著者

高橋 正紘

出版者

日本視覚学会

雑誌

VISION (ISSN:09171142)

巻号頁・発行日

vol.17, no.1, pp.11-22, 2005 (Released:2019-04-19)

著者

高橋 正紘

出版者

Japan Otological Society

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.18, no.2, pp.126-130, 2008-05-25 (Released:2011-06-17)

参考文献数

19

被引用文献数

3

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Patients with Meniere's disease who suffer for long, rarely show complete recovery of advanced hearing loss. I reported a 67-year-old patient with a history of 24 years, whose 60 dB hearing loss lasting for 8 years was cured by continuous aerobic exercise. From the start of exercise, it took 4 months to the beginning of recovery and 7 months till normal hearing, respectively. Although the hearing temporarily became worse when he caught cold and stopped exercise for three weeks, it recovered completely to normal hearing 4 months later, and tinnitus disappeared. This state has been preserved for 8 months. I presumed that aerobic exercise increased local blood flow and prompted restoring processes of the inner ear function.

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.73, no.3, pp.157-157, 2014-06-30 (Released:2014-08-01)

著者

高橋 正紘

出版者

一般社団法人 日本耳科学会

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.25, no.5, pp.828-835, 2015 (Released:2019-02-13)

参考文献数

19

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8年5ヶ月間のメニエール病1,008名の集計結果、罹病期間と聴力の関係、有酸素運動とストレス対策の治療成績を報告した。発症年齢は30〜50代が64.8%を占め、発症誘因上位は、男性は職場の多忙・ストレス、女性は家庭内不和・トラブル、多忙、職場ストレス、介護、子供(親)と同居、家族の病気・死であった。難聴は罹病期間の対数にほぼ正比例して進行し、罹病4〜8年で全音域障害が55.4%に達し、罹病>8年で両側障害が増加した。患側左が右の1.4倍と有意(p<0.005)に多かった。有酸素運動とストレス対策によりめまい発作は早期に消失した。初診時、低音障害は3ヶ月以上、高音・全音域障害は6ヶ月以上観察した319名(平均観察期間1年5ヶ月)で、治療後、罹病6ヶ月〜8年の集計と全集計で聴力正常の割合が有意(p<0.00001)に増加した。今回の結果から、メニエール病はストレスによる内耳恒常性の低下が原因であり、早期のストレス対策と有酸素運動で治癒可能な疾患と確認された。

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.73, no.3, pp.158-166, 2014-06-30 (Released:2014-08-01)

参考文献数

18

---

I analyzed 33 patients with mal de debarquement who visited my clinic in the past 7 years and 8 months. The ratio of female to male patients was 3: 1; 78.8% of the patients who became sick were in their 20s to 40s; 45.4% of the patients had suffered longer than a year. Symptoms were first provoked following travelling on ships in 10 patients, boarding airplanes in 5, taking trains in 3, getting on vehicles in an amusement park in 2, getting in high-speed elevators in 1 (all the above comprised 63.6% of the patients), huge earthquakes in 3, shaking in the building in 1, and giving shows with a grampus dolphin in an amusement aqua-park in 1. Excepting sensuous or visible continuous body sways, patients often complained of brain fatigue, photophobia, having sleepiness in the daytime, headache, and discomfort related with changes in the atmospheric pressure and temperature. Past histories such as dropping, falling down or heavy brows on the neck were found in 48.5% of the patients. Since 4 patients were finally diagnosed to have suffered from cerebrospinal fluid hypovolemia, patients who are suspected as having mal de debarquement should be examined to rule out this disease. The peculiar phenomena associated with the syndrome may be explained by supposing that the brain maintains the illusion of existing in a moving space even after the body has returned to a standstill, or to terra firma, because the brain had been in anomalous or exhausted states.

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.80, no.3, pp.195-199, 2021-06-30 (Released:2021-08-04)

参考文献数

18

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To clarify the dynamic changes in the membranous lesions of Meniere's disease, the effects of aerobic exercise on different symptoms were analyzed. Out of a total of 351 patients with Meniere's disease who performed aerobic exercises for 6 months or longer who were enrolled, 338 showed improvement of one or more symptoms: disappearance of vertigo in 97.6% of cases; complete resolution of ear fullness in 60.1% of cases; improvement of hearing impairment in 38.5% of cases; complete resolution or marked decrease of tinnitus in 29.6% of cases. On the other hand, complete recovery of hearing was noted in 29.5% of the 78 patients with low-tone loss, 12.5% of the 96 patients with high-tone loss, and only 4.1% of the 170 patients with hearing loss across all frequencies. More than half of the patients with high-tone hearing loss and hearing loss across all frequencies failed to show any change in the degree of hearing loss. Considering the findings of temporal bone pathology, it seems probable that the Reissner's membrane, being ballooned and highly distended by endolymphatic hydrops, disturbs conduction of low-frequency waves by the perilymph, and the membrane, once it loses tension, is not resonant with either high-frequency waves or indeed waves of any frequency. Although aerobic exercise is effective to cure hydrops and improve membranous tension by activating homeostasis, its effect worsens with decreasing membranous tension.

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.67, no.3, pp.170-181, 2008 (Released:2008-08-01)

参考文献数

33

被引用文献数

5 1

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The purpose of this paper is to give an account of the vestibular nuclei from the point of view of phylogeny, behaviors, and neural networks of the vestibular nuclei. In the early vertebrates, the vestibular endorgans developed by isolation of the lateral line organ from the body surface. Although vestibular control based on inertial inputs works ideally under a stationary space, it breaks down in moving spaces. To compensate for the shortcoming, discomfort (motion sickness) was utilized to avoid moving spaces. Along with progress of locomotion, the vestibular cerebellum developed as a supplementary route of the vestibular nuclei to stabilize the gaze and posture; the flocculus for visual-inertial integration, and the uvula-nodulus for gravito-inertial integration. Further, the vestibular cerebellum (vermis) and the somatically arranged lateral vestibular nucleus developed for coordination of posture and four-limb locomotion. The superior vestibular nucleus is distributed centrally by the canal fibers and flocculus fibers of visual origin, and peripherally by the uvula-nodulus fibers of otolith origin. The nucleus carries spatial rotation with gravito-inertial axis to the ocular motor nuclei. Body balance is maintained by a somatic-to-spatial transformation of the coordinates, that is, transfer of contents of the cerebellum-fastigial-and-vestibular nuclues routes to the vestibular nucleus-motor nucleus routes. Thus, gaze and posture are stable when spatial coordinates remain still in space, but they become unstable when the coordinates are moving in space.

著者

高橋正紘著

出版者

築地書館

巻号頁・発行日

1997

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.67, no.3, pp.213-221, 2008 (Released:2008-08-01)

参考文献数

23

被引用文献数

1 1

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From numerous clinical investigations and questionnaire surveys, I have obtained the following results regarding Meniere's disease. 1. Patients with Meniere's disease, as compared to the control population, differ little in lifestyles or daily anxieties, but possess significantly (p<0.01) stronger self-inhibition and engrossment. Meniere's disease may be caused by discontent with others' expression of gratitude or appraisal. 2. Low-tone sensorineural hearing loss, which resembles Meniere's disease except in not being associated with vertigo, is a milder form of Meniere's disease that occurs when the causative factors, both personal and environmental, are less severe or more transient. 3. Methods for prevention and therapy of Meniere's disease have been provided by our studies. Patients should be instructed (1) to understand the causative factors, (2) to decrease self-inhibition and not be concerned about others' expression of gratitude or appraisal, (3) to sleep well and to perform aerobic exercises, and (4) to enjoy chatting, singing or hobbies. 4. Long-lasting 60-dB hearing loss recovered to normal hearing in a 66-year-old patient with Meniere's disease after he performed aerobic exercises three times a week for several months. The results in this case suggest that the most important aspect in the treatment of Meniere's disease is increase of the local blood flow, which can be achieved by continuous aerobic exercises.

著者

高橋 正紘

出版者

一般社団法人 日本耳科学会

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.20, no.5, pp.727-734, 2010 (Released:2012-08-31)

参考文献数

20

被引用文献数

7

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めまい専門施設の4年間のメニエール病患者411名(男性162名、女性249名)に対し、ライフスタイル正常化と有酸素運動を実践し(1回1時間以上を週3回以上)、原則無投薬、月一回の受診の治療を実施した。6ヶ月以上観察した83名で、めまい消失55.4%、ほとんどない27.7%、時々ある10.8%、しばしばある6.0%であった。6ヶ月以上観察した102名129耳で、初診時の低音障害からの改善47.7%、高音障害からの改善33.3%、全音域障害からの改善26.6%であった。固定した高音障害、全音域障害の改善には、非日常的な頻度・量の有酸素運動が必要であった。有酸素運動が内耳局所の循環を改善させ、水腫を改善させると推測された。発症誘因の調査結果を考慮すると、メ病は心身の奉仕や頑張りに対する報酬不足が、情動中枢を介し内耳循環不全を招き、内リンパ水腫を生む可能性が示唆された。

著者

奥田 稔 高坂 知節 三宅 浩郷 原田 康夫 石川 哮 犬山 征夫 間口 四郎 新川 秀一 池野 敬一 松原 篤 稲村 直樹 中林 成一郎 後藤 了 小野寺 亮 遠藤 里見 亀井 民雄 室井 昌彦 馬場 廣太郎 島田 均 舩坂 宗太郎 大橋 伸也 鄭 正舟 小澤 実佳 八木 聰明 大久保 公裕 後藤 穣 服部 康夫 上野 則之 柏戸 泉 大塚 博邦 山口 潤 佃 守 池間 陽子 坂井 真 新川 敦 小林 良弘 佐藤 むつみ 山崎 充代 藤井 一省 福里 博 寺田 多恵 小川 裕 加賀 達美 渡辺 行雄 中川 肇 島 岳彦 齋藤 等 森 繁人 村上 嘉彦 久松 建一 岩田 重信 井畑 克朗 坂倉 康夫 鵜飼 幸太郎 竹内 万彦 増田 佐和子 村上 泰 竹中 洋 松永 喬 上田 隆志 天津 睦郎 石田 春彦 生駒 尚秋 鈴木 健男 涌谷 忠雄 宮國 泰明 夜陣 紘治 森 直樹 田頭 宣治 宮脇 浩紀 青木 正則 小林 優子 高橋 正紘 沖中 芳彦 遠藤 史郎 池田 卓生 関谷 透 奥園 達也 進 武幹 前山 忠嗣 恒冨 今日子 増山 敬祐 浅井 栄敏 土生 健二郎 中崎 孝志 吹上 忠祐 角田 憲昭 渡辺 隆 野口 聡 隈上 秀伯 吉見 龍一郎 茂木 五郎 鈴木 正志 大橋 和史

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.42, no.5, pp.633-658, 1996-09-20 (Released:2013-05-10)

参考文献数

21

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通年性アレルギー性鼻炎患者211例を対象に, KW-467910mg/日 (KW群) の有効性, 安全性および有用性をoxatomide 60mg/日 (OX群) を対照薬として多施設二重盲検群間比較試験により検討した.最終全般改善度の「改善」以上は, KW群61-6%, OX群57.6%で, 両群間に有意差は認められなかつたが, 同等性の検証を行った結果, KW群はOX群と比較して同等ないしそれ以上と考えられた. 概括安全度の「安全性に問題なし」と評価された症例は, KW群68.0%, OX群61.4%で, 両群間に有意差は認められなかった. 主な副作用症状は両群とも眠気であった. 有用度の「有用」以上は, KW群54.9%, OX群50.5%であり両群間に有意差はなかったが, KW群の方がやや有用率が高かった.以上の成績より, KW-4679は通年性アレルギー性鼻炎に対して, 臨床的に有用性の高い薬剤であると考えられた.

著者

高橋 正紘

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.70, no.3, pp.204-211, 2011 (Released:2011-08-01)

参考文献数

39

被引用文献数

1 2

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I have investigated lifestyles, behavior patterns, causative factors, and progression of hearing loss in many patients with Meniere's disease, and found that lack of recompense for pressure of business, patience or service is responsible for the onset or progression of the disease. Further, aerobic exercise proved very effective to stop vertigo and improve fixed hearing loss. Three years ago, I advocated a new therapy for Meniere's disease consisting of aerobic exercise and countermeasures to remove the harmful factors in daily life (aiming at good sleep, omission, and relaxation). Because the new therapy has been far more effective than any conventional therapies, we must renew the treatment concept of and therapeutic strategy for Meniere's disease. I suspect the possibility that the CNS emotional center, stimulated by lack of recompense against stress in activities of daily living, influences the hypothalamus, which in turn reduces blood flow to the inner ear, and produces endolymphatic hydrops. Aerobic exercise, together with correction of irregular or inactive lifestyles, removes unhealthy factors, improves the subject's general physical condition, and finally cures endolymphatic hydrops.