著者

ビジネスプロセス・アーキテクト(BPA-P)協会「プロジェクトのつぶやき」研究チーム

出版者

日経BP社

雑誌

日経コンピュータ (ISSN:02854619)

巻号頁・発行日

no.842, pp.92-95, 2013-09-05

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A部員:「ベテランだから西田くんをサポートしてほしい」と言われ、プロジェクトに参加しました。でも、私は営業のことは全く知りませんし、扱っていたのはずっとオフコンです。今回のようなWebシステムの開発は初めてでした。

著者

Oscar Rodrigo SIERRA MATIZ Rafaela Bortolotti VIERA Paulo Cesar JARK Denner SANTOS DOS ANJOS Julio Edward Hough MONTEIRO Andresa MATSUI Rosemeri de Oliveira VASCONCELOS Felipe Ruiz SUEIRO Sabryna Gouveia CALAZANS Mirela TINUCCI-COSTA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0594, (Released:2019-06-04)

被引用文献数

2

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A 10-year-old American Pit Bull dog was diagnosed with a metastatic undifferentiated carcinoma in scapula. Immunohistochemistry was positive for cytokeratins (AE1/AE3, 34BE12, CK7) and Vimentine confirming a squamous cell carcinoma. After a complete physical examination and imaging techniques no evidence of nodules were identified. A carcinoma of unknown primary was diagnosed. Amputation and adjuvant chemotherapy using doxorubicin and piroxicam were performed and after 737 days of diagnosis, patient died because of respiratory failure. Necropsy confirmed undifferentiated carcinoma infiltrating lungs and kidneys, showing same immunoexpression than tumor in scapula. Amputation associated with chemotherapy extended the overall survival time in this case.

著者

Mei-Ling Chen Jung-Lun Wu Michael Yu-Chih Chen Tsung-Cheng Hsieh

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-1304, (Released:2019-04-23)

参考文献数

32

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Background:Data on clinical outcome after drug-eluting stent (DES) vs. bare-metal stent (BMS) implantation in patients with end-stage renal disease (ESRD) under hemodialysis are limited and controversial.Methods and Results:We identified 4,970 patients under chronic hemodialysis from Taiwan National Health Insurance Research Database (NHIRD) who had their first coronary stenting between 1 January 2007 and 31 December 2012. After 1:1 propensity score matching, we evaluated clinical outcomes for 1,151 patients in the DES group and 1,151 patients in the matched BMS group. We used ICD-9 CM codes or operation code to identify all outcomes in the study cohort after the index procedure. Primary outcomes including composite endpoints of mortality, non-fatal myocardial infarction (MI), non-fatal stroke, and revascularization after the index procedure were similar in both groups (HR, 0.94; 95% CI: 0.81–1.09; P=0.399). The results were consistent in various generations of DES vs. BMS groups. Secondary outcomes including mortality, non-fatal MI, non-fatal stroke, revascularization, cardiovascular death, hospitalization for heart failure, peptic ulcer bleeding or blood transfusion were similar in both groups, except for a lower risk of peptic ulcer disease in the DES group (HR, 0.59; 95% CI: 0.41–0.83; P=0.003) than the BMS group.Conclusions:In patients on chronic hemodialysis, implantation of DES did not have a better clinical outcome than BMS.

著者

宋 江宁 SONG Jiang-ning 宋 江寧

出版者

岩手大学平泉文化研究センター

雑誌

岩手大学平泉文化研究センター年報 = Hiraizumi studies (ISSN:21877904)

巻号頁・発行日

vol.7, pp.21-28, 2019-03-29

著者

岡崎 祐一 Castaneda-Casas Jose Manuel Ortega-Zeifert Michel

出版者

公益社団法人 精密工学会

雑誌

精密工学会学術講演会講演論文集

巻号頁・発行日

vol.2006, pp.227-228, 2006

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メカトロニクス研修の課題として,卓上型数値制御工作機械の開発を与え,加工機の機構設計,制御機器設計および数値制御ソフトウェアの開発を行った.既製モジュールを活用し,ユニークな直交3軸の加工機を試作した.モーションコントローラを用い,LabVIEWにて開発したGコードコンパチブルの数値制御装置は,マニュアル,MDI,プログラム実行,編集などの各モードを備える.特定のマイクロ形状を加工するプログラムも付加的に開発できた.小径ボールエンドミルを用い,高硬度アルミニウム合金やプリハードン鋼へも微細加工ができた.

著者

Kei Segawa Miki Watanabe-Matsui Toshitaka Matsui Kazuhiko Igarashi Kazutaka Murayama

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.247, no.3, pp.153-159, 2019 (Released:2019-03-09)

参考文献数

30

被引用文献数

8

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Heme is one of the key factors involved in the oxidative stress response of cells. The transcriptional repressor Bach1 plays an important role in this response through its heme-binding activity. Heme inhibits the transcriptional-repressor activity of Bach1, and can occur in two binding modes: 5- and 6-coordinated binding. The Cys-Pro (CP) motif has been determined to be the heme-binding motif of Bach family proteins. The sequence of Bach1 includes six CP motifs, and four CP motifs are functional. With the aim of elucidating the molecular mechanism of heme-Bach1 regulation, we conducted biophysical analyses focusing on the C-terminal region of mouse Bach1 (residues 631-739) which is located after the bZip domain and includes one functional CP motif. UV-Vis spectroscopy indicated that the CP motif binds heme via 5-coordinated bond. A mutant, which included a cysteine to alanine substitution at the CP motif, did not show 5-coordination, suggesting that this binding mode is specific to the CP motif. Surface plasmon resonance revealed that the binding affinity and stoichiometry of heme with the Bach1 C-terminal region were KD = 1.37 × 10–5 M and 2.3, respectively. The circular dichroism spectrum in the near-UV region exhibited peaks for heme binding to the CP motif. No significant spectral shifts were observed in the far-UV region when samples with and without heme were compared. Therefore, disordered-ordered transition such as “coupled folding and binding” is not involved in the Bach1-heme system. Consequently, the heme response of this C-terminal region is accomplished by disorder-disorder conformational alteration.

著者

Chatterjee U. Shi M. Kaminski A. Kanigel A. Fretwell H. M. Terashima K. Takahashi T. Rosenkranz S. Li Z. Z. Raffy H. Santander-Syro A. Kadowaki K. Norman M. R. Randeria M. Campuzano J. C.

出版者

American Physical Society

雑誌

Physical review letters (ISSN:00319007)

巻号頁・発行日

vol.96, no.10, pp.107006, 2006-03

被引用文献数

74

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The autocorrelation of angle resolved photoemission data from the high temperature superconductor Bi2Sr2CaCu2O8+delta shows distinct peaks in momentum space which disperse with binding energy in the superconducting state, but not in the pseudogap phase. Although it is tempting to attribute a nondispersive behavior in momentum space to charge ordering, a deconstruction of the autocorrelation reveals that the nondispersive peaks arise from the tips of the Fermi arcs, which themselves do not change with binding energy.

著者

Camilo Barrios-Perez 岡田 謙介 Gabriel Garces-Varon

出版者

日本作物学会

雑誌

日本作物学会講演会要旨集 第247回日本作物学会講演会

巻号頁・発行日

pp.74, 2019 (Released:2019-03-26)

著者

SHINOBU ODA SEIYA NOMURA MANAMI NAKAGAWA KAZUO SHIN-YA NORITAKA KAGAYA TEPPEI KAWAHARA

出版者

The Society for Antibacterial and Antifungal Agents, Japan

雑誌

Biocontrol Science (ISSN:13424815)

巻号頁・発行日

vol.24, no.1, pp.47-56, 2019 (Released:2019-03-18)

参考文献数

33

被引用文献数

1

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A useful tool for the screening of fungi producing biologically active secondary metabolites such as antibiotics and cytotoxic substances has been developed. An agar plate-organic solvent interface cultivation (A/S-IFC) system, which comprised a hydrophobic organic solvent (upper phase) , a fungal mat (middle phase) and an agar plate (lower phase) , was constructed. The metabolite profiles were compared among the A/S-IFC, a traditional submerged cultivation (SmC) and an extractive liquid surface immobilization (Ext-LSI) system consisted of a hydrophobic solvent (upper phase) , a fungal cells–ballooned microspheres (middle phase) and a liquid medium (lower phase) , with high-performance liquid chromatography-photodiode array detector (HPLC-PDA) . In the A/S-IFC, many hydrophobic metabolites vastly different from those in the SmC were accumulated in the organic phase as with the Ext-LSI. For example, a valuable azaphilone, sclerotiorin, was remarkably produced into the organic phase in the A/S-IFC. The A/S-IFC was applied to the screening of antibiotic-producing fungi. As a result of paper disk method, it was found that 321 isolated among 811 strains produced antifungal metabolites (hit rate, 39.6%) . Furthermore, 8, 23, and 30 strains also produced cytotoxic metabolites against SKOV-3 (human ovary adenocarcinoma) , MESO-1 (human malignant pleural mesothelioma) , and Jurkat cells (immortalized human T lymphocyte) .

著者

Seoung-Woo LEE Hoon JI Su-Min BAEK A-Rang LEE Min-Ji KIM Sang-Joon PARK Seong-Kyoon CHOI Sungho YUN Tae-Hwan KIM Kyu-Shik JEONG Jin-Kyu PARK

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.2, pp.269-273, 2019 (Released:2019-02-28)

参考文献数

15

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A 2-year-old castrated male mongrel dog presented with a well-demarcated fluctuant dermal mass, located on the back of the neck. Grossly along with cystic structures filled with a black greasy fluid, when cut open. Microscopically, the mass was multi-lobulated. The lobules consisted of neoplastic basaloid cells and showed central degeneration, forming multiple central cystic structures filled with dark melanin-pigmented materials. Immunohistochemically, the neoplastic cells were strongly positive for CK14 and partially positive for CK19, but negative for CK7, CK8/18, CD34, S-100, Melan-A and α-SMA. Based on the findings, the present case was diagnosed as a feline-type basal cell tumor characterized by cystic structures filled with abundant black fluid.

著者

Hajime ASADA Osamu ICHII Hirotaka TOMIYASU Kazuyuki UCHIDA James K. CHAMBERS Yuko GOTO-KOSHINO Koichi OHNO Yasuhiro KON Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.3, pp.353-356, 2019 (Released:2019-03-14)

参考文献数

8

被引用文献数

1

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The mutations of TP53 gene are frequently observed in canine histiocytic sarcoma (HS). The objective of this study was to examine the distribution of tumor cells with TP53 gene mutations. Tumor tissues were divided into three or four regions and TP53 gene mutations were examined. TP53 gene mutations were detected only in parts of the HS tissues from six of the eight dogs, and the frequency of the mutant allele varied (0–65%) among the tumor regions. This study suggests that canine HS can exhibit intratumor heterogeneity. Further studies are needed to examine the clinical significance of the intratumor heterogeneity of TP53 gene mutations.

著者

Shiori GAMO Teruaki TOZAKI Hironaga KAKOI Kei-ichi HIROTA Kotono NAKAMURA Noriko NISHII Julio ALUMUNIA Masaki TAKASU

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.81, no.1, pp.91-94, 2019 (Released:2019-01-08)

参考文献数

15

被引用文献数

4

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A routine parentage test as part of a conservation program for Kiso horses identified a possible sex chromosome anomaly in a 7 months-old filly because of an aberrant result using LEX3, an X-linked marker. We then analyzed X-linked markers (LEX26, TKY38, and TKY270), Y-linked markers (Eca.YH12, Eca.YM2, Eca.YA16, and the sex-determining region Y gene), and an X/Y marker (Amelogenin gene). This analysis demonstrated that the filly had not inherited an X chromosome from her sire. A karyotyping analysis confirmed that the filly was 63,XO. As it was suspected that the horse would be sterile, we avoided using the horse as a broodmare; the information should also serve to prevent unnecessary conflict between owners transferring and receiving the horse.

著者

Morris-Suzuki Tessa 伊藤 茂

出版者

前夜

雑誌

前夜 第1期

巻号頁・発行日

no.3, pp.61-76, 2005-04

著者

Ibn al-Sāʿī edited by Shawkat M. Toorawa translated by the editors of the Library of Arabic literature introduction by Julia Bray foreword by Marina Warner volume editor Julia Bray

出版者

New York University Press

巻号頁・発行日

2015

著者

Karl Jansen-Winkeln

出版者

Harrassowitz

巻号頁・発行日

1996

著者

Hideki Nagase Kei-ichi Enjyoji Midori Shima Kenji Kitazato Akira Yoshioka Hidehiko Saito Hisao Kato

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.119, no.1, pp.63-69, 1996 (Released:2008-11-18)

参考文献数

37

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Our previous study has shown that depolymerized holothurian glycosaminoglycan (DHG) has two different inhibitory activities in the blood coagulation cascade: heparin cofactor II-dependent thrombin inhibition; and antithrombin III- and heparin cofactor II-independent inhibition of the intrinsic factor Xase complex [Nagase et al. (1995) Blood 85, 1527-1534]. In the present study, the effect of DHG on the activation of factor VIII and factor V by thrombin was examined with purified human components. DHG inhibited the activation of factor VIII by thrombin at concentrations exceeding 80nM, but not the activation of factor V by thrombin at concentrations of up to 8μM. On Western blot analysis, DHG inhibited the cleavage of factor VIII light chain at concentrations exceeding 0.8μM. The interaction between DHG and factors VIII and V and thrombin was examined with a DHG-cellulofine column. DHG had strong affinity for factor V and thrombin, but slight affinity for factor VIII. The interaction of DHG with thrombin was analyzed, using fluorescein isothiocyanate-labeled DHG. One mole of DHG bound 2mol of thrombin, with a dissociation constant (Kd) of 3.04×10-6M. These results suggest that DHG interferes with the interaction between thrombin and factor VIII, probably by making a binary complex through the anionic binding exosite II of thrombin.

著者

Hiromasa Otake Kosuke Tanimura Yoichiro Sugizaki Takayoshi Toba Hiroyuki Kawamori Toshiro Shinke Ken-ichi Hirata

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.2, pp.107-111, 2019-02-08 (Released:2019-02-08)

参考文献数

21

被引用文献数

2

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Background: Despite evidence of the effects of alirocumab on the incidence of acute coronary events, its impact on plaque stabilization remains uncertain. The present study will investigate the effect of alirocumab on fibroatheroma in patients who underwent recent percutaneous coronary intervention (PCI). Methods and Results: This phase IV, open-label, randomized, blinded near-infrared spectroscopy plus intravascular ultrasound (NIRS-IVUS) analysis, parallel-group, single-center study will enroll Japanese adults recently hospitalized for PCI with suboptimal low-density lipoprotein cholesterol (LDL-C) control (>70 mg/dL) despite stable statin therapy. Thirty patients will be randomized to receive either alirocumab or standard of care. The alirocumab group will receive alirocumab 75 mg every 2 weeks plus 10 mg rosuvastatin per day. The standard-of-care group will receive 10 mg rosuvastatin per day with dose adjustment to achieve LDL-C <70 mg/dL. Post-treatment NIRS-IVUS will be performed at week 36. The primary endpoint is the change in maximum lipid core burden index in 4-mm pullback compartments (maxLCBI[4 mm]) between baseline and week 36. Secondary endpoints include change in LCBI (lesion), angle of lipid core, plaque burden, and serum lipids and biomarkers related to atherosclerosis and inflammation. Conclusions: The study will clarify the effects of alirocumab on thin-cap fibroatheroma in patients who underwent recent PCI and who have suboptimal LDL-C control with stable statin therapy.

著者

Marcelo Martínez-Muñoz Óscar J. Ayala-Garay V. Heber Aguilar-Rincón Víctor Conde-Martínez Tarsicio Corona-Torres

出版者

The Japanese Society for Horticultural Science

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.UTD-044, (Released:2018-12-28)

被引用文献数

3

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This study was conducted to evaluate the influence of fruit maturity and postharvest storage on the physiological qualities of chili seeds during development. Two types of chili were used (ancho and guajillo). Fruits were harvested at 40, 60, 80, 100, 120 and 140 days after anthesis (daa) and stored for 0, 7 and 14 days after harvest (dah). The moisture content of guajillo seeds throughout development decreased from 86 to 17%, while ancho maintained moisture at 47% at 80 dda. It was confirmed that precocious harvest (40 daa) was not beneficial to the physiological quality of chili seeds, even when it was associated with 14 dah. Germinability was correlated with electrical conductivity (R = −0.76): Ancho seeds germinated starting from 472.5 μS·cm−1·g−1 and guajillo seeds from 679.3 μS·cm−1·g−1. In fruits harvested 80 daa, 14 dah was essential to ensure the physiological quality of seeds in both types of chilies: mean germination was above 93%, and seed vigor was higher (germination after accelerated aging and mean germination speed were more than 90% and 5.6 radicle d−1, respectively). Seeds harvested 120 daa were of high quality, and post-harvest storage of fruits was not necessary. Expression of two late embryogenesis abundant (LEA) proteins was detected in both types of chilies: the first synthesis (65 kDa) occurred 80 daa, and the second (50 kDa) occurred 120 daa and this was directly related to the maximal physiological quality of chili seeds.

著者

Mayumi Tsuji Chihaya Koriyama Yasuhiro Ishihara Megumi Yamamoto Kiwako Yamamoto-Hanada Kumiko Kanatani Yu Ait Bamai Kazunari Onishi Ayako Senju Shunsuke Araki Eiji Shibata Seiichi Morokuma Masafumi Sanefuji Hiroshi Kitazawa Mayako Saito Masakazu Umezawa Atsuto Onoda Koichi Kusuhara Rie Tanaka Toshihiro Kawamoto the Japan Environment & Children’s Study Group

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20180098, (Released:2019-01-12)

参考文献数

54

被引用文献数

7

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Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children’s Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.

著者

KAJINO Mizuo DEUSHI Makoto SEKIYAMA Tsuyoshi Thomas OSHIMA Naga YUMIMOTO Keiya TANAKA Taichu Yasumichi CHING Joseph HASHIMOTO Akihiro YAMAMOTO Tetsuya IKEGAMI Masaaki KAMADA Akane MIYASHITA Makoto INOMATA Yayoi SHIMA Shin-ichiro TAKAMI Akinori SHIMIZU Atsushi HATAKEYAMA Shiro SADANAGA Yasuhiro IRIE Hitoshi ADACHI Kouji ZAIZEN Yuji IGARASHI Yasuhito UEDA Hiromasa MAKI Takashi MIKAMI Masao

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2019-020, (Released:2018-12-09)

被引用文献数

36

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Model performance of a regional-scale meteorology – chemistry model (NHM-Chem) has been evaluated for the consistent predictions of the chemical, physical, and optical properties of aerosols. These properties are essentially important for the accurate assessment of air quality and health hazards, contamination of land and ocean ecosystems, and regional climate changes due to aerosol-cloud-radiation interaction processes. Currently, three optional methods are available: the 5-category non-equilibrium, 3-category non-equilibrium, and bulk equilibrium methods. These three methods are suitable for the predictions of regional climate, air quality, and operational forecasts, respectively. In this paper, the simulated aerosol chemical, physical, and optical properties and their consistency were evaluated by using various observation data in East Asia. The simulated mass, size, and deposition of SO42- and NH4+ agreed well with the observations, whereas those of NO3-, sea-salt, and dust needed improvement. The simulated surface mass concentration (PM10 and PM2.5) and spherical extinction coefficient agreed well with the observations. The simulated aerosol optical thickness and dust extinction coefficient were significantly underestimated.