著者
篠田正作 編
出版者
積善館
巻号頁・発行日
1891
著者
Naoki Shimizu Hannah Bersabe Junya Ito Shunji Kato Ryo Towada Takahiro Eitsuka Shigefumi Kuwahara Teruo Miyazawa Kiyotaka Nakagawa
出版者
公益社団法人 日本油化学会
雑誌
Journal of Oleo Science (ISSN:13458957)
巻号頁・発行日
pp.ess16159, (Released:2017-02-10)
被引用文献数
21

Squalene (SQ), a main component of human sebum, is readily photooxidized by exposure to sunlight, producing six squalene monohydroperoxide (SQ-OOH) isomers. Despite its known connection to various skin conditions, few studies have sought to analyze SQ-OOH at the isomeric level. In this study, we aimed to develop a method to discriminate each SQ-OOH isomer with the use of tandem mass spectrometry (MS/MS). The six standard SQ-OOH isomers were prepared by photooxidizing SQ in the presence of rose bengal, a photosensitizer, and isolated by semipreparative high-performance liquid chromatography (HPLC). To purify each isomer, 2-methoxypropene, which reversibly reacts with the hydroperoxide group of SQ-OOH, was utilized. Product ion scanning was then performed on the standard SQ-OOH isomers in the absence and presence of the sodium ion. In the absence of the sodium ion, the fragmentation patterns produced by atmospheric pressure chemical ionization were similar between the isomers, whereas in the presence of the sodium ion by electrospray ionization, unique fragmentation patterns were achieved. Based on these fragment ions, HPLC-MS/MS multiple reaction monitoring analysis was conducted on a mixture of the standard SQ-OOH isomers. We achieved discrimination of SQ-OOH isomers with high selectivity and detected SQ-OOH isomers at nanogram levels. These results may improve our understanding of the effect of SQ-OOH on skin conditions as well as the mechanism behind SQ peroxidation.
著者
小林 弘
出版者
英米文化学会
雑誌
英米文化 (ISSN:09173536)
巻号頁・発行日
no.37, pp.43-59, 2007-03-31

In his The Elements of Law, De Cive, and Leviathan, Thomas Hobbes says that the English common lawyers in the seventeenth century confused lex with jus, law with right. He emphasizes that "Right, consisteth in liberty to do, or to forbear; whereas Law, determinth, and bindeth to one of them." (Leviathan,117) In brief, he regards right as liberty, or the absence of obligation and law as restraint, or the imposition of obligation. And he insists on a sharp distinction between right and law, and that right is priority of law. Hobbes's distinction between right and law is criticized by many commentators. For example, Richard Peters criticizes the word right Hobbes says for "a strange use." On the other hand, Leo Strauss admits the comment that Hobbes subordinates law to right. And Richard Tuck follows Strauss. Which comments are true? This is one of my subjects, though it is very difficult to solve. I dealt with this subject by Hobbes's method and his linguistic theory in De Corpore. And I reached the conclusion that the comment of Strauss is more proper than that of R. Peters.
著者
丸本 裕一
出版者
JAPAN TECHNICAL ASSOCIATION OF THE PULP AND PAPER INDUSTRY
雑誌
紙パ技協誌 (ISSN:0022815X)
巻号頁・発行日
vol.66, no.10, pp.1115-1119, 2012-10-01

紙パルプ業界は,アジア需要の増加に伴う原材料の高騰と,国内需要減少による設備稼働率の低下により,国内工場の採算確保が厳しい状況が続いている。日本顧客特有の高品質要求を満たしながら利益を確保するには,継続的にコスト削減を実現する仕組み作りが必要となる。<BR>原料切替時の変動や試運転中の損紙費用の把握によるコスト削減を実現したリアルタイム原単位システムを紹介する。<BR>リアルタイム原単位管理システムの基本的な考え方は,プロセスのデータを本社,工場,製造現場共通の指標であるコストに変換してできるだけ早く見せることを実現することである。

1 0 0 0 OA 大日本史料

著者
東京帝国大学文学部史料編纂所 編
出版者
東京帝国大学
巻号頁・発行日
vol.第4編之9,
出版者
日経BP社
雑誌
日経コミュニケーション = Nikkei communications (ISSN:09107215)
巻号頁・発行日
no.636, pp.21-25, 2017-01-01

顧客の質問に自動回答するAIを構築するには、(1)回答する知識である「質問回答集」、(2)ユーザーが話しそうな、様々な言い回しや表現を使った質問文─の2つを用意するのが一般的な方法だ(図9)。ユーザーが話す揺らぎを持った質問文が、質問回答集のどの…
著者
桑原 進
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.67, no.7, pp.1377-1382, 1955-12-31

Reading tests were made with Ishihara's Charts (10th edition) under incandescent lamps, daylight fluorescent lamps. de luxe daylight fluorescent lamps, mixed light of daylight fluorescent lamps and incandescent lamps, and neutral daylight. The result was as follows: The reading accuracy was highest under the de luxe daylight fluorescent lamp, and neutral daylight. the daylight fluorcscent lamp, mixed light of the daylight fluorescent and the incandescent lamps followed in this order with slight differences, and the incandescent lamp was the lowest.