-20)

参考文献数

14

被引用文献数

28

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Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies. For example, diesel exhaust particles (DEPs), which are an agglomeration of particles and a wide array of chemical substances, aggravate asthma, primarily due to the principle organic chemical components of DEPs. In addition, environmental chemicals such as phthalate esters, which are commonly used as plasticizers in plastic products, also aggravate atopic dermatitis. It has also become evident that extremely small nanomaterials and Asian sand dust particles can enhance allergic inflammation. While the underlying mechanisms that cause such aggravation are becoming clearer at the cellular and molecular levels, methods to easily and quickly evaluate (screen) the ever-increasing amount of environmental pollutants for exacerbating effects on allergies are also under development. To eliminate and control allergic diseases, medical measures are necessary, but it is also essential to tackle this issue by ameliorating environmental changes.

著者

KIM Kyoo-Tae LEE Seung-Hun KWAK Dongmi

出版者

公益社団法人 日本獣医学会

雑誌

The Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.78, no.11, pp.1723-1726, 2016

被引用文献数

5

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<p>A 4-year-old female Siamese crocodile (<i>Crocodylus siamensis</i>) housed at a zoo died without any prior clinical signs. During necropsy, numerous scattered, well-demarcated, yellowish-white, firm nodules were observed throughout the liver and lungs. Microscopic examination with periodic acid-Schiff staining revealed granulomatous inflammation in the liver and lungs. Liver granulomas were characterized by the presence of a connective tissue barrier and hyphae, and the centers of the granulomas showed signs of necrosis. Lung samples showed characteristics similar to those observed in the liver samples. The fungus was identified as <i>Aspergillus fumigatus</i> based on its appearance on Sabouraud dextrose agar, microscopic examination with lactophenol cotton blue staining and genetic sequencing. Therefore, zoo veterinarians should pay close attention to fungal infections in captive animals.</p>

著者

黄 毓倫 HUANG Yu-Lun

出版者

お茶の水女子大学比較日本学教育研究センター

雑誌

お茶の水女子大学比較日本学教育研究センター研究年報

巻号頁・発行日

no.13, pp.60-66, 2017-03

著者

Kenichiro Sato Noritoshi Arai Aki Omori-Mitsue Ayumi Hida Akio Kimura Sousuke Takeuchi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.8394-16, (Released:2017-08-01)

参考文献数

18

被引用文献数

5

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Objective To identify the prehospital factors predicting the performance of tracheal intubation (TI) at the emergency department (ED) in patients with convulsive seizure or epilepsy. Methods We performed a retrospective analysis of seizure patients who underwent TI at the ED soon after arrival. The clinical variables obtained in the prehospital setting were reviewed. Patients The study population included consecutive adult patients who were transported to an urban tertiary care ED due to convulsive seizure between August 2010 and September 2015. Results Among the 822 eligible patients, 59 patients (7.2%) underwent TI at the ED. Four independent prehospital predictors were identified using multivariate analysis: age ≥50 years (+1 point), meeting the definition of convulsive status epilepticus (+4 points), and an on-scene heart rate of ≥120 bpm (+1 point) led to a higher likelihood of TI, while a higher on-scene (alert or confused) level of consciousness (-3 points) led to a lower likelihood of TI. The derived prediction rule (the sum of all points) had good predictive performance with an area under the curve of 0.88 (95% confidence interval: 0.79-0.97), a sensitivity of 0.62, a specificity of 0.91, and a positive likelihood ratio of 10.6, when the cut-off value was set to 5 points. Conclusion We constructed a simple prehospital prediction rule to help predict the need for TI in seizure patients, even in the prehospital phase. This may possibly lead to the more effective management of seizure patients in the ED.

著者

早坂 大亮 鈴木 一隆 是永 知子 諸岡(斎藤) 歩希 野村 拓志 深澤 圭太 Francisco Sánchez-Bayo 五箇 公一

出版者

日本農薬学会

雑誌

日本農薬学会誌 (ISSN:21870365)

巻号頁・発行日

vol.38, no.2, pp.101-107, 2013-08-20 (Released:2014-03-01)

参考文献数

36

被引用文献数

6 10

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The effects of two successive annual treatments of imidacloprid and fipronil on dragonfly nymph communities, which are one of the best-known bioindicators in Japanese agroecosystems, were monitored in experimental paddies. The abundance of dragonfly nymphs was lower in both insecticides-treated fields than it was in the controls, particularly following fipronil treatments. Residues of both insecticides were found in the soil throughout the two years, and imidacloprid persisted in water up to three months following each treatment. A Principal Response Curve analysis (PRC) showed that the second annual treatments caused greater structural changes in dragonfly nymph communities than the initial treatments caused, particularly for fipronil. The community structures continued to change even after the insecticides dissipated from the water. This suggests that ecological impacts, and therefore risks, of imidacloprid and fipronil on dragonfly nymph communities depend more on soil residues than they do on waterborne residues. As expected, susceptibility of dragonfly nymphs to these two insecticides differed among species.

著者

TSENG Fu-Min PETRIE Dennis LEON-GONZALEZ Roberto

出版者

GRIPS Policy Research Center

雑誌

GRIPS Discussion Papers

巻号頁・発行日

vol.14, 2014-09

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経済学 / EconomicsBereavement is a grieved and inevitable event in our life. For an aging society, the incidence of spousal bereavement and parental bereavement is higher than the other kinds of bereavement events. This study employs the difference-in-differences (DiD) strategy and the Taiwanese panel Survey of Health and Living Status of the Elderly (SHLSE) to evaluate the impact of losing a spouse on well-being measured by self-assessed health status, depression, and life satisfaction.The results show that spousal bereavement causes substantial depression and loss in life satisfaction. The spousal bereavement impact increases depression by 1.46 CES-D points and reduces life satisfaction by 0.71 points. The decay effect of time is not observed in this study. We also examine the demographic differences of the spousal bereavement impact and find that the gap in life satisfaction between the bereaved who received more than 9 years education and the bereaved who received 9 years or less is 1.43 points, which implies that spousal bereavement causes less impact on more educated people in terms of life satisfaction. The increase in depression for the bereaved in a larger household is smaller than that for those in a small household by 2.75 CES-D points but it is weakly significant.The self-reported health outcomes are the intermediate outcomes between spousal bereavement and societal costs such as healthcare utilisation and death. The association between self-reported health status and mortality and health utilization has been well documented by literature. Thus, our results also provide the policy insight that giving proper interventions on the onset of bereavement may cause less societal costs afterwards.http://www.grips.ac.jp/list/jp/facultyinfo/leon_gonzalez_roberto/