著者

LOVICH JEFFREY E. PUFFER SHELLIE R. AGHA MICKEY ENNEN JOSHUA R. MEYER-WILKINS KATHIE TENNANT LAURA A. SMITH AMANDA L. ARUNDEL TERENCE R. BRUNDIGE KATHLEEN D. VAMSTAD MICHAEL S.

出版者

日本爬虫両棲類学会

雑誌

Current herpetology (ISSN:13455834)

巻号頁・発行日

vol.37, no.1, pp.40-57, 2018

被引用文献数

3

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<p>Agassiz's desert tortoise (<i>Gopherus agassizii</i>) reaches the southern edge of its range in the Sonoran Desert of California. The reproductive ecology of this wide-ranging species is understudied here compared to populations in the adjacent Mojave Desert. Understanding potential geographic variation in reproductive ecology is important for effective management of conservation-reliant species like <i>G. agassizii</i>. We studied the fecundity and clutch phenology of female <i>G. agassizii</i> at two study sites in the Sonoran Desert region of Joshua Tree National Park over five years (1997–1999–2015–2016) spanning two of the strongest El Niño events on record and an epic drought. Across all years, mean clutch size was 4.3±1.5 eggs, mean clutch frequency was 1.78 clutches/female/year, and mean X-ray egg width was 36.51±1.56 mm, all of which are comparable to other published studies both in the Sonoran and Mojave deserts of California. Our results generally support earlier published findings that <i>G. agassizii</i> utilize a bet-hedging strategy of consistently producing small clutches almost every year, even during times of low annual primary productivity. A regionally warmer climate in the Sonoran Desert of California appears to have an effect on the timing of egg production, as the earliest dates of egg visibility in our study (April 6) were approximately two weeks earlier than the earliest dates reported for <i>G. agassizii</i> in the Mojave Desert. Shelled eggs were no longer visible in tortoises after mid-June in all years but the El Niño year 1998, when eggs were visible until mid-July.</p>

著者

Shinji Koba Makoto Ayaori Harumi Uto-Kondo Fumiaki Furuyama Yuya Yokota Fumiyoshi Tsunoda Makoto Shoji Katsunori Ikewaki Youichi Kobayashi

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.23, no.7, pp.865-877, 2016-07-01 (Released:2016-07-01)

参考文献数

42

被引用文献数

2 22

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Aim: Recent studies reported that low high-density lipoprotein (HDL)-mediated cholesterol efflux capacity rather than low HDL cholesterol (HDL-C) is strongly associated with the increased risk for coronary artery disease. It remains unclear whether exercised-based cardiac rehabilitation (CR) can increase HDL cholesterol efflux capacity.Method: This study is a retrospective analysis of stored serum from patients with acute coronary syndrome (ACS) who participated in outpatient CR program following successful percutaneous coronary intervention. We employed a cell-based cholesterol efflux system including the incubation of 3H-cholesterol labeled macrophages with apolipoprotein B-depleted serum at the onset or early phase of ACS and at 6-month follow-up periods in 57 male and 11 female patients with ACS. Cardiopulmonary exercise tests were performed at the beginning and end of CR program.Result: Fifty-seven patients completed the CR program. Compared with patients who dropped out from CR program (non-CR group), CR participants showed marked amelioration in serum lipid levels, increased efflux capacity, and improved exercise capacity. Spearman's rank correlation coefficient analysis revealed that the percent increases of efflux capacity were significantly associated with the percent increases in HDL-C (ρ=0.598, p<0.0001) and apolipoprotein A1 (ρ=0.508, p<0.0001), whereas no association between increases in efflux capacity and increases in cardiopulmonary fitness was observed. Increases in cholesterol efflux capacity were not seen in patients who continued smoking and those who did not achieve all risk factor targets and higher exercise tolerance.Conclusion: CR can markedly increase both HDL-C and HDL cholesterol efflux capacity. These results suggest that CR is a very useful therapy for reverse cholesterol transport and secondary prevention.

著者

Taichi Imaizumi Akira Kumakura Keiko Yamamoto-Shimojima Yumko Ondo

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

Intractable & Rare Diseases Research (ISSN:21863644)

巻号頁・発行日

vol.7, no.4, pp.245-250, 2018-11-30 (Released:2018-12-17)

参考文献数

18

被引用文献数

10

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Because biallelic SZT2 variants have been reported in patients with neurodevelopmental disorders associated with various degrees of developmental delay, intractable seizures, and distinctive features; this condition is recognized as an autosomal recessive disorder. Previously, eleven patients have been reported and most of them have compound heterozygous SZT2 variants, leading to premature termination. In these patients, all reported variants were unique and there were no common pathogenic variants identified. In this study, we identified a paternal uniparental disomy of chromosome 1 in a patient with a neurodevelopmental disorder associated with severe intellectual disability, intractable epilepsy, autistic features, distinctive features, and transient macrocephaly. This resulted in homozygous patterns through chromosome 1. Among the variants in chromosome 1, a rare SZT2 variant, NM_015284.3:c.6553C>T (p.Arg2185Trp), was selected as a powerful candidate variant in this patient. Although the clinical features of this patient are relatively milder than that reported previously, it may be derived from genetic heterogeneity. This is the first report of a homozygous missense SZT2 variant.

著者

Tomomi Kinoshita Shu-ichi Ikeda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.19, pp.2533-2533, 2015 (Released:2015-10-01)

参考文献数

3

著者

Kyu Kim Darae Kim Sang-Eun Lee In Jeong Cho Chi Young Shim Geu-Ru Hong Jong-Won Ha

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0609, (Released:2018-12-15)

参考文献数

22

被引用文献数

12

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Background: Infective endocarditis (IE) in cancer patients is increasing, but because little is known about it in these patients, we analyzed patient characteristics and outcomes and compared these factors in IE patients with and without cancer. Methods and Results: This retrospective cohort study included 170 patients with IE newly diagnosed between January 2011 and December 2015. Among 170 patients, 30 (17.6%) had active cancer. The median age of IE patients with cancer was higher than that of non-cancer patients. Nosocomial IE was more common in cancer patients. Non-dental procedures, such as intravenous catheter insertion and invasive endoscopic or genitourinary procedures, were more frequently performed before IE developed in cancer patients. Staphylococcus was the most common pathogen in cancer patients, whereas Streptococcus was the most common in non-cancer patients. In-hospital mortality was significantly higher in cancer patients with IE (34.4% vs. 12.4%, P<0.001). IE was an important reason for discontinuing antitumor therapy and withholding additional aggressive treatment in nearly all deceased cancer patients. Conclusions: IE is common in cancer patients and is associated with poorer outcomes. Patients with IE and cancer have different clinical characteristics. Additional studies regarding antibiotic prophylaxis before non-dental invasive procedures in cancer patients are needed, as cancer patients are not considered to be at higher risk of IE.

著者

Heerajnarain Bulluck Viviana Maestrini Stefania Rosmini Amna Abdel-Gadir Thomas A Treibel Silvia Castelletti Chiara Bucciarelli-Ducci Charlotte Manisty James C. Moon

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.3, pp.487-494, 2015-02-25 (Released:2015-02-25)

参考文献数

82

被引用文献数

37 65

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Cardiovascular magnetic resonance is a well-established tool for the quantification of focal fibrosis. With the introduction of T1 mapping, diffuse myocardial processes can be detected and quantified. In particular, infiltration and storage disorders with large disease-related changes, and diffuse fibrosis where measurement is harder but the potential impact larger. This has added a new dimension to the understanding and assessment of various myocardial diseases. T1 mapping promises to detect early disease, quantify disease severity and provide prognostic insights into certain conditions. It also has the potential to be a robust surrogate marker in drug development trials to monitor therapeutic response and be a prognostic marker in certain diseases. T1 mapping is an evolving field and numerous factors currently preclude its standardization. In this review, we describe the current status of T1 mapping and its potential promises and pitfalls. (Circ J 2015; 79: 487–494)

著者

Xue-Long Sun

出版者

FCCA(Forum: Carbohydrates Coming of Age)

雑誌

Trends in Glycoscience and Glycotechnology (ISSN:09157352)

巻号頁・発行日

vol.30, no.177, pp.E179-E193, 2018-11-25 (Released:2018-11-25)

参考文献数

90

被引用文献数

1 6

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Glycans (monosaccharides and oligosaccharides) and their conjugates (glycoproteins, glycolipids, and proteoglycans) are structurally diverse biomolecules that are involved in many biological processes of health and disease. The structural diversity of glycans and glycoconjugates is owed to their monosaccharide composition, anomeric state, glycosidic linkage, modification (phosphorylation, sulfation, acetylation, etc.) and aglycone (protein, lipid, etc.). These diverse structures are controlled by complex glycosylation processes in cells, which are mediated by various glycosyltransferases and glycosidases. Glycosylation processes can be chemically regulated by inhibition of glycosyltransferases or glycosidases with natural and synthetic molecules. Treatment of cells with inhibitors of these enzymes results in the production of glycans or glycoconjugates containing missing or altered glycan chains. This approach is highly useful for examining the potential functional role(s) of glycans and glycoconjugates in cells or tissues, and in biological processes of health and disease. Eventually, it will provide novel mechanisms for disease treatment. This review highlights recent developments in chemical regulation of glycosylation processes with specific targets including: inhibition of (1) N-glycosylation, (2) O-glycosylation, (3) O-linked GlcNAc glycosylation, (4) proteoglycan biosynthesis, (5) glycolipid biosynthesis, and (6) terminal glycosylation. The goal of this review is to provide researchers with more competent choices in their research and lay a foundation on which continued advancements can be made to promote further explorations in glycoscience and biomedical research and applications.

著者

廣橋 容子 李 相済 ヒロハシ ヨウコ リ サンジェ Yoko Hirohashi Sang-jae Lee

雑誌

国際研究論叢 : 大阪国際大学紀要 = OIU journal of international studies

巻号頁・発行日

vol.23, no.1, pp.35-47, 2009-10-31

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In this article, we make it clear that elderly people are placed in poorquality facilities with an unsuitable environment and are not treated with proper respect as human beings. And we point out that a delay in the improvement of welfare facilities for elderly people depended on policies. Visits to Savonlinna city in Finland were made in August 2008, with research being conducted at welfare facilities for the Elderly. The characteristics of the welfare facilities for elderly people in Finland are : 1. The care respected elderly people. 2. The switch from “a care offer type institution” to “an independence support model house”. From comparison with welfare facilities for elderly people in Finland, we explain the new role of welfare facilities for elderly people, and we also offer suggestions for the improvement of living conditions and environment of welfare facilities for the elderly.

著者

herausgegeben vom Deutschen Offizier-Bund

出版者

E.S. Mittler

巻号頁・発行日

1926

著者

Maryam MOSHAVERINIA Ali BORZABADI-FARAHANI Abdi SAMENI Alireza MOSHAVERINIA Sahar ANSARI

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.35, no.5, pp.817-821, 2016-09-29 (Released:2016-10-01)

参考文献数

25

被引用文献数

6 24

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Present study evaluated effects of addition of Nanoparticles fluorapatite (Nano-FA) on microhardness and fluoride release of a Glass Ionomer Cement (GIC, Fuji IX GP Fast). Forty-eight specimens prepared, divided equally into 4 groups (2 with Nano-FA); after 24 h and one week Vickers microhardness (HV) was measured. Nano-FA specimens were made from addition of nano-FA to Fuji IX powder (glass powder/Nano-FA ratio=20:1 wt/wt, 3.6:1 P/L ratio). At 24 h, mean (95% CI) HV for GIC and Nano-FA GIC were 40.59 (39.51–41.66) and 46.89 (45.95–47.82) kg/mm2, and at one week 44.98 (44.23–45.72), 53.29 (52.58–53.99) kg/mm2, respectively. Findings indicated higher HV in Nano-FA specimens (F=221.088, p<0.001). Twenty-eight days weekly cumulative fluoride release in both groups was not different (p>0.05). MTT assay exhibited no inhibition of cell proliferation or reduction in metabolic activity in experimental [84.0 (3.3)] or control groups [85.1 (4.7)] with no difference between groups (p>0.05). New nano-FA GIC was biocompatible and showed improved surface hardness. Future clinical trials can verify the usefulness of Nano-FA GIC.

著者

窪田 薫 白井 厚太朗 杉原 奈央子 清家 弘治 棚部 一成 南 雅代 中村 俊夫 Kubota Kaoru Shirai Kotaro Sugihara-Murakami Naoko Seike Koji Tanabe Kazushige Minami Masayo Nakamura Toshio

出版者

名古屋大学宇宙地球環境研究所

雑誌

名古屋大学年代測定研究

巻号頁・発行日

vol.2, pp.1-6, 2018-03-31

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Mercenaria stimpsoni (Stimpson's hard clam), found in shallow sandy seafloor of northeast Japan, has been proved to have longevity of more than 100 years, which is the longest record in Japan. The present study established nuclear bomb testing induced bomb-14C records from M. stimpsoni shells, for the first time in high latitude western North Pacific, in which chronology is robustly constrained from a synchronized annual growth width pattern among individuals. The record revealed a strong influence of Tsugaru Warm Current on shallow water of northeast Japan. Furthermore, age-determination of dead shells collected from the seafloor of the study region by utilizing the established bomb-14C records suggests that past tsunamis are one of the most important reasons of death of M. stimpsoni.東北日本(岩手県大槌)から見つかった二枚貝の一種ビノスガイ(Mercenaria stimpsoni)は100歳を超す寿命を持ち,日本産の二枚貝としては最長寿であることが最近明らかになった.本研究では,ビノスガイの殻を用いて,複数個体間で同期した年間成長パターンをもとに厳密な年代モデルを構築し,東北地域としては初となる核実験起源の放射性炭素曲線を復元した.その結果,三陸沖の浅海域においては,津軽暖流(対馬海流を起源とする)の影響が強く見られることがわかった.さらに,得られた放射性炭素曲線を大槌の海底から得られた死殻の死亡年代の推定に用いることで,過去の津波イベントがビノスガイの死を招く重要な要因になっている可能性が示された.

著者

KANG Yunhee JEONG Jong-Hoon YOU Cheol-Hwan LEE Dong-In

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2018-050, (Released:2018-07-13)

被引用文献数

2

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On July 13, 2012, the bow echo was observed over the lee side of the Mt. Halla (1950 m above sea level) on Jeju Island, Korea. Three-dimensional wind-field and surface observation analyses were carried out to understand the structure and evolution of convective system with bow echo on the bell-shaped terrain. The northeastward-moving convective system passed over the approximately bell-shaped, isolated mountain with a mean speed of 17 m s-1. On the windward side of the mountain, the convective system developed by the inflow of unstable warm air from the ocean and terrain-induced upward motion, even with a low CAPE value of 511 J kg-1. When passing the lee side of the mountain, the bow echo was formed in the convective system by the strongest winds behind the bow echo. Behind the leading edge of the bow echo, the strengthened rear-inflow jet (RIJ) descended with relatively dry air along the surface, resulted in enhancing evaporative cooling. The precipitation-induced downdrafts generated a cold pool on the lee side of mountain. The development of an RIJ and cold pool formation both contributed to the evolution of the bow echo. In addition, the isolated bell-shaped terrain had a major indirect influence on the evolution of convective system with bow echo in this event.

著者

早乙女 誉 S.Nicole CULOS-REED

出版者

日本スポーツ産業学会

雑誌

スポーツ産業学研究 (ISSN:13430688)

巻号頁・発行日

vol.28, no.4, pp.4_287-4_294, 2018 (Released:2018-10-12)

参考文献数

28

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The purpose of this article was to introduce the case of the Aspen Institute Project Play and to consider a few current topics in Japanese youth sports. In 2013 this project was launched by the Aspen Institute Sports and Society Program in the U.S. Subsequently, it has produced multiple reports regarding issues surrounding youth sports in the U.S and has held annual summits to address these issues (2016, 2017). Additionally, it has succeeded in obtaining various stakeholders’ support (e.g. MLB, NBA, NBC Sports Network and NIKE) through implementation of its nationwide projects. The primary issues around childhood play/movement that Project Play has highlighted are the impact of childhood obesity and inactive lifestyles. To address these concerns, they developed eight strategies, including the “Sport for All, Play for Life Model”. This model aims to encourage all young people in the U.S to participate in competitive and/or recreational sports throughout their lives. In summary, the strengths of this project can be described as improving the cycle “research → strategy → evaluation” based on the above-referenced model. Furthermore, the vast network of stakeholders has enhanced the impact of its resources. Therefore, in the Japanese youth sports setting, it might be useful to consider the development of a similar model which encompasses both competitive and lifelong sports. Two key steps, as demonstrated by Project Play, are development of an effective network and utilizing the existing data related to youth sports in Japan.

著者

劉 海宇 LIU Hai-yu

出版者

岩手大学平泉文化研究センター

雑誌

岩手大学平泉文化研究センター年報 = Hiraizumi studies (ISSN:21877904)

巻号頁・発行日

vol.6, pp.1-15, 2018-03-30

著者

Camilo Barrios-Perez 岡田 謙介

出版者

日本作物学会

雑誌

日本作物学会講演会要旨集 第246回日本作物学会講演会

巻号頁・発行日

pp.76, 2018 (Released:2018-09-03)

著者

Junichi MINAMI Noriyuki IWABUCHI Miyuki TANAKA Koji YAMAUCHI Jin-zhong XIAO Fumiaki ABE Naoki SAKANE

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.37, no.3, pp.67-75, 2018 (Released:2018-07-26)

参考文献数

43

被引用文献数

74

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Accumulating evidence suggests a relationship between the gut microbiota and the development of obesity, indicating the potential of probiotics as a therapeutic approach. Bifidobacterium breve B-3 has been shown to exert anti-obesity effects in high-fat diet-induced obese mice. In the present study, the anti-obesity effects of the consumption of B. breve B-3 by healthy pre-obese (25 ≤ BMI < 30) adults were investigated in a randomized, double-blind, placebo-controlled trial (trial registration: UMIN-CTR No. 000023919; preregistered on September 2, 2016). Eighty participants were randomized to receive placebo or B. breve B-3 capsules (2 × 1010 CFU/day) daily for 12 weeks. The visceral fat area significantly increased at weeks 4 and 8 in the placebo group only; no significant change was observed in the B-3 group. Body fat mass and percent body fat were significantly lower in the B-3 group than in the placebo group at weeks 8 and 12 (p<0.05, ANCOVA adjusted with baseline values). Although no significant differences were observed in blood parameters between the groups, the intake of B. breve B-3 slightly decreased triglyceride levels and improved HDL cholesterol from the baseline. No serious adverse effects were noted in either group. These results suggest that the probiotic strain B. breve B-3 has potential as a functional food ingredient to reduce body fat in healthy pre-obese individuals.

著者

Kang-Ling Wang Chern-En Chiang

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.9, pp.2242-2243, 2013 (Released:2013-08-23)

参考文献数

13

被引用文献数

6 10

著者

Hidetoshi Yoshitani Akihiro Isotani Jae-Kwan Song Shinichi Shirai Hiromi Umeda Jeong Yoon Jang Takeshi Onoue Misako Toki Byung-Joo Sun Dae-Hee Kim Nobuyuki Kagiyama Akihiro Hayashida Jong-Min Song Masataka Eto Yosuke Nishimura Kenji Ando Michiya Hanyu Kiyoshi Yoshida Robert A. Levine Yutaka Otsuji

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-0390, (Released:2018-08-22)

参考文献数

24

被引用文献数

3

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Background: Basal interventricular septum (IVS) hypertrophy (BSH) with reduced basal IVS contraction and IVS-aorta angle is frequently associated with aortic stenosis (AS). BSH shape suggests compression by the longitudinally elongated ascending aorta, causing basal IVS thickening and contractile dysfunction, further suggesting the possibility of aortic wall shortening to improve the BSH. Surgical aortic valve replacement (SAVR), as opposed to transcatheter AVR (TAVR), includes aortic wall shortening by incision and stitching on the wall and may potentially improve BSH. We hypothesized that BSH configuration and its contraction improves after SAVR in patients with AS. Methods and Results: In 32 patients with SAVR and 36 with TAVR for AS, regional wall thickness and systolic contraction (longitudinal strain) of 18 left ventricular (LV) segments, and IVS-aorta angle were measured on echocardiography. After SAVR, basal IVS/average LV wall thickness ratio, basal IVS strain, and IVS-aorta angle significantly improved (1.11±0.24 to 1.06±0.17; −6.2±5.7 to −9.1±5.2%; 115±22 to 123±14°, P<0.001, respectively). Contractile improvement in basal IVS was correlated with pre-SAVR BSH (basal IVS/average LV wall thickness ratio or IVS-aorta angle: r=0.47 and 0.49, P<0.01, respectively). In contrast, BSH indices did not improve after TAVR. Conclusions: In patients with AS, SAVR as opposed to TAVR improves associated BSH and its functional impairment.

著者

Nagaaki Katoh Ko-ichi Tazawa Wataru Ishii Masayuki Matsuda Shu-ichi Ikeda

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.47, no.12, pp.1133-1138, 2008 (Released:2008-06-16)

参考文献数

21

被引用文献数

11 21

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We report a patient with myeloma-associated systemic AL amyloidosis who showed chronic polyarthralgia as the main symptom. The clinical picture was similar to that of rheumatoid arthritis with regard to symmetrical swelling with tenderness in multiple joints, but inflammatory reactions were almost normal and autoantibodies were negative. He was diagnosed as having systemic AL amyloidosis based on deposition of κ-light chain-immunoreactive amyloid in biopsied tissue and Bence Jones protein in serum and urine. Magnetic resonance imaging and bone scintigraphy suggested this disease as the cause of the polyarthralgia. Systemic AL amyloidosis may be important in the differential diagnosis of chronic polyarthralgia.

著者

by the Inter-territorial Language Committee for the East African Dependencies under the direction of Frederick Johnson

出版者

Geoffrey Cumberlege

巻号頁・発行日

1939