著者

Hirose Ken Takahashi Makoto

出版者

京都大学数理解析研究所

雑誌

数理解析研究所講究録 (ISSN:18802818)

巻号頁・発行日

vol.516, pp.111-122, 1984-03

著者

大蔵省印刷局 [編]

出版者

日本マイクロ写真

巻号頁・発行日

vol.1930年04月19日, 1930-04-19

著者

大蔵省印刷局 [編]

出版者

日本マイクロ写真

巻号頁・発行日

vol.1935年05月18日, 1935-05-18

巻号頁・発行日

1957

著者

Christine Angelidi

出版者

Jaca Book

巻号頁・発行日

1998

出版者

京都大学附属図書館

雑誌

静脩 (ISSN:05824478)

巻号頁・発行日

vol.37, no.1, pp.13-13, 2000-05

著者

Mikio Ota Fumi Seshima Nobuki Okubo Takashi Kinumatsu Sachiyo Tomita Takeshi Okubo Atsushi Saito

出版者

Tokyo Dental College, Japan

雑誌

The Bulletin of Tokyo Dental College (ISSN:00408891)

巻号頁・発行日

vol.54, no.1, pp.51-57, 2013 (Released:2013-04-23)

参考文献数

22

被引用文献数

2 1

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As periodontal disease and diabetes mellitus (DM) have bidirectional interactions, an effective approach to periodontal treatment for patients with diabetes in the clinical setting is essential. This paper reports an effort in collaborative care for patients with periodontitis and diabetes between dental and medical professionals, and provides a preliminary evaluation regarding the clinical outcomes. We have introduced a clinical pathway program at our institution applicable to patients with periodontitis and DM. Physicians and dentists utilize the clinical pathway to share medical and dental information in order to provide the optimal care for each patient. So far, this clinical pathway has been applied to the treatment of 50 patients. We analyzed clinical outcomes in 10 patients with the chief complaint of periodontal problems who had also been diagnosed with type 2 DM. After initial periodontal therapy and diabetes care, a significant improvement in the mean value of glycated hemoglobin and fasting plasma glucose was observed, accompanied by clinical resolution of periodontal parameters. Within the limitations of the present study, the results suggest that collaborative care between periodontists and physicians based on the clinical pathway is effective in glycemic control of patients with periodontitis and type 2 DM. This indicates the need for closer collaboration between medical and dental professionals in improving the management of these diseases.

著者

熊澤 恵里子

出版者

早稲田大学大学院文学研究科

雑誌

早稲田大学大学院文学研究科紀要. 第1分冊, 哲学東洋哲学心理学社会学教育学 = Bulletin of the Graduate Division of Literature of Waseda University. I, Philosophy, oriental philosophy, psychology, sociology, education (ISSN:13417517)

巻号頁・発行日

vol.42, pp.159-170, 1996

著者

井上 琢智 Takutoshi Inoue

雑誌

経済学論究 (ISSN:02868032)

巻号頁・発行日

vol.63, no.3, pp.687-708, 2009-12-15

著者

竹内 孝 石黒 勝彦 木村 昭悟 澤田 宏

出版者

一般社団法人電子情報通信学会

雑誌

電子情報通信学会技術研究報告. IBISML, 情報論的学習理論と機械学習 = IEICE technical report. IBISML, Information-based induction sciences and machine learning (ISSN:09135685)

巻号頁・発行日

vol.112, no.279, pp.67-74, 2012-10-31

参考文献数

25

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本稿では,非負値制約下における複数行列の同時分解法(Stacked Non-negative Matrix Factorization:sNMF)を提案する.sNMFは,行列同士の関係を利用して複数の非負値行列を同時に分解する手法であり,NMFを一般化したモデルとして定式化される.sNMFは,未定義領域有りNMFの特殊な例とも解釈できる.本稿では,データマイニングの分野で関心を集めている,ソーシャルメディアからの話題トピックと話題に関するユーザクラスタの同時抽出問題にsNMFを適用した.NMFと比較して,定量的にも定性的にもsNMFの利用によって解析精度の向上が確認された.

著者

钟文典主编

出版者

广西师范大学出版社

巻号頁・発行日

1993

著者

古賀 勝次郎

出版者

早稲田大学社会科学部学会

雑誌

早稲田社會科學研究 = The Waseda journal of social science (ISSN:02861283)

巻号頁・発行日

vol.23, pp.43-64, 1981

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論文

著者

麻生 英樹

出版者

人工知能学会

雑誌

人工知能学会全国大会論文集 (ISSN:13479881)

巻号頁・発行日

vol.26, 2012

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自然言語の表層表現から意味表現を得るSemantic Parsing およびその逆である言語生成においては、表層表現と意味表現の間の構造の違いが問題になる。具体的には、表層表現は句構造を持ち、意味表現は依存構造を持つと考えられるが、本発表ではその違いとそれが生み出す問題について考察する。

著者

Hirotaka IGARASHI Koichi OHNO Aki OHMI Atsushi TSUKAMOTO Ko NAKASHIMA Yasuhito FUJINO Kazuyuki UCHIDA Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.4, pp.535-538, 2013 (Released:2013-05-02)

参考文献数

20

被引用文献数

5 8

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Two miniature dachshunds, a 7-year-old neutered male and an 8-year-old male, presented with chronic hematochezia and tenesmus. A solitary pedunculated or multiple diffuse colorectal polyps were identified by colonoscopy and resected by polypectomy. Inflammatory colorectal polyps (ICRPs) were diagnosed according to histopathological findings. Both cases were treated with immunosuppressive therapy, and the clinical signs were resolved, although the colorectal polyps remained to some extent. Several months after the initial diagnosis, both cases presented with recurrence of hematochezia and enlargement of the polyps. A second colonoscopic polypectomy was performed, and adenoma was diagnosed histopathologically in both cases. ICRPs are a nonneoplastic disease, but their long-term prognosis is unknown. Careful follow-up seems to be important, and repetitive biopsy is recommended when growth of polyps is identified in miniature dachshunds with ICRPs.

著者

Toyotaka SATO Shin-ichi YOKOTA Torahiko OKUBO Kanako ISHIHARA Hiroshi UENO Yasukazu MURAMATSU Nobuhiro FUJII Yutaka TAMURA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.4, pp.407-414, 2013 (Released:2013-05-02)

参考文献数

38

被引用文献数

17 30

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Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. The AcrAB-TolC efflux pump contributes to resistance against fluoroquinolone and other antimicrobials. In this study, we investigated a high-level mechanism of fluoroquinolone resistance in E. coli that was isolated from human clinical samples and canine fecal samples. E. coli strains with high levels of fluoroquinolone resistance have been found to be frequently resistant to cephalosporins. Strains with high-level fluoroquinolone resistance exhibited lower intracellular enrofloxacin (ENR) concentrations, higher expression of AcrA, and a greater reduction in the fluoroquinolone minimum inhibitory concentration for treatment with an efflux pump inhibitor. The frequency of strains with enhanced ENR resistance selection and the survival rate of E. coli in the presence of ENR in vitro were correlated well with AcrA protein expression levels in the parental strains. These results suggest that AcrAB-TolC efflux pump over-expression is related to high-level fluoroquinolone resistance and the selection of strains with enhanced fluoroquinolone resistance.

著者

Seishiro CHIKAZAWA Yasutomo HORI Fumio HOSHI Kazutaka KANAI Naoyuki ITO Jun SATO Koichi ORINO Kiyotaka WATANABE Sei-ichi HIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.4, pp.515-517, 2013 (Released:2013-05-02)

参考文献数

15

被引用文献数

5 7

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We established a homologous sandwich enzyme-linked immunosorbent assay (ELISA) to measure serum levels of canine ferritin. Our assay uses a rabbit anti-canine heart ferritin polyclonal antibody, and canine heart ferritin as a standard. Serum ferritin concentration in healthy dogs (n=163) was 789 ± 284 ng/ml (mean ± standard deviation), a value higher than reported previously. Confidence levels relating to repeatability, dilution and recovery for this method were high. Therefore, we believe our developed sandwich ELISA will be effective in evaluating serum levels of canine ferritin.

著者

Shinya FUKUMOTO Kiwamu HANAZONO Takahiro KOMATSU Hidetomo IWANO Tsuyoshi KADOSAWA Tsuyoshi UCHIDE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.4, pp.431-437, 2013 (Released:2013-05-02)

参考文献数

26

被引用文献数

7 9

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L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transporter recently has received attention because of its preferential and up-regulated expression in a variety of human tumors, in contrast to its limited distribution and low-level expression in normal tissues. In this study, to explore the feasibility of using LAT1 expression as a molecular marker in mammary gland tumors (MGT), we performed a comparative study of LAT1 expression at the mRNA and protein levels in normal mammary gland cells and tumor cells. Conventional RT-PCR and Western blotting were performed on MGT tissues from 16 dogs and normal organs from nine healthy dogs. LAT1 expression was detected in ten of the 16 MGT patients. As is the case in human tissues, LAT1 showed limited expressional distribution in normal canine organs. For quantitative expressional comparison, extensive real-time RT-PCR was performed on mRNA samples from 53 MGT patients. The comparison demonstrated that LAT1 mRNA levels from MGT tissues were 20 times higher than those in normal mammary gland tissues. Additionally, histologically invasive MGT showed a higher expression of LAT1 than non-invasive tumors. These findings suggest that LAT1 could be a clinical marker and therapeutic target for invasive malignant MGT.

著者

Michelle B. CHRISTENSEN Rebecca LANGHORN Amelia GODDARD Eva B. ANDREASEN Elena MOLDAL Asta TVARIJONAVICIUTE Jolle KIRPENTEIJN Sabrina JAKOBSEN Frida PERSSON Mads KJELGAARD-HANSEN

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.4, pp.459-466, 2013 (Released:2013-05-02)

参考文献数

28

被引用文献数

4 8

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Canine serum amyloid A (SAA) is a useful diagnostic marker of systemic inflammation. A latex agglutination turbidimetric immunoassay (LAT) was validated for automated measurements. The aim of the study was to evaluate the clinical applicability of SAA measured by the LAT. SAA was measured in 7 groups of dogs with and without systemic inflammation (n=247). Overlap performance was investigated. Diagnostic performance was compared to body temperature and leukocyte markers. Clinical decision limits for SAA were estimated. In dogs with neurological, neoplastic or gastrointestinal disorders (n=143), it was investigated whether a higher proportion of SAA positive dogs could be detected in cases of complications with risk of systemic inflammation. Significantly higher concentrations of SAA were measured in dogs with (range [48.75; 5,032 mg/l]), compared to dogs without systemic inflammation [0; 56.4 mg/l]. SAA was a more sensitive and specific marker of systemic inflammation (area under the receiver-operating characteristic curve (AUC) 1.00), compared to body temperature (0.6) and segmented neutrophils (best performing leukocyte marker, 0.84). A clinical decision limit of 56.4 mg/l was established giving close to perfect discrimination between dogs with and without systemic inflammation. Higher proportions of SAA-positive dogs were observed in dogs with neurological, neoplastic and gastrointestinal disorders with complications known to increase risk of systemic inflammation, compared to uncomplicated cases. The automated LAT makes SAA applicable as a relevant diagnostic marker of systemic inflammation in dogs for routine random-access real-time use in a general clinical setting.

著者

中金 聡

出版者

政治哲学研究会

雑誌

政治哲学

巻号頁・発行日

no.12, pp.148-182, 2012-02-29

著者

吉信 康夫

出版者

京都大学数理解析研究所

雑誌

数理解析研究所講究録 (ISSN:18802818)

巻号頁・発行日

vol.1202, pp.75-82, 2001-04