著者

斎藤 裕久 浜名 政和

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.99, no.1, pp.23-29, 1979-01-25 (Released:2008-05-30)

参考文献数

14

被引用文献数

1 3

---

Nitration of 1-cyanoisoquinoline 2-oxide (1) with potassium nitrate and sulfuric acid gave 5-and 6-nitro derivatives (2 and 3). The reaction was affected by the concentration of sulfuric acid, and 3 was obtained in small yields as the sole product from the reactions in the 85% acid at 70°. Nitration with fuming nitric acid (d=1.50) led to the formation of 3 in fairly good yields together with small amounts of 8-nitro derivative (7). Further, nitration of isoquinoline 2-oxide (9) with fuming nitric acid was found to give 5-, 6- and 8-nitro derivatives (10, 11 and 12). The orienting effect of the N-oxide function is apparently operative in the formation of 11 and 12.

著者

高 夢璇 佐藤 元重 池谷 裕二

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.6, pp.809-813, 2018-06-01 (Released:2018-06-01)

参考文献数

7

被引用文献数

2

---

During the preclinical research period of drug development, animal testing is widely used to help screen out a drug's dangerous side effects. However, it remains difficult to predict side effects within the central nervous system. Here, we introduce a machine learning-based in vitro system designed to detect seizure-inducing side effects before clinical trial. We recorded local field potentials from the CA1 alveus in acute mouse neocortico-hippocampal slices that were bath-perfused with each of 14 different drugs, and at 5 different concentrations of each drug. For each of these experimental conditions, we collected seizure-like neuronal activity and merged their waveforms as one graphic image, which was further converted into a feature vector using Caffe, an open framework for deep learning. In the space of the first two principal components, the support vector machine completely separated the vectors (i.e., doses of individual drugs) that induced seizure-like events, and identified diphenhydramine, enoxacin, strychnine and theophylline as “seizure-inducing” drugs, which have indeed been reported to induce seizures in clinical situations. Thus, this artificial intelligence-based classification may provide a new platform to pre-clinically detect seizure-inducing side effects of drugs.

著者

狭間 研至

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.1, pp.17-20, 2012-01-01 (Released:2012-01-01)

参考文献数

3

被引用文献数

3 2 1

---

In Japan, the proportion of elderly people had reached up to 23% in 2009. The number of elderly people in long-term nursing homes or nursing facilities will increase in the next decade. By 2025, the majority of the elderly people would have developed cancer, stroke, cardio-vascular diseases, and dementia. Almost all of them would be treated with prescribed drugs. They would also have dysphagia and have difficulties in remembering their medications in the long term. Therefore, for the benefit of such a community, the work force, especially in the field of drug distribution, will need to be increased to prevent the incidence of patients who forget to take their medications. Further, the educational curriculum for pharmaceutical students has been changed to a new version, and some Japanese pharmacy shops have been switching over to “Pharmacy 3.0,” which is the next generation model. In this pharmacy, the pharmacists will play an additional new role; they will not only dispense drugs but also support home recuperation leveraging some vital signs and physical assessments. In my opinion, this novel scheme of medical service developed with pharmacists playing this new role may be a boon to the patient/elderly community in Japan who are facing the collapse of healthcare systems. In conclusion, Collaborative Drug Therapy Management (CDTM) in the practice of the pharmacists is essential for increasing the efficiency of the Japanese healthcare systems.

著者

藤田 路一 川瀬 清

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.71, no.11, pp.1229-1231, 1951-11-25 (Released:2010-02-19)

参考文献数

5

---

For one year between 1950 and 1951, specific weight of tissue powder of rhizomes without roots of Scopolia japonica Maxim., growing wild in a certain area, was measured by Koketsu's powder method and a marked seasonal variation was found to exist (Table I and Fig. 1). The cause of this variation was found to be due to the amount of starch accumulated (Table I and Fig. 2). Consequently, it was proposed that tne customary representation of its component content by the weight percentage was of little physiological significance. Therefore, the determined values of total alkaloid and total nitrogen were shown by the volume percentage calculated from specific weight of tissue powder (Table I and Fig. 3). From these values, a large seasonal variation of alkaloidal content could not be detected.

著者

柊元 巌

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.1, pp.75-79, 2019-01-01 (Released:2019-01-01)

参考文献数

13

---

Persistent infection with oncogenic human papillomaviruses (HPVs) is necessary for the development of cervical cancer, although the accumulation of somatic mutations in the host genome is also required for the generation of invasive cervical cancer. Recent studies have demonstrated concomitant genetic changes in the HPV genome; however, their relevance to cervical carcinogenesis is poorly understood. Here we review our recent study investigating the within-host genetic diversity of HPV and its relationship with cervical cancer progression through deep sequencing analyses of viral whole-genome sequences in clinical specimens. Intriguingly, HPV genomes within individual clinical samples show an astonishingly high level of nucleotide variation across all histological grades of cervical lesions. Among the various substitution patterns, C-to-T and C-to-A substitutions are the predominant changes observed in the HPV genomes. Analysis of the trinucleotide context for substituted bases reveals that TpCpN (N is any nucleotide), which is a preferred target sequence for the cellular apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) proteins, is the major target for C-to-T substitutions in the HPV genomes. These mutational signature analyses strongly imply that within-host HPV variations are mostly generated through APOBEC-mediated mutagenesis. Because the HPV oncogenes E6 and E7 harbor APOBEC-related mutations, we propose a potential role for APOBEC-mediated mutagenesis in cervical carcinogenesis.

著者

中西 秀之 樋口 ゆり子 川上 茂 山下 富義 橋田 充

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.129, no.12, pp.1433-1443, 2009-12-01 (Released:2009-12-01)

参考文献数

58

被引用文献数

3 3

---

Transposons are mobile genetic elements that move between or within vectors and chromosomes. For the transposition, an enzyme called transposase recognizes transposon-specific terminal inverted repeat sequences (IRs) located on both ends of transposons, and remove them from their original sites and, integrates them into other sites. Because of this feature, transposons containing genes of interest between their two IRs are able to carry the genes from vectors to chromosomes. Transposons are promising systems for chromosomal integration because they can not only integrate exogenous genes efficiently, but also be transfected to a variety of cells or organs using a range of transfection methods. In this review, we focused on the therapeutic application of transposons. A few transposons can integrate transgenes into mammalian chromosomes. They have been used in preclinical studies of gene therapy and cell therapy. In addition, they have recently been used for generation of induced pluripotent stem cells. Transposon-based integrative vector systems have two components. One is the transposon containing transgenes, and the other is the expression cassette of the transposase. Both viral and non-viral vectors have been used to deliver these two components to mammalian cells or organs, and sustained transgene expression has been achieved. Transposon-mediated sustained transgene expression has also produced therapeutic effect in disease models of hereditary and chronic diseases. Although transposon-based integrative vector systems have problems, such as insertional mutagenesis, studies to overcome these problems have been progressing, and these vector systems will become indispensable tools to cure refractory diseases.

著者

砂田 久一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.128, no.8, pp.1087-1107, 2008-08-01 (Released:2008-08-01)

参考文献数

49

被引用文献数

3 4

---

My main research fields are powder technology, especially solid dosage form, from basic ones to applied ones. Basic ones are physical properties of powder and its packing, compression and computer simulation. Applied ones are preparation and evaluation of granulation, tableting, improvement of solubility of water poor-soluble drug, controlled release tablet and fast disintegrating tablet in the oral cavity. As the chair man of the Standard Formulation Research Council, I have obtained many variable and excellent results. Several results are shown as follow.

著者

森田 直賢 清水 岑夫 竹崎 孝行

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.88, no.10, pp.1277-1280, 1968-10-25 (Released:2008-05-30)

参考文献数

14

被引用文献数

9 12

---

A new glycoside (I), C24H26O18·11/2H2O, mp 274-275°, was isolated from Chrysosplenium grayanum MAXIM. (Japanese name"Nekonomeso"), and a glycoside (II), C24H26O12·2H2O, mp 175-176°, from C. flagelliferum FR. SCHM. (Japanese name"Tsurunekonomeso"). I was determined as oxyayanin-A (5, 2', 5'-trihydroxy-3, 7, 4'-trimethoxyflavone)-2'-glucoside, and was named chrysosplenoside-A, and II as pendulin (5, 4'-dihydroxy-3, 6, 7-trimethoxyflavone-4'-glucoside).

著者

岩出 賢太郎 下路 静佳 正木 秀典 酒井 隆全 田辺 公一 後藤 伸之 大津 史子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

pp.18-00205, (Released:2018-12-05)

参考文献数

19

被引用文献数

1

---

We investigated the possibility that having pharmacists give asthma patients informational sheets on climate and environmental changes at insurance pharmacies during patient counseling might prevent the worsening of asthma symptoms. Patients with hyperlipidemia were comparative subjects. We created informational sheets about climate and environmental changes and their influence on asthma. During patient counseling, pharmacists gave them to all asthma patients who visited insurance pharmacies over a period of 2 months, between November and December 2017. Based on previous studies, we called days which showed certain climate or environmental changes as compared to the previous day “change days”. We compared the number of visiting patients on change days after preventative information was provided (between January and March 2018) with the number before information was provided (between January and March 2017). In addition, we compared those numbers with the number of patients who visited the target pharmacies between January and March 2016 in order to examine the influence of yearly climate change. The same procedure was used with hyperlipidemic patients. The number of visiting asthma patients after information was provided significantly decreased (5.1±2.1, p=0.03) compared with the number before information was provided, between January and March 2017 (6.1±2.8). The number of aforementioned visits compared to those between January and March 2016 also significantly decreased (p=0.01). Our results suggest that preventative information about climate and environmental changes provided by pharmacists during patient counseling might influence the number of asthma patient visits and prevent the exacerbation of their symptoms.

著者

原野 一誠

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.125, no.6, pp.469-489, 2005-06-01 (Released:2005-06-01)

参考文献数

55

被引用文献数

7 7

---

Chugaev reaction provides access to olefins from alcohols without rearrangement through pyrolysis of O-alkyl S-alkyl dithiocarbonates (xanthates) via cis elimination. Xanthates having no β-hydrogens undergo thione-to-thiol rearrangement to give S,S-dialkyl dithiocarbonates (thiolcarbonates). Based on these backgrounds, we intended to use the dithiolcarbonates as precursors of thiols. Xanthates could be converted to the corresponding dithiolcarbonates by Lewis-acid catalysis. Pyridine N-oxides and 4-dimethylaminopyridine also catalyzed the rearrangement reaction. On the other hand, O-(2-alkenyl) S-alkyl dithiocarbonates undergo [3,3]-sigmatropic rearrangement to give the allylically rearranged S-(2-alkenyl) S-alkyl dithiocarbonates. The homoallylic xanthates gave the corresponding dithiolcarbonates on heating with phenols. Pyrolysis of allylic dithiolcarbonates caused retro-ene type reaction to give the allylic sulfides in which allylic rearrangement also occurs. Coupling of these pericyclic reactions with intramolecular Diels-Alder reaction affords a one-pot synthetic method for the construction of hydroisobenzothiophenes. The mechanisms of the cascade and related reactions are demonstrated by location of the transition states using molecular orbital calculation method at various levels of theory involving density functional theory (DFT).

著者

山口 秀夫 有本 正生 田之口 真理子 沼田 敦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.101, no.5, pp.485-488, 1981-05-25 (Released:2008-05-30)

参考文献数

12

被引用文献数

5 7

---

Two kinds of reactions were carried out on the components of the seeds of Hernandia ovigera L. The reaction of lead tetraacetate on desoxypodophyllotoxin (I) and its analogous compounds caused the cleavage of methylenedioxyl group, affording the corresponding diphenols. In the case of 3, 4-methylenedioxypropylbenzene (XII), an intermediate acetoxyl compound (XIII) was isolated. The reactions of 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ) on I and its analogous compounds afforded smoothly aromatized compounds. By the same reaction on bursehernin (III), cyclization and aromatization occurred simultaneously affording chinensin (XVIII) which was confirmed by direct comparison with authentic speciemen. The results of the cleavage reaction on I and XII by use of borontrichloride were also described.

著者

山口 秀夫 有本 正生 山本 起巳子 沼田 敦

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.99, no.6, pp.674-677, 1979-06-25 (Released:2008-05-30)

参考文献数

15

被引用文献数

12 14

---

Four kinds of lignans were isolated from the seeds of Hernandia ovigera L. collected in Okinawa besides the previously reported desoxypodophyllotoxin (I). Oily substance II, named bursehernin, C21H22O6, was confirmed to be lignan-2 isolated from Bursera schlechtendalii. III, mp 171-173°, and IV, mp 125-126°, were determined as desoxypicropodophyllin and podorhizol obtained from Podophyllum emodi WALL. respectively. V, mp 270-275°, could not be clarified due to its small amount.

著者

大橋 一智 上田 浩史 山崎 正利 木村 貞夫 安部 茂 山口 英世

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.112, no.12, pp.919-925, 1992-12-25 (Released:2008-05-30)

参考文献数

18

被引用文献数

10 10

---

The biological activity of a preparation of heat killed cells of Enterococcus faecalis, FK-23 which was isolated from the feces of a healthy human, was investigated in C3H/He mice. Intraperitoneal injection of the preparation caused an accumulation of neutrophils and macrophages in the peritoneal cavity of the mice 6 h later. As a parameter of the activation of macrophages, the effect of the FK-23 preparation on the production of tumor necrosis factor (TNF) was examined. The mice were given two consecutive intravenous injections of the preparation at a dose of 10μg/mouse and, 3 h later, of 300μg/mouse. The TNF level in the sera reached 99 U/ml in mice 2 h after the second injection. This preparation also stimulated peritoneal macrophages to produce TNF in vitro and increased the capacity of neutrophils to adhere to plastic plates and to release active oxygens, but did not induce blastogenic transformation of lymphocytes. These results suggest that the FK-23 preparation is a biological response modifier (BRM) with various activities on phagocytes similar to a streptococcal antitumor agent, OK432.

著者

永田 亘 成定 昌幸 吉岡 美鶴 吉田 正 尾上 弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.111, no.2, pp.77-102, 1991-02-25 (Released:2008-05-30)

参考文献数

60

被引用文献数

1 5

---

A pioneering work in the field of oxacephem antibiotics which had been carried out in our research laboratories is reviewed. Our research of β-lactam antibiotics was started in 1974 with the policy to make chemical modification at the nuclei but not the side chain of the existing β-lactam antibiotics, with an expectation to discover a new type of antibiotics. After the success in establishing an efficient synthetic method for 3'-nor-cephalosporin, we started oxacephem research in 1975. We succeeded in developing three synthetic methods starting from penicillins which efficiently served to prepare numerous oxacephem (1-oxa-1-dethia-cephalosporin) derivatives. It turned out that the oxacephem nucleus was much more distorted with an increased ring strain, resulting in reduction of the β-lactam amide resonance to a greater extent than the cephalosporin nucleus. This physicochemical properties conferred an increased chemical reactivity on the nucleus as evidenced by an increased hydrolysis rate as compared with the corresponding 1-thia counterpart. This increased chemical reactivity coupled with the reduced hydrophobicity of the oxacephem nucleus as evidenced by the lower distribution constant in a water-octanol system, characterized unique biological properties of oxacephem derivatives. These include (1) 2-16 times increase in antibacterial activity with emphasis against gram-negative bacteria ; (2) increased protecting effect in vivo parallel to the increased in vitro activity ; (3) reduction of the stability to β-lactamases leading to decreased antibacterial activity against the β-lactamase producing strains ; (4) 1.6-3.2 times increase in penetrability through the outer membrane of certain gram-negative bacteria, the increase being due to the increased hydrophilicity of the oxacephem nucleus ; (5) remarkably reduced binding to human serum albumin improving the efficacy of the oxacephems in the blood ; (6) a remarkable change in the excretion pattern, i.e. recovery in the bile reduced and that in the urine increased. These biological characteristics are generally favorable for antibacterial agents against pathogenic diseases except for the reduced stability to β-lactamases. This unfavorable property of the oxacephem nucleus was the only barrier for developing a new agent of the oxacephem nucleus. However, this problem was relatively easily solved by introduction of (1) the methoxy group at 7α and (2) appropriately α-substituted acyl amide side chain at 7β ; the former and the latter substituent effectively stabilized the oxacephems to various kinds of penicillinases and cephalosporinases, respectively. It turned out that both effects were complementary and, thus, combination of both substituents produced perfect stabilization of the oxacephems to β-lactamases, and brought about the complete recovery of the activity against resistant strains. Extensive studies were performed to obtain deep and broad knowledge in structureactivity relationships in the field of the newly explored oxacephems. As the results of these efforts we succeeded in obtaining two important and useful oxacephem compounds, i.e. latamoxef 18 and flomoxef 19. Latamoxef 18 is a very potent and broadly active third generation β-lactam antibiotic, and perfectly stable to various kinds of β-lactamases showing efficacy against most of the resistant bacteria. Moreover, it has very favorable pharmacological properties, such as a high blood level and a long half-life, which are essential for efficacy in human body. One of the drawback of this antibiotic, as commonly observed in the third generation antibiotics, was the rather weak activity against grampositive bacteria, especially against Staphylococcus aureus. This weak point was basically improved by introducing a new 7β-acylamido side chain and by a minor structural change in the N-methyl-tetrazol part, as seen in structure 19. [the rest omitted]

著者

清水 當尚 宇野 準 伊藤 継孝 増田 義信 黒川 美貴雄

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.116, no.7, pp.533-547, 1996-07-25 (Released:2008-05-30)

参考文献数

55

被引用文献数

4 8

---

Zonisamide (1, 2-benzisoxazole-3-methanesulfonamide, AD-810) is a broad spectrum antiepileptic drug which has been launched in Japan and South Korea. It lacks the ureide structure included in most of the existing antiepileptic drugs. Zonisamide was synthesized by the sulfonation and the successive amination of 1, 2-benzisoxazole-3-acetic acid in a very poor yield. After several efforts to optimaize the compound, zonisamide was selected based on the balance of the efficacy and safety. The yield was greatly improved by the development of new synthetic routes. Zonisamide suppressed maximal electroshock seizures in mice, rats, rabbits and dogs. Its therapeutic plasma concentration range between anticonvulsant and neurotoxic effects was much wider than that of the existing antiepileptic drugs. In electroencephalographic studies on animal models of epilepsy, zonisamide, like phenytoin and carbamazepine, restricted the spread or propagation of seizures and, like sodium valproate, it suppressed the epileptogenic focus activity. Zonisamide was effective in several kindling models. In clinical studies, zonisamide exerted the efficacy against partial seizures (simple, complex, secondarily generalized seizures) and some generalized seizures (tonic-clonic, tonic, atypical absence seizures) that were comparable to that of carbamazepine and sodium valproate, respectively. Zonisamide was also effective in monotherapy. The adverse effects related with zonisamide were mainly drowsiness, ataxia, loss of appetite and gastrointestinal symptoms. Serious adverse effects which may be life-threatening have not been reported.

著者

柴崎 正勝

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.101, no.12, pp.1073-1091, 1981-12-25 (Released:2008-05-30)

参考文献数

69

被引用文献数

2 3

---

The present article describes our recent synthetic studies on various biologically active compounds, including synthesis and biological properties of prostacyclins, synthetic approach toward thromboxanes, and total syntheses of coriolin and hirsutic acid C. In the final part of this review, some new reactions, exploited in connection with synthetic studies on prostacyclins, are also described.

著者

坪島 正巳 松本 公一郎 新井 義信 若塚 弘久 川崎 晃義

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.112, no.7, pp.447-469, 1992-07-25 (Released:2008-05-30)

参考文献数

54

被引用文献数

3 4

---

The therapeutic use of prostaglandins (PGs) which contain various biological activities and are unstable was successfully achieved. PGs were produced in a large scale according to the Corey method and could be stabilized by the formation of a clathrate compound with cyclodextrin, which enabled the production of marketable form of highly pure PGs. Diligence in the development of native PGs and their structural analogs for human therapy resulted in the following six drugs now being on the market in Japan : PGF2α as the first drug of PGs in the world which induces labor ; PGE2 as an orally active labor inducing drug ; PGE1 for the treatment of peripheral vascular diseases ; gemeprost for therapeutic abortion in the middleterm ; ornoprostil, as an oral anti-ulcer agent ; limaprost for the treatment of peripheral vascular diseases as an oral agent.

著者

鶴田 峯生 三ケ島 浩 大江 孝範 川崎 和幸 瀬戸口 信郎 中 洋一 田原 哲治

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.109, no.1, pp.33-45, 1989-01-25 (Released:2008-05-30)

参考文献数

28

被引用文献数

7 5

---

Several imidazolylpyridinemethanols and imidazolylbenzenemethanols were prepared and evaluated for an inhibitory activity against arachidonic acid-induced platelet aggregation. The result shows that the arylmethanol moiety is essential for the activity and may correspond to the 15-OH group of prostagrandin H2 (PGH2). Among the compounds tested, 4-[α-hydroxy-5-(1-imidazolyl)-2-methylbenzyl]-3, 5-dimethylbenzoic acid (XV) was found to have a potent inhibitory activity and a long duration of action. Structureactivity relationships are also discussed briefly.

著者

坂井 進一郎 山中 悦二 横溝 理 松本 緑

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.95, no.12, pp.1511-1516, 1975-12-25 (Released:2008-05-30)

参考文献数

10

被引用文献数

1 2

---

It has been found that a reaction of the cyclic imino ether in gardneramine (I) with MeI afforded N-methylated oxindole (III). Synthesis of a compound (XIV)) having a cyclic imino ether system and its reaction with MeI are described. An alcohol (X) was prepared by the Michael reaction of N-acetyl-3-ethyloxindole (VII) with ethyl acrylate, followed by LiA1H4 reduction. On treatment with p-toluenesulfonyl chloride in pyridine, X afforded a tosylate (XI) and a chloride (XII). The imino ether (XIV), synthesised by the reaction of XII with potassium t-butoxide in dimethyl sulfoxide-benzene (1 : 1), reacted with MeI to afford N-methyl-3-(3-iodopropyl)oxindole (XX). The reductive dehalogenation of XX with NaBH4/Me2SO gave N-methyl-3-ethyl-3-propyloxindole (XXI), which was identical with the authentic sample prepared from XII by a different route.

著者

古谷 力

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.106, no.10, pp.856-866, 1986-10-25 (Released:2011-01-31)

参考文献数

25

被引用文献数

3 3

---

Plant tissue culture is profitably used in biotechnology today to produce valuable compounds and to rapidly and uniformly propagate economically important plants.The main objective of this review is to outline the advances in the production of medicaments and biochemicals by plant tissue cultures. In relation to this objective, the development of newly advanced techniques such as transformation, cell fusion, biotransformation, bioreactor with immobilized plant cells, and synthetic seeds, is briefly discussed.Recent studies in my laboratory on the bioconversion of 2-phenylpropionic acid (mainly glycosylation) and l-menthol (glycosylation and hydroxylation) by plant suspension cells, and of codeinone (reduction) by the bioreactor with immobilized opium poppy cells, and on the de novo synthesis of stress metabolites in the immobilized licorice cells, are described. The production of Korean ginseng and saponin ginsenosides in Korean ginseng suspension cells, and of Vitamin E in safflower cells are also discussed.