著者

加藤 金治 宮田 節男

出版者

Japan Society of Spring Engineers

雑誌

ばね論文集 (ISSN:03856917)

巻号頁・発行日

vol.1980, no.25, pp.34-38, 1980-03-25 (Released:2010-02-26)

参考文献数

5

著者

井浪 義博 安東 嗣修 佐々木 淳 倉石 泰

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.11, pp.1225-1230, 2012 (Released:2012-11-01)

参考文献数

17

被引用文献数

1 1

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The primary function of surfactants is to remove dirt, exfoliated corneum cells, and microorganisms from the skin. However, the use of toiletries such as soaps and shampoos containing surfactants may cause adverse effects such as cutaneous irritation, dryness, and itching. Recently, skin pathologies, including dry skin, rough skin, and sensitive skin, have increased because of changes in living conditions and lifestyle. Although many people with skin pathologies complain of itching during and/or after skin washing using detergents, the mechanisms of detergent-induced itch are yet to be elucidated. Therefore, in this study, we investigated the mechanisms underlying surfactant-induced itching. We found that topical application of an anionic surfactant sodium laurate at an alkaline pH, but not N-lauroylsarcosine sodium salt at neutral pH, to mouse skin induced scratching, an itch-related response. Additionally, we found that the sodium laurate-induced scratching was inhibited by H1 histamine receptor antagonist, but not mast cell deficiency. Sodium laurate application increased histamine content and the level of the active form (53 kDa) of L-histidine decarboxylase (HDC) in the mouse epidermis, but not the dermis. Furthermore, addition of sodium laurate to a human epidermal cell culture increased histamine release and HDC levels, without affecting cell viability. These results suggest that surfactants with alkaline properties are pruritogenic and that the pruritus is induced by the histamine released from epidermal keratinocytes. The increase in histamine release may be attributable to the activation of HDC in epidermal keratinocytes.

著者

木戸 敏郎

出版者

日本アルバン・ベルク協会

雑誌

ベルク年報 (ISSN:09143327)

巻号頁・発行日

no.13, pp.41-54, 2008

著者

蔡 江華

出版者

名古屋大学大学院 国際言語文化研究科 日本言語文化専攻

雑誌

言葉と文化 (ISSN:13455508)

巻号頁・発行日

no.8, pp.21-36, 2007-03-31

著者

鈴木 和枝 藤田 弘美 橋場 直彦 本吉 光隆 池田 義雄

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.59, no.10, pp.706-712, 2016-10-30 (Released:2016-10-30)

参考文献数

8

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過去30年間における糖尿病栄養指導の推移を把握するために,1982年から10年間隔で合計4回実施したアンケート調査結果を比較した.調査は,過去3回に準じて全国1,961の医療機関のうち回答を得た915施設を対象に実施した.管理栄養士・栄養士の雇用率と,個人指導の実施率は,過去30年間高い割合で推移した.日本糖尿病療養指導士(Certified Diabetes Educator of Japan:CDEJ)の雇用率は,発足当初の10年前52.1 %,今回62.9 %であった.時間がかかる指導内容として,「糖尿病食事療法のための食品交換表の説明」と答えた施設の割合は30年前75.0 %,20年前58.8 %を占めたが,10年前37.6 %,今回は28.0 %になった.このことは,CDEJ資格取得のための教育効果によって管理栄養士・栄養士の知識・意欲が向上し,糖尿病栄養指導の在り方が変貌した結果として捉えられた.

著者

蒋 忠新 大江 平和

出版者

東洋哲学研究所

雑誌

東洋学術研究 (ISSN:02876086)

巻号頁・発行日

vol.38, no.1, pp.184-170, 1999-05

著者

朝倉 輝一

出版者

東洋大学法学会

雑誌

東洋法学 (ISSN:05640245)

巻号頁・発行日

vol.58, no.3, pp.270-251, 2015-03

著者

服部文四郎 著

出版者

巌松堂

巻号頁・発行日

1909

著者

丹羽 さよ子 田口 朋子 松田 史代 榊間 春利 森本 典夫

出版者

鹿児島大学

雑誌

鹿児島大学医学雑誌 (ISSN:03685063)

巻号頁・発行日

vol.65, no.2, pp.37-47, 2014-03

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Purpose: To investigate age-related changes in visual functions and risk factors for visual impairment in community-dwellingJapanese elderly. Visual function assessment included static visual acuity (SVA), kinetic visual acuity (KVA), dynamic visual acuity(DVA), night vision (NV), depth perception (DP), ocular motor skill (OMS), and visual reaction time (VRT).Methods: A total of 321 community-dwelling people (112 men and 209 women, mean age: 67.3 ± 10.4, range: 40 to 91 years old)participated in this study. They reported any history of eye or chronic diseases in a self-administered questionnaire. Functionalcapacity was evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG Index). Visualassessments were made using a visual acuity measurement device.Data analysis: SVA and KVA were converted into logarithms of the minimum angle of resolution for analysis, while participantswere classified into 4 age groups: 40 to 54 (early middle-aged); 55 to 64 (late middle-aged); 65 to 74 (young-old); and 75 and over(old-old). Statistical analyses were performed using a Jonckheere-Terpstra trend test, a Mantel-Haenszel test, and logistic regressionanalyses (univariate and multivariate analyses). Logistic regression analyses were performed with the visual functions as dependentvariables and sex, age group, history of eye disease, and history of chronic disease as independent variables. In logistic regressionanalyses with visual functions other than SVA, SVA was included as a moderator variable. For statistical analysis, IBM SPSS version21.0 was used, while setting the significance level at 5%.Results: A marked tendency for scores of the TMIG-index to decrease with age was observed (p=0.012). In measurements of DVA,NV, KVA, and DP, some participants had difficulty in reading the target. There was a marked tendency for this proportion to increasewith age. Similarly, analysis of the data regarding visual functions, excluding data of participants with reading difficulty, revealedthat all these functions, except for NV, markedly decrease with age. According to multivariate analysis, risk of impaired KVA beganto increase in the late middle-aged group compared to the early middle-aged group. Risk of impaired DVA, NV, DP, and VRT began to increase in the young-old group, and risk of impaired SVA and OMS began to increase in the old-old group. Risk of impaired DPwas higher in women than in men. Furthermore, univariate analysis showed that a history of eye disease was significantly associatedwith impaired DP, and a history of chronic disease was significantly associated with impaired OMS and impaired VRT.Conclusion: Visual impairments in community-dwelling elderly increase with age. According to multivariate analysis, age wasa significant risk factor of each impaired visual function examined in this study, and sex was a significant risk factor of impairedDP. Considering that impaired visual functions particularly affect ADL and QOL in the elderly, it is important to take preventivemeasures against such impairment. However, since it is difficult to routinely assess visual functions, visual impairments arecommonly overlooked in community-dwelling elderly. Therefore, the findings obtained from this study may be useful for thoseexamining appropriate methods to support community-dwelling elderly with visual impairment.

著者

次田 元文

出版者

高知海南史学会

雑誌

海南史学 (ISSN:03894096)

巻号頁・発行日

no.49, pp.69-91, 2011-08

著者

McKinnon Cheryl 青木 延一

出版者

ARMA International東京支部

雑誌

Records & information management journal = レコード&インフォメーションマネジメントジャーナル : the information management professionals

巻号頁・発行日

no.42, pp.24-27, 2020-04

著者

白川 栄美

出版者

ARMA International東京支部

雑誌

Records & information management journal = レコード&インフォメーションマネジメントジャーナル : the information management professionals

巻号頁・発行日

no.42, pp.13-17, 2020-04

著者

McKinnon Cheryl 青木 延一

出版者

ARMA International東京支部

雑誌

Records & information management journal = レコード&インフォメーションマネジメントジャーナル : the information management professionals

巻号頁・発行日

no.42, pp.18-21, 2020-04

著者

西川 康男

出版者

ARMA International東京支部

雑誌

Records & information management journal = レコード&インフォメーションマネジメントジャーナル : the information management professionals

巻号頁・発行日

no.42, pp.1-4, 2020-04

著者

松岡 資明

出版者

ARMA International東京支部

雑誌

Records & information management journal = レコード&インフォメーションマネジメントジャーナル : the information management professionals

巻号頁・発行日

no.42, pp.10-12, 2020-04

著者

香川 幹一

出版者

古今書院

雑誌

地理 (ISSN:05779308)

巻号頁・発行日

vol.12, no.6, pp.99-102, 1967-06

著者

香川 幹一

出版者

古今書院

雑誌

地理 (ISSN:05779308)

巻号頁・発行日

vol.2, no.8, 1957-08

著者

香川 幹一

出版者

公益社団法人 日本地理学会

雑誌

地理

巻号頁・発行日

vol.5, no.4, pp.522-523, 1942

著者

齋藤 之誉

出版者

日本地理教育学会

雑誌

新地理 (ISSN:05598362)

巻号頁・発行日

vol.53, no.3, pp.20-37, 2005

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The aim of this study is analyzing the process of making up a teaching method for regional geography education on Kanichi Kagawa, which includes his practices, to make clear fundamental principles of teaching method.<br>The contents of this paper are as follows;<br>I. Introduction<br>II. The essence of theory and practice for regional geography education on Kanichi Kagawa<br>III. The process of making up a teaching method for regional geography education<br>IV. Analyzing the practice for the Chugoku District as a geographical education unit on Kanichi Kagawa<br>V. Conclusion<br>The Teaching method on Kanichi Kagawa has four specific features. The first is to be developed a original immediate map-drawing method. The second is to be developed a teaching model to make students look at geographical regions. The third is to be developed a new method to construct contents to introduce the theory for teaching geographical region. The fourth is to be developed a new method to divide the geographical region in Japan for making up subject matter unit.

著者

香川 幹一

出版者

古今書院

雑誌

地理 (ISSN:05779308)

巻号頁・発行日

vol.12, no.10, pp.99-102, 1967-10