著者

Aman B Pulungan Carine de Beaufort Amajida F Ratnasari Helena A Puteri Laura Lewis-Watts Zulfiqar A Bhutta

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.32, no.3, pp.137-146, 2023 (Released:2023-06-24)

参考文献数

35

被引用文献数

1

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A decade since the discovery of insulin, the increasing prevalence of type 1 diabetes mellitus (T1DM) has underscored the prevailing inequalities in the provision of essential care for T1DM worldwide. However, the details on the availability of insulin types and associated medical devices remain unclear. A cross-sectional electronic survey was distributed across a global network of pediatric societies under the umbrella of the International Pediatric Association (IPA). Access to and availability of pediatric diabetes care were investigated using standardized questions. Responses from 25 of 132 pediatric societies across six regions were included. Pediatric endocrinologists typically manage T1DM together with pediatricians or adult endocrinologists. Nonetheless, 24% of the respondents reported pediatricians to be the sole healthcare professionals. According to the respondents, the patients were either partially or completely responsible for payments of insulin (40%), A1C (24%), C-peptide (28%), and antibody testing for diagnosis (28%). Government support is generally available for insulin, but this was merely 20% for insulin pumps and 12% for continuous glucose monitors. There are considerable disparities in the access, availability, and affordability of diabetes testing, medications, and support between countries with significant out-of-pocket payments for care. Country- and region-specific improvements to national programs are necessary to achieve optimal pediatric diabetes care globally.

著者

Ma. LaRue E. Ballesfin Ricky B. Vinarao Janice Sapin Sung-Ryul Kim Kshirod K. Jena

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.68, no.4, pp.474-480, 2018 (Released:2018-10-10)

参考文献数

34

被引用文献数

9 9

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An intergeneric hybrid was successfully developed between Oryza sativa L. (IRRI 154) and Leersia perrieri (A. Camus) Launert using embryo rescue technique in this study. A low crossability value (0.07%) implied that there was high incompatibility between the two species of the hybrid. The F1 hybrid showed intermediate phenotypic characteristics between the parents but the plant height was very short. The erect plant type resembled the female parent IRRI 154 but the leaves were similar to L. perrieri. Cytological analysis revealed highly non-homology between chromosomes of the two species as the F1 plants showed 24 univalents without any chromosome pairing. The F1 hybrid plant was further confirmed by PCR analysis using the newly designed 11 indel markers showing polymorphism between O. sativa and L. perrieri. This intergeneric hybrid will open up opportunities to transfer novel valuable traits from L. perrieri into cultivated rice.

著者

W.B.シーブルック著 林剛至訳

出版者

大陸書房

巻号頁・発行日

1969

著者

William B. Grant

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.82, no.8, pp.2215, 2018-07-25 (Released:2018-07-25)

参考文献数

8

著者

Ngoc B. Nguyen Nguyet T. M. Nguyen Nhai T. Nguyen Linh H. Le Nghia T. La Thuy T. T. Nguyen Mary Jeany Yanoria Nagao Hayashi Hiroki Saito Mitsuhiro Obara Tadashi Sato Yoshimichi Fukuta

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

vol.73, no.2, pp.193-203, 2023 (Released:2023-06-06)

参考文献数

40

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A unique genetic variation with respect to blast resistance was clarified in 201 rice accessions from Vietnam. These accessions were classified into three clusters—A, B1, and B2—based on their reactions to 26 standard differential blast isolates selected in Vietnam. Cluster A was the dominant cultivar group in Vietnam and the most susceptible of the three clusters. Cluster B1 was the smallest group and the most resistant. Cluster B2 was the second-most dominant group and of intermediate resistance between clusters A and B1. The percentages of accessions comprising each cluster varied by region and area. Accessions in cluster A were distributed widely throughout Vietnam and had the highest frequencies in both the Central and North regions. Accessions in cluster B2 were found with highest frequencies in the mountainous and intermediate areas of the North region. Accessions in cluster B1 were found with highest frequencies in the Central region and Red River Delta area (North region). These results suggest that rice accessions in Vietnam were basically susceptible (cluster A) or of intermediate resistance (cluster B2), and that high-resistance cultivars were mainly distributed in the low altitude areas, such as the Red River Delta area and Central region.

著者

edited by T.F. Cheeseman with the assistance of W.B. Hemsley the plates drawn by Matilda Smith

出版者

John Mackay

巻号頁・発行日

1914

著者

published and conducted by J. Linden and Ed. André assisted by W.B. Hemsley

出版者

[s.n.]

巻号頁・発行日

1874

著者

by W.B. Hemsley with an introduction by Edward S. Rand junr

出版者

Estes & Lauriat

巻号頁・発行日

1873

著者

W.B. Hemsley

出版者

IDC Publishers

著者

by W.B. Hemsley

出版者

Longmans, Green

巻号頁・発行日

1877

著者

A A B A A A A B 上田 亨 辰野 高司

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.4, no.11, pp.867-873, 1968-11-15 (Released:2018-08-26)

著者

内海 好規 吉田 真由美 Perigio B. Francisco Jr. 澤田 隆行 北村 進一 中村 保典

出版者

日本応用糖質科学会

雑誌

Journal of Applied Glycoscience (ISSN:13447882)

巻号頁・発行日

vol.56, no.3, pp.215-222, 2009 (Released:2010-01-29)

参考文献数

42

被引用文献数

9 15

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植物はデンプンを合成するために進化の過程で異なる機能を持つ酵素アイソザイムを分化させてきた.デンプン枝作り酵素(BE)はα-グルカンのα-1,6グルコシド結合を形成する唯一の酵素であり,アミロペクチンのタンデムクラスター構造の形成に必須である.アミロペクチン分子の分岐結合の位置と数に認められる高度の規則性はBE反応により制御されており,アミロペクチン構造のバリエーションはデンプンの性質を決定する重要な因子である.したがってデンプン構造の生合成調節メカニズムを解明する上でBEの特性に関する理解は不可欠であるが,BEの反応メカニズムは依然ほとんど不明である.BE特性解明の第一歩は酵素動力学的解析であるが,再現性良く活性を定量し,しかも多数のサンプルを簡便に分析できる方法がなかった.本研究では,BE枝作り反応の結果,生ずるα-1,6グルコシド結合を枝切り処理後,増加する還元末端数を定量することによって活性を直接測定する方法を確立することを目的とした.まず,還元末端数を定量できる銅-ビシンコニニック酸法(BCA法)の基本特性を調べた.その結果,1)BCA法では,560 nmの吸光度をマイクロプレートリーダーで測定することにより,測定液150 μLあたり0-3.75 nmol(0-25 μM相当)のマルトースを定量することができ,その吸光度は呈色反応終了後10時間まで安定であった.2)グルコースからグルコース数平均重合度(DPn)1658の酵素合成アミロースに対して,分子数あたりの還元糖量は一定で,DP値の影響を受けなかった.3)大腸菌に発現させたイネリコンビナントBEIIb(rOsBEIIb)の活性と特性を調べた結果,酵素合成アミロースやアミロペクチンに対して信頼性の高いKm値やVmax値を求めることができた.結論として,BCA法は従来法に比べて,BE活性を定量するための優れた方法であることが明らかになった.

著者

Seth B. ANDERSON

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会誌 (ISSN:00214663)

巻号頁・発行日

vol.28, no.320, pp.438-449, 1980-09-05 (Released:2009-05-25)

参考文献数

16

著者

João M. Santos Sara Pereira Diana B. Sequeira Ana L. Messias João B. Martins Henrique Cunha Paulo J. Palma Ana C. Santos

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.61, no.1, pp.171-177, 2019 (Released:2019-03-28)

参考文献数

30

被引用文献数

13 31

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This study evaluated the biocompatibility of a new silicone-based sealer (GuttaFlow Bioseal) in rat subcutaneous tissue and compared the results with those for GuttaFlow2 and AH Plus. Each of 16 Wistar rats received four subcutaneous tissue implants, namely, GuttaFlow Bioseal, GuttaFlow2, AH Plus, and one empty polyethylene tube. Eight rats were euthanized at day 8 and the remaining eight at day 30. Histological sections were stained with haematoxylin and eosin and analysed with a light microscope. Scores were established for inflammatory reaction, macrophage infiltrate, thickness of the fibrous capsule, and vascular changes. Differences between groups were assessed by using the Friedman test with Bonferroni correction. Histological analysis showed that GuttaFlow Bioseal had the lowest inflammatory reaction of all tested sealers at day 8. At day 30, the silicone-based sealers had similar inflammation profiles, but inflammation scores were nonsignificantly higher for AH Plus than for the negative control. The inflammatory reaction decreased from day 8 to day 30 in all sealers. GuttaFlow Bioseal had the most macrophage infiltrate. Under the present experimental conditions, GuttaFlow Bioseal induced limited inflammatory reactions at days 8 and 30, and initial inflammatory reactions to GuttaFlow2 and AH Plus subsided within 30 days. All tested sealers exhibited satisfactory biocompatibility at day 30 after subcutaneous implantation.

著者

W.B.イェイツ [著] 尾島庄太郎訳

出版者

角川書店

巻号頁・発行日

1999

著者

Laura B. ALLEN Jill T. EHRENREICH David H. BARLOW

出版者

Japanese Association for Behavioral and Cognitive Therapies( JABCT )

雑誌

行動療法研究 (ISSN:09106529)

巻号頁・発行日

vol.31, no.1, pp.3-30, 2005-03-31 (Released:2019-04-06)

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Cognitive behavioral therapies are now considered the treatment of choice for a wide variety of emotional disorders. Despite the increasing utilization of these techniques, the majority of practicing clinicians are unfamiliar with cognitive behavioral treatments. Some have concluded that complex manualized protocols have discouraged dissemination and effective training. Yet, as research on the etiology and nature of emotional disorders progresses, it is becoming clear that the various emotional disorders may actually emerge from similar latent structures or processes. This new understanding suggests the possibility of extracting a set of psychological principles that could be integrated into a single, cohesive treatment protocol and applied to any emotional disorder. Based on emerging data and theory from learning, emotional development and regulation, and cognitive science, three principles have been identified that may be fundamental to the treatment of emotional disorders. These include (a) altering antecedent cognitive reappraisals; (b) preventing emotional avoidance; and (c) modifying action tendencies. Data from the clinical application of the protocol will be presented for an adult population. In addition, the evolution and initial usage of an adaptation of the treatment of emotional disorders in adolescents will be reviewed. Although still in the early stages of development, this unified approach may represent a more efficient, and possibly more efficacious, way to ameliorate overlapping emotional disorder symptomatology (comorbidity) ; in addition to facilitating effective dissemination of empirically supported treatments to practicing clinicians.

著者

Paulo H. Barbosa Júlio B. B. de Camargo Tiago V. Braz Luan O. Col Marcelo S. Aoki Paulo H. Marchetti Jonato Prestes Charles R. Lopes

出版者

Active Aging Research Center

雑誌

Journal of Trainology (ISSN:21865264)

巻号頁・発行日

vol.12, no.1, pp.1-4, 2023-01-10 (Released:2023-01-22)

参考文献数

14

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Objective: The aims of this study were to: 1) quantify the weekly volume of sets prescribed for each muscle group of the lower limbs in recreationally-trained women; 2) assess the association between resistance training experience and the weekly volume. Design and Methods: The training programs of 1019 recreationally-trained women subjects were analyzed. Data was ana lyzed for the following lower limb muscle groups: quadriceps femoris, knee flexors, hip adductors, gluteus medius, gluteus maximus, triceps surae, and tibialis anterior. A k-cluster analysis was performed to subdivide the weekly volume of sets into 3 groups (low, medium, and high). Results: A significant difference in RT experience (years) and weekly frequency was observed between the 3 groups. For relative (%) weekly volume of sets, a larger number was noted for quadriceps femoris (34.29%), followed by gluteus maximus (28.57%), knee flexors (11.43%), and hip adductors, gluteus medius and triceps surae (all 8.57%). A moderate correlation was observed between RT experience and AVS (rs = 0.56; 95% CI = 0.50 to 0.59; p = 0.001) and a strong correlation between weekly frequency and AVS (rs = 0.73; 95% CI = 0.69 to 0.75; p = 0.001). Conclusion: In conclusion, strength coaches usually prescribe high weekly volumes of sets for lower limb muscle groups. Additionally, a higher weekly volume of sets was prescribed for the quadriceps femoris and gluteus maximus muscles when compared to the knee flexors. This results suggest that training experience positively correlates with to the absolute weekly volume of sets.

著者

E.B.アンドレーエヴァ 著

出版者

岩波書店

巻号頁・発行日

1963

著者

B.ラッセル 著

出版者

理想社

巻号頁・発行日

1959

著者

B. R. ウィルソン

出版者

南山大学

雑誌

研究所報

巻号頁・発行日

no.9, 1999