著者

野崎 章仁

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.88, no.4, pp.203-204, 2014

著者

湯浅 正洋 松本 希美 渡邊 敏明

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.12, pp.678-684, 2012

参考文献数

32

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Biotin is a water soluble vitamin that is a cofactor for carboxylases in fatty acid synthesis, gluconeogenesis, and amino acids metabolism. Biotin deficiency is very rare in humans since biotin is widely contained in various foods. However, biotin deficiency has been reported in infants using "infant formulas" made in Japan. Biotin deficiency is especially developed in infants with special formulas, high-calorie infusion with low biotin contents and anticonvulsants. Biotin deficiency is sometimes shown in infant patients with milk allergies caused by amino acid formula with low biotin contents. In this article, we reviewed the biotin deficiency induced by special formulas in Japanese infants. From previous reports, the biotin content in Japanese formulas is lower than the recommended dietary amount of FAO/WHO (1.5 μg/100kcal) and that of United States products. Urinary biotin concentration in formula-fed infants is lower than breast-fed infants, because biotin contents in Japanese formulas are much less. From these findings, biotin should be added to Japanese infant formulas as soon as possible, and it is necessary to make clinical staffs, such as dietitians and pediatricians, and neonatal intensive care unit staffs recognize that the biotin contents in special formula are not enough for maintaining the nutritional status of biotin.

著者

田中 清 青 未空

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.10, pp.621-623, 2017

著者

成澤 邦明

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.72, no.2, pp.70-71, 1998

著者

鈴木 洋一 坂本 修 李 雪 楊 雪 青木 洋子 平塚 真弘 成澤 邦明 工藤 純 清水 信義

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.73, no.5, pp.330-331, 1999

著者

谷口 歩美 渡邊 敏明

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.81, no.3, pp.101-104, 2007

参考文献数

17

著者

野崎 章仁 湯浅 正洋 沈 婉〓 渡邊 敏明

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.89, no.3, pp.119-124, 2015

著者

野崎 章仁 福田 篤志

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.91, no.11, pp.633-636, 2017 (Released:2018-11-30)

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Attention has been paid to secondary carnitine deficiency in children. However, secondary carnitine deficiency in pediatric patients has been reported repeatedly. In this study, the questionnaire survey of medical worNers on secondary carnitine deficiency in children was conducted. In the study, 125 individuals including 22 pediatricians, 18 non-pediatric doctors, 80 nurses, and 5 pharmacists in our hospital were enrolled. As a result, the response rate to secondary carnitine deficiency in children was insufficient. In addition, there was a statistically significant difference in the response rate between pediatricians and other medical workers. Pediatric practice consists of not only pediatricians but also other medical workers. Therefore, it is important that all medical staffs participating in pediatric practice deepen their knowledge of secondary carnitine deficiency and thereby prevent the deficiency.

著者

小川 真弘 原田 直樹 山地 亮一

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.87, no.8, pp.450-453, 2013-08-25 (Released:2017-08-10)

参考文献数

35

著者

久田 四郎 羽土 妙子

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.21, pp.85-90, 1960

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Glutamic acid decarboxylase and γ-aminobutyric acid occur only in the brain among animal tissues, and their relation to psychotropic effects are to be considered. Effects on avoidance responses and behaviour of rats and monkeys were investigated, with glutamic acid, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, β-hydroxyglutamic acid, δ-aminovaleric acid and INAH. As a result, inhibition was brought by decarboxylation and activity was increased by β-hydroxylation. γ-Amino-β-hydroxybutyric acid and β- hydroxyglutamic acid which were antagonistic had more remarkable activity than glutamic acid, while δ-aminovaleric acid had no effect upon them. Different effects based upon species and conditons used in the experiment were discussed.

著者

久田 四郎 羽土 妙子 中島 敏夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.21, pp.76-80, 1960

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In mice fed on a vitamin B_6 deficient diet, even in the cases which had no remarkable symptoms of the deficiency, the activity of brain glutamic acid decarboxylase was markedly low. In rats, however, the amounts of glutamic acid, γ-aminobutyric acid and aspartic acid in the brain were not affected by vitamin B_6 deficiency. Addition of chlorpromazine to a cell-free preparation of the brain homogenate caused an increase of the enzymatic activity. The amount of brain glutamic acid decreased by an administration of chlorpromazine, while the substance exerted no effect on the amounts of γ-aminobutyric acid and aspartic acid. In vitamin B_6 deficiency, the hypnotic effect of chlorpromazine was lowered markedly in both mice and rats. These results were discussed in the point of view of central depression due to decarboxylation of glutamic acid in the brain.

著者

小熊 敦之 芦沢 萌恵 江草(雜賀) 愛 片山 努 古屋 元宏 赤尾 友雪 西村 敏英

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.87, no.10, pp.543-548, 2013-10-25 (Released:2017-08-10)

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We examined the effects of vitamin B_1 (B_1) and fat added to a feed on their accumulation and glucose- and lipid-metabolism in the porcine liver. B_1 content in the livers of pigs fed a feed supplemented with 15 ppm B_1-supplemented feed (B+ group) was significantly higher than that in the livers of pigs fed the usual dosage of 1.5 ppm B_1 (Control group). B_1 content in the livers of pigs given a feed with 1.5 ppm B_1 plus 3% fat (F+ group) or a feed with 15 ppm B_1 plus 3% fat (B+F+ group) was significantly higher than that in pigs given a feed with 15 ppm B_1 (B+ group) or controls. The liver fat content in the B+F+ group was lower than that in the B+ group. Analysis of liver mRNA levels showed that gene expression of β-oxidation-related proteins increased in B_1-supplemented groups. Glycolytic pathway- and TCA cycle-related gene expression levels were also increased with fat supplementation. These results indicated that, in pigs with co-supplementation of high dose of B_1 and fat, glucose and lipid metabolism was enhanced in the liver.

著者

錦見 盛光

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.81, no.1, pp.1-8, 2007-01-25 (Released:2017-10-10)

参考文献数

35

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L-Ascorbic acid is synthesized by animals and plants, and its analogues in fungi. Studies in the 1950s showed that scurvy-prone species, such as humans, other primates, and guinea pigs, do not possess L-gulono-γ-lactone oxidase, the terminal enzyme of the L-ascorbic acid biosynthetic pathway in animals. We first cloned a cDNA for this enzyme of rat, with which the isofunctinal enzymes of plants and fungi were later shown to be homologous at the gene level. Using the cDNA as a probe, its related DNA sequences of human and guinea pig were cloned and their gene structures were disclosed. Of note is the tremendous deterioration of the genes such as deletion of exons and nucleotide(s), nonconformity to the GT/AG rule at the intronexon junction, and occurrence of stop codons as well as a large number of substations at the amino acid level. In contrast, the genetic abnormality of osteogenic disorder Shionogi (ODS) rat was found to be due to a single missense mutation in the L-gulono-γ-lactone oxidase gene. Recent our study revealed that the knockout mouse deficient for senescence marker protein-30 was subject to scurvy when fed a vitamin C deficient diet. As a matter of fact, this protein was proven to be the gluconolactonase that catalyzes the penultimate step of the L-ascorbic acid biosynthetic pathway.

著者

錦見 盛光 河合 敏秀 八木 國夫

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.66, no.11, pp.655-660, 1992-11-25 (Released:2018-03-17)

被引用文献数

2

著者

辻村 卓 日笠 志津 荒井 京子

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.72, no.11, pp.613-617, 1998

被引用文献数

3

著者

鈴木 洋一 坂本 修 真下 陽一 羽田 明

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.9, pp.499-507, 2012-09-25 (Released:2017-10-10)

参考文献数

31

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Biotin is a water-soluble vitamin and a cofactor of several types of carboxylases. Insufficient intake of biotin and a congenital deficiency of enzymes requiring biotin as a cofactor in cells cause clinical symptoms called multiple carboxylase deficiency (MCD). In recent years, several reports have shown that infants with food allergy and/or atopic eczema have developed MCD after being fed with peptide formulas. Peptide formulas available in Japan contain very little biotin because biotin has not been permitted to be added to regular foods as an additive. This, however, may lead to nutritional biotin deficiency in some infants fed with such a peptide milk. We investigated the incidence of nutritional biotin deficiency and congenital enzyme deficiency in Japan. We sent a questionnaire to 921 hospitals with a pediatric department to cover all areas of Japan. The response rate was 64%. The rate of hospitals that use peptide milk in the therapy of allergic diseases was 49%. The estimated incidence of biotin deficiency was at least 70 cases in the last 10 years. Since the first diagnosis of holocarboxylase synthetase deficiency (HCSD) in 1982, HCSD and biotinidase deficiency have been confirmed in 28 and 2 cases, respectively. These data suggest that the incidence of congenital enzyme deficiency is about 1 case per year. Supplementation of biotin is highly recommended when infants are fed with peptide milk in Japan.

著者

二木 鋭雄

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.86, no.9, pp.519-520, 2012-09-25 (Released:2017-10-10)

参考文献数

13

被引用文献数

2

著者

中山 亨

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.90, no.9, pp.458-459, 2016 (Released:2017-12-26)

著者

薮田 行哲 重岡 成

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.79, no.8, pp.395-398, 2005-08-25 (Released:2017-10-10)

著者

柘植 治人

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.75, no.8, pp.421-425, 2001-08-25 (Released:2017-12-26)

参考文献数

17

被引用文献数

1