著者

Iwao Sugitani Naoyoshi Onoda Ken-ichi Ito Shinichi Suzuki

出版者

The Medical Association of Nippon Medical School

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.85, no.1, pp.18-27, 2018-01-15 (Released:2018-03-15)

参考文献数

24

被引用文献数

23

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Anaplastic thyroid carcinoma (ATC) accounts for only 1 to 2% of all thyroid carcinomas, but it is one of the most lethal neoplasms in humans. To obtain further insights into this "orphan disease," we have established the ATC Research Consortium of Japan (ATCCJ) in 2009. It represents a multicenter registry for ATC that have been treated in Japan. To date, 67 institutions have taken part in the collaborative research system and over 1,200 cases have been accumulated in its database. Using this big data, several retrospective studies were carried out to evaluate 1) prognostic factors to determine initial treatment policy, 2) significance of extended radical surgery for Stage IVB cases, 3) characteristics of ATC incidentally found on pathological examination and 4) pathological features of ATC with long-term survival. Moreover, the ATCCJ has conducted an investigator-initiated, nationwide, prospective clinical trial since 2012; namely, the feasibility, safety and efficacy study of weekly paclitaxel administration for patients with ATC (UMIN: 000008574). Revised Japanese guidelines for treatment of thyroid tumors are going to adopt the recommendations from the results of this research. Since 2016, the ATCCJ has started the phase II study assessing the efficacy and safety of lenvatinib, a newly developed tyrosine kinase inhibitor for ATC (UMIN: 000020773). Our nationwide clinical trial network will strengthen the activity to recruit orphan disease patients and may discover new strategies to conquer this dismal malignancy in the near future.

著者

慎 斗範 Doo-Boem Shin

出版者

国際基督教大学

雑誌

社会科学ジャーナル (ISSN:04542134)

巻号頁・発行日

vol.30, no.1, pp.1-19, 1991-06

著者

ACHARYA Chakra Pani LEON-GONZALEZ Roberto

出版者

GRIPS Policy Research Center

雑誌

GRIPS Discussion Papers

巻号頁・発行日

vol.17-13, 2018-02

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Despite a large growth in domestic and international migration and remittances in recent decades, there are limited works that systematically identify and establish interactions between internal and international migration. Using primary data from new urban areas of Nepal, we identify households that had migrated from rural to urban areas, explore their migration practices and educational investment behaviors, and analyze the effects of international migration and remittances on investment in education. The results show that, despite their lower income and consumption, migrant households that have members abroad have higher human capital investment measured by the level and budget share of expenditure on children’s education and the time their children spend for studying at home than do urban-native and other types of migrant households. Our findings suggest that searching for better education is one important motivation for migrating to urban areas among rural households having members abroad.

著者

Jin Gyeong BAEK Soon-Mi SHIM Dae Young KWON Hyung-Kyoon CHOI Choong Hwan LEE Young-Suk KIM

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.74, no.9, pp.1860-1868, 2010-09-23 (Released:2010-09-23)

参考文献数

36

被引用文献数

62

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Metabolite profiling of Cheonggukjang inoculated with different Bacillus strains including Bacillus amyloliqueciens CH86-1, Bacillus licheniformis 58, and Bacillus licheniformis 67 during fermentation, was performed using gas chromatography-time of flight-mass spectrometry after derivatization, combined with multivariate statistical analysis. A total of 20 amino acids, 10 sugars, five sugar alcohols, and seven organic acids were identified in three Cheonggukjang samples. With fermentation time, most of the amino acids showed increasing amounts. On the other hand, most of the sugars including sucrose, fructose, and glucose decreasing patterns, and the amounts of organic acids varied. In order to observe differences in metabolites with fermentation time and inoculated Bacillus strains, principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were carried out, respectively. On PCA plots, some sugars and organic acids including sucrose, fructose, glucose, mannose, succinic acid, and malonic acid, as well as most of the amino acids, contributed mainly to differentiation of the Cheonggukjang samples fermentation time. On the other hand, on PLS-DA, mannose, xylose, glutamic acid, and proline were mainly responsible for differentiating the Cheonggukjang among into various inoculated strains.

著者

Shin-ichi SUZUKI Takeshi MAESAKA Koyuru IWANAMI Shingo SHIMIZU Kaori KIEDA

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.96A, pp.25-33, 2018 (Released:2018-02-19)

参考文献数

20

被引用文献数

4

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X-band dual-polarization (multi-parameter) radars were used to observe a supercell storm that generated an F3 tornado in Ibaraki Prefecture, Japan on 6 May 2012. The observed data collected for this storm clearly exhibited the typical polarimetric features of a supercell storm, such as the ZDR (differential reflectivity) arc, ZDR column, and the KDP (specific differential phase) column, as well as their time evolution. The ZDR arc emerged at 10 to 15 min before the tornadogenesis. The ZDR column appeared approximately 1 h before the formation of the ZDR arc and was intermittent until tornadogenesis. As the ZDR arc appeared, the column became tall and stable and lasted until the dissipation of the tornado. These ZDR signatures of the supercell storm persisted for approximately half an hour.

著者

Seol-Jung Kang Jong-Hyu Kim Zhao Gang Young-Sook Yook Jea-Ryang Yoon Gi-Chul Ha Kwang-Jun Ko

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.1, pp.169-173, 2018 (Released:2018-01-27)

参考文献数

43

被引用文献数

22

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[Purpose] The purpose of this study is to investigate the effects of circuit exercise on obesity index, appetite regulating hormones and insulin resistance in middle-aged obese women. [Subjects and Methods] The subjects of this study were 26 obese middle-aged women who were selected among participants in exercise class at K Region Health Promotion Center in South Korea and were randomly assigned to the exercise group (n=13; age 50.15 ± 3.82, % body fat 38.79 ± 3.28) and the control group (n=13; age 49.84 ± 2.96, % body fat 37.46 ± 2.51). Circuit exercise consisted of aerobic exercise and resistance exercise for 5 weeks and 50 minutes for 12 weeks. Before and after exercise we measured obesity index, leptin, ghrelin, fasting blood glucose, insulin, and insulin resistance in all subjects. A repeated-measured two-way of variance was performed for comparison of the treatment effects between the exercise and control groups. [Results] Body weight, BMI, and body fat percentage of obese index decreased significantly. Leptin of dietary regulation hormone was significantly decreased and ghrelin was significantly increased. Insulin and insulin resistance was significantly decreased. [Conclusion] Circuit exercise can be viewed as an effective exercise program to induce changes in appetite regulating hormones and to improve insulin resistance by mechanisms of energy homeostasis by weight loss.

著者

Niclas G. Karlsson Chunsheng Jin Miguel A. Rojas-Macias Barbara Adamczyk

出版者

FCCA(Forum: Carbohydrates Coming of Age)

雑誌

Trends in Glycoscience and Glycotechnology (ISSN:09157352)

巻号頁・発行日

vol.29, no.166, pp.E35-E46, 2017-03-25 (Released:2017-03-25)

参考文献数

77

被引用文献数

12

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The adaption of methods from last century’s glycoanalysis into packages for performing the 21st century’s O-linked glycomics has been slow. However, the involvement of O-linked glycans in many of the physical barriers in the body (cell membranes, epithelial and mucosal layers and cartilage surface) points towards a role in many of this century’s health sector challenges. These include but are not limited to inflammation, infections, and degradation of tissue due to aging. This review focus on the development of O-linked glycomics, including current state-of-the-art release methods, analytical characterisation using mass spectrometry and liquid chromatography. The future outcome emerging technologies for O-linked glycomics including novel chemistry, analytical methods for quantification and characterisation and glycobioinformatics is presented.

著者

Hironori Imano Hiroyasu Iso Akihiko Kitamura Kazumasa Yamagishi Mina Hayama-Terada Isao Muraki Takeo Okada Mitsumasa Umesawa Tetsuya Ohira Tomoko Sankai Renzhe Cui Takeshi Tanigawa Masahiko Kiyama on behalf of the CIRCS Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-17-0950, (Released:2018-02-14)

参考文献数

44

被引用文献数

6

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Background:The effect of postprandial glucose on the risk of cardiovascular disease has been emphasized, but it is controversial whether nonfasting glucose is related to incident stroke and its types.Methods and Results:We investigated the associations of nonfasting glucose with incident stroke and its types among 7,198 participants aged 40–74 years from the Circulatory Risk in Communities Study, enrolled in 1995–2000. We estimated multivariable hazard ratios (HR) using Cox proportional hazard models. Over a median follow-up of 14.1 years, 291 cases of total stroke (ischemic strokes: 191 including 109 lacunar infarctions) were identified. Nonfasting glucose concentration was associated with greater risk of incident total stroke, ischemic stroke and lacunar infarction when modeled categorically (for prediabetic type: 7.8–11.0 mmol/L vs. normal type: <7.8 mmol/L among all subjects, HR for lacunar infarction was 2.02, 95% confidence interval (CI): 1.19, 3.43) or continuously (per one standard deviation increment among all subjects, HR for lacunar infarction was 1.29, 95% CI: 1.15, 1.45). Diabetic type showed similar results. Population attributable fractions of nonfasting hyperglycemia were 13.2% for ischemic stroke and 17.4% for lacunar infarction.Conclusions:Nonfasting glucose concentration, either as a diagnosis of prediabetic and diabetic types or as a continuous variable, proved to be an independent predictor significantly attributed to incident total stroke, especially ischemic stroke and lacunar infarction, in the general population.

著者

Lobna Alkebsi Yuki Ideno Jung-Su Lee Shosuke Suzuki Junko Nakajima-Shimada Hiroshi Ohnishi Yasunori Sato Kunihiko Hayashi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.28, no.1, pp.34-40, 2018-01-05 (Released:2018-01-05)

参考文献数

37

被引用文献数

7

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Background: Although several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019).Methods: The impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders.Results: Compared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively.Conclusion: In this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.

著者

Serge Térestchenko (Dmitri Novik) traduit du russe par H. Pelle Desforges préface du vice-amiral Kedrov

出版者

Payot

巻号頁・発行日

1931

著者

李 徳方 劉 海宇 Li De-fang Liu Hai-yu

出版者

国立大学法人岩手大学平泉文化研究センター

雑誌

岩手大学平泉文化研究センター年報

巻号頁・発行日

vol.1, pp.29-35, 2013-03-01

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平泉山荘は唐代の宰相李徳裕(787-849)が洛陽郊外に建てた別荘である。山荘は私邸の郊野庭園の特徴を備え、景勝は当時最も優れていたとされている。『旧唐書・李徳裕伝』に「東都伊闕の南に平泉別墅を置き、清流翠筱あり、樹石奇幽なり」という。康駢『劇談録』に「李徳裕の東都平泉荘、洛城を去ること三十里、卉木台榭あり、仙府に造るが如し。虚檻対引し、泉水縈回すること有り」とある。張洎『賈氏談録』に「平泉荘周囲十里にして、台榭百余所を構ふ」と見える。李徳裕『霊泉賦』に「余西嶺に居り、平壌より泉を出だし、広さ尋を逾えずして、深さ則ち尺を盈す」という。唐末宋代以降、山荘は廃れ果てて、後人は遂にその所在を求めがたい。今の伊闕(龍門)西南梁村溝村付近は、史書に記載する山荘の位置と基本的に一致し、世にここは山荘の旧跡と言い伝えられ、園林史学者の王鐸先生はそのために山荘の位置示意図を描き出した。それでは、今の梁村溝一帯は果たして山荘の旧跡であるのか。手がかりとなる歴史遺跡がある程度残されているのか。これらの疑問を抱えて、2012年の冬日に筆者たちは梁村溝付近で現地踏査を行った。ここで今回踏査の収穫を簡略に記す。

著者

Eden DEBELLEMANIERE Danielle GOMEZ-MERINO Mégane ERBLANG Rodolphe DOREY Michel GENOT Edith PERREAUT-PIERRE André PISANI Laurent ROCCO Fabien SAUVET Damien LÉGER Arnaud RABAT Mounir CHENNAOUI

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.2017-0092, (Released:2018-01-13)

被引用文献数

9

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Insufficient sleep is a common occurrence in occupational settings (e.g. doctors, drivers, soldiers). The resulting sleep debt can lead to daytime sleepiness, fatigue, mood disorder, and cognitive deficits as well as altered vascular, immune and inflammatory responses. Short daytime naps have been shown to be effective at counteracting negative outcomes related to sleep debt with positive effects on daytime sleepiness and performance after a normal or restricted night of sleep in laboratory settings. However, the environmental settings in the workplace and the emotional state of workers are generally not conducive to beneficial effects. Here, we tested whether relaxation techniques (RT) involving hypnosis might increase total sleep time (TST) and/or deepen sleep. In this study, eleven volunteers (aged 37-52) took six early-afternoon naps (30 minutes) in their occupational workplace, under two different conditions: control ‘Naps' or ‘Naps + RT' with a within-subjects design. Our results demonstrate that adding RT to naps changes sleep architecture, with a significant increase in the TST, mostly due to N2 sleep stage (and N3, to a lesser extent). Therefore, the deepening of short naps with RT involving hypnosis might be a successful non-pharmacological way to extend sleep duration and to deepen sleep in occupational settings.

著者

Min-Seok Kim Jae-Joong Kim

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.5, pp.942-947, 2015-04-24 (Released:2015-04-24)

参考文献数

74

被引用文献数

4 33

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Heart failure (HF) is a highly prevalent disorder worldwide and, consequently, a burden on the healthcare systems of many nations. Although the effects of HF are systemic, many therapeutic targets are focused on cardiac dysfunction. The brain is closely related to the heart, but there are few reports on the relationship between these organs. We describe the effects of the brain on HF progression. Specific brain regions control sympathetic drive and neurohumoral factors, which play an important role in disease exacerbation. In addition, we review some of our previous studies on deranged cerebral metabolism and reduced cerebral blood flow during HF. Although the reasons underlying these effects during HF remain uncertain, we propose plausible mechanisms for these phenomena. In addition, the clinical implications of such conditions in terms of predicting prognosis are discussed. Finally, we investigate cognitive impairment in patients with HF. Cognitive impairment through cerebral infarction or hypoperfusion is associated with adverse outcomes, including death. This brief review of brain function during the development of HF should assist with future strategies to better manage patients with this condition. (Circ J 2015; 79: 942–947)

著者

Mitsuo Miyazawa Hirotoshi Utsunomiya Ken-ichi Inada Tomoki Yamada Yoshiharu Okuno Harunari Tanaka Masae Tatematsu

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.29, no.1, pp.172-173, 2006 (Released:2006-01-01)

参考文献数

16

被引用文献数

24 56

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A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 μg/ml and the IC50 value was 50 μg/ml.

著者

Olav GEIL Stefano MARTIN Umberto MARTÍNEZ-PEÑAS Ryutaroh MATSUMOTO Diego RUANO

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences (ISSN:09168508)

巻号頁・発行日

vol.E100.A, no.12, pp.2699-2708, 2017-12-01 (Released:2017-12-01)

参考文献数

32

被引用文献数

3

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Asymptotically good sequences of linear ramp secret sharing schemes have been intensively studied by Cramer et al. in terms of sequences of pairs of nested algebraic geometric codes [4]-[8], [10]. In those works the focus is on full privacy and full reconstruction. In this paper we analyze additional parameters describing the asymptotic behavior of partial information leakage and possibly also partial reconstruction giving a more complete picture of the access structure for sequences of linear ramp secret sharing schemes. Our study involves a detailed treatment of the (relative) generalized Hamming weights of the considered codes.

著者

大西 範和 斎藤 真 大平 肇子 小松 美砂 長谷川 智之 西濵 里英 松島 至俊 HUANG Ya-wen 近藤 晃一 坂本 直久 松岡 敏生

出版者

一般社団法人 日本人間工学会

雑誌

人間工学 (ISSN:05494974)

巻号頁・発行日

vol.53, no.Supplement1, pp.S266-S267, 2017-06-01 (Released:2017-09-07)

著者

Carolina Carvalho Bortoletto Mônica da Consolação Canuto Salgueiro Renata Valio Yara Dadalti Fragoso Pamella de Barros Motta Lara Jansiski Motta Fernanda Yukie Kobayashi Kristianne Porta Santos Fernandes Raquel Agnelli Mesquita-Ferrari Alessandro Deana Sandra Kalil Bussadori

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.29, no.11, pp.1889-1892, 2017 (Released:2017-11-22)

参考文献数

32

被引用文献数

16

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[Purpose] Present study aimed to evaluate the relationship between sleep bruxism and headache in school children. [Subjects and Methods] This study was conducted with 103 children aged 3–6 years. The exclusion criteria were early tooth loss, dental appliance was used, physical or psychological limitations, chronic disease and continuous medication. Sleep bruxism was diagnosed based on an indication by parents of the occurrence of teeth clenching/grinding and incisor/occlusal tooth wear, following the criteria of the American Academy of Sleep Medicine. Sleep quality was evaluated by a questionnarie, detailing the child’s sleep characteristics. [Results] Forty-nine children (47.6%) were diagnosed with sleep bruxism. Those with sleep bruxism were 3.25-fold more likely to present headache. Children whose parents were separated had a significantly greater frequency of sleep bruxism and primary headache. The relative risk of exhibiting primary headache was 13.1 among children with sleep bruxism whose parents were separated. [Conclusion] Children with SB demonstrated a greater risk of having primary headache and those whose parents were separated had a greater chance of having headache. Only sleep bruxism was associated with headache, clenching the teeth during waking hours was not correlated with primary headache.

著者

Meina TEI Kazuyuki UCHIDA James K. CHAMBERS Ken-ichi WATANABE Takashi TAMAMOTO Koichi OHNO Hiroyuki NAKAYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0447, (Released:2017-12-04)

被引用文献数

5

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Amyloid A (AA) amyloidosis, a fatal systemic amyloid disease, occurs secondary to chronic inflammatory conditions in humans. Although persistently elevated serum amyloid A (SAA) levels are required for its pathogenesis, not all individuals with chronic inflammation necessarily develop AA amyloidosis. Furthermore, many diseases in cats are associated with the elevated production of SAA, whereas only a small number actually develop AA amyloidosis. We hypothesized that a genetic mutation in the SAA gene may strongly contribute to the pathogenesis of feline AA amyloidosis. In the present study, genomic DNA from four Japanese domestic cats (JDCs) with AA amyloidosis and from five without amyloidosis was analyzed using polymerase chain reaction (PCR) amplification and direct sequencing. We identified the novel variation combination of 45R-51A in the deduced amino acid sequences of four JDCs with amyloidosis and five without. However, there was no relationship between amino acid variations and the distribution of AA amyloid deposits, indicating that differences in SAA sequences do not contribute to the pathogenesis of AA amyloidosis. Immunohistochemical analysis using antisera against the three different parts of the feline SAA protein—i.e., the N-terminal, central, and C-terminal regions—revealed that feline AA contained the C-terminus, unlike human AA. These results indicate that the cleavage and degradation of the C-terminus are not essential for amyloid fibril formation in JDCs.

著者

Y-h. Taguchi

出版者

The Japanese Biochemical Society/The Molecular Biology Society of Japan

雑誌

ConBio2017

巻号頁・発行日

2017-10-31

著者

TEE Hyang PAKHRIN Bidur BAE Il-Hong SHIN Nam-Shik LEE Su-In YOO Han-Sang KIM Dae-Yong

出版者

社団法人日本獣医学会

雑誌

The journal of veterinary medical science (ISSN:09167250)

巻号頁・発行日

vol.69, no.8, pp.851-852, 2007-08-25

参考文献数

10

被引用文献数

8

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Staphylococcus intermediusが分離された腎孟腎炎が4歳,雌のシベリアトラ(Panthera tigris altaica)に診断された.剖検では,左腎孟が大量の化膿性滲出液により拡張していた.顕微鏡的には,腎孟と髄質での病変は,主に多量の変性好中球が混在した壊死巣,少量のリンパ球,形質細胞やマクロファージから構成されていた.細菌学検査では,Sraphylococcus intermediusの存在が確認された.これは野生のネコ科動物でのStahpyococcus inermediusによる腎孟腎炎の初めての報告である.